SEURAT-1 - Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing

‘Stem Cells for Relevant efficient extended and normalized TOXicology’ (SCR&Tox): Stem cell differentiation for providing human-based organ specific target cells to assay toxicity pathways in vitro Scientific coordinator: Marc Peschanski, INSERM/UEVE 861, I-STEM/AFM, Evry / France

‘Hepatic Microfluidic Bioreactor’ (HeMiBio): Development of a hepatic microfluidic bioreactor mimicking the complex structure and function of the human liver Scientific coordinator: Catherine Verfaillie, Interdepartmental Stem Cell Institute, Katholieke Universiteit Leuven / Belgium

‘Detection of endpoints and biomarkers for repeated dose toxicity using in vitro systems’ (DETECTIVE): Identification and investigation of human biomarkers in cellular models for repeated dose in vitro testing Scientific coordinator: Jürgen Hescheler, Institute for Neurophysiology, University Hospital Cologne / Germany

‘Integrated In Silico Models for the Prediction of Human Repeated Dose Toxicity of COSMetics to Optimise Safety’ (COSMOS): Delivery of an integrated suite of computational tools to predict the effects of long-term exposure to chemicals in humans based on in silico calculations Scientific coordinator: Mark Cronin, School of Pharmacy and Chemistry, Liverpool John Moores University / United Kingdom

‘Predicting long term toxic effects using computer models based on systems characterization of organotypic cultures’ (NOTOX): Development of systems biological tools for organotypic human cell cultures suitable for long term toxicity testing and the identification and analysis of pathways of toxicological relevance Scientific coordinator: Elmar Heinzle, Biochemical Engineering, Saarland University, Saarbrücken / Germany

‘Supporting Integrated Data Analysis and Servicing of Alternative Testing Methods in Toxicology’ (ToxBank): Data management, cell and tissue banking, selection of “reference compounds” and chemical repository Scientific coordinator: Barry Hardy, Douglas Connect, Zeiningen / Switzerland

‘Coordination of projects on new approaches to replace current repeated dose systemic toxicity testing of cosmetics and chemicals’ (COACH): Cluster level coordinating and support action Coordinator: Bruno Cucinelli, ARTTIC, Paris / France.