SEURAT-1 – Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing

SEURAT-1 at the “European Commission Scientific Conference Non-animal approaches – the way forward” on 6 and 7 December 2016 The European Commission organised a scientific conference in Brussels on 6 and 7 December 2016 to engage the scientific community and relevant stakeholders in a debate on how to exploit cutting edge advances in biomedical and … Read more


On behalf of the SEURAT-1 Symposium Organising Committee, we are proud to announce that the registrations to the to the SEURAT-1 Symposium entitled Painting the future animal-free safety assessment of chemical substances: Achievements of SEURAT-1 taking place on 4 December 2015 in Brussels are now open! The Symposium is open to the public, you can … Read more


Glossary: 3Rs   Reduction, replacement, refinement – defined by Russel & Birch 1959 ADME Absorption, Distribution, Metabolism, and Excretion. ADME describes the disposition of a pharmaceuticalcompound within an organism. Analogue and / or category approach The terms category approach and analogue approach describe techniquesfor grouping chemicals. The term analogue approach is used when the grouping is … Read more

SEURAT-1 Annual Reports

The SEURAT-1 research initiative will publish a series of six Annual Reports. These Annual Reports provide a comprehensive overview about developments ultimately targeting the replacement of animal tests in the field of repeated dose systemic toxicity assessment. The Annual Reports will be made available through the SEURAT-1 secretariat (COACH), in the form of printed books … Read more


The SEURAT-1 cluster joins the research efforts of over 70 European universities, public research institutes and companies and collaborates with organisations in the US. The participation of SMEs in the Research Initiative is high (more than 30%). This may be partly due to the nature of the Research Initiative and partly due to the simplified … Read more

SEURAT-1 Fourth Annual Meeting

The SEURAT-1 cluster assembled for its fourth annual meeting in Barcelona on 5-6 February 2014. With the collective aim of ultimately replacing in vivo repeated dose systemic toxicity testing with animal-free solutions, SEURAT-1 is the largest EU initiative ever undertaken on alternative methods. The cluster comprises 70 European research partners that are co-financed (equally) through … Read more

Partners and People

The composition of the SEURAT-1 cluster is unique, as toxicologists, biologists from different disciplines, pharmacists, chemists, bioinformaticians and leading experts from other domains will closely work together on common scientific objectives. SEURAT-1 is open for collaboration with other, related international activities. SEURAT-1 is unique in several aspects: Joint funding by the European Commission and a … Read more


The goal of HeMiBio is to develop a hepatic microfluidic bioreactor from human iPSC-derived hepatocytes, hepatic sinusoidal endothelial cells (HSEC) and stellate cells (HSC), suitable for inclusion in a repeated dose toxicity testing strategy of pharmaceuticals/cosmetic ingredients. The successful creation of such a liver-device requires (a) homotypic and heterotypic interactions between the three cell types … Read more

SEURAT-1 in the press

SEURAT-1 : Bilan de 5 ans de recherches sur les alternatives aux tests sur animaux (in French), 11 December 2015. Read the article on Premium Beauty News. SEURAT-1: The results of a five-year research program on animal-free assessment of chemical substances, 11 December 2015. Read the article on Premium Beauty News. Seurat-1 holds final symposium, … Read more

Other related documentation

To read articles mentioning SEURAT-1 in the scientific and non-scientific press, see the section Press Corner. Related documents published online: Joint Research Centre (JRC), Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches, September 2015 European Chemicals Agency (ECHA), Read-Across Assessment Framework (RAAF), May 2015 European Food Safety Authority (EFSA), Modern methodologies and tools … Read more