SEURAT-1 - Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing

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last name	first name	project involved	institution name
Alov	Petko	COSMOS	Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences	Petko Alov +359 2 9793647 - petko[dot]alov[at]biophys[dot]bas[dot]bg Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences Acad. G. Bonchev Str., Bl. 105, 1113 Sofia, Bulgaria, Bulgaria Resume Petko Alov, graduated with a MSc degree in neurobiology from the Moscow State University "M. Lomonosov" (1980). He worked in the fields of free-radical mediated toxicity and antioxidant research in the Institute of Physiology, Bulg. Acad. Sci. and Facolta di Farmacia, Universita degli studi di Siena, and currently in the fields of bioinformatics and computational chemistry in the Institutes of Biophysics and Biomedical Engineering and of Mathematics and Informatics, Bulg. Acad. Sci. Current research interests include QSAR and quantum mechanics modelling of antioxidant reactions. Publications Dikalov S., P. Alov, D. Rangelova - Role of Iron Ion Chelation by Quinones in Their Reduction, OH-Radical Generation and Lipid Peroxidation, Biochem. Biophys. Res. Commun. 195: 113-119 (1993). Alov P., M. Koleva, A. Kastelova. In vitro effect of calcium channel blockers and beta-adrenergic blocking agents on microsomal lipid peroxidation and cytochrome P-450 content. - Exp. Toxicol. Pathol. 51: 277-281 (1999). Alov P., Valoti M., Sgaragli G.-P., Pessina F., Saponara S. Inhibition of iron-dependent decomposition of H₂O₂ as a method for assessing the free-radical-scavenging activity of novel antioxidants in a hydrophilic environment, In: "Proceedings of FAIR conference on food antioxidants and human health", Siena, 35-46 (2001). Contribution to the project Participation in: (i) collection of relevant information and data related to the in vivo toxicity of cosmetics; (ii) evaluation of existing QSAR models predicting the chronic toxicity endpoints for groups of chemicals of the cosmetic inventory; (iii) application of in silico methods for the purpose of long-term toxicity prediction of cosmetic ingredients: grouping of chemicals into categories and read-across, development of new QSAR models. Involved http://www.biomed.bas.bg/
Andersson	Tommy	SCR&Tox	Clinical Pharmacology and DMPK	Tommy Andersson + 46 31 7761534 - Tommy[dot]b[dot]andersson[at]astrazeneca[dot]com Clinical Pharmacology and DMPK AstraZeneca R&D, Mölndal, S-431 83 Mölndal, Sweden Resume Tommy B. Andersson is Senior Principal Scientist in drug disposition in the DMPK Centre of Excellence. Tommy joined Astra Hässle 1993 and has held various positions in DMPK. From 2003 through 2008 he was the preclinical scientific lead for Exanta hepatotoxic investigations. In 2003 he was also appointed Professor at Karolinska Institutet, Department of Physiology and Pharmacology, Section of Pharmacogenetics in Stockholm. Tommy has an extensive experience in leading and coordinating international industrial and academic research collaborations. He has published over 125 original articles and reviews in the fields of environmental toxicology and drug metabolism in refereed journal. Publications Ainscow EK, Pilling JE, Brown NM, Orme AT, Sullivan M, Hargreaves AC, Cooke EL, Sullivan E, Carlsson S, Andersson TB (2008) Investigations into the liver effects of ximelagatran using high content screening of primary human hepatocyte cultures. Expert Opinion on Drug Safety 7: 351-365. Kanebratt KP, Andersson TB (2008) Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies. Drug Metab Dispos. 36: 1444-1452. Keisu M, Andersson TB (2010) Drug induced liver injury in human: The case of ximelagatran. Handbook of experimental Pharmacology 196, Adverse drug reactions, pp 407-418, Springer –Verlag Berlin Heidelberg. Contribution to the project In WP2 Clinical Pharmacology and DMPK will perform functional analysis of the cells developed for tox screening. Partner 10 will functionally characterize both xenobiotic metabolism and important transporter functions like the OATP and OCT uptake transporters and several efflux transporters (Pgp, BSEP, BCRP, MRP2 and MATE). In WP3 develop assays for toxicity and analyse toxicity response (dose response) in differentiated hES cells and iPS cells with cell lines as compared with cell lines. Involved www.astrazeneca.com
Arvidson	Kirk	COSMOS	U.S. FDA, Office of Food Additive Safety	Kirk Arvidson 1-301-436-1152 - kirk[dot]arvidson[at]fda[dot]hhs[dot]gov U.S. FDA, Office of Food Additive Safety 5100 Paint Branch Parkway, College Park, MD 20740, U.S.A. Resume Ph.D. in Organic Chemistry, Iowa State University, 1998; B.S. in Chemistry, Purdue University, 1992; September 2000 – Present. U.S. FDA, Chemistry Review Scientist, Office of Food Additive Safety, U.S. FDA. Duties include the scientific review of chemistry information in premarket notifications for food-contact substances and the estimation of probable consumer exposure to these additives from their notified and regulated uses in or on food, and estimating exposure to adulterants in food. Team Leader for the Office’s SAR Team. The five-member team provides structure activity relationship and computational toxicology analyses of food additives and their impurities for regulatory decisions regarding the safety and authorization of food-contact substances. Publications Luis G Valerio Jr, Chihae Yang, Kirk B Arvidson and Naomi L Kruhlak“A structural feature-based computational approach for toxicology predictions” Expert Opinion on Drug Metabolism & Toxicology, 2010, 6(4), 505. Kirk B. Arvidson. Luis G. Valerio, Jr., Marilyn Diaz, and Ronald F. Chanderbhan “In Silico Toxicological Screening of Natural Products” Toxicology Mechanisms and Methods, 2008, 18, 229. C. Yang, C. H. Hasselgren, S. Boyer, K. Arvidson, S. Aveston, P. Dierkes, R. Benigni, R. D. Benz, J. Contrera, N. L. Kruhlak, E. J. Matthews, X. Han, J. Jaworska, R. A. Kemper, J. F. Rathman and A. M. Richard “Understanding Genetic Toxicity Through Data Mining: The Process of Building Knowledge by Integrating Multiple Genetic Toxicity Databases” Toxicology Mechanisms and Methods, 2008, 18(2-3), 277. Contribution to the project - Involved www.fda.gov
Balbirnie	Edward	SCR&Tox	Ectycell SAS	Edward Balbirnie +33 141 83 99 09 ext 758 - Edward[dot]balbirnie[at]cellectis[dot]com Ectycell SAS 102 avenue Gaston Roussel, 93235 Romainville, France Resume Edward Balbirnie, Ph.D., joined Ectycell as Chief Operations Officer in July 2010 with 23 years international experience in the biotechnology and pharmaceutical industry. Prior to joining Ectycell, Dr. Balbirnie was Director of Bioproduction at LFB Biotechnologies in Paris, France with responsibility for process development and clinical manufacture of a number of monoclonal antibodies and transgenic proteins. Prior to this, he helds the positions of Director of Quality Assurance at Elan's solid dose manufacturing site in Athlone, Ireland during the validation and start-up of a new sterile fill finish facility, Director of Quality Operations with overall responsibility for all quality aspects relating to the development of anti-cancer cell therapy therapeutics at IDM in Paris, France and Quality Control Manager on gene therapy and other biotech pipeline products at Pfizer Ireland Pharmaceuticals, Dublin, Ireland. Dr. Balbirnie started his career in the diagnostics industry in Ireland focusing on infectious diseases and held a number of supervisory and management positions with Noctech Ltd., Cambridge Biotech Corporation, Biotrin International and Trinity Biotech over an 11 year period. Dr. Balbirnie holds a B.Sc. in Biotechnology from Dublin City University, a M.Sc. in Pharmaceutical Manufacturing Technology (Qualified Person) from Trinity College Dublin and Ph.D. in Medical Microbiology from University College Dublin. He was also awarded the Certified Diploma in Accounting and Finance from the Association of Chartered Certified Accountants. Publications Breslin NP, Lee JM, Buckley MJ, Balbirnie E, Rice D, O'Morain CA. Validation of serological tests for Helicobacter pylori infection in an Irish population. Ir J Med Sci. 2000 Gilks CF, Balbirnie E. Testing sputum samples for HIV antibodies, using a rapid, saliva-card test system. Ann Trop Med Parasitol. 1997 Contribution to the project Team Manager Involved http://www.cellectis.com
Barbe	Laurent	HeMiBio	CSEM SA, Nanomedicine Division	Laurent Barbe + 41 81 307 81 31 - laurent[dot]barbe[at]csem[dot]ch CSEM SA, Nanomedicine Division Bahnhofstrasse 1, CH-7302 Landquart, Switzerland Resume Laurent Barbe received his MSc degree in Physics in 1997 and got his PhD degree in Biomedical Engineering in 2001 from University Paris 7 in the field of blood and biomaterials. He successively worked in the field of Bioengineering and Proteomics at University of Technology of Compiegne (France), Harvard Med. School (USA) and KTH (Sweden) focusing on bioreactor, microfluidics and microscopy. In 2008, he pursued his research at the CSEM SA, Nanomedicine Division, in Landquart, Switzerland, as a project leader in the Cell Systems Section dealing with microfluidics and 3D cell culture systems. Publications Barbe Let al., Molecular and Cellular Proteomics, 2008, 7, pp.499-508. Berthiaume F., Barbe L et al., J Surg Res, 2008, 152, pp.54-60. David B., Barbe L et al., Int J of Artif Organs , 2006, 29, pp.756-763. Contribution to the project The role of the CSEM in HeMiBio is to develop and integrate innovative electro-chemical microsensors, such as ion-selective electrodes, in the 3D-bioreactors to allow assessment of liver function (e.g. oxygen uptake, ammonium). Among the microsensors that will be selected to monitor specific hepatic functions ammonium-selective microelectrode, will be located in the direct vicinity of the cells. One of the critical hepatic functions is the ability to detoxify ammonia by converting it to urea within the urea cycle. At physiological pH, ammonia, NH3, mainly appears in the protonated form NH4+ that can easily be detected by ion-selective microelectrode technique. As a Bio-engineer, the specific role of Dr. Barbe in the project will be to bridge the requirements from the biologists in the consortium and available technologies from the sensor specialists. Involved www.csem.ch
Bassan	Arianna	COSMOS	S-IN Soluzioni Informatiche srl	Arianna Bassan +39 0444 1821160 - arianna[dot]bassan[at]s-in[dot]it S-IN Soluzioni Informatiche srl Via Ferrari 14, 36100 Vicenza, Italy Resume Dr Arianna Bassan is an applications scientist. She is a well-recognized investigator in computational chemistry with significant experience with the use of in silico methods for the regulatory assessment of chemicals. She had acquired a diverse and in-depth knowledge in the fields of: a) computational chemistry especially for systems of biological interest (Stockholm University); b) computational toxicology (European Commission); c) project information support and chemoinformatics (Merck & Co); e) data mining (S-IN Soluzioni Informatiche). Publications BassanA, Worth AP (2007) Computational Tools for Regulatory Needs in Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals, S. Ekins (editor), Wiley & Sons, Inc BassanA., Worth A. P., The Integrated Use of Models for the Properties and Effects of Chemicals by means of a Structured Workflow, QSAR Comb. Sci., 27, 6-20, (2008) BassanA., Zou W., Reyes E., Himo F., Cordova A., The Origin of Stereoselectivity in Primary Amino Acid Catalyzed Intermolecular Aldol Reactions, Angew. Chem. Int. Edit., 43, 7028-7032, (2005). Contribution to the project She is part of the team who will aim at optimising in silico methods, such as (Q)SAR and read-across, for the purpose of long-term toxicity prediction of cosmetic ingredients. The tasks of the team include: a) Characterisation of the chemical space of cosmetic inventories; b) Read-across, grouping and structural analogues analysis; c) Evaluation of existing QSAR models and expert systems for cosmetic ingredients; d) Development of new QSAR regression and classification models. e) Application of innovative chemometric tools. Involved www.s-in.it
Bataller	Ramon	HeMiBio	Liber Unit, Hospital Clinic, IDIBAPS, Barcelona	Ramon Bataller 34606304372 - bataller[at]clinic[dot]ub[dot]es Liber Unit, Hospital Clinic, IDIBAPS, Barcelona Villarroel 170, Barcelona 08036, Spain Resume Physician-scientist. Faculty member of the Liver Unit, Hospital Clinic, Barcelona (2003-). PhD in the Cellular Basis of Hepatic Fibrosis (2000). Post-doctoral followship in the University of North Carolina at Chapel Hill (2000-2003). Member of the Scientific Committee of EASL. Associate Editor of Gut. Publications Bataller R, Schwabe RF, Choi YH, et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 2003;112:1383-1394. Sancho-Bru P, Bataller R, Gasull X, Colmenero J, Khurdayan V, Gual A, Nicolas JM, Arroyo V, Gines P. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol. 2005 Aug;43(2):272-82 Domínguez M, Miquel R, Colmenero J, et al.. Hepatic expression of CXC chemokines influence survival and portal hypertension in patients with alcoholic hepatitis. Gastroenterology 2009;136:1639-50. Contribution to the project Partners in WP1, 3, 5 and coordinator of WP6. IDIBAPS will be involved in: 1- the isolation of primary human hepatic stellate cells and other liver cells as a reference for cells generated from iPS; 2- the development of culture conditions to expand quiescent and activated stellated cells; 3- providing quiescent and activated stellate cells for WP1, 3 and 5; 4- evaluating the effect of ECM and medium modifications on primary HSC phenotype; 5- evaluating stellate cell phenotype in 2D and 3D culture; 6-developing in vitro conditions for human precision cut liver slices. Involved www.idibaps.org
Batista Leite	Sofia	HeMiBio	Vrije Universiteit Brussel	Sofia Batista Leite +3224774419 - Sofia[dot]Batista[dot]Leite[at]vub[dot]ac[dot]be Vrije Universiteit Brussel Laarbeeklaan 103, 1090 Brussel, Belgium Resume Sofia Batista Leite finished her PhD degree on March 2012 on Biochemistry specialization in Biotechnology at Instituto de Tecnologia e Quimica Biologica (ITQB) from Universidade Nova de Lisboa, entitled Novel Approaches for Culturing Hepatocytes for Drug Testing Applications. During her PhD, under the supervision of Dr. Paula Alves at Animal Cell Technology (ACT) Unit - IBET/ITQB she worked with 3D spheroid hepatocyte cultures in stirred tanks. Part of her PhD was developed on the European reference Laboratory on Alternative Methods (ECVAM – European Center for Validation of Alternative Methods, Ispra, Italy) under the supervision of Dr. Sandra Coecke where she also got the opportunity to be enrolled in other projects regarding Animal Alternative Testing Systems (February 2010 – June 2011). Before her PhD Sofia had worked with 3D brain cultures in stirred systems at ACT Unit - IBET/ITQB (October 2005 – October 2007). Publications Leite SB, Wilk-Zasadna I, Zaldivar JM, Airola E, Minnecozzi M, Reis-Fernandes M, Guillouzo C, Guillou C, Chesne C, Guillou C, Alves PM, Coecke S. “3D HepaRG Model for Toxicokinetic and Toxicodynamic Purposes” (submited). Coecke S, Pelkonen O, Leite SB, Bernauer U, Bessems J, Bois F, Gunder-remy U, Loizou G, Testai E, Zaldivar JM. “Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches.” Toxicology in Vitro (submited). Tostões RM, Leite SB, Brito C, Serra M, Jensen J, Bjorquist P, Carrondo MJT, Alves PM. “Human liver cell spheroids in extended perfusion bioreactor culture for repeated dose drug testing.” Hepatology 55(4) (2012):1227-36 Contribution to the project HeMiBio: Hepatic Stellate Cells Biologist Involved http://cyto.vub.ac.be/
Benfenati	Emilio	ToxBank	Istituto di Ricerche Farmacologiche Mario Negri	Emilio Benfenati +39-02-39014420 - emilio[dot]benfenati[at]marionegri[dot]it Istituto di Ricerche Farmacologiche Mario Negri Via Giuseppe La Masa 19, Italy Resume He is the Head of the Laboratory of Environmental Chemistry and Toxicology at the Mario Negri Institute. He has long experience in the coordination of EC projects (13), and in the participation of several (16) others, many of them on toxicity and environmental modelling. He has organized international workshops on (Q)SAR. He is organizing the 2011 SETAC Meeting in Milan. He is author or co-author of more than 200 papers in international journals. His research activities include: Computational chemistry; (Q)SAR; Toxicity prediction; Environmental toxicology and l management; Environmental chemistry; Analysis of organic compounds by mass spectrometry; Metabolism studies and Risk assessment. Publications Boriani E, Mariani A, Baderna D, Moretti C, Benfenati E, ERICA: a multiparametric toxicological risk index for the assessment of environmental healthiness, Environmental International, 2010 36 : 665–674 Benfenati E, Benigni R, DeMarini D M, Helma C, Kirkland D, Martin T M, Mazzatorta P, Ouédraogo-Arras G, Richard A, Schilter B, Schoonen W G E J, Snyder R D, Yang C. Predictive models for carcinogenicity and mutagenicity: frameworks, state-of-the-art, and perspectives. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2009 ; 27 : 57-90. Roncaglioni A, Benfenati E, In silico-aided prediction of biological properties of chemicals: oestrogen receptor-mediated effects, Chem Soc Rev 2008 37: 441-450 Contribution to the project Project administrative coordination Development of test compounds selection criteria Coordination of compound repository and related activities Scientific dissemination and workshops organization Involved www.marionegri.it
Berthold	Michael R.	COSMOS	KNIME.com AG	Michael R. Berthold +49 7531 88 2202 - michael[dot]berthold[at]knime[dot]com KNIME.com AG Technoparkstrasse 1, 8005 Zurich, Switzerland Resume since Aug 2006 - CEO of KNIME – the company behind the open source data mining platform KNIME since Oct 2003- Full Professor, Nycomed-Chair for Applied Computer Science, University of Konstanz, Germany. 2000 - 2003- Director of Data Analysis, Tripos Inc., South San Francisco, USA. 1999 - 2000- Lecturer, University of California at Berkeley, USA. 1997 - 1999- Research Fellow, Berkeley Initiative in Soft Computing (BISC), University of California at Berkeley, USA. 4/1994 - 6/1994- Visiting Research Assistant, Sydney University, Australia. 9/1993 - 8/1997- Research Assistant, Karlsruhe University, Germany. 1/1993 - 7/1993- Research Engineer, Intel Corp., Santa Clara, USA. 10/1991 - 12/1992- Visiting Researcher, Carnegie Mellon University, Pittsburgh, USA. Publications Christian Borgelt, Michael R. Berthold, Mining Molecular Fragments: Finding Relevant Substructures of Molecules, IEEE Data Mining, pp. 51-58, IEEE Press, 2002 (http://www.inf.uni-konstanz.de/bioml2/publications/Papers2002/BoBe02_mofa_icdm.pdf) Michael R. Berthold, Christian Borgelt, Frank Höppner and Frank Klawonn: Guide to Intelligent Data Analysis, Springer Verlag, 2010 (ISBN: 978-1-84882-259-7, http://www.springer.com/computer/ai/book/978-1-84882-259-7) Berthold, Michael R., Cebron, Nicolas, Dill, Fabian, Gabriel, Thomas R., Kötter, Tobias, Meinl, Thorsten, Ohl, Peter, Thiel, Kilian, Wiswedel, Bernd, KNIME - The Konstanz Information Miner, SIGKDD Explorations, vol. 11, no. 1, 2009 (http://www.sigkdd.org/explorations/issues/11-1-2009-07/p4V11n1.pdf) Contribution to the project The open source platform KNIME is the application that is used to integrate the project’s algorithms and the partner’s software into a central common workflow platform that is freely available. KNIME.com is a software company. Our contribution is in making available the KNIME platform, and giving free access to our commercial professional software tools around the open source platform. KNIME.com is educating the project partners in the usage of the KNIME platform and the integration possibilities it provides. Partner’s software developers are trained to integrate their software and algorithms seamlessly into the platform. They are guided and supported in their development. In addition KNIME.com works together with the partners in order to assure best possible integration and compliance with the KNIME methodology. KNIME.com is consulting partners during the creation of workflows in KNIME that implement the project’s flows and make them easily available and accessible to others. KNIME.com also consults in any data mining or machine learning task and general KNIME extension programming issues. Involved http://www.knime.com
Bertile	Fabrice	NOTOX	CNRS-UdS, UMR7178, Institut Pluridisciplinaire Hubert Curien, LSMBO	Fabrice Bertile +33.(0)3.68.85.26.81 - fbertile[at]unistra[dot]fr CNRS-UdS, UMR7178, Institut Pluridisciplinaire Hubert Curien, LSMBO ECPM, Bat R5-0, 25 rue Becquerel, F-67087 Strasbourg, France Resume Fabrice Bertile is a permanent researcher of the French National Center for Scientific Research (CNRS). He mainly investigates the adaptive mechanisms to environmental changes through multidisciplinary approaches, including metabolic biochemistry and analytical chemistry. His domain embeds the physiology of energy homeostasis together with developments of functional proteomics approaches. Publications F. Bertileet al, 2009, Aproteomic approach to identify differentially expressed plasma proteins between the fed and prolonged fasted states, Proteomics, 9:148-158 F. Bertileet al., 2008, Proteomicscan help to gain insights into metabolic disorders according to body reserve availability, Current Medicinal Chemistry, 15:2545-2558 F. Bertileet al., 2007, Endogenous plasma peptide detection and identification in the Rat by a combination of fractionation methods and mass spectrometry, Biomarker Insights, 2: 385-401. Contribution to the project Proteomics of HepaRG cells (2D cultures and spheroids); Differential proteomics: HepaRG intracellular proteome and secretome in response to drugs Involved http://www.iphc.cnrs.fr/
Bjorquist	Petter	SCR&Tox	Cellartis AB	Petter Bjorquist 46317580940 - petter[dot]bjorquist[at]cellartis[dot]com Cellartis AB Arvid Wallgrens Backe 20, 41346 Göteborg, Sweden Resume Dr. Petter Björquist: Principal Senior Scientist, Department Head, at Cellartis AB since 2002, responsible for the areas stem cell-derived hepatocytes and beta-cells. PB has about 10 years of experience from AstraZeneca R&D, Sweden, where he was previously active in a project management team in the therapeutic area Cardiovascular Diseases. PB has gained deep knowledge in the handling of human pluripotent stem cells, differentiation of these cells into endodermal cell types, and the use of stem cells in various medicinal and industrial applications. PB is member of the company management team, is the author of ≈ 40 scientific articles, and is today heading a team of about 15 scientists at Cellartis. He is also supervising both PhD-students and postdocs, and is coordinating the major collaboration between Novo Nordisk and Cellartis on using regenerative medicine for treatment of diabetes. Publications Jensen J, Hyllner J and Björquist P. Human embryonic stem cell technologies and drug discovery. Review. Journal of Cellular Physiology. J. Cell Physiol. 219:513-9, 2009. Synnergren J, Heins N, Brolén G, Lindahl P, Hyllner J, Olsson B, Sartipy P and Björquist P. Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further towards the hepatic lineage. Volume 00, Number 00, 2009, DOI:10.1089/scd.2009.0220, Stem Cells & Development, 2009. Brolén G, Sivertsson L, Björquist P, Eriksson G, Ek M, Semb H, Johansson I, Andersson T, Ingelman-Sundberg M and Heins N. Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage. Journal of Biotechnology. 145 (2010) 284–294. Contribution to the project PB is heading all work on differentiation of pluripotent stem cells to endoderm and hepatic cell types in SCR&Tox. Involved www.cellartis.com
Boecker	Julia	NOTOX	European Research and Project Office GmbH, EURICE	Julia Boecker 4968195923397 - j[dot]boecker[at]eurice[dot]eu European Research and Project Office GmbH, EURICE Science Park Saar, Stuhlsatzenhausweg 69, 66123 Saarbrücken, Germany Resume Julia Boecker has a degree in languages and communication and has been working in EU funded projects since 2008. She joined Eurice in 2010 as a project officer. Julia is involved in the coordination and administration of EU-funded projects in the Life-Sciences sector. Her responsibilities include management and coordination of project activities, contractual management, decision making management, communication and support of dissemination and publication activities. Publications Contribution to the project Project Officer working for the Management Partner within NOTOX. Involved in the administration and management of NOTOX. Involved www.eurice.eu
Braspenning	Joris	HeMiBio	Medicyte GmbH	Joris Braspenning +49 6221 72925-32 - j[dot]braspenning[at]medicyte[dot]com Medicyte GmbH Im Neuenheimer Feld 581, Germany Resume Dr. Braspenning has been working in life science for more than 15 years. During this period he gained extensive experience in protein biochemistry and cell biology. His work was mainly focussed on the development of cell based assays used in the pre-clinical drug development process. At Medicyte, Dr. Braspenning applied his knowledge in the field of primary human cell culture, and first time managed to establish proliferating human hepatocyte culture systems. After expansion, cells differentiated and retained their typical hepatocellular characteristics.Dr. Braspenning has been working in life science for more than 15 years. During this period he gained extensive experience in protein biochemistry and cell biology. His work was mainly focussed on the development of cell based assays used in the pre-clinical drug development process. At Medicyte, Dr. Braspenning applied his knowledge in the field of primary human cell culture, and first time managed to establish proliferating human hepatocyte culture systems. After expansion, cells differentiated and retained their typical hepatocellular characteristics. Publications Braspenning, J., Marchini, A., Albarani, V., Levy, L., Ciccolini, F., Ralston, R., Gissmann, L., and Tommasino, M. (1998a). The CXXC Zn binding motifs of the Human Papillomavirus type 16 E7 onco-protein are not required for its in vitro transforming activity in rodent cells. Oncogene. 16, 1085-108 Braspenning, J., Meschede, W., Marchini, A., Müller, M., Gissmann, L., and Tommasino, M. (1998b). Secretion of heterologous proteins from Schizosaccharomyces pombe using the homologous leader sequence of phol+ acid phosphatase. BBRC. 245, 166-171 Gadal O, Strauss D, Braspenning J, Hoepfner D, Petfalski E, Philippsen P, Tollervey D, Hurt E. (2001). A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits. EMBO J 16;(14): 3695-04 Contribution to the project Using Medicyte´s innovative upcyte® technology, differentiated primary cells are driven into proliferation, without loss of phenotype. In a first step Medicyte will select, from its proprietary gene pool, a set of optimal genes that may enable in vitro cell proliferation and a better production of the required primary cells like, hepatocytes, stellate cells and sinusoidal endothelial cells. In a second step, the cells will be expanded and characteristics monitored during the proliferation and upscaling phase. Cells will be harvested and stored ready for use and growth in the bioreactor device. Involved www.medicyte.com
Bremer-Hoffmann	Susanne	SCR&Tox, DETECTIVE, COACH	Joint Research Centre, Institute for Health and Consumer Protection	Susanne Bremer-Hoffmann +39/332/785914 - Susanne[dot]Bremer[at]jrc[dot]ec[dot]europa[dot]eu Joint Research Centre, Institute for Health and Consumer Protection Via E. Fermi, 2749; I-21027 Ispra (VA), Italy Resume Susanne Bremer is holding a PhD degree in biology obtained from the Charite University Hospital Berlin in Germany. After post-doctoral research at the Federal Institute for Risk Assessment in Germany, S. Bremer joint the Institute for Health & Consumer Protection (IHCP) at the European Commission’s Joint Research Centre (JRC) and became a team member of the European Centre for the Validation of Alternative Methods (ECVAM) in 1995. Currently S. Bremer coordinates institutional activities related to test development which includes the participation in several FP 6 and FP 7 projects. S.Bremer provides support to test developer in order to ensure that toxicological in vitro tests will meet ECVAM’s criteria for entering into (pre)validation Publications Pazos P, Pellizzer C, Stummann TC, Hareng L, Bremer S. (2010) The test chemical selection procedure of the European Centre for the Validation of Alternative Methods for the EU Project ReProTect. (Reprod Toxicol. 2010 Aug;30(1):161-99). Luciano AM, Franciosi F, Lodde V, Corbani D, Lazzari G, Crotti G, Galli C, Pellizzer C, Bremer S, Weimer M, Modina SC. Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect. Reprod Toxicol. 2010 Aug;30(1):81-8 Vojnits K, Bremer S. Challenges of using pluripotent stem cells for safety assessments of substances. Toxicology. 2010 Mar 30;270(1):10-7 Contribution to the project Susanne Bremer acts as principle investigator for the JRC in SCR&TOX and DETECTIVE. In the SCR&TOX project the JRC is involved in the development of quality control criteria for iPSCs and the differentiation of pluripotent stem cells in toxicological target cells. Susanne Bremer leads the workpackage on “Assay development”. In the DETECTIVE project Susanne Bremer takes care on the coordination of the subproject “Functional Readouts”. The JRC will provide expertise to DETECTIVE on high-throughput imaging relevant for hepatoxicity and cardiotoxicity testing. Finally Susanne Bremer supports the COACH project on a day-to-day basis. Involved http://ihcp.jrc.ec.europa.eu/
Bucher	Joachim	NOTOX	Insilico Biotechnology AG	Joachim Bucher +49 711 46059421 - joachim[dot]bucher[at]insilico-biotechnology[dot]com Insilico Biotechnology AG Meitnerstraße 8, 70563 Stuttgart, Germany Resume 2011-now: Insilico Biotechnology AG, Stuttgart 2004-2010: Doctoral studies in the area of systems biology, Institute of Biochemical Engineering, University of Stuttgart 1997-2004: Study of process engineering, University of Stuttgart Publications J. Bucher, S. Riedmaier, A. Schnabel, K. Marcus, G. Vacun, T. S. Weiss, W. E. Thasler, A. K. Nüssler, U. M. Zanger and M. Reuss: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes, BMC Systems Biology, 2011, 5:66. J. Bucher, M. Reuss, U.M. Zanger: Robustness of the Drug Detoxification Metabolism in Liver Cells, Systems Biolog: Results, Progress and Innovations from BMBF Funding, 2008, Forschungszentrum Jülich, Germany. J. Bucher, T. Saußele, U. M. Zanger and M. Reuss: Robustness of the Isoenzymes Mediated Drug Detoxification Metabolism in Human Hepatocytes, Proceedings of the 2nd Conference on Foundations of Systems Biology in Engineering (FOSBE), pp. 249-254, Stuttgart, Germany, 2007. Contribution to the project Modelling of combined hepatic metabolic and regulatory network models. Modelling of pathways of toxicological relevance and of long-term toxicity Involved www.insilico-biotechnology.com
Buyl	Karolien	HeMiBio	Vrije Universiteit Brussel – Department of Toxicology	Karolien Buyl +32.2.477.45.85 - Karolien[dot]Buyl[at]vub[dot]ac[dot]be Vrije Universiteit Brussel – Department of Toxicology Laarbeeklaan 103 – 1090 Brussels , Belgium Resume Predoctoral researcher at the Department of Toxicology of the Vrije Universiteit Brussel-Belgium. Her expertise is situated in the field of liver-based in vitro modelling through the means of adult stem cell isolation, cultivation and hepatic differentiation. She is co-author of 2 publications in peer-reviewed journals. Publications Vinken M., Buyl K., Vanhaecke T., Rogiers V. (2011) Effects of RNA interference-mediated suppression of connexin43 production on the expression of differentiation markers in cultures of adult primary rat hepatocytes. ALTEX 29:3-12. De Kock J., Najar M., Bolleyn J., Al Battah F.,Rodrigues R., Buyl K., Raicevic G., Govaere O., Branson S., Meganathan K., Gaspar J., Roskams T., Sachinidis A., Lagneaux L., Vanhaecke T., Rogiers V. (2012) Mesoderm-derived stem cells: the link between the transcriptome and their differentiation potential. Stem Cells and Development:submitted. Contribution to the project Workpackage 5: * Selection of chemicals for testing hepatocellular functionality and toxicity. * Selection of cosmetic ingredients for testing hepatocellular toxicity. * Establishment of standard operating procedures for hepatocellular functionality testing. * Establishment of standard operating procedures for hepatocellular toxicity testing. Involved http://minf.vub.ac.be/~fafy/
Castiglioni	Vittorio	ToxBank	Istituto di Ricerche Farmacologiche Mario Negri	Vittorio Castiglioni +39-2-39014394 - vittorio[dot]castiglioni[at]marionegri[dot]it Istituto di Ricerche Farmacologiche Mario Negri Via Giuseppe La Masa 19, Italy Resume He works since 2005 as management assistant for the Laboratory of Environmental Chemistry and Toxicology, led by Emilio Benfenati, at the Mario Negri Institute. His role is mainly focused on the management of organizational and financial issues related to EC projects (such as CAESAR and ORCHESTRA). Other tasks include the management of internal laboratory activities, the organization of courses and workshops (he is currently involved in the organization of a workshop on REACH and QSAR and of the 2011 SETAC Meeting in Milan) and dissemination activities, with contributions to the graphic layout of publications and websites. Publications Contribution to the project Contribution to management activities of the project, as assistant of the project coordinator, with particular reference to reporting procedures. Involved www.marionegri.it
Cathomen	Toni	HeMiBio	Medizinische Hochschule Hannover	Toni Cathomen 495115325170 - Cathomen[dot]Toni[at]mh-hannover[dot]de Medizinische Hochschule Hannover Carl-Neuberg-Strasse 1, Germany Resume Dr. Cathomen’s main interest is the characterization of the mechanisms that regulate the repair of DNA double-strand breaks (DSBs) and the exploitation of this knowledge to specifically alter the genetic makeup of cells. His rational genome engineering approach is mainly based on the use of zinc-finger nucleases (ZFNs), which can be designed to insert a site-specific DSB in a given gene of interest. The lab has made seminal contributions to the field by applying protein engineering technologies to improve the specificity of these designer nucleases. The long-term goal of his lab is to introduce specific alterations in the genome of pluripotent and multipotent stem cells to improve our understanding of DNA repair in somatic stem cells and to develop novel treatment options for patients suffering from hereditary disorders. Publications Söllü C., Pars K., Cornu T.I., Thibodeau-Beganny S., Maeder M.L., Joung J.K., Heilbronn R., and Cathomen T. (2010) Autonomous zinc-finger nucleases for targeted chromosomal deletion. Nucleic Acids Res 38, 8269-76. Händel E.-M., Alwin S., and Cathomen T. (2009) Expanding or restricting the target site repertoire of zinc-finger nucleases: The inter-domain linker as a major determinant of target site selectivity. Mol Ther 17, 104-111. Szczepek M., Brondani V., Büchel J., Serrano L., Segal D.J., andCathomen T. (2007) Structure-based redesign of the dimerization interface reduces the toxicity of zinc finger nucleases. Nat Biotechnol 25, 786-793. Contribution to the project The Cathomen lab has extensive experience with targeted modification of complex genomes using designer nucleases, such as zinc finger nucleases (ZFNs). Precise genome engineering is based on homologous recombination, which occurs with very low efficiencies in mammalian cells, including human iPSCs. The Cathomen lab will generate and apply designer nucleases in human iPSC (i) to specifically tag relevant genes with a fluorescent marker and (ii) to insert reporter cassettes into “neutral sites” in the human genome, such as the AAVS1 locus, to monitor in real-time cytotoxicity, genotoxitiy and apoptosis. Involved www.mh-hannover.de
Cellière	Géraldine	NOTOX	INRIA Paris-Rocquencourt	Géraldine Cellière +33 1 39 63 55 14 - Geraldine[dot]celliere[at]gmail[dot]com INRIA Paris-Rocquencourt Domaine de Voluceau Rocquencourt - BP 105 78153 Le Chesnay Cedex, France Resume Géraldine Cellière started her PhD under the supervision of Dirk Drasdo in October 2012, after a MSc in Cell Biology at ETH Zürich, and a French engineering school (Ecole Polytechnique). Géraldine is currently working in the fields of agent-based modeling of cell populations, including extensions to continuous reaction-diffusion equations, intracellular ODEs models and PBPK modeling. Publications Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis. Cellière G, Menshykau D, Iber D. Biol Open. 2012 Aug 15;1(8):775-88. doi: 10.1242/bio.20121339. Epub 2012 Jun 27. Plasticity of TGF-β signaling. Cellière G, Fengos G, Hervé M, Iber D. BMC Syst Biol. 2011 Nov 3;5:184. doi: 10.1186/1752-0509-5-184. Contribution to the project I am mainly involved in the WP4 of the Notox project: agent-based models of the drug toxicity on cells in monolayers, spheroids and in vivo. Involved http://www.inria.fr
Chen	Yemiao	HeMiBio	Interdepartmental Stem Cell Institute	Yemiao Chen +32-(0)16-330295 - yemiao[dot]chen[at]med[dot]kuleuven[dot]be Interdepartmental Stem Cell Institute O&N I Herestraat 49 - box 804, Leuven, Belgium Resume Yemiao CHEN, PhD, obtained his PhD degree at the China Agricultural University (CAU) in Biochemistry and Molecular biology, and did his first postdoctoral research at the National Institute of Biological Sciences, Beijing (NIBS) on the mechanism of small RNAs in Arabidopsis. He joined the laboratory of Dr. Verfaillie at K.U.Leuven in June, 2010 to work on the function of small RNAs in guiding hiPSCs differentiation towards hepatocyte-like cells. Publications Mi, S. J., Cai, T. (co-first author), Hu, Y. G., Chen, Y. M., Hodges, E., Ni, F. R., Wu, L., Li, S., Zhou, H. Y., Long, C. Z., Chen, S., Hannon, J. G., & Qi, Y. J. (2008). Sorting of Small RNAs into Arabidopsis* Argonaute Complexes is Directed by the 5’ Terminal Nucleotide. Cell, 133, 116-127. Sun, J. Y., Chen, Y. M. (co-first author), Wang, Q. M., Chen, J. & Wang, X. C. (2006). Glucose Inhibits the Expression of Triose Phosphate/phosphate Translocator Gene in Wheat via Hexokinase-dependent Mechanism. Int. J. Biochem. Cell Biol., 38, 1102-1113. Chai, M. F., Chen, Q. J., An, R., Chen, Y. M., Chen, J. & Wang, X. C. (2005). NADK2, an Arabidopsis* Chloroplastic NAD Kinase, Plays a Vital Role in Both Chlorophyll Synthesis and Chloroplast Protection. Plant Mol. Biol., 59, 553-564. Contribution to the project Enrichment of staged cells (mesendodermal, hepatoblast, fetal stage hepatocytes and adult hepatocytes) of hiPSC commitment towards hepatocytes-like cells. Transcriptome and miRNome analysis to find known/new miRNAs and their target genes during different stages of hiPSC differentiation towards hepatocyte-like cells. Potential application of these miRNAs and their target genes in regulating liver development. High-throughput deep sequencing to find potential other kind of small RNAs (e.g. siRNAs, lncRNAs) during the differentiation approach, and their function analysis. Involved none
Chesne	Christophe	NOTOX	Biopredic	Christophe Chesne +33 2 99 143614 - christophe[dot]chesne[at]biopredic[dot]com Biopredic 14 RUE JEAN PECKER , RENNES , FRANCE Resume PharmD, university of Rennes PhD, university of Rennes Scientist at Servier, Drug development lab, Orleans Scientist at Biopredic, Rennes Publications Functional expression, inhibition and induction of CYP enzymes in HepaRG cells. Toxicology in vitro Vol. 23 (4): 748-53, 2009 Utility of long-term cultured human hepatocytes as an in vitro model for cytochrome p450 induction. Drug metabolism and disposition:, Vol. 35 (2): 215-20, 2007 In vivo identification of solar radiation-responsive gene network: role of the p38 stress-dependent kinase. PloS one, Vol. 5 (5): e10776, 2010 Contribution to the project Involved www.biopredic.com
Christiaens	Wim	HeMiBio	CMST	Wim Christiaens +32-9-2645371 - W[dot]Christiaens[at]elis[dot]ugent[dot]be CMST Technology Park 914, B-9052 Gent-Zwijnaarde, BELGIUM Resume WIM CHRISTIAENS graduated from Ghent University as an electrical engineer with majors in Micro- and Opto-Electronics in 2004, and obtained his PhD in electronic engineering from Ghent University in Jan. 2009. His research was focused on the embedding of active and passive components in polyimide substrates. From Feb.1, 2009 on, he serves as a full-time exploitation manager and business developer at CMST for the valorisation of the developed CMST technologies on wearable and implantable flexible and stretchable electronics and sensor circuit technologies and applications. Publications J. Govaerts, E. Bosman, W. Christiaens, J. Vanfleteren, “Fine-Pitch Capabilities of the Flat Ultra-Thin Chip Packaging (UTCP) Technology”, IEEE Trans. on Advanced Packaging, Vol.33, No.1, pp. 72-78, Feb. 2010. P. Bauwens, A. Monte, W. Christiaens, J. Doutreloigne, J. VanfleterenImproved passive-matrix multiplexability with a modular display and UTCP technology DISPLAYS, Vol. 30(2), pp. 71-76 (2009) W. Christiaens, T. Loeher, B. Pahl, M. Feil, B. Vandevelde, J. Vanfleteren, “Embedding and Assembly of Ultrathin Chips in Multilayer Flex Boards”, Circuit World, Vol.34, No.3, pp. 3-8, 2008. Contribution to the project Main tasks of IMEC in HeMiBio are the following : integration of sensors for real-time basic culture conditions integration of sensors in 2D-bioreactors development of technology for 3D-multi-well bioreactor fabrication, esp. development of technology for sensor arrays and read-out electronics integration in a 3D-bioreactor Organisation of training events for HeMiBio partners on microsystem engineering, interconnection and packaging technology Involved http://www.cmst.be/
Clark	Matthew	ToxBank	Pharmatrope	Matthew Clark +001 610 772 4652 - mclark[at]pharmatrope[dot]com Pharmatrope 324 Croton Road, Wayne PA 19087, USA Resume 2009-present, co-founder and CSO, Pharmatrope. 2001-2008, Senior Director Scientific Computing: design and application of software to compute ligand binding free energy. 1999-2001, Product Director, SciQuest: design of enterprise software for compound safety data and inventory management. 1995-1999, Director of Marketing and New Product Development, Institute for Scientific Information: responsible for Web-delivered chemistry information products featuring structure and reaction searching, including the ISI Chemistry Server. 1988-1995, Director of Marketing, Tripos: responsible for all marketing of computational chemistry software and combinatorial library services with additional contributions to development of key algorithms. Education: Univ. Alabama, PhD. Publications Clark, Matthew; Wiseman, Jeffrey Fragment-Based Prediction of Clinical Occurrence of Long QT Syndrome and Torsade de Pointes Accepted by J. Chem. Inf. Model September 2009. Matthew Clark, Sia Meshkat, George Talbot, Zenon Konteatis, Jennifer Ludington, Jinming Zou, and Jeffrey S. Wiseman* Developing Technologies in Biodefense Research: Computational Drug Design Drug Development Research, 2009, 70, 279–287. Clark, Matthew; Meshkat, Sia; Talbot, George; Carnevali, Paolo; Jennifer Ludington, Jennifer; Fujimoto, Ted; Wiseman , Jeff Fragment-Based Computation of Binding Free-Energies by Systematic Sampling Accepted J. Chem. Inf. Model April 2009. Clark, Matthew; Meshkat, Sia; Wiseman, Jeff Grand Canonical Free Energy Calculations of Protein-Ligand Binding J. Chem. Inf. Model., 2009, 49 (4), pp 934–943 Clark, Matthew; Song, M. Development and Evaluation of an in Silico Model for hERG Binding J. Chem. Inf. Comput. Sci. 2006; 46(1); 392-400. Clark, Matthew; Guarnieri, Frank; Shkurko, Igor; Wiseman, Jeff Grand Canonical Monte Carlo Simulation of Ligand-Protein Binding J. Chem. Inf. Comput. Sci.; 2006; 46(1); 231-242. Clark, Matthew Generalized Fragment-Substructure Based Property Prediction Method J. Chem. Inf. Model; 2005; 45(1); 30-38. Contribution to the project Dr Clark brings to the project extensive experience in drug discovery, cheminformatics, and enterprise-level scientific software development. He published the first QSAR models for toxicity based on human adverse events data. These models provide high reliability and at the same time link chemical structure to toxicity in a way that is directly interpretable. His primary contributions to the project are based on extensive past experience building and managing enterprise cheminformatics systems as well as a scientific expertise in computational chemistry. These contributions include: Compounds Database user requirements gathering and analysis, establishing selection criteria for ToxBank Gold Compounds, development and distribution of protocols and SOPs, and operation and support of the ToxBank Gold Compounds Database. Involved www.pharmatrope.com
Coll	Mar	HeMiBio	Institut d’Investigacions Biomediques August Pi I Sunyer	Mar Coll 93 2275400 ext 4535 - mdcoll[at]clinic[dot]ub[dot]es Institut d’Investigacions Biomediques August Pi I Sunyer C/ Rosellón, 153, Planta 3, Barcelona, 08036, Spain Resume Mar Collreceived her Ph.D in 2010 from the University Autonomous of Barcelona. She worked on the molecular mechanisms involved in the physiopathology of portal hypertension in the Liver Unit of Hospital Vall d’Hebron de Barcelona, Institut de recerca Vall d’Hebron (VHIR). In september 2011 she joined the group of Dr. Ramon Bataller and Dr.Pau Sancho-Bru, at the Liver Unit of Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)as a postdoctoral researcher and worked on the role of liver progenitor/stem cells in chronic liver disease. Publications Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension.Coll M, Genescà J, Raurell I, Rodríguez-Vilarrupla A, Mejías M, Otero T, Oria M, Esteban R, Guardia J, Bosch J, Martell M. J Hepatol. 2008 Jul;49(1):43-51 Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension.Coll M, Martell M, Raurell I, Ezkurdia N, Cuenca S, Hernández-Losa J, Esteban R, Guardia J, Bosch J, Genescà J. Liver Int. 2010 Apr;30(4):593-602 Physiopathology of splanchnic vasodilation in portal hypertension.Martell M, Coll M, Ezkurdia N, Raurell I, Genescà J. World J Hepatol. 2010 Jun 27;2(6):208-20. Contribution to the project Partners in WP1, 3, 5 and coordinator of WP6. IDIBAPS will be involved in: 1- the isolation of primary human hepatic stellate cells and other liver cells as a reference for cells generated from iPS; 2- the development of culture conditions to expand quiescent and activated stellated cells; 3- providing quiescent and activated stellate cells for WP1, 3 and 5; 4- evaluating the effect of ECM and medium modifications on primary HSC phenotype; 5- evaluating stellate cell phenotype and function in 2D and 3D culture; 6-developing in vitro conditions for human precision cut liver slices. Involved www.idibaps.org
Collas	Philippe	HeMiBio	University of Oslo	Philippe Collas +47 22 85 10 66 - Philippe[dot]collas[at]medisin[dot]uio[dot]no University of Oslo IMB, Dep of Biochemistry, PO Box 1112 Blindern, 0317 Oslo, Norway Resume Education:1989: MS, Ecole Supérieure d’Agriculture, Angers, France; University of Massachusetts, Amherst, MA, USA; 1991: Ph.D., University of Massachusetts, Amherst, MA, USA. Positions 1991‑1993: Research Scientist, Genmark, Inc., Salt Lake City, UT, USA 1993‑1995: Postdoc, Dept. of Biology, Amherst College, Amherst, MA, USA 1995-2002: Adjunct Professor, University of Massachusetts, Amhest, MA, USA 1995-1998: Research Scientist, Norwegian College of Veterinary Medicine, Oslo, Norway 1999-2003: Senior Research Scientist, Fellow of the Norwegian Cancer Society, Institute of Medical Biochemistry, University of Oslo, Norway 2003-present:Professor, Institute of Basic Medical Sciences, University of Oslo Research Activities: Epigenetic reprogramming of nuclear function; Epigenetic control of gene expression in mesenchymal stem cells Other professional Activities: Invited speaker at over 170 Conferences and Universities Honors and awards Recipient of a Young Investigator Award from the Research Council of Norway Elected Member of the Norwegian Academy of Science and Letters Publications Håkelien, A.M., Landsverk, H.B., Robl, J.M., Skålhegg, B.S., and Collas, P. 2002. Reprogramming of fibroblast function in a cell-free extract: Nature Biotechnol. 20, 460-466 Boquest, A.C., Noer, A., Sørensen, A.L., Vekterud, K., and Collas, P. 2007. CpG methylation profiles of endothelial cell-specific gene promoter regions in adipose tissue stem cells suggest restrictive differentiation potential toward the endothelial cell lineage. Stem Cells 25, 852-861. Sørensen, A.L., Reiner, A.H., Jacobsen, B.M., and Collas, P. 2010. Promoter DNA methylation patterns of differentiated cells are largely programmed at the progenitor stage. Mol. Biol. Cell, 21, 2066-2077. Contribution to the project DNA methylat ion and ChIP analysis on selected hepatic and control genes, from the various cell populations emanating from the microfluidic prototypes. Involved www.uio.no
Colleoni	Silvia	SCR&Tox	Avantea	Silvia Colleoni +390372437242 - silviacolleoni[at]avantea[dot]it Avantea Via Porcellasco 7/f, 26100 Cremona, Italy Resume Silvia Colleoni, PhD in Biotechnologies. Field of research: Biotechnologies and Assisted Reproductive Techniques. Current research activity is mainly focused on differentiation and culture of human embryonic stem cells and on development of in vitro toxicological tests. Regarding stem cells field she has experience on human stem cells culture and differentiation with particular focus on neural differentiation. In the past she has also worked on mesenchymal stem cells and on differentiation and characterization of neural crest stem cells. Publications Colleoni S, Galli C, Gaspar JA, Meganathan K, Jagtap S, Hescheler J, Sachinidis A, Lazzari G. Characterisation of a neural teratogenicity assay based on human ESCs differentiation following exposure to valporic acid. Current Medicinal Chemistry (2012) 19, 6065-6071 Colleoni S, Galli C, Gaspar JA, Meganathan K, Jagtap S, Hescheler J, Sachinidis A, Lazzari G. Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Tox Sciences (2011), 124(2), 370-377 Colleoni S, Galli C, Giannelli SG, Armentero MT, Blandini F, Broccoli V, Lazzari G. Long-term culture and differentiation of CNS precursors derived from anterior human neural rosettes following exposure to ventralizing factors. Exp Cell Res. (2010), 316(7):1148-58. Brown BD, Gentner B, Cantore A, Colleoni S, Amendola M, Zingale A, Baccarini A, Lazzari G, Galli C, Naldini L. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nat Biotechnol (2007) 25: 1457-1467. Contribution to the project Avantea is involved in WP1 and 3. In WP1 Avantea will provide proliferating neural precursors and terminally differentiated neurons derived from human embryonic stem cells. In WP3 it will develop a toxicological assay on the fully differentiated neurons based on a repeated dose exposure. Involved www.avantea.com
Cotgreave	Ian		AstraZeneca Safety Assessment	Ian Cotgreave +46 733 54 22 72 - Ian[dot]Cotgreave[at]astrazeneca[dot]com AstraZeneca Safety Assessment S-15185 Södertälje, Sweden Resume Ian Cotgreave possesses a Ph.D. in pharmacology and Biochemistry from St Marys Hospital medical School, University of London, with a focus on drug metabolism. Ian Cotgreave is Currently Director of Molecular Toxicology in Safety Assessment within AstraZeneca and is also responsible for coordination of stem cell activities within the company. Ian has been with the company 7 years and before that was Professor of Toxicology at the Karolinska Institute in Stockholm. Research interests include mechanistic aspects of toxicity, including oxidative stress research, the development of biological test systems for the prediction of human toxicity and the application of human stem cell technologies to drug discovery and safety assessment. Ian is a current member of Swedish Science Research Councils review committee for 3Rs research and is also an advisor to several European initiatives within the area of application of stem cell technologies to pharmaceutical research, including the UK-based Stem Cells for Safety of Medicines (SC4SM) and the DG/COLIPA consortium modeling chronic toxicity. Ian has published over 140 peer reviewed articles in his areas of scientific interest. Publications SöderdahlT, LundbergM, Enoksson M, Holmgren A, Ottersen OP, BocsfoldiG and Ian A Cotgreave (2002). Visualisation of the compartmentalisation of glutathione and protein-glutathione mixed disulphides in cultured cells. FASEB J Express, 10.1096/fj.02-0259fje Dandrea T, Bajak T, Nini, Helmold H, Wärngård L and Cotgreave IA (2004). The transcriptosomal response of human A549 lung cells to hydrogen peroxide: Relationship to DNA damage, cell cycle arrest and apoptotic priming. Free Radicals in Biology and Medicine. 36; 881-889. Ek M, Söderdahl, T, Kupper-Munter B, Björquist P, Cotgreave IA, Andersson, TB, Ingelan-Sundberg M and Johansson, I (2007) Expression of drug metabolising enzymes in hepatocytes-like cells derived from human embryonic stem cells. Biochem. Pharnacol. 74, 496-503. Contribution to the project Involved www.Astrazeneca.com
Cronin	Mark	COSMOS	School of Pharmacy and Chemistry, Liverpool John Moores University	Mark Cronin + 44 (0)151 231 2402 - m[dot]t[dot]cronin[at]ljmu[dot]ac[dot]uk School of Pharmacy and Chemistry, Liverpool John Moores University Byrom Street, Liverpool, L3 3AF, England Resume Mark Cronin is Professor of Predictive Toxicology at Liverpool John Moores University, England. His expertise relates to the prediction of toxicity including human health effects using alternative approaches, the use of in silico techniques including category formation and read-across, (Q)SARs. He has experience in international and national projects funded by the EU (e.g. OSIRIS, OECD (Q)SAR Toolbox, InSilicoTox), CEFIC, UK Defra etc. Mark Cronin has published three books and over 170 papers. Publications MTD Cronin, JC Madden (eds) (2010)In Silico Toxicology: Principles and Applications. The Royal Society of Chemistry, Cambridge,England SJ Enoch, MTD Cronin (2010) A review of the electrophilic reaction chemistry involved in covalent DNA binding. Critical Reviews in Toxicology 40: 724-748. CM Ellison, JC Madden, P Judson, MTD Cronin (2010) Using in silico tools in a weight of evidence approach to aid toxicology assessment. Molecular Informatics 29: 97-110. Contribution to the project Toxicological data retrieval, curation, quality and databasing (WP1) Development of innovative computational approaches to predict toxicity (WP3) Dissemination of results and integration of COSMOS with other projects (WP6) Co-ordination and management of the project (WP7) Involved http://www.staff.livjm.ac.uk/phamcron/qsar/qsar1.htm
Cucinelli	Bruno	COACH	ARTTIC	Bruno Cucinelli +33 1 53 94 54 61 - bcucinelli[at]arttic[dot]eu ARTTIC 58A rue du Dessous des Berges, 75013 PARIS, France Resume Senior Consultant at ARTTIC, Bruno has an industrial experience of over 18 years as electronic design engineer, project manager and technical manager. In his previous jobs and since he joined ARTTIC in January 1993, he participated to the set-up and management of many of international R&D cooperation projects in information technologies and life sciences / health. In the FP6 and FP7 Health domain, he was involved in the Integrated Projects FunGenES “Functional Genomics in Engineered ES cells”, RIGHT “Interference Technology as Human Therapeutic Tool”, INCA “The role of chronic infections in the development of cancer”, and in the STREPs COBRED “Colon and Breast cancer Diagnostics”, FOCUS “Fixed Dose Combination drugs for Secondary Cardiovascular Prevention” and METAFIGHT “Understanding and fighting metastasis via dissection of the Core Invasive Machinery”. Bruno has also acted as technical expert (proposal evaluation, workshop reporteur) for the European Commission and managed several coordination/networking projects, in particular: DEUCALION: Support secretariat for the European initiative PROMETEUS, a large network of technical experts in Learning Technologies EUCLID: “European initiative for a Citizen ID solution”, a coordination and support action for a network of technical experts and public administrations aiming at harmonising the introduction of electronic identity cards in Europe RESET: “Roadmaps for European research on Smartcard Technologies”, a coordination and support action for a network of technical experts and companies aiming at establishing a common strategic roadmap for applied research Publications Contribution to the project Bruno is the coordinator of the COACH project. Involved www.arttic.fr
Da Silva	Emmanuelle	COACH	ARTTIC	Emmanuelle Da Silva +33 1 53 94 54 78 - coach-arttic[at]eurtd[dot]com; dasilva[at]arttic[dot]eu ARTTIC 58A rue du Dessous des Berges, 75013 PARIS, France Resume At ARTTIC since 2000, Emmanuelle is a project manager currently in charge of running the COACH Project Office. Emmanuelle managed several ICT and Life Sciences projects since FP5 and was involved in several successful proposals within the EU frameworks, EUREKA and National programme such as the FP6 Network of Excellence “CONTICANET”, dedicated to rare cancers. Before joining ARTTIC, Emmanuelle was working in the international sales dept. of a Chicagoan SME in the automotive sector. Publications Contribution to the project Emmanuelle will run the COACH project office and carry out project management activities. She will contribute to : The facilitation of information exchange and collaboration between the different cluster projects Monitoring the progress towards the goals of the SEURAT initiative The collection, elaboration and dissemination of information The organisation and follow-up of annual workshops, Scientific expert panels, summer schools and additional ad-hoc meetings The preparationof strategic information material and targeted dissemination activities Involved www.arttic.fr
Dascher-Nadel	Christiane	SCR&Tox & HeMiBio	Inserm Transfert – Dpt European and International Affairs	Christiane Dascher-Nadel +33 4 91 82 70 13 - christiane[dot]dascher-nadel[at]inserm-transfert[dot]fr Inserm Transfert – Dpt European and International Affairs 18 avenue Mozart, 13276 Marseille Cedex 09, France Resume Dr. Christiane Dascher-Nadel, Senior Project Manager at Inserm Transfert since 2003. Christiane received her PhD in molecular genetics at the Max Planck Institute, Göttingen, Germany in 1991 and worked as a post-doctoral fellow at the Scripps Research Institute in La Jolla, CA, USA, in the department of cell biology (1992 – 1996). In 1996 she joined the Novartis Institute for BioMedical Research (NIBR), Vienna, Austria, first as a laboratory head then as head of a R&D programme in the departments of Immunology and Inflammatory Diseases (1996 – 2001). With international experiences gained in both academic and industrial research she joined Inserm Transfert’s European Department in 2003 with the aspiration to contribute to the technology transfer between academic research and industry. Since 2006 C. Dascher-Nadel heads the team within the European and International Affaires Department which manages European projects mainly related to stem cells and biotherapy. Publications Contribution to the project Project Management and Coordination Involved http://www.inserm-transfert.fr
De Kock	Joery	HeMiBio	Vrije Universiteit Brussel - Department of Toxicology	Joery De Kock +32 2 477 45 17 - jdekock[at]vub[dot]ac[dot]be Vrije Universiteit Brussel - Department of Toxicology Laarbeeklaan 103 - 1090 Brussels, Belgium Resume Predoctoral researcher at the Department of Toxicology of the Vrije Universiteit Brussel-Belgium. His expertise is situated in the field of stem- and progenitor cells and stem- and progenitor cell-based in vitro modelling. He is author of about 15 publications in peer-reviewed journals and books. Publications De Kock J., Vanhaecke T., Biernaskie J., Rogiers V. and Snykers S. (2009) Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development. Toxicol In Vitro. 23(8): 1522-1527. De Kock J., Ceelen L., De Spiegelaere W., Casteleyn C., Claes P., Vanhaecke T., Rogiers V. (2011) Simple and quick method for whole-liver decellularization: a novel in vitro three-dimensional bioengineering tool? Arch Toxicol. 85(6):607-612. De Kock J., Rodrigues R.M., Bolleyn J., Vanhaecke T. and Rogiers V. (2012) Focus on stem cells as sources of human target cells forin vitro research and testing. ALTEX 29: in press. Contribution to the project Workpackage 5: * Selection of chemicals for testing hepatocellular functionality and toxicity. * Selection of cosmetic ingredients for testing hepatocellular toxicity. * Establishment of standard operating procedures for hepatocellular functionality testing. * Establishment of standard operating procedures for hepatocellular toxicity testing. Involved http://minf.vub.ac.be/~fafy/
De Kok	Theo	DETECTIVE	Maastricht University, department of Toxicogenomics	Theo De Kok + 31 43 3881091 - t[dot]dekok[at]maastrichtuniversity[dot]nl Maastricht University, department of Toxicogenomics P.O. Box 616; 6200 MD Maastricht, the Netherlands Resume Dr. T. de Kok graduated in 1988 as biologist at the Radboud University, Nijmegen, The Netherlands, with Microbiology and Toxicology as majors. He received his PhD in 1992 at the University of Limburg. He is registered as Toxicologist by the National Committee for Post-Doctoral Medical-Biological Research training in The Netherlands. His research interests focus environment-gene interactions with respect to the process of cancer formation and prevention using genomics approaches, both in human studies and in vitro. He has been involved in several (ongoing) European projects, including ECNIS, NewGeneris, Envirogenomarkers, BRAFO and CarcinoGENOMICS. Publications De Kok, T.M., van Breda, S.G. and Briedé, J.J. (2011) Genomics-based identification of molecular mechanisms behind the cancer preventive action of phytochemicals: potentials and challenges. Curr. Pharmaceutical Biotechnol. In Press. (IF 3.4) Hebels, D.G., Briede, J.J., Khampang, R., Kleinjans, J.C., de Kok, T.M. (2010) Radical mechanisms in nitrosamine and nitrosamide-induced whole genome gene expression modulations in Caco-2 cells. Toxicol. Sci. 116, 194-205. (IF 4.8) Hebels, D.G., Jennen, D.G., Kleinjans, J.C., de Kok, T.M. (2009) Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis. Toxicol. Sci., 108, 290-300. (IF 4.8) Contribution to the project To perform analysis of epigenetics (whole genome DNA methylation and histone acetylation) in combination with whole genome gene expression analysis on a limited set of samples from exposed in vitro liver and heart models. To perform whole genome miRNA analysis in combination with whole genome gene expression analysis on a subset of samples.To perform integrated transcriptomics – epigenetics data analysis and transcriptomic - miRNA data analysis and data interpretation aiming at the identification of compound-induced modulation of toxicologically relevant molecular pathways. Involved http://www.maastrichtuniversity.nl/
Diaz Ochoa	Juan Guillermo	COSMOS	Insilico Biotechnology AG	Juan Guillermo Diaz Ochoa - Juan[dot]diaz[at]insilico-biotechnology[dot]com Insilico Biotechnology AG Meitnerstrasse 8, D-70563 Stuttgart, Germany Resume Juan G. Diaz Ochoa is a project leader at Insilico Biotechnology AG. He has experience dealing with complex systems as complex networks in biology and physics, statistical mechanics, fluid dynamics, and soft condensed mater. His present research interests are the coupling of multiscale models including single cell, tissue dynamics and tissue/ cell mechanics. Juan G. Diaz has published several articles, in particular about biological systems and statistical mechanics. Publications Diaz Ochoa J.G., Voigt A., Briesen H., Sundmacher K., „Modeling of innate immune responses of cells for vaccine production “, Chem. Eng. Sci. 66, 3954 (2011). Diaz Ochoa J.G., “Stochastic time delays in regulatory networks and model reduction”, J. Mod. Phys. C, 22, 385 (2011). Diaz Ochoa J.G. “Infection spread and virus release in vitro in cell populations as a system with percolation”, Int. J. Mod. Phys. C, 22, 249 (2011). Contribution to the project Development of multiscale models that incorporate single cell dynamics for the modelling of 2D and 3D tissues in order to track toxicological effects from single cells to whole organisms. Involved www.insilico-biotechnology.com
Diemer	Hélène	NOTOX	CNRS-UdS, UMR7178, Institut Pluridisciplinaire Hubert Curien, LSMBO	Hélène Diemer +33 (0)3 68 85 26 80 - hdiemer[at]unistra[dot]fr CNRS-UdS, UMR7178, Institut Pluridisciplinaire Hubert Curien, LSMBO ECPM, Bat R5-0, 25 rue Becquerel, F-67087 Strasbourg, France Resume Hélène DIEMER, 34 years old Education : DESS (Master) Imagerie et Méthode d’Analyses Chimiques, Spectroscopiques, Electroniques et Nucléaires, Université de Strasbourg, 2001. Actual position : Ingénieur d’étude, 2ème classe, CNRS. Expertise : Mass spectrometry of biomolecules, peptides and proteins (MALDI and electrospray ionisation, tandem mass spectrometry, nano-, micro- and analytical chromatography) Specialized in proteomics and characterization of natural and recombinant proteins. Developpement of methodologies for the analysis of post-translational modifications. Publications Van Dorsselaer A, Carapito C, Delalande F, Schaeffer-Reiss C, Thierse D, Diemer H, McNair DS, Krewski D, Cashman NR. Detection of prion protein in urine-derived injectable fertility products by a targeted proteomic approach. PLoS One. 2011 Mar 23;6(3):e17815. Diemer H, Elias M, Renault F, Contreras-Martel C, Schaeffer C, Van Dorsselaer A, Chabriere E. Tandem use of X-ray crystallography and mass spectrometry to obtain ab initio the complete and exact amino acids sequence of HPBP, a human 38kDa apolipoprotein. Proteins. 2008 Jun;71(4):1708-20 Chevallet M, Diemer H, Van Dorsselaer A, Villiers C, Rabilloud T. Towards a better analysis of secreted proteins : the example of the myeloid cells secretome. Proteomics. 2007 Jun;7(11):1757-70 Contribution to the project Proteomics of HepaRG cells (2D cultures and spheroids); Differential proteomics: HepaRG intracellular proteome and secretome in response to drugs Involved http://www.iphc.cnrs.fr/
Dietz	Lisa	DETECTIVE	Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V.	Lisa Dietz +49-1392-4218 - Lisa[dot]dietz[at]isas[dot]de Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Otto-Hahn-Str.6b, 44227 Dortmund, Germany Resume Since May 2011: Postdoctoral Fellow at Systemanalyse, ISAS, Dortmund, Germany and active participant of DETECTIVE July 2010-April 2011: Parental leave Oct. 2007 - July 2010: Postdoctoral Fellow and active participant in WP5 and WP3 of sens-it-iv (www.sens-it-iv.eu), at the University Medical Centre, Department of Dermatology, Medical Faculty Mannheim, University of Heidelberg, Germany. Research Associate at the Laboratory of Functional Proteome Analysis, DKFZ, Heidelberg, Germany. Oct.2004 - Nov. 2007: Doctoral thesis (Dr. sc. hum.) at the Department of Toxicology, Institute of Legal Medicine, University of Heidelberg, Germany Publications Dietz L, Esser P, Schmucker S, Goette I, Richter A, Schnoelzer M, Martin SF and Thierse HJ.Tracking human contact allergens: From mass spectrometric identification of peptide-bound reactivesmall chemicals to chemical-specific naive human T cell priming. Toxicol Sci. 117 (2) 336 – 347 (2010). Dietz L, Bosque A, Pankert P, Merz P, Ohnesorge S, Anel A, Schnoelzer M and Thierse HJ. Quantitative Fluorescent DY-maleimide-based Proteomic 2-DE Labeling Strategies Using Human Skin Proteins. Proteomics 9: 4298-4308. (2009) Dietz L, Glaz-Sandberg A, Nguyen H, Skopp G, Mikus G and Aderjan R. The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9- tetrahydrocannabinol in Humans. Ther Drug Monit 29: 368-372 (2007). Contribution to the project Qualitative and Quantitative Proteomics using LCMSMS systems Involved www.isas.de
Dolle	Laurent	HeMiBio	Vrije Universiteit Brussel	Laurent Dolle +32-2-4774413 - ldolle[at]vub[dot]ac[dot]be Vrije Universiteit Brussel Laarbeeklan 103, Brussels, Belgium Resume From 2007 Second post-doctoral position at the LIVR lab (VUB). Work: Liver progenitor cells and niches (IUAP grant) 2003-2006 Post-Doctoral position in Ghent Hospital (UZ). Tutors Prof. Bracke. Work: Implication of Nerve Growth Factor in invasion of breast cancer cells. European contract (HPRN-CT-2002-00246) 2003 Thesis. Tutor Prof. Hondermarck. Work: Autocrine stimulation of the growth of breast cancer cells by the Nerve Growth Factor. Scholarship: Region of the North of France and the Center of Oscar Lambret 1998 Master’s Degree in Cell Biology; Tutor Prof. Hondermarck. Work: Analyse of the effect of 4-OH-tamoxifen on the proliferation induced by Nerve Growth Factor in breast cancer cells Publications Dollé L, Best J, Mei J, Al Battah F, Reynaert H, van Grunsven L, Geerts A. The quest for liver progenitor cells: a practical point of view. Journal of Hepatology 2010, 52: 117-29. Dollé L, Depypere H and Bracke M. Anti-invasive and anti-metastasis strategies: new roads, new tools and new hopes.Current Cancer Drug Targets 2006, 6, 613-622. Dollé L, Oliveira M-J, Bruyneel E, Hondermarck H, and Bracke M. Nerve Growth Factor mediates its pro-invasive effect in parallel with the release of soluble E-cadherin fragment from breast cancer MCF-7/AZ cells. J. Dairy Res. 2005, 72, 20-26. Dollé L, Adriaenssens E, El Yazidi-Belkoura I, Le Bourhis X, Nurcombe V, and Hondermarck H. Nerve growth factor receptors and signaling in breast cancer. Current Cancer Drug Targets 2004, 4, 463-470. Dollé L, El Yazidi-Belkoura I, Adriaenssens E, Nurcombe V, and Hondermarck H. Nerve growth factor over-expression and autocrine loop in breast cancer cells. Oncogene 2003, 22, 5592-601. El Yazidi-Belkoura I, Adriaenssens E, Dollé L, Descamps S, and Hondermarck H. Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells. J Biol Chem. 2003, 278, 16952-16956. Contribution to the project Characterisation of specific markers for non-parenchymal liver cells Isolation of human Hepatic Stellate Cells Liver progenitor cell isolations Involved http://cyto.vub.ac.be/
Drasdo	Dirk	NOTOX	INRIA (lnstitut National de Recherche en Informatique et en Automatique)	Dirk Drasdo 0033 1 39635036 - dirk[dot]drasdo[at]inria[dot]fr//dirk[dot]dras[at]gmail[dot]com INRIA (lnstitut National de Recherche en Informatique et en Automatique) Domaine de Voluceau-Rocquencourt, B.P. 105, 78153 Le Chesnay Cedex, France Resume Senior researcher (Directeur de Recherche) INRIA, head of group on "Multi-cellular Systems Biology" co-localized at the Interdisciplinary Center for Bioinformatics, Univ. of Leipzig, Germany and at INRIA, France. Before faculty position at the Mathematics Dept. and the Center for Systems Biology at Univ. of Warwick, UK, and research associate positions at the Max-Planck-Institutes for Mathematics in the Sciences in Leipzig, and Colloid and Interface Science in Golm, as well as at the Institute for Medical Informatics, Statistics and Epidemiology at the Medical Faculty of Leipzig University. Habilitation degree in Computer Science (Univ. of Leipzig), PhD in Physics (MPI for Biophys. Chemistry and Univ. of Göttingen), master degree in Physics from the TU Aachen. Main research topic: multiscale modeling of tissues, applied to in-vitro systems, liver regeneration, tumor growth and early development. Publications Hoehme, S., Brulport, M., Bauer, A., Bedawy, E., Schormann, W., Gebhardt, R., Zellmer, S., Schwarz, M., Bockamp, E., Timmel, T., G. Hengstler, J.G., and Drasdo, D. (2010). Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration. Proc. Natl. Acad. Sci. (USA), 107(23), 10371-10376. Hoehme S and Drasdo D. (2010) A cell-based simulation software for multicellular systems. Bioinformatics, 2010 Oct 15;26(20):2641-2. Ramis-Conde I., Drasdo D., Anderson ARA, Chaplain MA J. (2008) Modeling the influence of the Ecadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach. Biophys. J. 95 , 155-165 Contribution to the project Main contribution will be multi-scale modelling of tissue formation and stability, and of long term toxicity in sandwich culture, spheroids, membrane bioreactor. Models will mainly be single-cell-based, displaying each cell thereby reflecting the spatial-temporal architecture of cultured cells in-vitro. The effect of drugs will be incorporated into each cell individually and molecular interactions, transport and metabolism being integrated. Finally, the model calibrated in-vitro will be used to predict liver toxicity in-vivo. Involved www.msysbio.com
Duhamel	Marianne	SCR&Tox	Ectycell SAS	Marianne Duhamel +33 141 83 99 09 ext 558 - marianne[dot]duhamel[at]cellectis[dot]com Ectycell SAS 102 avenue Gaston Roussel, 93235 Romainville, France Resume PhD in Immunology/Haematology (2004-2007) Pitié-Salpêtrière Hospital, Paris (2004-2007, epigenetic and transcriptional regulation of B lymphopoiesis, application to CLL). Marianne has worked as a researcher in cellular and molecular biology: L’Oréal (2002-2003, reconstructed epidermis), and with Sanofi-Aventis (2008-2010, oncology targets validation and biomarker research). Publications Duhamel M, Navarro P, Cario-Andre M, Billot K, Arrouss I, Rebollo A. Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells. FEBS Lett. 2008 Duhamel M, Arrouss I, Merle-Béral H, Rebollo A. The Aiolos transcription factor is up-regulated in chronic lymphocytic leukemia. Blood. 2008 Fleischer A, Duhamel M, Lopez-Fernandez LA, Muñoz M, Rebollo MP, Alvarez-Franco F, Rebollo A. Cascade of transcriptional induction and repression during IL-2 deprivation-induced apoptosis. Immunol Lett. 2007 Ghadiri A, Duhamel M, Fleischer A, Reimann A, Dessauge F, Rebollo A. Critical function of Ikaros in controlling Aiolos gene expression. FEBS Lett. 2007 Dessauge F, Cayla X, Albar JP, Fleischer A, Ghadiri A, Duhamel M, Rebollo A. Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis. J Immunol. 2006 Fleischer A, Ghadiri A, Dessauge F, Duhamel M, Rebollo MP, Alvarez-Franco F, Rebollo A. Modulating apoptosis as a target for effective therapy. Mol Immunol. 2006 Fleischer A, Ghadiri A, Dessauge F, Duhamel M, Cayla X, Garcia A, Rebollo A. Bad-dependent rafts alteration is a consequence of an early intracellular signal triggered by interleukin-4 deprivation. Mol Cancer Res. 2004 Contribution to the project Use of meganucleases to generate clean iPS cells for WP2. Field of expertise: cell biology. Involved http://www.cellectis.com
Duprat	Sebastien	SCR&Tox	INSERM – ISTEM/UEVE/AFM	Sebastien Duprat +33 (0)1 69 90 85 41 - sduprat[at]istem[dot]fr INSERM – ISTEM/UEVE/AFM Campus 1, Genopole, 5 rue H. Desbruères – 91030 Evry, France Resume 2009-Present: Director of Business Development and Partnership in ISTEM, Evry – France 2007-2009: Training and outreach manager, FP6 project ESTOOLS – Based at Sheffield – UK 2000-2006: Research position at the University of Helsinki – Finland 2 books and several publications outside the academic field. Publications Duprat S. Art and Human Embryonic Stem Cells: from the bench to the high street. Stem Cell Research 2009, Mar; 2(2): 97-100 Duprat S, Lemaitre G, Onteniente B. Embryonic stem cells and therapeutic applications. Revue Francophone des Laboratoires 2010, Dec; 427: p41-46. (Review in French) Academic book chapter: “Translational stem cell research: Navigating out of the fog. Ethical, regulatory, communicational and psychological issues beyond the debate on human embryo research”. From the book series: “Stem Cell Biology and Regenerative Medicine”. Chapitre 7.2: “Communicating translational stem cell research to the general public: Challenges and suggestions”, Sébastien Duprat. Springer publishing group 2011– ISBN : 978-1-60761-958-1. Contribution to the project SCR&Tox WP5 leader (Training and Dissemination). Member of the SCR&Tox Executive Committee. Involved www.istem.eu
Duschl	Claus	HeMiBio	Fraunhofer Institute for Biomedical Engineering (IBMT)	Claus Duschl +49 / 3 31 / 581 87 - 300 - claus[dot]duschl[at]ibmt[dot]fraunhofer[dot]de Fraunhofer Institute for Biomedical Engineering (IBMT) Am Muehlenberg 13, 14476 Potsdam, Germany Resume - Publications Guido, I.; Jaeger, M. S.; Duschl, C.: Dielectrophoretic stretching of cells allows for characterization of their mechanical properties. (2010) Eur Biophys J DOI: 10.1007/s00249-010-0646-3 Guido, I.; Jaeger, M. S.; Duschl, C.: Influence of medium consumption on cell elasticity. (2010) Cytotechnology 62:257-263. Uhlig, K.; Wischerhoff, E.; Lutz, J.-F.; Laschewsky, A.; Jaeger, M. S.; Lankenau, A.; Duschl, C.: Monitoring cell detachment on PEG-based thermoresponsive surfaces using TIRF microscopy. (2010) Soft Matter 6:4262-4267. Contribution to the project To develop sensors for real-time basic culture conditions To develop sensors for real-time cell function Develop a 2D bioreactor for the efficient isolation of differentiated iPSC mixtures by trapping different cell types on micropatterned surfaces Fabrication of high-throughput microfluidics addressable array Fabricated multi-electrode plate Integrate sensor electronics using UTCP Computer interface and recording subrouting Involved www.ibmt.fraunhofer.de
Egesipe	Anne-Laure	SCR&Tox	INSERM/UEVE UMR861, I-STEM, AFM	Anne-Laure Egesipe +33 1 69 90 85 27 - aegesipe[at]istem[dot]fr INSERM/UEVE UMR861, I-STEM, AFM Génopole Campus 1 5 rue Henri Desbruères 91030 Evry cedex , France Resume 2011: Engineer INSERM/UEVE UMR861, at ISTEM, SCR&Tox Program. 2009-2010: Qualified research technician, at ISTEM in the “Muscle” team. 2009: Expertise of biotechnology (Sup’biotech, Villejuif, France) Publications Contribution to the project Differentiation of hESC and hiPSC into mesenchymal progenitor cells and myoblasts. Banking and characterization. Involved www.istem.eu
El Taghdouini	Adil	HeMiBio	Vrije Universiteit Brussel	Adil El Taghdouini 0032024774259 - aeltaghd[at]vub[dot]ac[dot]be Vrije Universiteit Brussel Liver Cell Biology Lab, Department of Cell Biology, Faculty of Medicine and Pharmacy, Laarbeeklan 103, 1090 Brussels, Belgium, Belgium Resume El Taghdouini Adil, M.Sc., obtained his M.Sc. degree at the Free University of Brussels (VUB) in 2011. His master thesis, entitled “The selective delivery of doxorubicin to hepatic stellate cells by using vitamin A-coupled liposomes”, was supervised by Prof. Dr. L.A. van Grunsven. From August 2011, Adil started as a PhD student in the lab of Prof. Dr. Van Grusnven, where his main task is the development of conditions that will allow the expansion of human quiescent HSCs to be used in mid-high throughput screenings for anti-fibrotic compounds and for populating artificial liver devices for drug and cosmetic toxicity assays. Publications Contribution to the project Characterisation of specific markers for non-parenchymal liver cells. Derivation of hepatic stellate cells from iPS cells. Involved http://cyto.vub.ac.be/
Elcombe	Cliff	SCR&Tox	CXR Bioaciences Ltd	Cliff Elcombe 441382432163 - cliffelcombe[at]cxrbiosciences[dot]com CXR Bioaciences Ltd James Lindsay Place, Dundee, DD1 5JJ, UK Resume Dr Cliff Elcombe is co-founder and the Research Director of CXR Biosciences Ltd. He is also a faculty member the Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee. He joined the University of Dundee in 1997 after an 18-year career (1979-1997) at Zeneca's (formerly ICI) Central Toxicology Laboratory in Cheshire, England, where he was a Senior Scientist in Investigative Toxicology. Dr. Elcombe received his BSc (1972) and PhD (1976) in biochemistry from the University of Surrey. He received a Royal Society travelling fellowship award to post-doc in Germany (1976) and then was appointed an Assistant Professor at the Medical College of Wisconsin (1977-1978). He is the author or co-author of over 120 peer-reviewed publications and has served on several national and international advisory committees including the UK Advisory Committee on Pesticides and the UK Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment. Dr. Elcombe’s research interests are focussed on understanding mechanisms of target organ toxicity thereby facilitating scientifically based risk assessment. He has long standing research interests in non-genotoxic carcinogenicity and the development of in vitro methods for prediction of toxicity and hazard assessment. Publications Ross J, Plummer SM, Rode A, Scheer N, Bower NC, Vogel O, Henderson CJ,Wolf CR and Elcombe CR. (2010). Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo. Toxicol. Sci. 116, 452–466. Elcombe CR, Elcombe BM, Foster JR, Farrar DG, Jung R, Chang S-C, Kennedy GL and L. Butenhoff JL. (2010). Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARalphaand CAR/PXR. Arch Toxicol. 84, 787–798. Hay DC, Zhao D, Fletcher J, Hewitt ZA, McLean D, Urruticoechea-Uriguen A, Black JR, Elcombe C, Ross JA, Wolf Rand Cui W. (2008). Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo. Stem Cells26, 894-902. Contribution to the project CXR in collaboration with other partners will characterize the relevant gene expression of the hepatocyte systems with respect to mRNA and protein levels of specific relevant genes encoding drug transporters and drug metabolising enzymes. We will characterize the expression profile of xenobiotic metabolising enzymes and transporters in the hepatocyte types developed for toxicity screening. Methodologies such as real time PCR and immunoblotting will be used to identify critical signaling pathways and xenobiotic metabolising enzymes. The functionality of these pathways will be assessed using model substrates and LC/MS/MS analysis. These technologies will also be used to assess perturbation of pathways and functionality induced by known hepatotoxins Involved www.cxrbiosciences.com
Enoch	Steve	COSMOS	School of Pharmacy and Chemistry, Liverpool John Moores University	Steve Enoch + 44 151 231 2422 - s[dot]j[dot]enoch[at]ljmu[dot]ac[dot]uk School of Pharmacy and Chemistry, Liverpool John Moores University Byrom Street, Liverpool, L3 3AF, England Resume Steve Enoch is a post-doctoral researcher in Predictive Toxicology at Liverpool John Moores University, England. His expertise relates to the use of mechanistic chemistry to form chemical categories for the prediction of toxicity including human health effects. He has experience in the development of alternative methods in a number of international and national projects funded by the EU (e.g. OSIRIS, OECD (Q)SAR Toolbox). Steve Enoch has contributed to three books and published 20 scientific papers. Publications SJ Enoch, MTD Cronin (2010) A review of the electrophilic reaction chemistry involved in covalent DNA binding. Critical Reviews in Toxicology 40: p724-748. SJ Enoch (2010) Chemical category formation and read-across for the prediction of toxicity. In Recent Advances in QSAR Studies: Methods and Applications. p209-219 SJ Enoch, DW Roberts, MTD Cronin (2010) Mechanistic category formation for the prediction of respiratory sensitisation. Chemical Research in Toxicology 23: p1547-1555 Contribution to the project Toxicological data retrieval, curation, quality and databasing (WP1) Development of innovative computational approaches to predict toxicity (WP3) Dissemination of results and integration of COSMOS with other projects (WP6) Co-ordination and management of the project (WP7) Involved http://www.staff.livjm.ac.uk/phamcron/qsar/qsar1.htm
Epinat	Jean Charles	SCR&Tox	Cellectis SA	Jean Charles Epinat +33 141 83 99 25 - Jean-charles[dot]epinat[at]cellectis[dot]com Cellectis SA 102 avenue Gaston Roussel, 93235 Romainville, France Resume Jean-Charles Epinat, received his Ph.D. in Molecular and Cellular Genetics from University of Paris VI after working on the regulation of NF-B transcription factors at the Institut Pasteur. He then spent 3 years as a postdoctoral fellow at Boston University. He joined Cellectis at the very beginning of the company and developed selection and screening methods based on Meganuclease activity in yeast that are used today. Publications Grizot S, Epinat JC, Thomas S, Duclert A, Rolland S, Pâques F, Duchateau P. Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds. Nucleic A cids Res. 2010 Prieto J, Epinat JC, Redondo P, Ramos E, Padró D, Cédrone F, Montoya G, Pâques F, Blanco FJ. Generation and analysis of mesophilic variants of the thermostable archaeal I-DmoI homing endonuclease. J Biol Chem. 2008 Arnould S, Perez C, Cabaniols JP, Smith J, Gouble A, Grizot S, Epinat JC, Duclert A, Duchateau P, Pâques F. Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells. J Mol Biol. 2007 Prieto J, Redondo P, Padró D, Arnould S, Epinat JC, Pâques F, Blanco FJ, Montoya G. The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage. Nucleic Acids Res. 2007. Smith J, Grizot S, Arnould S, Duclert A, Epinat JC, Chames P, Prieto J, Redondo P, Blanco FJ, Bravo J, Montoya G, Pâques F, Duchateau P.A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences. Nucleic Acids Res. 2006 Arnould S, Chames P, Perez C, Lacroix E, Duclert A, Epinat JC, Stricher F, Petit AS, Patin A, Guillier S, Rolland S, Prieto J, Blanco FJ, Bravo J, Montoya G, Serrano L, Duchateau P, Pâques F. Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets. J Mol Biol. 2006 Chames P, Epinat JC, Guillier S, Patin A, Lacroix E, Pâques F. In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination. Nucleic Acids Res. 2005 Epinat JC, Arnould S, Chames P, Rochaix P, Desfontaines D, Puzin C, Patin A, Zanghellini A, Pâques F, Lacroix E. A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells. Nucleic Acids Res. 2003 Contribution to the project Meganucleases engineering for WP2 and WP3. Field of expertise: meganucleaes and uses thereof. Involved http://www.cellectis.com
Farret	Rosila	DETECTIVE	ARTTIC	Rosila Farret + 33 1 53 94 54 85 - farret[at]arttic[dot]eu ARTTIC 58a, Rue du Dessous des Berges – 75013 Paris, France Resume Rosila FARRET served as a Project Assistant at Egis Avia (Issy-les-Moulineaux, France) for 5 years. Within the Airport consulting and engineering unit, she assisted with special projects linked to Air Traffic Management and Airport. She also worked at the Vision Institute (Paris, France) as an Administrative Assistant where she served as liaison to all Human Resources related issues, organized various scientific seminars and assisted both Programs and Platforms Directors. Rosila grew up in multilingual environment and studied in Europe for many years. She holds a University Technology Diploma and a Master’s degree in English with which she performed as a teacher for 5 years. She has been recruited by ARTTIC as Project Administrator and is involved in different projects. Publications Contribution to the project In DETECTIVE, ARTTIC constitutes the Project Office and provides methods, tools and operational support for the project collaboration. ARTTIC thus supports the consortium in the daily management and administrative tasks to ensure the collaboration is working, the project is properly monitored and decisions and actions are prepared and taken according to the project progress. ARTTIC’s role is also to simplify the work of the researchers and to develop a collaborative team spirit inside the consortium. As part of the day-to-day operational project management, Rosila is responsible for the handling of all administrative aspects as well as the preparation and follow-up of project meetings. Involved http://www.arttic.com/
Fioravanzo	Elena	COSMOS	S-IN Soluzioni Informatiche srl	Elena Fioravanzo 3904441821160 - elena[dot]fioravanzo[at]s-in[dot]it S-IN Soluzioni Informatiche srl Via Ferrari 14, 36100 Vicenza, Italy Resume Elena Fioravanzo is the managing director at S-IN Soluzioni Informatiche. She is the project manager of scientific/technical projects under EFSA framework contract. She is also responsible for coordinating contracted research in collaboration with industrial and academic research centres in chemistry-related frameworks. Until December 2010, she was consultant and applications specialist in computer aided drug design, cheminformatics, info- and chemo-metrics, molecular modelling, computational toxicology, in silico properties prediction and optimization. Publications Pavan, M., Fioravanzo, E., Bassan, A., Mostrag-Szlichtyng, A., Worth, A. Role of in silico genotoxicity tools in the regulatory assessment of pharmaceutical impurities. In press on SAR and QSAR in Environmental Research, 2012. Mabilia, M., Bacilieri, M., Bassan, A., Broccardo,L., Fioravanzo, E., Moro, S., Sartori, L., Stocchero, M. Chemoinformatica - Soluzioni e strumenti per scienze e tecnologie biomediche, Springer-Verlag Italia, 2011. Bassan, A., Fioravanzo, E., Pavan, M, Stocchero, M. Report on Applicability of physicochemical data, QSARs and read-across in Threshold of Toxicological Concern assessment. EFSA Technical Report EFSA-Q-2009-00919, 2011. Contribution to the project She is part of the team who will aim at optimising in silico methods, such as (Q)SAR and read-across, for the purpose of long-term toxicity prediction of cosmetic ingredients. The tasks of the team include: a) Characterisation of the chemical space of cosmetic inventories; b) Read-across, grouping and structural analogues analysis; c)Evaluation of existing QSAR models and expert systems for cosmetic ingredients; d) Development of new QSAR regression and classification models. e) Application of innovative chemometric tools. Involved www.s-in.it
Forster	Roy	SCR&Tox	CIT	Roy Forster +33 2 3229 2626 - roy[dot]forster[at]citox[dot]com CIT BP 563, 27005 EVREUX, FRANCE Resume Dr. Roy Forster is Scientific Director of CIT, a leading European Contract Research Organisation performing preclinical safety, efficacy and pharmacokinetics studies. In this role, Dr. Forster advises many Sponsor companies on the nonclinical safety aspects of the development of their candidate drugs, biologics and vaccines. He has been active in preclinical safety and drug development for many years, working in France, England and Italy. He is a Fellow of the Royal Society of Medicine, London; Editorial Board member of several journals, visiting lecturer at Kings College, University of London and was coordinator of the FP7 RETHINK project on minipigs in toxicology. He is author of more than 50 scientific articles. Publications D. Renzi, M. Valtolina and R. Forster (1993), Evaluation of a multi-endpoint cytotoxicity assay system, Alternatives to Laboratory Animals, 21, 89-96 P. Ancian, S. Leuillet, S. Artaud, J-J. Legrand and R. Forster (2008) Toxicogenomics for regulatory use: the view from the bench, in Toxicogenomics: A Powerful Tool for Toxicity Assessment, Saura Sahu(Editor), ISBN: 978-0-470-51823-6, 422 pages, John Wiley and Sons Ltd. Chichester, UK Forster R, P Ancian, M Fredholm, H Simianer and B Whitelaw, under the auspices of the Steering Group of the RETHINK Project (2010), The minipig as a platform for new technologies in toxicology, Journal Pharm Tox Methods, Vol 62 (3) pp227 - 235 Contribution to the project As a partner in SCR&Tox, in WP4 of the project we have the responsibility of establishing the industrial scale platform of the screening assays developed in the previous work packages. Once established, an extensive chemical set will be tested for validation purposes. Involved www.citox.com
Fredriksson Puigvert	Lisa	NOTOX	Karolinska Institutet	Lisa Fredriksson Puigvert +46 (0)8 524 87762 - lisa[dot]fredriksson[at]ki[dot]se Karolinska Institutet Nanna Svartz väg 2, 171 77 Stockholm, Sweden Resume 2003-2008 – Master of Pharmacy, Licensed pharmacist, Uppsala University, Sweden 2008-2012 – PhD program, Leiden University, the Netherlands – studying the role of the immune system in drug-induced liver injury in vitro 2012-2013 – Post doc, Leiden University, the Netherlands – studying the role of the immune system in drug-induced liver injury in vitro 2013-present – Post doc, Karolinska Institute, Stockholm, Sweden – investigating long term toxic effects of drugs in 3D hepatocyte in vitro systems Publications Fredriksson L, Herpers B, Benedetti G, Matadin Q, Puigvert JC, de Bont H, Dragovic S, Vermeulen NP, Commandeur JN, Danen E, de Graauw M, van de Water B. Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis. Hepatology. 2011 Jun;53(6):2027-41. Benedetti G, Fredriksson L, Herpers B, Meerman J, van de Water B, de Graauw M. TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells. Biochem Pharmacol. 2013 Jan 15;85(2):274-86. Di Z, Herpers B, Fredriksson L, Yan K, van de Water B, Verbeek FJ, Meerman JH. Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening. PLoS One. 2012;7(12):e52337. Contribution to the project I am currently studying the repeated dose toxicity of drugs, such as valproic acid, in a 3D hepatocyte model (using HepaRG cells). Samples from this model are being collected for i.e. transcriptomics and the results will ultimately be used to create a model for prediction of toxicity. Involved www.ki.se
Gasteiger	Johann	COSMOS	Molecular Networks	Johann Gasteiger 499 131 815 668 - Gasteiger[at]molecular-networks[dot]com Molecular Networks Henkestr. 91, 91052 Erlangen, Germany Resume Prof. Johann Gasteiger studied and had positions at the University of Munich, Germany, University of California, Berkley, USA, and Technical University of Munich. In 1994 he moved to the University of Erlangen-Nuremberg, Germany, where he co-founded the "Computer-Chemie-Centrum". He is one of the initiators of Chemoinformatics in Germany and has produced more than 250 scientific publications in this field. His work has been recognized by several awards: In 1991 the Gmelin-Beilstein Medal of the German Chemical Society, in 1997 the Herman-Skolnik-Award of the American Chemical Society, in 2005 the Mike Lynch Award of the Chemical Structure Association Trust, and in 2006 the American Chemical Society Award for Computers in Chemical and Pharmaceutical Research. In 1997 he founded Molecular Networks GmbH (www.molecular-networks.com), a company developing and distributing software for chemical applications. Publications Gasteiger, J 2003. Handbook of Chemoinformatics - From Data to Knowledge, Wiley-VCH, Weinheim, Germany. Gasteiger, J 2006. Of molecules and humans. J. Med. Chem. 49, 6429-6434. Gasteiger, J. 2007. Modeling chemical reactions for drug design. J. Comput. Aided Mol. Des. 21, 33-52. Contribution to the project Provision of Molecular Networks software, such as ADRIANA.Code, isoCYP, MOSES.Metabolism Development of TTC categories based on structural categories and physicochemical properties Analysis of metabolic rules as part of the molecular descriptors for prediction of chronic toxicity Generation and ranking of conceivable metabolites by MOSES.Metabolism software Extension of knowledge base of isoCYP and MOSES.Metabolism to cover cosmetic ingredients Delivering analysis tools and QSAR/computational models as software tools Involved www.molecular-networks.com
Generelli	Silvia	HeMiBio	CSEM SA – Nanomedicine Division	Silvia Generelli +41 81 307 8139 - silvia[dot]generelli[at]csem[dot]ch CSEM SA – Nanomedicine Division Bahnhofstrasse 1 – CH-7302 Landquart, Switzerland Resume Dr Silvia Generelli graduated as a Chemical Engineer from the Ecole Polytechnique Fédérale de Lausanne, Switzerland, and earned her Ph. D. Degree in 2008 from the University of Neuchâtel, Switzerland. After a short postdoctoral period in the BioMEMS lab of the Ecole Polytechnique of Montréal, Canada, she joined the CSEM Cell System section, where she’s responsible for the development of electrochemical sensors. Publications Generelli S, Jacquemart R, Jolicoeur M, Koudelka-Hep M, Guenat O T, Potentiometric platform for the quantification of cellular potassium efflux, Lab Chip, vol. 8, 1210-1215 Guenat O T, Generelli S, de Rooij N F, Koudelka-Hep M, Berthiaume F, Yarmush M T, Development of an array of ion-selective microelectrodes aimed for the monitoring of extracellular ionic activities, Anal. Chem., vol. 78, 7453-7460 Contribution to the project The role of the CSEM in HeMiBio is to develop and integrate innovative electro-chemical microsensors, such as ion-selective electrodes, in the 3D-bioreactors to allow assessment of liver function (e.g. oxygen uptake, ammonium). Among the microsensors that will be selected to monitor specific hepatic functions ammonium-selective microelectrode, will be located in the direct vicinity of the cells. One of the critical hepatic functions is the ability to detoxify ammonia by converting it to urea within the urea cycle. At physiological pH, ammonia, NH3, mainly appears in the protonated form NH4+ that can easily be detected by ion-selective microelectrode technique. The specific role of Dr. Generelli will be the development of electrochemical sensors for the monitoring of liver cells toxicity. Involved www.csem.ch
Giehl	Claudia	NOTOX	European Research and Project Office GmbH (Eurice)	Claudia Giehl 4 968 195 923 378 - c[dot]giehl[at]eurice[dot]eu European Research and Project Office GmbH (Eurice) Science Park 1, Stuhlsatzenhausweg 69, 66123 Saarbrücken, Germany Resume Claudia Giehl has a background in Medicine, a degree in languages and communication, and own research experience in both fields. She has been working in EU funded projects since 1998 and has joined Eurice in 2006 as a project manager. Claudia Giehl is involved in training and capacity building, proposal writing and identification of suitable funding opportunities, as well as research and project management, and currently heading the Eurice LifeSciences division, coordinating a portfolio of 30 ongoing EU-funded projects. Publications - Contribution to the project NOTOX Project Manager, supporting the consortium in all aspects related to contractual and financial issues, general project management, communication, as well as project dissemination and exploitation, including advise on IPR management. Involved www.eurice.eu
Gill	Jason	COSMOS	University of Bradford	Jason Gill +44 127 4233232 - j[dot]gill1[at]bradford[dot]ac[dot]uk University of Bradford Institute of Cancer Therapeutics, Richmond Road, Bradford BD7 1DP, UK Resume Dr. Jason Gill is Senior Lecturer in Molecular Pharmacology within the Institute of Cancer Therapeutics. He completed his PhD in Molecular Toxicology in 1998 as a CASE studentship between the University of Manchester and AstraZenecas’s Central Toxicology Laboratory. He worked as a researcher in both molecular genetics of cancer and cancer drug discovery. His research focuses on discovery and development of new cancer therapeutics, drug target selectivity and drug safety. He is a committee member of the National Toxicology Training Forum, and is co-chair of the Safety Pharmacology Society certification committee. Jason has published extensively in experimental toxicology and cancer research. Publications Behrens, D., Gill, J.H., Fichtner, I., (2007), "Loss of tumoreginicityof stably ER-b transfected MCF-7 breast cancer cells", Molecular and Cellular Endocrinology, in press. Krippner-Heidenreich A, Grunwald I, Zimmermann G, Gerspach J, Sterns T, Shnyder S, Gill JH, Pfizenmaier K, Männel D, Scheurich P (2008) Single chain TNF, a TNF derivative with enhanced stability and antitumoral activity. J Immunol 180: 8176-8183. Seargent JM, Loadman PM, Martin SW, Naylor B, Bibby MC, Gill JH* (2005) Expression of MMP-10 in Human Transitional-Cell Carcinoma of the Bladder. Urology: 65(4) 815-820 Contribution to the project The UNIBRAD team contribute on data curation and data mining, multivariate modelling and predictive toxicology model management as WP1 coordinator and contributor to WP3 and WP5. The key tasks allocated to UNIBRAD are data representation, data curation, development of computational intelligence techniques, data and model integration, and data mining tools. Involved http://www.brad.ac.uk/ict/research/preclinical-pharmacology/research-team/jason_gill/Full_details_16426_en.php
Giraud-Triboult	Karine	SCR&Tox	INSERM/UEVE UMR861, I-STEM, AFM	Karine Giraud-Triboult +33 1 69 90 85 18 - kgiraud[at]istem[dot]fr INSERM/UEVE UMR861, I-STEM, AFM Génopole Campus 1 5 rue Henri Desbruères 91030 Evry cedex , France Resume 2011: Associate Engineer at ISTEM, SCR&Tox Program. 2010: Associate Engineer at ISTEM in the “Neuroplasticity and therapeutics” team (Dr Alexandra Benchoua, collaboration with ROCHE) 2005-2010: Associate Engineer at ISTEM in the “Pathological modelling of neuromuscular diseases” team (Dr Geneviève Piétu). 2004: Master in Engineering Functional Genomics (Evry University, France) Publications Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1. Giraud-Triboult K, Rochon-Beaucourt C, Nissan X, Champon B, Aubert S, Piétu G. Physiol Genomics. 2011 Jan 1;43(2):77-86. Epub 2010 Nov 16. Comparison of gene expression pattern in SP cell populations from four tissues to define common "stemness functions". Rochon C, Frouin V, Bortoli S, Giraud-Triboult K, Duverger V, Vaigot P, Petat C, Fouchet P, Lassalle B, Alibert O, Gidrol X, Piétu G. Exp Cell Res. 2006 Jul 1;312(11):2074-82. Epub 2006 Apr 19. Contribution to the project Functional genomics’ exploration of pluripotent stem cells-derived models (RNA interference, over-expression) Assay development, automation. Involved www.istem.eu
Gocht	Tilman	COACH	Eberhard Karls University Tuebingen, Institute for Experimental and Clinical Pharmacology and Toxicology and Center for Applied Geoscience	Tilman Gocht +49 7071 2974407 - Tilman[dot]gocht[at]uni-tuebingen[dot]de Eberhard Karls University Tuebingen, Institute for Experimental and Clinical Pharmacology and Toxicology and Center for Applied Geoscience Wilhelmstr. 56, Germany Resume Research Fellow at the University of Tuebingen in two Institutes, the Centre for Applied Geosciences and the Institute for Experimental and Clinical Pharmacology and Toxicology. Environmental Scientists with background in organic environmental chemistry and geosciences. Research in environmental fate of organic pollutants. Currently coordinator for a Collaborative Research Centre focusing on biological effects of particle-associated chemical agents, and member of the COACH Team. Publications Schwarz, K., Gocht, T., Grathwohl, P. (2011): Transport of polycyclic aromatic hydrocarbons in highly vulnerable karst systems.- Environ. Poll., 159: 133-139. Bergknut, M., Laudon, H., Jansson, S., Larsson, A., Gocht, T., Wiberg, K. (2011): Atmospheric deposition, retention, and stream export of dioxins and PCBs in a pristine boreal catchment.- Environ. Poll., 159: 1592-1598. Obst, M., Grathwohl, P., Kappler, A., Eibl, O., Peranio, N., Gocht, T. (2011): Quantitative high-resolution mapping of phenanthrene sorption to black-carbon particles.- Environ. Sci. Technol., 45: 7314-7322. Contribution to the project Member of the COACH Team. Preparation of the Annual Report of the SEURAT-1 Research Initiative. Communication of the strategic planning (cluster level) to the research projects. Facilitation of information exchange and collaboration between the different cluster projects Involved http://www.geo.uni-tuebingen.de/index.php?id=1812
Groebe	Karlfried	DETECTIVE	ProteoSys AG	Karlfried Groebe +49 6131 50192-42 - groebe[at]proteosys[dot]com ProteoSys AG Carl-Zeiss-Str. 51, 55129 Mainz, Germany Resume since 2004 Medical Director, Head of Data Analysis at ProteoSys AG 2001 – 2004 IT service consultant, focus on biomedical problems 1984 – 2001 Research Associate/Privatdozent at Dept. of Physiology, Univ. of Mainz, Mathematical modelling of physiological transport processes 1995 Habilitation in Physiology 1987 – 1988 Research Associate at the Univ. of Rochester, USA 1987 Ph.D. in Physiology 1984 M.D. 1977 – 1984 Mathematician/head of mathematics group at Max-Planck, Institute & Dept. of Meteorology, Mainz 1971 – 1984 Studies of Mathematics, Physics, Medicine at Tübingen, München, Mainz Publications Groebe K, Hayess K, Klemm M, Schwall GP, Wozny W, Steemans M, Peters AK, Sastri C, Jaeckel P, Stegmann W, Zengerling H, Schoepf R, Poznanović S, Stummann TC, Seiler A, Spielmann H, Schrattenholz A (2010). Protein biomarkers for in vitro testing of embryotoxicity. J Proteome Res 9: 5727-5738 Schrattenholz A, Groebe K and Šoškić V (2010). Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-Target Drugs , Methods Mol Biol 662: 29-58 Schostak M, Schwall GP, Poznanović S, Groebe K, Müller M, Messinger D, Miller K, Krause H, Pelzer A, Horninger W, Klocker H, Hennenlotter J, Feyerabend S, Stenzl A, Schrattenholz A (2009). nnexin A3 in Urine: A Highly Specific Noninvasive Marker for Prostate Cancer Early Detection , J Urol 181: 343-353 Contribution to the project Quantitative differential proteomic analysis of toxicant treated vs. untreated samples resulting in candidate protein biomarker signatures. Biomarker validation by repeated quantification of marker candidates under various experimental conditions. Expertise in standardized data models and database solutions for data from -omics techniques, in particular from proteomics. Statistical data analysis, amongst others for protein biomarkers discovery. Bioinformatics/systems biology approaches for analyzing the effects of differential protein expressions upon pertinent pathway functions. Involved http://www.proteosys.com/
Guimaraes	Eduardo	HeMiBio	Vrije Universiteit Brussel	Eduardo Guimaraes 32024774259 - eguimara[at]vub[dot]ac[dot]be Vrije Universiteit Brussel Laarbeeklan 103, Brussels, Belgium Resume 2006 -Phd student at LIVR laboratory Vrije Universiteit Brussel 2004-2006 -Master Biochemistry. Universidade Federal do Rio Grande do Sul, UFRGS, Rio Grande do Sul, Brasil. Scholarship: CAPES Master study title: Modulation of PPARs during phenotypic transformation of a hepatic stellate cell line 1999 – 2003 Graduate: Biological Sciences. Universidade Federal do Rio Grande do Sul, UFRGS, Rio Grande do Sul, Brasil. Graduate final work: Cytokines effects on cell cycle, proliferation and lipoperoxidation levels in a model of hepatic stellate cells Tutor: Fátima Theresinha Costa Rodrigues Guma. Scholarship: Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPQ, Brasil. Publications Guimarães EL, Empsen C, Geerts A, van Grunsven LA. Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells. J Hepatol. 2010 Mar;52(3):389-97. Guimarães EL, Franceschi MF, Andrade CM, Guaragna RM, Borojevic R, Margis R, Bernard EA, Guma FC. Hepatic stellate cell line modulates lipogenic transcription factors.Liver Int. 2007 Nov;27(9):1255-64 Guimarães EL, Franceschi MF, Grivicich I, Dal-Pizzol F, Moreira JC, Guaragna RM, Borojevic R, Margis R, Guma FC Relationship between oxidative stress levels and activation state on a hepatic stellate cell line.Liver Int. 2006 May;26(4):477-85. Contribution to the project Characterisation of specific markers for non-parenchymal liver cells. Derivation of hepatic stellate cells from iPS cells. Involved http://cyto.vub.ac.be/
Hardy	Barry	ToxBank	Douglas Connect	Barry Hardy +41 61 851 0170 - Barry[dot]Hardy[at]douglasconnect[dot]com Douglas Connect Baermeggenweg 14, Zeiningen, CH-4314, Switzerland Resume Dr. Barry Hardy is Director, Community of Practice & Research Activities of Douglas Connect, Switzerland. He is currently serving as coordinator for the OpenTox FP7 Health project in Predictive Toxicology and for the collaborative research activities in drug design and toxicology for the SYNERGY FP7 ICT project on knowledge-oriented collaboration. He directs the program activities of the InnovationWell and eCheminfo communities of practice which have goals and activities aimed at improving human health and safety and developing new solutions for neglected diseases. Dr. Hardy obtained his Ph.D. in 1990 from Syracuse University working in the area of computational science. He was a National Research Fellow at the FDA Center for Biologics and Evaluation, a Hitchings-Elion Fellow at Oxford University and CEO of Virtual Environments International. With OpenTox he is leading the development of an interoperable platform whose goal is to satisfy the needs of the predictive toxicology field through the creation of applications linking resources together for data, algorithms and models. Publications Collaborative Development of Predictive Toxicology Applications Journal of Cheminformatics 2010, 2:7 (31 August 2010), Full text and supplementary information available in Open Access at: www.jcheminf.com/content/2/1/7 B. Hardy; The Growing Significance of Communities & Collaboration in Discovery & Development, Future Medicinal Chemistry, Vol. 1, No. 3, Pages 435-449, June 2009. B. Hardy; Linking Trust, Change, Leadership & Innovation – Ingredients of a Knowledge Leadership Support Framework; KM Review, Nov/Dec 2007, Vol 10, Issue 5, pp 18-23. B. Hardy; Collaboration, Culture, and Technology – Contributions to Confidence in Leadership Support; KM Review, Jan/Feb 2008, Vol 10, Issue 6, pp 18-23. B. Hardy, P. Elkin, J. Averback, A.L. Fontaine, S. Kahn; Improving Confidence in Safety in Clinical Drug Development: The Science of Knowledge Management, The Monitor, Association of Clinical Research Professionals, October 2006, 37-41. Cheminfostream: http://barryhardy.blogs.com/cheminfostream/ The Ferryman: http://barryhardy.blogs.com/theferryman/ Contribution to the project Dr. Barry Hardy is serving as the scientific coordinator of the ToxBank infrastructure project. His involvement includes activities in requirements analysis, service development, knowledge management, interoperable approaches to linked resource development, software development and deployment, investigating approaches to integrated data analysis, development of collaborative approaches to data management and predictive toxicology model development, and encouraging the deployment of common approaches to protocols, vocabulary, and ontology. He initiated and facilitates cross-project interaction and discussions in the Data Analysis Working Group and the Compound Selection Working Group. Involved www.douglasconnect.com
Heimann	Marcus	HeMiBio	Fraunhofer Institute for Reliability and Microintegration	Marcus Heimann +49(0)30/ 46403743 - marcus[dot]heimann[at]izm[dot]fraunhofer[dot]de Fraunhofer Institute for Reliability and Microintegration Gustav-Meyer-Allee 25, 13355 Berlin, Germany Resume Marcus Heimann received his Diploma in electro technical engineering in 2011 from the Technical University of Berlin. He joined the group of Dr. Henning Schröder at the Fraunhofer IZM in February 2011. He has a background in microelectronics and microoptics with a focus in polymer optics and optical sensors. Publications M. Heimann, H. Schröder, S. Marx, K.-D. Lang „ Dielectric Elastomer Actuators for adaptive photonic microsystems” Proc. SPIE 8622, doi:10.1117/12.2004334 (2013) M. Heimann, M. Liesegang, N. Arndt-Staufenbiel, H. Schröder, K.-D. Lang „Optical System Components for Navigation Grade Fiber Optic Gyroscopes” Proc. SPIE 8899, doi:10.1117/12.2029097 (2013) Contribution to the project The Fraunhofer IZM is involved in WP4 of HeMiBio with the design and fabrication of flow through micro fluidic bioreactors in COC (Cyclo-Olifin-Copolymere). Involved http://www.izm.fraunhofer.de/en.html
Heinz	Stefan	HeMiBio	Medicyte GmbH	Stefan Heinz 0049-6221-7292544 - s[dot]heinz[at]medicyte[dot]com Medicyte GmbH Im Neuenheimer Feld 581, 69120 Heidelberg, Germany Resume Since 2009 Principal Scientist at Medicyte GmbH 2007 – 2008 Research Associate, Faculty of Medicine, University of Frankfurt 2002 – 2006 PhD, Faculty of Biochemistry, Chemistry and Pharmacy, University of Frankfurt/Main; Thesis title: „Improvement of recombinant expression of coagulation factor VIII at the transcriptional and post-transcriptional level“ 1996 – 2002 Study of Biological Science M.Sc, University of Bonn , Main subjects: Genetics, Biochemistry and Cell Biology Publications Heinz S, Schüttrumpf J, Simpson JC, Pepperkok R, Nicolaes GA, Abriss D, Milanov P, Roth S, Seifried E, Tonn T. Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII. Thromb Haemost. 2009 Nov;102(5):925-35. Delev D, Pavlova A, Heinz S, Seifried E, Oldenburg J., Factor 5 mutation profile in German patients with homozygous and heterozygous factor V deficiency. Haemophilia. 2009 Sep;15(5):1143-53. Epub 2009 May 26. Lotz GP, Brychzy A, Heinz S, Obermann WM. A novel HSP90 chaperone complex regulates intracellular vesicle transport. J Cell Sci. 2008 Mar 1;121(Pt 5):717-23. Epub 2008 Feb 12. Contribution to the project Medicyte (Partner 9 of the HeMiBio Project) focuses on the controlled and scalable proliferation of human primary cells whilst maintaining primary phenotype of the cells. For the HeMiBio project Medicyte will apply its upcyte® proliferation technology on primary human hepatocytes, stellate cells and liver sinusoidal endothelial cells. After expansion and initial characterization the cells will be provided to the HeMiBio project partners for the development of a hepatic microfluidic bioreactor model. Involved www.medicyte.com
Heinzle	Elmar	NOTOX	Saarland University	Elmar Heinzle 496 813 022 905 - e[dot]heinzle[at]mx[dot]uni-saarland[dot]de Saarland University Biochemical Engineering, Campus A1.5, Germany Resume Study of Biochemical Engineering at TU Graz, Austria including PhD (1978). Postdoc and assistant at ETH Zurich, Switzerland and at Joanneum Research Center in Graz, Austria. Since 1997 professor for Biochemical Engineering at the Saarland University, Germany. Guest professor at University of Minnesota and University of Kyoto in 2004. Member of the Center for Human and Molecular Biology and the Center of Bioinformatics of the Saarland University. Primary research interests in metabolic network characterisation and modelling and applications to metabolic engineering and toxicology. Publications Niklas J, Schneider K, Heinzle E (2010) Metabolic Flux Analysis in Eukaryotes. Curr Opin Biotechnol 21:63–69. 10.1016/j.copbio.2010.01.011. Niklas J, Schräder E, Sandig V, Noll T, Heinzle E (2011) Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. Bioproc Biosys Eng, DOI : 10.1007/s00449-010-0502-y Niklas J, Noor F, Heinzle E (2009) Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicol Appl Pharmacol. 240:327-36. Contribution to the project Coordinator of NOTOX. Long term organotypic cultures of hepatic cells using membrane reactors, spheroids and sandwich cultures with corresponding toxicological studies. Characterisation of metabolome and fluxome of 3D cultures. Modelling of bioreactors for quantitative data evaluation, e.g. 13C dynamic and steady state labelling experiments for metabolic flux quantification. Involved http://www.uni-saarland.de/fak8/heinzle
Heke	Michael	DETECTIVE	University Hospital Cologne, Institute for Neurophysiology	Michael Heke +49 (221) 478-97883 - michael[dot]heke[at]uni-koeln[dot]de University Hospital Cologne, Institute for Neurophysiology Robert-Koch-Strasse 39, 50931 Cologne, Germany Resume PhD in Biology. Career: Bayer AG (GER) 1989-1998; EMBL (GER) 1998-1999, Rockefeller University (USA) 1999-2005, JBL University of Turku (FIN) 2005-2006, University Hospital Düsseldorf (GER) 2006-2010, since 11/2011 at UKK. Focus on stem cell research for the past 10 years with the primary interest to gain an understanding of the molecular basis of hESCs, as well as elucidating to their genetic route taken as they develop into an organism. Later, shift of attention towards clinical applications of stem cells, e.g. clinical trial of applied stem cell therapy in cardiac surgery. Has since joined the DETECTIVE project to lead its knowledge management and scientific coordination. Publications Klein HM, Assmann A, Lichtenberg A, Heke M. Intraoperative CD133+ stem cell transplantation during coronary artery bypass grafting in ischemic cardiomyopathy. MMCTS 2010 Aug 9; doi:10.1510/ mmcts.2009.0039472009 Assmann A, Heke M, Schubert D, Lichtenberg A, Klein M. INSTEM trial - intraoperative, autologous CD133+ stem cell isolation and TMLR-supported transplantation during CABG. Human Gene Therapy 2009 Nov; Vol.20 (Issue 11): 1389-1389 Klein HM, Ruhparwar A, Heke M, Gams E. Intramyocardial Implantation of CD 133+Stem Cells Improve Cardiac Function without Bypass Surgery. Tissue Engineering, 2009 Mar; Vol.15 (Issue 3): 715-715 Contribution to the project Knowledge Management and Scientific Coordination Involved http://www.uni-koeln.de/med-fak/physiologie/np/index.htm
Helma	Christoph	ToxBank	in silico toxicology gmbh	Christoph Helma +41 774339164 - helma[at]in-silico[dot]ch in silico toxicology gmbh Altkircherstr. 4, 4054 Basel, Switzerland Resume Dr. Christoph Helma is the founder and owner of in silico toxicology. He received his Ph.D. in chemistry and a Masters in toxicology. His main research interest is the application of data mining techniques to solve real-world toxicological problems. He has more than 10 years experience in predictive toxicology research and has published more than 50 peer reviewed research papers. He was editor for the ‘Predictive Toxicology’ textbook and for special sections in ‘Bioinformatics’ and ‘Combinatorial Chemistry and High Throughput Screening’, invited speaker for major (Q)SAR conferences and main organizer of the ‘Predictive Toxicology Challenge’. He developed and implemented the lazar program, that was awarded with the Research Price for Alternative Methods to Animal Experiments (German Federal Ministry on Consumer Protection, Food and Agriculture, 2005) and the Research Prize for Cancer Research without Animal Experiments (Doctors Against Animal Experiments, 2006). He is currently developing an Inductive Database for the FP6 Sens-it-iv project and coordinates the scientific aspects of the OpenTox Framework for predictive toxicology. He will provide strong technical linkage between the OpenTox FP7 project and the proposed ToxBank DW platform and compound database, whose infrastructure will be reused for the purpose of the current proposal. Publications Claudia Suenderhauf, Felix Hammann, Andreas Maunz, Christoph Helma, and Jo¿rg Huwyler. Combinatorial qsar modeling of human intestinal absorption. Molecular Pharmaceutics, 8(1):213-224, 2011. Andreas Maunz, Christoph Helma, and Stefan Kramer. Efficient mining for structurally diverse subgraph patterns in large molecular databases. Machine Learning, pages 1-26, 2010. Barry Hardy, Nicki Douglas, Christoph Helma, Micha Rautenberg, Nina Jeliazkova, Vedrin Jeliazkov, Ivelina Nikolova, Romualdo Benigni, Olga Tcheremenskaia, Stefan Kramer, Tobias Girschick, Fabian Buchwald, Joerg Wicker, Andreas Karwath, Martin Gutlein, Andreas Maunz, Haralambos Sarimveis, Georgia Melagraki, Antreas Afantitis, Pantelis Sopasakis, David Gallagher, Vladimir Poroikov, Dmitry Filimonov, Alexey Zakharov, Alexey Lagunin, Tatyana Gloriozova, Sergey Novikov, Natalia Skvortsova, Dmitry Druzhilovsky, Sunil Chawla, Indira Ghosh, Surajit Ray, Hitesh Patel, and Sylvia Escher. Collaborative development of predictive toxicology applications. Journal of Cheminformatics, 2:7, 2010. Contribution to the project WP2 leader; Technical design and Implementation tasks in WP1 and WP2 Incorporation and Development of OpenTox components Integration and Reuse of Bioinformatics resources Involved www.in-silico.ch
Helsen	Nicky	HeMiBio	KU Leuven	Nicky Helsen +3216379815 - nicky[dot]helsen[at]med[dot]kuleuven[dot]be KU Leuven Herestraat 49 bus 804 O&N4 , Belgium Resume Nicky Helsen received her PharmD degree in 2012 at the Catholic University of Leuven. For her master thesis, she investigated RNA aptamers targeting tPA at the University of Aarhus under direction of Dr. P.A. Andreasen. From September 2012, she started as a PhD student in the lab of Dr. Verfaillie where she will investigate the infection of stem cell-derived hepatocytes with hepatotropic viruses including the hepatitis C, hepatitis E and hepatitis B virus. Publications Contribution to the project I will investigate if stem cell-derived hepatocytes can be infected with different liver specific viruses. This includes optimization of the hepatic differentiation to make a more robust cell culture system. Infection of stem cell-derived hepatocytes provides a novel tool to elucidate the biology of hepatotropic viruses and will aid in antiviral drug development. Involved http://www.kuleuven.be/samenwerking/scil/
Hengstler	Jan	NOTOX & DETECTIVE	IFADO	Jan Hengstler 492311084348 - Hengstler[at]ifado[dot]de IFADO Ardeystrasse 67, Germany Resume Jan G. Hengstler, Professor MD, born July 05, 1965 in Heidelberg. He studied medicine at the University of Mainz from 1984 to 1990. 1991-2002 Institute of Toxicology, University of Mainz, 1998 Habilitation in Pharmacology and Toxicology. 2003-2006 Director of the Centre for Toxicology, University of Leipzig. Since 2007 Head of the Department of Toxicology, IfADo – Leibniz Research Centre in Dortmund. Research interests: Liver toxicity and regeneration, carcinogenesis, hepatocyte in vitro systems. Publications Hoehme S, Brulport M, Bauer A, Bedawy E, Schormann W, Hermes M, Puppe V, Gebhardt R, Zellmer S, Schwarz M, Bockamp E, Timmel T, Hengstler JG, Drasdo D, Cell alignment along micro-vessels as order principle to restore tissue architecture during liver regeneration: from experiment to virtual tissues and back, PNAS, 2010 Jun 8;107(23):10371-6. Godoy P, Hengstler JG, Ilkavets I, Meyer C, Bachmann A, Müller A, Tuschl G, Mueller SO, Dooley S. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology. 2009 Jun;49(6):2031-43. Rothman N, Garcia-Closas M, Chatterjee N, …Hengstler JG, … Chanock SJ. A multi-stage genome-wide association study identifies multiple susceptibility loci. Nat Genet. 2010 Nov;42(11):978-84. Contribution to the project Hepatocyte in vitro systems Identification of toxic mechanisms Establishment of classification systems for toxic compounds Imaging (confocal, 3D reconstruction), cell and molecular biology Involved http://www.ifado.de/forschung_praxis/projektgruppen/susceptibility/index.php
Hescheler	Juergen	DETECTIVE	University Hospital Cologne, Institute for Neurophysiology	Juergen Hescheler +49 (221) 478-6960 - j[dot]hescheler[at]uni-koeln[dot]de University Hospital Cologne, Institute for Neurophysiology Robert-Koch-Strasse 39, 50931 Cologne, Germany Resume Director of the Institute of Neurophysiology at the University of Cologne, has been working with ESCs for over 20 years. Beginning with studies on cellular signal transduction, he has defined many important basic aspects both for fundamental research as well as for clinical applications He has a strong interest in the therapeutic application of ES and iPS cells. He received several awards for alternative testing research, including the Bundesminister für Jugend, Familie, Frauen und Gesundheit Award (1992), the Dorothy Hegarty Award (1999) and an Honorary Doctorate of the Tongji Medical Faculty of the Huazhong University in Wuhan (China) (2009). Publications Illich DJ, Demir N, Stojković M, Scheer M, Rothamel D, Neugebauer J, Hescheler J, Zöller JE. Induced Pluripotent Stem (Ips) Cells and Lineage Reprogramming: Prospects for Bone Regeneration. Stem Cells. 2011 Feb 4. doi: 10.1002/stem.611. Gupta MK, Illich DJ, Gaarz A, Matzkies M, Nguemo F, Pfannkuche K, Liang H, Classen S, Reppel M, Schultze JL, Hescheler J, Sarić T. Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar. BMC Dev Biol. 2010 Sep 15;10:98 Kuzmenkin A, Liang H, Xu G, Pfannkuche K, Eichhorn H, Fatima A, Luo H, Saric T, Wernig M, Jaenisch R, Hescheler J. Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro. FASEB J. 2009 Dec;23(12):4168-80. Epub 2009 Aug 24. Pfannkuche K, Liang H, Hannes T, Xi J, Fatima A, Nguemo F, Matzkies M, Wernig M, Jaenisch R, Pillekamp F, Halbach M, Schunkert H, Sarić T, Hescheler J, Reppel M. Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility. Cell Physiol Biochem. 2009;24(1-2):73-86 Mauritz C, Schwanke K, Reppel M, Neef S, Katsirntaki K, Maier LS, Nguemo F, Menke S, Haustein M, Hescheler J, Hasenfuss G, Martin U. Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation. 2008 Jul 29;118(5):507-17 Contribution to the project Prof. Hescheler is the Coordinator of the DETECTIVE Consortium. His general expertise includes electrophysiological characterization of cardiac muscle cells, iPS cells and differentiation into functional somatic cell types, as well as generating genetically intact iPS cell lines with defined cardiac and neural differentiation potential As Coordinator he is responsible for all aspects of the interface between the project and the EC. The Coordinator is the focal point for all technical and administrative content of the project and leads the complete EU-wide partnership. He also serves as member of The Scientific Expert Panel to the SEURAT Cluster. Involved http://www.uni-koeln.de/med-fak/physiologie/np/index.htm
Hoercher	Renate	DETECTIVE	Roche Diagnostics GmbH	Renate Hoercher +49885660-7341 - Renate[dot]hoercher[at]roche[dot]com Roche Diagnostics GmbH Nonnenwald 2, 82377 Penzberg, Germany Resume Dr. rer.nat. in Molecular Biology at the Department of Physiological Chemistry in Marburg / Lahn, Germany. “Post-Doc" fellowship at the Department of Organic Chemistry and Biochemistry, Technical College Darmstadt, in a research project of the German research foundation (DFG). Employment with Boehringer – Mannheim GmbH, then Roche Diagnostics GmbH in various functions, currently Senior Director in the Public Funding Office. Publications - Contribution to the project Coordination of the Roche contribution Involved www.roche.de
Horvat	Tomislav	COACH	European Commission, Joint Research Center	Tomislav Horvat +39 033278-9382 - tomislav[dot]horvat[at]ec[dot]europa[dot]eu European Commission, Joint Research Center Via E. Fermi 2749, I-21027 Ispra (VA), Italy Resume Tomislav Horvat graduated with a degree in molecular biology from the University of Zagreb in Croatia, followed by a double mentorship PhD between University Paris 6 (France) and University of Zagreb (Croatia). He has been working in the fields of epigenetics and glycobiology, and currently is involved in predictive toxicology and elucidation of adverse outcome pathways (AOPs) in liver toxicities. Publications Zoldos, V., Horvat, T. and Lauc, G. (2013) Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies. Current Opinion in Chemical Biology. 17, 34-40. Zoldos, V., Horvat, T., Novokmet, M., Cuenin, C., Knezevic, A., Pucic, M., Huffman, J.E., Gornik, O., Polasek, O., Campbell, H., Hayward, C., Wright, A.F., Rudan, I., Owen, K., McCarthy, M.I., Herceg, Z. and Lauc, G. (2012) Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome. Epigenetics. 7, 164-172. Horvat, T., Muzinic, A., Barisic, D., Herak Bosnar, M., Zoldos, V. (2011) Epigenetic modulation of HeLa cell membrane N-glycome. BBA-General subjects. 1820, 1412-1419. Contribution to the project Participation in development of a Mode of Action (MoA)-based classification model to distinguish between potential hepatotoxicants and non-hepatotoxicants. Selection of assays for specific endpoint measurements; exposing HepaRG cells to selected chemicals and performing the measurements. Participation in the evaluation of the classification model. Involved http://ihcp.jrc.ec.europa.eu/
Hyllner	Johan	SCR&Tox	Cellartis AB	Johan Hyllner 0046 31 7580902 - Johan[dot]hyllner[at]cellartis[dot]com Cellartis AB Arvid Wallgrens backe 20, Sweden Resume Positions 2003- CSO/COO, Cellartis AB 2001-2003 CEO, Cellartis AB 2001-2002 CSO, Vitrolife AB 2000-2001 Manager, SMA, Vitrolife AB 1998-2000 CEO and Founder, SQC Laboratories AB 1997-1998 Project Manager, Vitrolife AB 1996-1997 Research Associate, Göteborg University 1995-1996 Research Scientist, UMDNJ, NJ, USA 1994-1995 Research Fellow, RIMB, Hoffman-LaRoche, NJ, USA Exams 1994 Ph.D. degree in Zoophysiology,Gothenburg University. . 1988 B.Sc. in Biology/Chemistry, Gothenburg University, Publications and patents Hyllner has published more than 50 full length international scientific publications. Hyllner is a co-inventor of four patent and pending patent applications. Publications Latest three original full-length publications (March, 2011) Both SK, van Apeldoorn AA, Jukes JM, Englund MC, Hyllner J, van Blitterswijk CA & de Boer J (2011) Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells.J. Tissue Eng. Regen. Med. 5: 180-90. Bigdeli N, de Peppo GM, Lennerås M, Sjövall P, Lindahl A, Hyllner J & Karlsson C (2010) Superior Osteogenic Capacity of Human Embryonic Stem Cells Adapted to Matrix-Free Growth Compared to Human Mesenchymal Stem Cells.Tissue Eng Part A. 16: 3427-40 Serra M, Brito C, Sousa MF, Jensen J, Tostões R, Clemente J, Strehl R, Hyllner J, Carrondo MJ & Alves PM (2010) Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control.J Biotechnol. 148: 208-15 Contribution to the project Hyllner will provide: management skills in-depth knowledge in stem cell biology in-depth know-how in industrial manufacturing and bioprocessing methods Regulatory expertise Expertise in industrial transformation Involved www.cellartis.com
Ingelman-Sundberg	Magnus	SCR&Tox & NOTOX	Karolinska Institutet, Department of Physiology and Pharmacology	Magnus Ingelman-Sundberg +468-52487735 - Magnus[dot]ingelman-sundberg[at]ki[dot]se Karolinska Institutet, Department of Physiology and Pharmacology , Sweden Resume Magnus Ingelman-Sundberg is a PhD and BSc.Med . He has 350 original papers, 18 500 citations and an h-factor of 74. He is ranked as the 4th most highly impact researcher of 4,000 in the field of drug metabolism (www.cytochrome.net ) and one of the worlds most cited authors within the category Pharmacology http://isihighlycited.com/ . The current research is centered about genetic predictors for drug response and adverse drug reactions. In addition, new in vitro systems are developed for identification of new biomarkers predicting drug hepatotoxicity using 3D reactors from Stem Cell Systems where intact liver structures are obtained as usable for several weeks. Publications Ingelman-Sundberg M. Pharmacogenomic biomarkers for prediction of severe adverse drug reactions. N Engl J Med. 2008; 358:637-9. Butura A, Nilsson K, Morgan K, Morgan TR, French SW, Johansson I, Schuppe-Koistinen I, Ingelman-Sundberg M. The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model. J Hepatol. 2009; 50:572-83. Sim SC, Ingelman-Sundberg M. Pharmacogenomic biomarkers in current and future drug therapy. Trends Pharmacol Sci, 2011; 32:72-81 Contribution to the project Equipment and competence for toxicological analyses, heterologous expression, drug metabolism and toxicity analyses, molecular genetics, cell biology; Bioreactor system set up which allows studies of metabolism and toxicity in an in vivo like hepatic structure.; Characterisation of cell systems with respect to competence for xenobiotic metabolism and toxicity ; Toxicity testing of cells in artificial devices; Bioreactor systems based on primary human hepatocytes; Characterisation of xenobiotic metabolism Involved http//:ki.se/pharmacology/pharmacogenetics
Ivana	Toth	NOTOX	Cambridge Cell Networks Ltd	Toth Ivana +38121533909 - ivana[dot]toth[at]camcellnet[dot]com Cambridge Cell Networks Ltd St John's Innovation Centre, Cowley Road, CB4 0WS Cambridge, United Kingdom Resume I hold PhD in Organic chemistry from BOKU University, Vienna (AT) and M.Sc. in Chemistry from University of Novi Sad (SR). I was doing research in organic synthesis of novel carbohydrates and chemical modifications of biomaterials. I have experience in scientific writing-publications and annual reports, as well as in marketing strategy within pharmaceutical company. For the last year I have been responsible for scientific knowledge extraction and data integration in field of toxicology, management duties and organization of events. I work on systems biology data (knowledge bases and various –omics data) in order to create models of mechanism of action and biological pathways. Publications Müller Y., Toth I., Potthast A., Rosenau T., Zimmermann R., Eichhorn K.J., Nitschke C., Scherr G., Freudenberg U., Werner C. ’’The impact of esterification reactions on physical properties of cellulose thin films’’ Soft Matter 2010, 6, 3680-3684. Toth I., Müller Y., Werner C., Rosenau T., Potthast A. ’’A novel, mild and selective methylation of carboxyl groups in cellulosic pulps’’ Holzforschung 2009, 63 (6), 657-663. Toth I., Krainz K., Potthast A., Suess U., Rosenau T. ’’Comparative Synthesis Studies Towards Methyl and Phenyl 4-Deoxy-β-L-threo-hex-4-enopyranosiduronic Acid as Model Compounds of Hexenuronic Acid Moieties in Hardwood Pulps’’ Macromol. Symp. 2008, 262 (1), 182-189. Contribution to the project CCN will be involved in the knowledge extraction from the legacy publication, tools for modelling of biological pathways, integration of the data generated by the experimental partners. CCN will conduct a systematic knowledge extraction from the literature and all other publicly available resources and create the most comprehensive NOTOX Knowledge Base. CCN will integrate relevant data from the experimental partners and map them onto existing NOTOX knowledge base. CCN will design, implement and test the systems biology data integration and deliver NOTOX pathway models in a form of a database and an easy-to-use visualization module. By combining the legacy literature data and the experimental results, CCN will create predictive methods for a) predicting the toxicity of compounds and b) creating hypothesis on mechanistic models. CCN will run multiple workshops and trainings. Involved www.camcellnet.com
Jaeger	Magnus	HeMiBio	Fraunhofer Institute for Biomedical Engineering (IBMT)	Magnus Jaeger +49 / 3 31 / 581 87 - 305 - magnus[dot]jaeger[at]ibmt[dot]fraunhofer[dot]de Fraunhofer Institute for Biomedical Engineering (IBMT) Am Muehlenberg 13, 14476 Potsdam, Germany Resume Publications Jaeger, M. S.; Uhlig, K.; Schnelle, T.; Mueller, T.: Contact-free single-cell cultivation by negative dielectrophoresis. (2008) J Phys D Appl Phys 41:175502. Jaeger, M. S.; Uhlig, K.; Clausen-Schaumann, H.; Duschl, C.: The structure and functionality of contractile forisome protein aggregates. (2008) Biomaterials 29:247–256. Jaeger, M. S.; Mueller, T.; Schnelle, T.: Thermometry in dielectrophoresis chips for contact-free cell handling. (2007) J Phys D Appl Phys 40:95–105. Contribution to the project To develop sensors for real-time basic culture conditions To develop sensors for real-time cell function Develop a 2D bioreactor for the efficient isolation of differentiated iPSC mixtures by trapping different cell types on micropatterned surfaces Fabrication of high-throughput microfluidics addressable array Fabricated multi-electrode plate Integrate sensor electronics using UTCP Computer interface and recording subrouting Involved www.ibmt.fraunhofer.de
Jagiella	Nick	NOTOX	INRIA Rocquencourt	Nick Jagiella 33677485481 - Nick[dot]jagiella[at]inria[dot]fr INRIA Rocquencourt Domaine de Voluceau – Rocquencourt, B.P. 105 - 78153 Le Chesnay, France Resume 2001 – 2007 University of Leipzig Study of Computer Science 2007 Degree: Diplom-Informatiker Field of study: Bioinformatik 2007 – 2010 INRIA Rocquencourt Doctoral Studies Ph.D. Thesis: Modeling of Multi-Cellular Systems in Biotechnological Applications. Publications Drasdo, D., Jagiella, N., Ramis-Conde, I., Vignon-Clémentel, I., Weens, W. Modeling steps from a benign tumor to an invasive cancer: examples of intrinsically multi-scale problems. In: From single scale-based models to multiscale modeling, Eds. Chauvière, A. and Preziozi, L. and Verdier, C., 2009. Contribution to the project Image processing on microscopic images (confocal, bright field) of collaborating partners (NKI, DFKI, IFAD, USAAR-EH) to extract statistical information about the three-dimensional architecture before and after intoxication. Development of a multi-scale model of homogeneous/mono-cell-type cultures (spheroid and sandwich bioreactors; IFAD, BIOP, USAAR-EH) as well as three-dimensional multi-scale model of organotypic cultures (in membrane bioreactors; KI, USAAR-EH). Model parameterization from in-vitro and in-vivo data sources. Prediction of possible in-vivo toxicity of certain compounds on organs. Involved http://www-rocq.inria.fr/bang/DD/
Jeliazkov	Vedrin	ToxBank	Ideaconsult Ltd	Vedrin Jeliazkov +359 8 87818654 - vedrin[dot]jeliazkov[at]gmail[dot]com Ideaconsult Ltd Angel Kanchev Str 4, Sofia 1000, Bulgaria Resume Vedrin Jeliazkov received a M.Sc. in Computer Science from Université Paris Diderot, France in 1998.He began his professional career as a software developer at the R&D department of Electricité de France (EDF), Clamart, France – 1996-1998. He joined the Bulgarian Academy of Sciences in 1998 as a researcher and network engineer at the Network Operating Centre of the Bulgarian National Research and Education Network. He is founder and co-owner of Ideaconsult Ltd and is a full time researcher at the company since 2007. He participated in a number of R&D projects in France, Belgium and Bulgaria. Publications Jeliazkova, N.; Jeliazkov, V.; AMBIT RESTful web services: an implementation of the OpenTox application programming interface, Journal of cheminformatics, 3, 18, 2011, BioMed Central Hardy, B.; Douglas, N.; Helma, C.; Rautenberg, M.; Jeliazkova, N.; Jeliazkov, V.; Nikolova, I.; Benigni, R.; Tcheremenskaia, O.; Kramer, S.; Girschick, T.; Buchwald, F.; Wicker, J.; Karwath, A.; Gütlein, M.; Maunz, A.; Sarimveis H.; Melagraki, G.; Afantitis, A.; Sopasakis, P.; Gallagher, D.; Poroikov, V.; Filimonov, D.; Zakharov, A.; Lagunin, A.; Gloriozova, T.; Novikov, S.; Skvortsova, N.; Druzhilovsky, D.; Chawla, S.; Ghosh, I.; Ray, S.; Patel, H; Escher, S.; Collaborative development of predictive toxicology applications, Journal of cheminformatics, 2, 1, 1-29, 2010, Springer Hanemann, A.; Jeliazkov, V.; Kvittem, O.; Marta, L.; Metzger, J.; Velimirovic, I.; Complementary visualization of perfSONAR network performance measurements, International Conference on Internet Surveillance and Protection, 6-6, 2006, IEEE Jeliazkova, N.; Iliev, L.; Jeliazkov, V.; PerfsonarUI-a standalone graphical user interface for querying perfSONAR services, John Vincent Atanasoff 2006 International Symposium on Modern Computing, 77-81, 2006, IEEE Contribution to the project Collaborator in ToxBank WP1 (Data Warehouse), WP2 (Compound Database) and WP5 (Dissemination). Involved http://www.ideaconsult.net/
Jeliazkova	Nina	ToxBank	Ideaconsult Ltd	Nina Jeliazkova 359886802011 - Jeliazkova[dot]nina[at]gmail[dot]com Ideaconsult Ltd Angel Kanchev Str 4, Sofia 1000, Bulgaria Resume Nina Jeliazkova received a M.Sc. in Computer Science from the Institute for Fine Mechanics and Optics, St. Petersburg, Russia in 1991, followed by a PhD in Computer Science (thesis "Novel computer methods for molecular modelling") in 2001 in Sofia, Bulgaria, and a PostDoc at the Central Product Safety department, Procter & Gamble, Brussels, Belgium (2002 - 2003) Her professional career started as a software developer first at the oil refinery Neftochim at Burgas, Bulgaria (1991 - 1995), then at the Laboratory for Mathematical Chemistry, Burgas, Bulgaria (1996 - 2001). She joined the Bulgarian Academy of Sciences in 1996 as a researcher and network engineer at the Network Operating Centre of the Bulgarian National Research and Education Network. She is founder and co-owner of Ideaconsult Ltd and is technical manager of the company since 2009. She participated in a number of R&D projects in Belgium and Bulgaria, authored and co-authored about 40 scientific papers in Bulgarian and international journals and textbooks, as well as several book chapters. Publications Jeliazkova N., Jeliazkov V. AMBIT RESTful web services: an implementation of the OpenTox application programming interface, Journal of Cheminformatics 2011, 3:18, doi:10.1186/1758-2946-3-18. Jeliazkova N., Kochev N. Ambit-SMARTS: Efficient Searching Of Chemical Structures And Fragments, Molecular Informatics, 2011;30(8):707-720. doi:10.1002/minf.201100028 Willighagen E., Jeliazkova N., Hardy B., Grafstrom R., Spjuth O., Computational toxicology using the OpenTox application programming interface and Bioclipse, BMC Research Notes 2011 4 (1), 487 Noel M O'Boyle , Rajarshi Guha , Egon L Willighagen , Samuel E Adams , Jonathan Alvarsson , Jean-Claude Bradley , Igor V Filippov , Robert M Hanson , Marcus D Hanwell , Geoffrey R Hutchison , Craig A James , Nina Jeliazkova , Andrew SID Lang , Karol M Langner , David C Lonie , Daniel M Lowe , Jerome Pansanel , Dmitry Pavlov , Ola Spjuth , Christoph Steinbeck , Adam L Tenderholt , Kevin J Theisen and Peter Murray-Rust, Open Data, Open Source and Open Standards in chemistry: The Blue Obelisk five years on Journal of Cheminformatics 2011, 3:37, doi:10.1186/1758-2946-3-37. Bhhatarai B., Teetz W., Liu T., Oberg T., Jeliazkova N., Kochev N., Pukalov O., Tetko I., Kovarich S., Papa E., Gramatica P., CADASTER QSPR Models for Predictions of Melting and Boiling Points of Perfluorinated Chemicals, Molecular Informatics 2011;30(2-3):189–204. Jeliazkova N., Jaworska J., Worth A. (2010) Chapter 17. Open Source Tools for Read-Across and Category Formation, In M. Cronin, & Madden J. (Eds.), In Silico Toxicology : Principles and Applications (pp. 408-445). Cambridge, UK: RSC Publishing B. Hardy, N. Douglas, C. Helma, M. Rautenberg, N. Jeliazkova, V. Jeliazkov, I. Nikolova, R. Benigni, O. Tcheremenskaia, S. Kramer, T. Girschick, F. Buchwald, J. Wicker, A. Karwath, M. Gütlein, A. Maunz, H. Sarimveis, G. Melagraki, A. Afantitis, P. Sopasakis, D. Gallagher, V. Poroikov, D. Filimonov, A. Zakharov, A. Lagunin, T. Gloriozova, S. Novikov, N. Skvortsova, D. Druzhilovsky , S. Chawla, I. Ghosh, S. Ray, H. Patel, S. Escher, Collaborative Development of Predictive Toxicology Applications, Journal of Cheminformatics 2010, 2:7doi:10.1186/1758-2946-2-7. Nina Jeliazkova, Computer tools for Threshold of Toxicological Concern elucidation, Toxicology Letters, Abstracts of the 46th Congress of the European Societies of Toxicology, Volume 189, Supplement 1, 13 September 2009, Page S10 R. Benigni, A. Worth, T. Netzeva, N. Jeliazkova, C. Bossa, A. Gruska, R. Franke, Structural motifs modulating the carcinogenic risk of aromatic amines, Environmental and Molecular Mutagenesis, 2009, 50:152161 Patlewicz G, Jeliazkova N, Safford RJ, Worth AP, Aleksiev B. An evaluation of the implementation of the Cramer classification scheme in the Toxtree software. SAR QSAR Environ Res. 2008;19(5-6):495-524. G. Patlewicz, N. Jeliazkova, A. Gallegos Saliner, A. P. Worth, Toxmatch-a new software tool to aid in the development and evaluation of chemically similar groups,SAR and QSAR in Environmental Research, 19:3, 397 — 412(2008) Joanna Jaworska, Nina Nikolova-Jeliazkova, How can structural similarity analysis help in category formation, SAR and QSAR in Environmental Research, vol 18, 3-4 (2007) Joanna Jaworska, Nina Nikolova-Jeliazkova, Tom Aldenberg QSAR Applicability Domain Estimation by Projection of the Training Set in Descriptor Space: A Review, ATLA, 33, 445–459 (2005) Nina Nikolova-Jeliazkova, Joanna Jaworska An Approach to Determining Applicability Domains for QSAR Group Contribution Models: An Analysis of SRC KOWWIN, ATLA, 33, 461–470 (2005) T.I. Netzeva, A.P. Worth,T. Aldenberg, R. Benigni, M.T.D. Cronin, P. Gramatica, J.S. Jaworska, S. Kahn, G. Klopman, C.A. Marchant, G. Myatt, N. Nikolova-Jeliazkova, G.Y. Patlewicz, R. Perkins, D.W. Roberts, T.W. Schultz, D.T. Stanton, J.J.M. van de Sandt, W. Tong, G. Veith & C. Yang ECVAM WORKSHOP REPORT Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships , ATLA, 33, 155-173 (2005) Aynur O. Aptula, Nina G. Jeliazkova,, Terry W. Schultz, Mark T. D. Cronin The Better Predictive Model: High q2 for the Training Set or Low Root Mean Square Error of Prediction for the Test Set?, QSAR and Combinatorial Science 2005, 24, 385-396 (2005) Contribution to the project ToxBank WP1 (Data Warehouse) leader. Design, development and support of ToxBank warehouse. Integration of multiple partner data and software tools, as a set of distributed web services, supporting public OpenTox API standards. Involved http://www.ideaconsult.net/
Jennings	Paul	DETECTIVE	Innsbruck Medical University	Paul Jennings 43512900370826 - Paul[dot]Other[at]gmail[dot]com Innsbruck Medical University Fritz-Pregl-Strasse-3, Austria Resume Born 1974 in Dublin Ireland. Graduated with a honours Bachelor of Science degree in 1996 from University College Dublin. PhD thesis was conducted under Prof. Michael P. Ryan at the Dept. of Pharmacology, Dublin, entitled "Novel approaches for in vitro nephrotoxicity testing". Graduated with PhD in 2001. Completed his habilitation in 2009 at the Physiology Dept. of the Innsbruck Medical University, entitled "Epithelial Cell Cultures as tools to study human disease and the adverse effects of pharmaceuticals and chemicals"23/05/2011 Currently working primarily investigating underlying mechanisms of chronic renal disease. Dr. Jennings is a principal investigator in the 7th Framework Project Predict-IV and the 6th Framework Project Carcinogenomics. Dr. Jennings is also the principal investigator in the Medizinische Forschungsförderung Innsbruck (MFI) funded project, "Investigation of immune mechanisms in uromodulin associated kidney disease" Publications Wilmes, A., D. Crean, S. Aydin, W. Pfaller, P. Jennings, and M. Leonard, Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity. Toxicology In Vitro, 2011. [IN PRESS.] Signorelli, S., P. Jennings, M.O. Leonard, and W. Pfaller, Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells. Cell Physiol Biochem, 2010. 25(1): p. 135-44. Schmid, M., S. Prajczer, L.N. Gruber, C. Bertocchi, R. Gandini, W. Pfaller, P. Jennings, and M. Joannidis, Uromodulin facilitates neutrophil migration across renal epithelial monolayers. Cell Physiol Biochem, 2010. 26(3): p. 311-8. Contribution to the project Human renal epithelial cell culture models and development and elucidation of molecular mechanisms of chemical induced toxicity and biomarker discovery. Involved http://physiologie.i-med.ac.at/jennings
Jiang	Xiaoqi	DETECTIVE	German Cancer Research Center, Division of Biostatistics	Xiaoqi Jiang +49-(0)6221-42 2387 - xiaoqi[dot]jiang[at]dkfz[dot]de German Cancer Research Center, Division of Biostatistics Im Neuenheimer Feld 280, D - 69120 Heidelberg, Germany Resume Xiaoqi Jiang is a biostatistician at the German Cancer Research Center (DKFZ) in Heidelberg. After graduating with a M.Sc. degree in Biostatistics from University of Munich, she joined the Division of Biostatistics of DKFZ and followed by a PhD in 2011. PhD thesis entitled "Estimation of effective concentrations from in vitro dose-response data using the log-logistic model" was finished in 2013. Her research area focuses on statistical dose-response modeling and estimation of effective concentration (dose). Publications Weimer, M., Jiang, X., Ponta, O., Stanzel, S., Freyberger, A. and Kopp-Schneider, A. (2012). The impact of data transformations on concentration-response modeling, Toxicology Letters 213: 292 - 298. Jiang, X. and Kopp-Schneider, A. (2013). Summarizing EC50 estimates from multiple dose-response experiments: a comparison of a meta-analysis strategy to a mixed-effects model approach, Biometrical Journal, in press. Contribution to the project Experimental design Data management and monitoring Statistical analysis of derived endpoints, e.g. EC50 estimation Identification and analysis ob biomarkers for toxicity Analysis of the relationship between molecular biomarkers, functional readouts, and clinical signs Involved www.dkfz.de
Kavlock	Robert	COSMOS	National Center for Computational Toxicology, US EPA	Robert Kavlock 9 195 412 326 - Kavlock[dot]robert[at]epa[dot]gov National Center for Computational Toxicology, US EPA Research Triangle Park, NC, 27711, USA Resume Bob Kavlock is the Director of EPAs National Center for Computational Toxicology (NCCT) since 2005. The mission of the NCCT is to provide improved hazard and risk identification for assessment of environmental chemicals through the blending of advances in modern molecular biology with computational sciences. Priorly he spent 15 years as the Director of the Reproductive Toxicology Division in EPAs Office of R&D. In 2007 he was the recipient of ORDs Statesmen of the Year Award. He has published more than 200 scientific papers, 16 book chapters, and edited three books, including a co-editor of the Global Assessment of the State-of-the-Science of Endocrine Disruptors (WHO, 2002). He is a past president of the Teratology Society and is active in the Society of Toxicology. He is a member of the editorial boards of Environmental Health Perspectives, the Journal of Toxicology and Environmental Health, and Birth Defects Part B: Developmental and Reproductive Toxicity. Publications Judson RS, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Mortensen HM, Reif DM, Rotroff DM, Shah I, Richard AM, Dix DJ. In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. Environ Health Perspect. 2010 Apr;118(4):485-92 Mrtin MT, Dix DJ, Judson RS, Kavlock RJ, Reif DM, Richard AM, Rotroff DM,Romanov S, Medvedev A, Poltoratskaya N, Gambarian M, Moeser M, Makarov SS, Houck KA. (2010). Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem Res Toxicol. 23(3):578-90. Kavlock, R. Austin, CP and Tice, RR (2009). Toxicity Testing in the 21^st Century: Implications for Human Health Risk Assessment. Risk Analysis 29: 485-487. Contribution to the project The NCCT was formed in 2005 to facilitate and bring focus to EPA’s efforts to characterize exposure, hazard, and risk through the broad use of modern biological tools, information technologies, and computational models. NCCT’s flagship project is ToxCast™, which is being developed as a cost-effective approach for prioritizing the toxicity testing of large numbers of chemicals in a short period of time. NCCT scientists are leading the development of a Virtual Liver and a Virtual Embryo, which are multi-scale computational models of tissue organization and function. These projects aim to advance the long-term goal of understanding and predicting the risks posed by environmental chemicals in these tissues. The key tasks allocated to NCCT in the COSMOS project include: Toxicological data retrieval, curation, quality and databasing (WP1) Threshold of Toxicological Concern (WP2) Development of innovative computational approaches to predict toxicity (WP3) Metabolic considerations in toxicity (WP5) Dissemination of results and integration of COSMOS with other projects (WP7) Involved Epa.gov/ncct
Keller	Detlef	COSMOS	HENKEL AG & Co. KGaA	Detlef Keller +49 (0) 211797 7841 - detlef[dot]keller[at]henkel[dot]com HENKEL AG & Co. KGaA 40589 Düsseldorf, Germany Resume Dr Detlef Keller joined Henkel in 2004 and has more than 15 years of experience in the human safety assessment of numerous chemicals and products which he achieved during his work at the Henkel KGaA, the Beiersdorf AG, the Fraunhofer Institute of Toxicology and Aerosol Research (now ITEM), and the Fraunhofer Institute for Environmental Chemistry and Ecotoxicology (now IME). He is the responsible toxicologist for cosmetic products and risk assessment of processes. Detlef Keller is a member of the COLIPA CCC Science Committee, the former COLIPA PT Toxicology, and several working groups in context with the implementation of the REACH legislation. Publications D.Keller et. al. 2009. Feasibility study to support a threshold of sensitization concern concept in risk assessment based on human data. Archives of Toxicology 83:1049–1060, 2009. (http://www.springerlink.com/content/u88klv56q12j2684/fulltext.pdf?page=1)) D. Keller & W. Aulmann 2008. Deriving Surrogate DNELs for Preparations under the Scope of REACH. Talk and poster at the German Federal Institute for Occupational Safety and Health REACH-Workshop in Dortmund, 2008. (http://www.baua.de/nn_56166/en/Topics-from-A-to-Z/Hazardous-Substances/Workshops/Limit-values/pdf/poster-03.pdf)) D. Keller 2007. Safe use of chemicals in mixtures. Presentation at the annual workshop of the German Social Accident Insurance in Laubach, 2007. (http://exinfo.de/files/497/Keller.pdf) Contribution to the project a) TTC approaches for endpoints relating to human repeated dose toxicity, and b) Selection of chemical substances relevant for cosmetic formulas. Involved www.henkel.com
Keun	Hector	DETECTIVE	Imperial College London	Hector Keun +44 207 59 43161 - h[dot]keun[at]imperial[dot]ac[dot]uk Imperial College London Exhibition Rd, South Kensington, London SW7 2AZ, UK Resume Chemist/Biochemist with expertise in metabolic profiling (metabonomic/metabolomics), and computational pattern recognition and multivariate analysis. Research focus on metabolomics applied to toxicology and tumour metabolism. Publications Yakoub D, Keun HC, Goldin R, et al, Metabolic profiling detects field effects in nondysplastic tissue from esophageal cancer patients., Cancer Res, 2010, Vol:70, Pages:9129-9136, ISSN:1538-7445(doi) Dumas ME, Wilder SP, Bihoreau MT, et al, Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models., Nat Genet, 2007, Vol:39, Pages:666-672, ISSN:1061-4036(doi) Ebbels TM, Keun HC, Beckonert OP, et al, Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach., J Proteome Res, 2007, Vol:6, Pages:4407-4422, ISSN:1535-3893(doi) Contribution to the project Metabolomic analyses, and support for data integration/bioinformatics with expertise in metabolic pathway analysis. Involved www.imperial.ac.uk
Kidd	Darren	SCR&Tox	Covance Laboratories Ltd	Darren Kidd +44 (0)1423 500011 - darren[dot]kidd[at]covance[dot]com Covance Laboratories Ltd Harrogate, UK Resume I have worked for Covance Laboratories since 2000 holding a number of increasingly senior, predominantly lab-based roles and currently work in Research and Development in Genetic Toxicology and In Vitro Toxicology. I hold a PhD in Gene Mutations and Cellular Biology (2011) from the University of York, York, UK and a honors Bachelors degree from the University of Plymouth, UK. Publications Kidd, D. et al (2007) Development of an In Vitro Corrosion / Irritation Prediction Assay Using the EpiDerm™ Skin Model. Toxicology In Vitro21(7):1292-1297 Lloyd M. and Kidd D (2012) The Mouse Lymphoma Assay. Methods in Molecular Biology 817:35-54 Contribution to the project I am the lead scientist for Covance and have responsibility for delivering the project goals as determined for us by working directly under and for the Principle Investigator at Covance Involved www.covance.com
Kirschbaum	Michael	HeMiBio	Fraunhofer Institute for Biomedical Engineering (IBMT)	Michael Kirschbaum +49 / 3 31 / 581 87 - 305 - michael[dot]kirschbaum[at]ibmt[dot]fraunhofer[dot]de Fraunhofer Institute for Biomedical Engineering (IBMT) Am Muehlenberg 13, 14476 Potsdam, Germany Resume - Publications Kirschbaum, M.; Jaeger, M. S.; Duschl, C.: Correlating short-term Ca2+ responses with long-term protein expression after activation of single T cells. (2009) Lab Chip 9:3517-3525. Kirschbaum, M.; Jaeger, M. S.; Schenkel, T.; Breinig, T.; Meyerhans, A.; Duschl, C.: T cell activation on a single-cell level in dielectrophoresis-based microfluidic devices. (2008) J Chromatogr A, 1202:83–89. Contribution to the project To develop sensors for real-time basic culture conditions To develop sensors for real-time cell function Develop a 2D bioreactor for the efficient isolation of differentiated iPSC mixtures by trapping different cell types on micropatterned surfaces Fabrication of high-throughput microfluidics addressable array Fabricated multi-electrode plate Integrate sensor electronics using UTCP Computer interface and recording subrouting Involved www.ibmt.fraunhofer.de
Klein	Sebastian	NOTOX	Biochemical Engineering, Saarland University	Sebastian Klein - sebast[dot]klein[at]googlemail[dot]com Biochemical Engineering, Saarland University Campus A1.5, 66111 Saarbruecken, Germany Resume Publications Mueller, D., L. Kramer, E. Hoffmann, S. Klein and F. Noor (2014). "3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies." Toxicol In Vitro 28(1): 104-112 DOI: 10.1016/j.tiv.2013.06.024 Klein, S., D. Mueller, V. Schevchenko and F. Noor (2013). "Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study." J Appl Toxicol DOI: 10.1002/jat.2929. Klein, S. and E. Heinzle (2012). "Isotope labeling experiments in metabolomics and fluxomics." Wiley Interdiscip Rev Syst Biol Med 4(3): 261-272 DOI: 10.1002/wsbm.1167. Contribution to the project Involved www.notox-sb.eu
Kleinjans	Jos	DETECTIVE	Maastricht University, department of Toxicogenomics	Jos Kleinjans + 31 43 3881096 - j[dot]kleinjans[at]maastrichtuniversity[dot]nl Maastricht University, department of Toxicogenomics P.O. Box 616; 6200 MD Maastricht, the Netherlands Resume He is Professor of Environmental Health Science, head of the Department of Toxicogenomics at the Maastricht University. Furthermore, Prof. Kleinjans is currently coordinator of two Integrated Projects under FP6 (carcinoGENOMICS and NewGeneris) and scientific director of the Netherlands Toxicogenomics Centre a public/private Consortium consisting of 8 academic and 12 private partners. Publications van Delft JH, Mathijs K, Staal YC, van Herwijnen MH, Brauers KJ, Boorsma A, Kleinjans JC. Time series analysis of benzo[A]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets. Toxicol Sci. 2010 Oct;117(2):381-92. Mathijs K, Brauers KJ, Jennen DG, Boorsma A, van Herwijnen MH, Gottschalk RW, Kleinjans JC, van Delft JH. Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time. Toxicol Sci. 2009 Dec;112(2):374-84. Van Summeren A, Renes J, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC. Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2010 Dec 16. [Epub ahead of print] Contribution to the project Overall coordination of subproject 3, on the omics analyses in the DETECTIVE project. Supervision of the integrated transcriptomics – epigenetics data analysis and transcriptomic - miRNA data analysis and data interpretation aiming at the identification of compound-induced modulation of toxicologically relevant molecular pathways. Involved http://www.maastrichtuniversity.nl/
Knight	Derek	SEP Member	European Chemicals Agency	Derek Knight 00358 9 6861 8215 - derek[dot]knight[at]echa[dot]europa[dot]eu European Chemicals Agency Annankatu 18, P.O. Box 400, FI-00121 Helsinki, Finland Resume Dr Derek J Knight (who is British) has been the Senior Scientific Advisor to the Executive Director of the European Chemicals Agency (ECHA) since September 2008. Before this for almost 18 years he headed a team of regulatory affairs professionals at a UK contract research organisation, specialising in safety assessments of chemicals and biocides for regulatory schemes worldwide. He has gained a broad understanding of the regulation of chemicals from the perspective of the various interested parties. He is especially interested in approaches to hazard and risk assessment using non-standard and non-test data. He is a Fellow of the Royal Society of Chemistry, a Chartered Scientist and a Fellow of The Organisation of Professionals in Regulatory Affairs. His doctoral studies at the University of Oxford in the UK were in organosulphur chemistry. Publications REACH: Registration Data & the Chemical Safety Assessment’, D J Knight, in ‘Chemistry in the Oil Industry XI: Regulation meets Innovation – Moving Forward’, Royal Society of Chemistry, 2009, pp 3 to 10. ‘Preparing for REACH: the New EU Chemical Control Scheme’, D J Knight, Regulatory Rapporteur, vol. 4, no. 3, March 2007, pp 12 to 18. ‘Intelligent Approaches to Safety Evaluation’, D J Knight, in ‘Alternatives to Animal Testing’, Issues in Environmental Science and Technology, Royal Society of Chemistry, Cambridge, vol. 23, 2006. ‘New EU Regulation of Chemicals: REACH’, D J Knight, Rapra Review Report, vol. 16, no. 1, November 2005, pp 1 to 25. ‘Safety Evaluation: Intelligent approaches to Safety Evaluation’, D J Knight, Regulatory Rapporteur, vol. 2, no. 9, September 2005, pp 5 to 10. ‘Rapra Review Report: The Regulation of Food Packaging in Europe and the US’, D J Knight and L A Creighton, Vol. 15, No. 5, Rapra Technology, Shrewsbury, UK, 2004. ‘Practical Guide to Chemical Safety Testing’, ed. D J Knight and M B Thomas, Rapra Technology, Shrewsbury, UK, 2003, p 39 to 47. ‘Chemists’ Toolkit: Biocides on Target’, D J Knight and M Cooke, Chemistry in Britain, vol.38, no. 5, May 2002, 26 to 29. ‘The Biocides Business Regulation, Safety and Applications’, D J Knight and M Cooke, Wiley-VCH, Weinheim, Germany, 2002. ‘Alternatives to Animal Testing in the Safety Evaluation of Products’, D J Knight and D Breheny, ATLA, vol 30, no. 1, pp 7 to 22, 2002. ‘Ensuring Safety of Food Packaging in the USA : the New Notification Process’, D J Knight Regulatory Review, Vol 3, Issue 5, pp 12 to 16, August 2000. Contribution to the project Involved www.echa.europa.eu
Kohonen	Pekka	ToxBank	Karolinska Institutet	Pekka Kohonen +46704893801 - Pekka[dot]kohonen[at]ki[dot]se Karolinska Institutet Nobelsväg 13, Box 210, 171 77 Stockholm, Sweden Resume Birth: February 9th, 1975 2010 Ph.D. (Immunology, Bioinformatics), Univ. Turku 2008 MSc. Univ. Turku, Finland. 2002 M.A. Univ. Cambridge, England. 1998 B.A.N.S. Univ. Cambridge, England in Biochemistry. 2012- Post-doc Karolinska Institutet/IMM, Stockholm. Prof. Grafström, Prof. Fadeel 2006-2011 Research Scientist (Bioinformatics, high-throughput screening data analysis, OMICS), Prof. Olli Kallioniemi, M.D. Ph.D. at the VTT and Univ. Turku, Dept. Med. Biotech.,Finland. EU FP7 ProspeR, Apo-sys, GENICA, etc. Contract Research at VTT. 1999-2006 Grad. Stud. Prof. Olli Lassila, Dept. Med. Microbiol. &Immunol., Univ.Turku, Finland Publications Rafn B, Nielsen CE et al. , Molecular Cell, Accepted December 2011. Östling P, et al. Cancer Res. 2011 Mar 1;71(5):1956-67 Leivonen SK, et al. Oncogene. 2009 Nov 5;28(44):3926-36. Contribution to the project ToxBank WP1: Maintaining/developing the Semantic MediaWiki based “gold compound database” at Karolinska Institutet. OMICS advice and some data analysis. Discussions with SEURAT-1 partners about the database and analysis requirements and standards. Involved Ki.se/imm
Kolde	Raivo	DETECTIVE	Quretec OÜ	Raivo Kolde 3 725 067 961 - rkolde[at]gmail[dot]com Quretec OÜ Ülikooli 6a, 51003 Tartu, Estonia Resume Has a degree in mathematical statistics from University of Tartu. Since 2006 been working within different EU projects such as FunGenES, COBRED and ESNATS to provide bioinformatics support and develop web based tools for accessing and analysing the data, The main expertise is analysis of gene expression microarray and epigenetics data. Publications Adler P, Kolde R, Kull M, Tkachenko A, Peterson H, Reimand J, Vilo J. Mining for coexpression across hundreds of datasets using novel rank aggregation and visualization methods. Genome Biol. 2009;10(12):R139. Schulz H , Kolde R , Adler P, Aksoy I, Anastassiadis K, Bader M, Billon N, Boeuf H, Bourillot PY, Buchholz F, Dani C, Doss MX, Forrester L, Gitton M, Henrique D, Hescheler J, Himmelbauer H, Hübner N, Karantzali E, Kretsovali A, Lubitz S, Pradier L, Rai M, Reimand J, Rolletschek A, Sachinidis A, Savatier P, Stewart F, Storm MP, Trouillas M, Vilo J, Welham MJ, Winkler J, Wobus AM, Hatzopoulos AK; Functional Genomics in Embryonic Stem Cells Consortium. The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One. 2009 Tserel L, Kolde R, Rebane A, Kisand K, Org T, Peterson H, Vilo J, Peterson P. Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells.BMC Genomics. 2010 Contribution to the project Database solutions for the DETECTIVE project and contributions to integrative analysis of the omics data, produced in the project. Involved http://www.quretec.com/
Kopp-Schneider	Annette	DETECTIVE	Deutsches Krebsforschungszentrum	Annette Kopp-Schneider +49 (0)6221 42-2391 - kopp[at]dkfz[dot]de Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Resume Prof. Dr. Annette Kopp-Schneider is acting head of the Department of Biostatistics at the German Cancer Research Center (DKFZ) in Heidelberg. Trained as a mathematician she has served as a biostatistician for 20 years and has experience in clinical as well as nonclinical biostatistics. Her research area is in statistical and stochastic dose-response modeling, focusing on experimental in vivo and in vitro studies. She is (co)author of 90 peer reviewed papers. Publications Oberemm, A., Ahr, H.-J., Bannasch, P., Ellinger-Ziegelbauer,H., Fella, K., Glückmann, M., Hellmann, J., Ittrich, C., Kopp-Schneider, A., Kramer, P.-J. , Krause, E., Kröger, M., Kiss, E., Richter-Reichhelm, H.-B., Scholz, G., Weimer, M., Gundert-Remy, U. (2009) Toxicogenomic analysis of N-nitrosomorpholine induced changes in rat liver: comparison of genomic and proteomic responses and anchoring to histopathological parameters. Toxicology and Applied Pharmacology 241, 230-45 Groos J, Kopp-Schneider A. (2010) Application of a two-phenotype color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment. Mathematical Biosciences 224, 95-100. Schneider, K., Schwarz, M., Burkholder, I., Kopp-Schneider, A, Edler, L., Kinsner-Ovaskainen, A, Hartung, T, Hoffmann, S. (2009) "ToxRTool", a new tool to assess the reliability of toxicological data. Toxicology Letters 189, 138-44. Contribution to the project Experimental design Data management and monitoring Statistical analysis of derived endpoints, e.g. EC50 estimation Identification and analysis of biomarkers for toxicity Analysis of the relationship between molecular biomarkers, functional readouts, and clinical signs Involved www.dkfz.de
Kovarich	Simona	COSMOS	S-IN Soluzioni Informatiche srl	Simona Kovarich - Simona[dot]kovarich[at]s-in[dot]it S-IN Soluzioni Informatiche srl Via Ferrari 14, 36100 Vicenza, Italy Resume Simona Kovarich is a computational (eco-)toxicologist at S-IN Soluzioni Informatiche since November 2012. She graduated in Biological Sciences (with a specialization in Ecotoxicology) in 2008 and got the Ph.D. in Chemistry in January 2013 with a thesis entitled “QSAR models for the (eco-)toxicological characterization and prioritization of emerging pollutants: case studies and potential applications within REACH” (Tutor: Dr. Ester Papa, Supervisor: Prof. Paola Gramatica), which was developed in the context of the European project CADASTER (FP7). From 2008 till 2012 she was part of the QSAR Research Unit in Environmental Chemistry and Ecotoxicology of the University of Insubria (Varese), focusing her research activities on QSAR modelling and its application in chemical risk assessment and regulation. Publications Kovarich, S.; Papa, E.; Li, J.; Gramatica, P. QSAR classification models for the screening of the Endocrine Disrupting activity of perfluorinated compounds. SAR and QSAR in Environmental Research (proceedings of CMTPI 2011). 2012, 1-14. Roy, P.P.; Kovarich, S.; Gramatica, P. QSAR model reproducibility and applicability: a case study of rate constants of hydroxy radical reaction models applied to Polybrominated Diphenyl Ethers and (Benzo-)Triazoles. Journal of Computational Chemistry, 2011, 32, 2386-2396 Kovarich, S.; Papa, E.; Gramatica, P. QSAR classification models for the prediction of endocrine disrupting activity of brominated flame retardants. Journal of Hazardous Materials, 2011, 190 (1-3), 106-112. Papa E.; Kovarich, S.; Gramatica, P. On the use of local and global QSARs for the prediction of Physico-Chemical Properties of Polybrominated Diphenyl Ethers. Molecular Informatics, 2011, 30, 232–240. Contribution to the project She is part of the team who will aim at optimising in silico methods, such as (Q)SAR and read-across, for the purpose of long-term toxicity prediction of cosmetic ingredients. The tasks of the team include: a) Characterisation of the chemical space of cosmetic inventories; b) Read-across, grouping and structural analogues analysis; c)Evaluation of existing QSAR models and expert systems for cosmetic ingredients; d) Development of new QSAR regression and classification models. e) Application of innovative chemometric tools. Involved www.s-in.it
Kreisel	Beate	DETECTIVE	ARTTIC	Beate Kreisel +33 1 53 94 54 75 - kreisel[at]arttic[dot]eu ARTTIC 58A, Rue du Dessous des Berges - 75013 Paris, France Resume Experienced in the financial administration of EU projects, Beate is currently involved in the day-to-day management of several FP7 projects in the Health and Aeronautic themes. In addition to her financial and administrative responsibilities (e.g. verification and consolidation of cost statements, follow-up of payments, preparation and consolidation of management reports), Beate is also in charge of the preparation and follow-up of consortium meetings and project reviews. Publications - Contribution to the project In DETECTIVE, ARTTIC constitutes the Project Office and provides methods, tools and operational support for the project collaboration. ARTTIC thus supports the consortium in the daily management and administrative tasks to ensure the collaboration is working, the project is properly monitored and decisions and actions are prepared and taken according to the project progress. ARTTIC’s role is also to simplify the work of the researchers and to develop a collaborative team spirit inside the consortium. As part of the day-to-day operational project management, Beate is responsible for the handling of all administrative and financial aspects as well as the preparation and follow-up of project meetings. Involved http://www.arttic.com
Lan	Yang	COSMOS	University of Bradford	Yang Lan 0044 1274 233792 - Y[dot]Lan[at]bradford[dot]ac[dot]uk University of Bradford Department of Computing, University of Bradford, Bradford, BD7 1DP, UK, UK Resume Dr. Yang Lan is Research Assistant in Department of Computing. His research interests encompass a number of areas related to Data Mining, Machine Learning, Artificial Intelligence, currently, his research addresses computational intelligence techniques and approaches for predictive toxicology and applications. Publications Lan Y and Neagu D (2011): "A New Approach and Its Applications for Time Series Analysis and Prediction based on Moving Average of nth-order Difference", Data Mining: Foundations and Intelligent Paradigms, D. Holmes (ed.), Springer. Lan Y and Neagu D (2007): "A New Time Series Prediction Algorithm Based on Moving Average of nth-order Difference", The Sixth International Conference on Machine Learning and Applications (ICMLA), Cincinnati, Ohio, USA. Lan Y and Neagu D (2007): "Applications of Moving Average of nth-order Difference Algorithm for Time Series Prediction", The Third International Conference on Advanced Data Mining and Applications (ADMA), Harbin, China Contribution to the project The UNIBRAD team contribute on data curation and data mining, multivariate modelling and predictive toxicology model management as WP1 coordinator and contributor to WP3 and WP5. The key tasks allocated to UNIBRAD are data representation, data curation, development of computational intelligence techniques, data and model integration, and data mining tools. Involved http://scim.brad.ac.uk/staff/?u=ylan
Landesmann	Brigitte	COACH	Joint Research Centre, Institute for Health and Consumer Protection	Brigitte Landesmann +39 0332 789496 - brigitte[dot]landesmann[at]ec[dot]europa[dot]eu Joint Research Centre, Institute for Health and Consumer Protection Via E. Fermi 2749, 21027 Ispra (VA) , Italy Resume Brigitte Landesmann has a professional background in clinical medicine and joined the Systems Toxicology Unit of the Institute for Health and Consumer Protection of the European Commission's Joint Research Centre in 2010. She is involved in the generation and application of knowledge of MoA /AOP. In the context of SEURAT-1 she has worked on the mechanism-based chemical selection (Gold Compounds), elaborated liver toxicity MoAs related to repeated dose toxicity and is co-chair of the Mode-of-Action Working Group, which aims to facilitate cross-cluster cooperation between projects and people and to generate and disseminate MoA/AOP knowledge. She received her MD from University of Vienna and her MSc in Public Health from London University (LSHTM). Publications B. Landesmann, M. Goumenou, S. Munn, M. Whelan, Description of Prototype Modes-of-Action Related to Repeated Dose Toxicity, JRC Scientific and Policy Report, 2012 M. Mennecozzi, B. Landesmann, G. Harris, R. Liska, M. Whelan, Hepatotoxicity Screening Taking a Mode-Of-Action Approach Using HepaRG Cells and HCA, Altex Proceedings, 1/12, Proceedings of WC8 Contribution to the project Co-chair of the mode-of-action working group (MAWG) Involved http://ihcp.jrc.ec.europa.eu/
Larsen	Jakob Bonne	HeMiBio	CSEM SA – Nanomedicine Division	Jakob Bonne Larsen +41 76 984 5503 - Jakobbonne[dot]larsen[at]csem[dot]ch CSEM SA – Nanomedicine Division Bahnhofstrasse 1 – CH-7302 Landquart, Switzerland Resume Msc Jakob Bonne Larsen graduated as an Engineer in Physics and Nanotechnology from the Technical university of Denmark in 2011. He joined the CSEM Cell System section, where he is taking his PhD in the development of electrochemical sensors. Publications Thor Ansbæk, Dirch H. Petersen, Ole Hansen, Jakob B. Larsen, Torben M. Hansen, Peter Bøggild, Fundamental size limitations of micro four-point probes, Microelectronic Engineering, vol. 86, 987-990 Contribution to the project The role of the CSEM in HeMiBio is to develop and integrate innovative electro-chemical microsensors, such as ion-selective electrodes, in the 3D-bioreactors to allow assessment of liver function (e.g. oxygen uptake, ammonium). Among the microsensors that will be selected to monitor specific hepatic functions ammonium-selective microelectrode, will be located in the direct vicinity of the cells.One of the critical hepatic functions is the ability to detoxify ammonia by converting it to urea within the urea cycle. At physiological pH, ammonia, NH3, mainly appears in the protonated form NH4+ that can easily be detected by ion-selective microelectrode technique. The specific role of Jakob Larsen will be the development of electrochemical sensors for the monitoring of liver cells toxicity. Involved www.csem.ch
Laustriat	Delphine	SCR&Tox	INSERM/UEVE 861, I-STEM, AFM	Delphine Laustriat +33 1 69 90 85 44 - dlaustriat[at]istem[dot]fr INSERM/UEVE 861, I-STEM, AFM Genopole Campus 1, 5 rue Henri Desbruères - 91030 Evry cedex , France Resume 2011: Research associate, SCR&Tox Program team leader at I-STEM 2006-2010: PhD (Evry University, France) at I-STEM (Dr M. Peschanski and Dr S. Baghdoyan). Pluripotent stem cells in disease modelling for the identification of new therapeutic targets: application to Myotonic Dystrophy type 1. 2006: Industrial/research PharmD (Strasbourg University, France) Publications Human pluripotent stem cells in drug discovery and predictive toxicology. Laustriat D, Gide J, Peschanski M. Biochem Soc Trans, 2010; 38(4) :1051-7 Les cellules souches embryonnaires humaines et la pharmacologie. Laustriat D, Gide J, Héchard C, Peschanski M. Med Sci (Paris), 2009; 25 (hors série n°2) :32-8 Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, Kieffer BL. Proc Natl Acad Sci U S A, 2006; 103(25):9691-6 Contribution to the project Functional genomic screening (extinction/overexpression), assay development, automation. Involved http://www.istem.eu/
Lazzari	Giovanna	SCR&Tox	Avantea	Giovanna Lazzari 390 372 437 242 - giovannalazzari[at]avantea[dot]it Avantea Via porcellasco 7f, Italy Resume Giovanna Lazzari holds a degree in Veterinary Medicine and did her postdoctoral studies in Cambridge (UK) on germ cells biology. Currently she is Scientific Director of Avantea srl and teaches as contract Professor at two italian universities. Her research interests include biotechnology of reproduction, basic and applied research in molecular embryology with particular emphasis on oocye and preimplantation embryo biology, reproductive toxicology, embryonic stem cells, development of alternative toxicological tests. She is project leader in 2 ongoing EU FP7 projects (Esnats, Plurisys). Publications Lazzari G, Tessaro I, Crotti G, Galli C, Hoffmann S, Bremer S, Pellizzer C. Development of an in vitro test battery for assessing chemical effects on bovine germ cells under the ReProTect umbrella.Toxicol Appl Pharmacol. 2008, ;233(3):360-70. Colleoni S, Galli C, Giannelli SG, Armentero MT, Blandini F, Broccoli V, Lazzari G. Long-term culture and differentiation of CNS precursors derived from anterior human neural rosettes following exposure to ventralizing factors. Exp Cell Res. 2010, ;316(7):1148-58. Schenk B, Weimer M, Bremer S, van der Burg B, Cortvrindt R, Freyberger A, Lazzari G, Pellizzer C, Piersma A, Schäfer WR, Seiler A, Witters H, Schwarz M. The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants.Reprod Toxicol. 2010,30(1):200-18. Contribution to the project Avantea is involved in WP1 and 3. In WP1 Avantea will provide undifferentiated hES and committed neural precursors primed towards a dopaminergic neural fate. In WP3 it will develop a toxicological assay on the neural precursors exposing them for at least 14 days to testing chemicals selected within the consortium. Involved www.avantea.com
Lee	Dongtao	SCR&Tox	Fraunhofer Institute for Biomedical Engineering (IBMT)	Dongtao Lee +44 (0)1382 432147 - DongtaoLee[at]cxrbiosciences[dot]com Fraunhofer Institute for Biomedical Engineering (IBMT) Am Muehlenberg 13, 14476 Potsdam, Germany Resume I am a senior scientist working at CXR Biosciences, UK. After graduating in medicine in China, I worked in Qidong Liver Cancer Institute and Beijing Cancer Institute for 6 years before I came to Britain to pursue a PhD. I received my PhD in 2000 after studying molecular pharmacogenetics of phase I drug metabolism enzyme cytochrome P450s at University of Dundee. After obtaining a PhD, I worked as a Postdoctoral Fellow at University of Dundee. My research was focused on the earliest stages of the immune response when pathogens and their products are first detected by immune cells. Currently, my research interests focused on biomarker and cytotoxicity in drug development. Publications Maki Hasegawa, Yury Kapelyukh, Harunobu Tahara, Jost Seibler, Anja Rode, Sylvia Krueger, Dongtao N. Lee, C. Roland Wolf, Nico Scheer (submitted) Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanised mouse line. Li DN, Matthews SP, Antoniou AN, Mazzeo D, Watts C.(2003) Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo. J Biol Chem. 278: 38980-38990. Li DN, Seidel A, Pritchard MP, Wolf CR, Friedberg T.(2000) Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol. Pharmacogenetics 10(4):343-53. Contribution to the project Characterize hepatocyte-like cells derived from stem cells in functional and genomic assays Contribute know-how in the field of reporter design and construction as well as the transfection of cell lines with key drug metabolising enzymes. Evaluate prototype reporter or “tool” cell lines at low throughput using relevant biochemical and histochemical techniques. Develop drug discovery relevant assays utilising the tool cell lines produced in WP2 Involved www.ibmt.fraunhofer.de
Lostia	Alfonso	COACH	Joint Research Centre, Institute for Health and Consumer Protection	Alfonso Lostia - alfonso[dot]lostia[at]ec[dot]europa[dot]eu Joint Research Centre, Institute for Health and Consumer Protection Via E. Fermi 2749, I-21027 Ispra (VA), Italy Resume Alfonso Lostia graduated in Biology in 2005 at the University Sapienza of Rome. He spent then six months in the Guy's Hospital of London working in the area of metabolic disorders in neonatal screening and after he went back to Italy where he started his PhD in Biochemistry. During his PhD, he focused his research on the development and validation of analytical techniques, mainly mass spectrometry, for “therapeutic drug monitoring” of different classes of drugs. Since April 2009, he worked in the Drug Control Centre, King's College London, which is a laboratory accredited by the World Anti-Doping Agency and certified with ISO 17025 to perform anti-doping drug testing analysis. He focused his expertise on the development of analytical methods to detect prohibited substances in sport. In the summer of 2012 he was part of the team responsible to perform the anti-doping drug testing for London 2012 Olympics and Para-Olympics Games. Alfonso joined the Systems Toxicology Unit at the Institute for Health and Consumer Protection in September 2012. Publications 1. Measurement of Ethyl Glucuronide, Ethyl Sulphate and Their Ratio in the Urine and Serum of Healthy Volunteers after Two Doses of Alcohol. Lostia AM, Lobo Vicente J, Cowan DA. Alcohol Alcohol. 2013;48:74-82. 2. A Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of 5 Fluorouracil Degradation Rate by Intact Peripheral Blood Mononuclear Cells. Lostia AM, Lionetto L, Ialongo C, Gentile G, Viterbo A, Malaguti P, Paris I, Marchetti L, Marchetti P, Blasi AD, Simmaco M. Ther Drug Monit. 2009;31:482-8. 3. Serum Levels of Risperidone and Its Metabolite, 9-Hydroxyrisperidone: Correlation Between Drug Concentration and Clinical Response. Lostia AM, Mazzarini L, Pacchiarotti I, Lionetto L, Rossi PD, Sanna L, Sani G, Kotzalidis GD, Girardi P, Simmaco M, Tatarelli R. Ther Drug Monit. 2009;31:475-81. Contribution to the project My main role is to support activities to implement the second level of the SEURAT-1 proof of concept. Particularly, I am involved in defining and describing the process of how the mechanistic knowledge of an adverse outcome, described to a sufficient extent in a MoA format, can be used as blueprint to design integrated alternative testing strategies to predict toxicity and support chemical safety assessment and decision making. Involved http://ihcp.jrc.ec.europa.eu/
Luttun	Aernout	HeMiBio	Katholieke Unversiteit Leuven (KULeuven)	Aernout Luttun +32-16-345772 - aernout[dot]luttun[at]med[dot]kuleuven[dot]be Katholieke Unversiteit Leuven (KULeuven) Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, B-3000, LEUVEN, BELGIUM Resume Aernout Luttun received his PharmD degree in 1996 and worked on vascular biology and disease during his PhD in the lab of Dr. P. Carmeliet and as a post-doc in the lab of Dr. C. Verfaillie. He was appointed as associate professor at K.U.Leuven since October 2009 and leads since 2006 the Endothelial Cell Biology Unit in the Center for Molecular and Vascular Biology (CMVB), focused on stem cell biology in vascular maintenance and disease. Publications Hendrickx B, Van den Berge S, Verdonck K, Dickens S, Eriksson E, Vranckx JJ and Luttun A. Integration of blood outgrowth endothelial cells in dermal fibroblast sheets promotes full thickness wound healing. Stem Cells 28(7): 1165-1177 (2010) Aranguren XL, McCue JD, Hendrickx B, Zhu XH, Du F, Chen E, Pelacho B, Peñuelas I, Abizanda G, Uriz M, Frommer SA, Ross JJ, Schroeder BA, Seaborn MS, Adney JR, Hagenbrock J, Harris NH, Zhang Y, Zhang X, Nelson-Holte MH, Jiang Y, Billiau AD, Chen W, Prósper F, Verfaillie CM, Luttun A. Multipotent adult progenitor cells sustain function of ischemic limbs in mice. J Clin Invest. 118(2): 505-514 (2008) Aranguren XL, Luttun A,** Clavel C, Moreno C, Abizanda G, Barajas MA, Pelacho B, Uriz M, Araña M, Echavarri A, Soriano M, Andreu EJ, Merino J, Garcia-Verdugo JM, Verfaillie CM, Prósper F. In vitro* and in vivo arterial differentiation of human multipotent adult progenitor cells. Blood109(6): 2634-2642 (2007) ;* equal contribution Contribution to the project Partner in HeMiBio in WPs 1, 3, 4, and 5, more specifically involved in derivation of primary HSEC (hepatic sinusoidal endothelial cells), BOEC (blood outgrowth endothelial cells) derivation, (HS)EC sorting from hiPSC cultures, HSEC/BOEC patterning in 2D-reactor and endothelial functional and transcriptional characterization. Involved http://www.kuleuven.be/kuleuven/
Madden	Judith	COSMOS	School of Pharmacy and Chemistry, Liverpool John Moores University	Judith Madden + 44 (0)151 231 2032 - j[dot]madden[at]ljmu[dot]ac[dot]uk School of Pharmacy and Chemistry, Liverpool John Moores University Byrom Street, Liverpool, L3 3AF, England Resume Judith Madden is a Reader in Molecular Design at Liverpool John Moores University, England. She has experience in the use of in silico tools for the prediction of bioactivity and toxicokinetics. She has worked on national projects such as UK Defra and international projects including EU funded projects (CAESAR, OSIRIS and InSilico Tox). She has co-authored over 40 journal articles and is co-editor of the book In Silico Toxicology: Principles and Applications. Publications MTD Cronin, JC Madden (eds) (2010)In Silico Toxicology: Principles and Applications. The Royal Society of Chemistry, Cambridge,England Madden, JC(2010) “In silico approaches for predicting ADME properties” in Recent Advances in QSAR Studies: Methods and Applications.T Puzyn, J Leszczynski and MTD Cronin (Eds) Springer, Chichester, England, pp.283-304 Hewitt, M, Ellison, CM, Enoch, SJ, Madden, JC, Cronin, MTD (2010) Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity.Reproductive Toxicology 29: 147-160. Contribution to the project Toxicological data retrieval, curation, quality and databasing (WP1) Development of innovative computational approaches to predict toxicity (WP3) Dissemination of results and integration of COSMOS with other projects (WP6) Co-ordination and management of the project (WP7) Involved http://www.staff.livjm.ac.uk/phcjmadd/
Maggioni	Silvia	ToxBank		Silvia Maggioni +39-2-39014716 - silvia[dot]maggioni[at]marionegri[dot]it Via La Masa 19, 20156 Milan, Italy Resume She got the master degree in Environmental Sciences at the University of Milan in 2004 and started working as a scientific researcher in the Laboratory of Environmental Chemistry and Toxicology at Mario Negri Institute for Pharmacological Research, where she attended the three years specialization course in Pharmacological Research. Her role is concentrated on the development and application of analytical methods through chromatographic techniques combined with mass spectrometry (LC-MS/MS; GC-MS) for the analysis of chemicals in biological, environmental and food matrices. She contributed to the EC- funded projects: EASYRING, CASCADE, SAFEFOODNET. Publications D. Baderna, S. Maggioni, E. Boriani, S. Gemma, M. Molteni, A. Lombardo, A. Colombo, S. Bordonali, G.Rotella, M. Lodi, E. Benfenati. A combined approach to investigate the toxicity of an industrial landfill's leachate: chemical analyses, risk assessment and in vitro assays. Manuscript accepted by Environmental Research (2011). S. Maggioni, E. Benfenati, C. Colosio, A. Moretto, O. Roots, S. Tasiopoulou, S. Visentin and the SAFEFOODNET consortium. Food contamination control in European New Member States and Associated Candidate Countries; data collected within the SAFEFOODNET project. Journal of Environmental Science and Health Part B 44 (2009) 407-414. L. Viganò, E. Benfenati, J.K. Eidem, C. Erratico, A. Goksøyr, W. Kloas, S. Maggioni, A. Mandich, R. Urbatzka. Estrogenicity profile and estrogenic compounds determined in river sediments by chemical analysis, elisa and yeast assays. Chemosphere 73 (2008) 1078–1089 Contribution to the project Contribution to development of test compounds selection criteria Development of analytical methods for the determination of selected test compounds Development and application of procedures for the determination of test compounds stability Development of standard operating procedures and protocols for test compounds handling and use Involved www.marionegri.it
Mahony	Catherine	SEP Member	Colipa (Procter & Gamble)	Catherine Mahony - mahony[dot]c[at]pg[dot]com Colipa (Procter & Gamble) London Innovation Centre, Whitehall Lane, Egham, Surrey, TW20 9NW, UK Resume Dr. Catherine Mahony is a Senior Scientist for Procter & Gamble, UK with more than ten years of Product Safety experience in the consumer product industry. Within that role, Dr. Mahony is responsible for providing scientific leadership for assessments aimed at characterising the safety of ingredients and new products. This includes pre-clinical evaluations utilizing an array of alternative models, as well as clinical evaluations, Her experience in the field of animal alternatives includes oversight of the Colipa Systemic Toxicity Alternatives Task Force, of which she is Chair. Dr. Mahony is the author or co-author on a number of publications and is a member of both the UK register of Toxicologists and the European Register of Toxicologists. She is also a member of the British Toxicology Society. Dr. Mahony received her Ph. D from King’s College, University of London. Publications - Contribution to the project Involved www.colipa.eu (www.pg.com)
Maletta	Max	NOTOX	NKI	Max Maletta +3120 – 512 2023 - m[dot]maletta[at]nki[dot]nl NKI Plesmanlaan 121, 1066 CX Amsterdam, Netherlands Resume Skills and expertise: Cryo-sectioning of High pressure frozen specimen Structural study of bio-molecular complex by cryo-E.M. EM structure determination software (IMAGIC, Boxer, Spider). Protein crystallization techniques (vapor diffusion, batch-crystallization, soaking, seeding). CCP4 tools for X-ray structure determination (molecular replacement). CETOVIS (cryo-electron tomography of vitreous sections) Expression of protein with fermentors. Purification of proteins and of protein-DNA complexes. Knowledge of NMR techniques (1D, 2D and 3D experiments for protein structure determination). NMR titration: determination of binding constant by following shifting of peaks in HSQC. Protein assignment and structure determination software (Sparky, AMBER, Cyana, CARA,) Basic knowledge of docking and molecular dynamics programs (AMBER, Autodock, Haddock, GOLD). ITC, FRET and Fluorimetric techniques for study binding constant and thermodynamic parameters of lead and candidate drugs. Drug Design background. Basic programming in PERL. Bio-inorganic chemistry background. Education: 30/06/2009-03/07/2009 Practical Workshop on Characterization of protein Complexes in Structural Biology (EMBL Hambourg) 10/09/2007-20/09/2007EMBO Course on Image Processing for Cryo EM (Birkbeck college, London) 1/1/2004-2007 Ph.D. degree in Chemistry, at CERM (Center of magnetic resonance), Dept. of Chemistry, University of Florence, Florence, Italy. Thesis title: “Structural and mechanistic features of metalloproteinases and their interactions with candidate drugs” (supervisors: Claudio Luchinat CERM University of Florence Italy) 2003 Course of Nuclear Magnetic Resonance organized by SOFTEL 1997-2003 Degree in Chemistry, Faculty of Chemistry, University of Naples, Naples, Italy. Thesis title: “Structural study of the HIV-1 gp160 cleavage site by native and modified sequences” (supervisors: G. D’Auria, Livio Paolillo Inorganic Department of Chemistry of University of Naples, Naples, Italy). Work experience: 04/02/2007-04/03/2011 Post-doc in Strasbourg France at IGBMC under the supervision of B.P. Klaholz on "The three-dimensional organization of the nuclear receptor EcR/USP complex on an inverted DNA repeat". 04/04/2011-today Post-doc in Amsterdam Netherlands at NKI under the supervision of Peter J. Peters on "CETOVIS as tool to Interpret toxicity at macromolecular level in cellula". Publications Maletta M., Billas I. M., Moras D. and Klaholz B. P. “The three-dimensional organization of the nuclear receptor EcR/USP complex on an inverted DNA repeat as seen by cryo-EM”submitted In the following papers the name are written in alphabetical order: Bertini, I., Calderone, V., Fragai, M., Luchinat, C., and Maletta, M., “Snapshots of the reaction mechanism of Matrix metalloproteinases.” Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5 Bertini I, Calderone V., Fragai M, Luchinat C, LoConte M, Maletta M, Yeo KJ. “Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases” J Am Chem Soc. 2007 Mar 7;129(9):2466-75. Contribution to the project High-resolution structures of macromolecular complexes bound to chemicals have constituted, in the last few decades, a valid tool in the field of drug design. Thanks to them it has been possible to interpret toxicity and selectivity of candidate drug at the molecular level. Unfortunately, structures obtained by NMR, X-ray diffraction and single particle cryo-electron microscopy lack the cellular context. In the cell, quite often chemicals that were supposed to bind a specific target in vivo show lower affinity (lack in efficiency) and are not delivered to the target (biodisponibility) or they interact with unpredicted cellular components with possible toxic side effects. Cryo-electron tomography of vitreous sections is a new emerging tool that allows us to visualize macromolecular complexes within high pressure frozen cells (Kühner et al.). The new generation of electron microscopes and cameras provide us better image-contrast also on frozen specimen. Together, with novel iterative reconstruction techniques, developed within the project, we are able to push forward the resolution to the point of identifying structural changes induced by drugs on macromolecular complexes in a native cellular context (Dudkina et al). The implementation of this technology in the NOTOX project will bring additional dimension to our understanding of the toxic effect of chemicals in the cell. Involved http://www.nki.nl/
Manelfi	Candida	COSMOS	S-IN Soluzioni Informatiche srl	Candida Manelfi +393484761827 - candida[dot]manelfi[at]s-in[dot]it S-IN Soluzioni Informatiche srl Via Ferrari 14, 36100 Vicenza, Italy Resume Chemistry degree. Researcher at CNR (2006-2008). Experience about organic synthesis, oligonucleotide-protein complex preparation, purification and crystallization. Researcher at Angelini (2009-2011), in Molecular Modelling. Experience in Structure based and ligand based drug design methods and Chemoinformatics. Application specialist at S-IN. Research activity using the in silico toxicology (computational methods for grouping, read-across, QSAR and expert systems), molecular modelling methods and chemoinformatics approaches. Phisicochemical, ADME and toxicological properties predictions. Publications Glycogen synthase kinase 3 (GSK-3β) an emerging target for neurological disease: in silico study to investigate the binding mode of trazodone. R.Ombrato. M.A.Alisi, N.Cazzolla, G.Corso, C.Manelfi, G.Mangano, M.Magnani, C.Milanese, L.Polenzani, L.Olivieri. Angelini Research Center. The Journal of the European College of Neuropsychopharmacology, Vol 19, Supp3, Page 447, 22nd ECNP Congress, 12-16-September 2009, Istanbul, Turkey. Contribution to the project Use and optimization of an integrated suite of computational methods to predict the long-term toxicity of cosmetic ingredients, including grouping, read-across, (quantitative) structure activity relationships and expert (knowledge-based) systems. In particular the team carries out the tasks to a) Characterize the chemical space of cosmetic inventories; b) Perform read-across, grouping and structural analogues analysis; c) Investigate existing QSAR models and expert systems for cosmetic ingredients; d) Develop new QSAR regression and classification models; e) Apply innovative chemometric tools. Involved www.s-in.it
Mangelsdorf	Inge	DETECTIVE	Fraunhofer Institute for Toxicology and Experimental Medicine ITEM	Inge Mangelsdorf +49 (0)511 5350 303 - inge[dot]mangelsdorf[at]item[dot]fraunhofer[dot]de Fraunhofer Institute for Toxicology and Experimental Medicine ITEM Nikolai-Fuchs-Straße 1, D-30625 Hannover, Germany Resume Dr. Inge Mangelsdorf, biologist and toxicologist, is head of the Department of Chemical Risk Assessment. She has more than 20 years experience in toxicological risk assessment. She is or was involved in German Activities (BUA, MAK-Kommission, Committee for Indoor Air), European Activities (EU Existing Chemicals Programm, SCHER, ILSI taskforce on TTC) and International activities (WHO, as author of EHCs and CICADs and as temporal advisor, OECD existing chemicals programm). Her major research interest is developing concepts for the Risk Assessment of Chemicals also involving Structure Activity Relationships. Publications Hahn T, Stauber J, Dobson S, Howe P, Kielhorn J, Koennecker G, Diamond J, Lee-Steere C, Schneider U, Sugaya Y, Taylor K, Van Dam R & Mangelsdorf I (2009) Reducing Uncertainty in ERA: Clearly Defining Acute and Chronic Toxicity Tests.Learned Discourses - Integrated Environmental Assessment and Management. 5(1), 175.177 Hoffmann S , Kinsner-Ovaskainen A, Prieto P, Mangelsdorf I, Bieler C & Cole T (2010) Acute oral toxicity: Variability, reliability, relevance and interspecies comparison of rodent LD(50) data from literature surveyed for the ACuteTox project. Regul. Toxicol. Pharmacol. in press:13 p. Cole T, Hoffmann S, Kolman A, Bieler C, Mangelsdorf I, Clemedson C, Toft E (2006) Database of documented in vivo acute toxicity: animal LD 50 experiments and human poisoning cases compiled for “A Cute Tox” reference chemicals. INVITOX, 5-7 October 2006, Ostende, Belgium (lecture contribution) Contribution to the project Collection of in vivo data and evaluation of the results with respect to the relevance for risk assessment. Involved www.item.fraunhofer.de
Marcelino Rodrigues	Robim	DETECTIVE	Vrije Universiteit Brussel (VUB)	Robim Marcelino Rodrigues +32 2 4774585 - rmarceli[at]vub[dot]ac[dot]be Vrije Universiteit Brussel (VUB) Laarbeeklaan 103 – 1090 Brussels , Belgium Resume Predoctoral researcher at the Department of Toxicology of the Vrije Universiteit Brussel-Belgium. The main focus of my research lies on the hepatic differentiation of adult stem cells isolated from human skin and their application in in vitro toxicity testing. I gained experience in in vitro toxicology and cell biology during my stay at the Systems Toxicology Unit of the Joint Research Center of the European Commission and at Beta-Cell NV, a spin-off company of the VUB enrolled in applied research on diabetes. Publications Robim M. Rodrigues, Peter Macko, Taina Palosaari, Maurice P. Whelan. Autofluorescence microscopy: A non-destructive tool to monitor mitochondrial toxicity. Toxicology Letters. (2011) Volume 206, Issue 3, Pages 281-288 (doi:10.1016/j.toxlet.2011.06.025) Artur Bednarkiewicz, Robim M. Rodrigues, Maurice P. Whelan. Enrichment of hepatocytes in a HepaRG culture using spatially selective photodynamic treatment. Journal of Biomedical Optics (2010) Volume 15, Issue 2, Article Number: 028002 (doi: 10.1117/1.3369000) D.J. Scott, A.S. Devonshire, Y.A. Adeleye, M.E. Schutte, M.R. Rodrigues, T.M. Wilkes, M.G. Sacco, L. Gribaldo, M. Fabbri, S. Coecke, M. Whelan, N. Skinner, A. Bennett, A. White, C.A. Foy. Inter- and intra-laboratory study to determine the reproducibility of toxicogenomics datasets. Toxicology (2011). Volume 290, Issue 1, Pages 50–58 (doi:10.1016/j.tox.2011.08.015) Contribution to the project - Subproject 2 – workpackage 4: * Establishment of standard operating procedures for the characterization of functionality and the testing of toxicity in cultures of primary hepatocytes. - Subproject 4: * Selection and reporting of functional read-outs as in vitro biomarkers. * Selection and reporting of -omics read-outs as in vitro biomarkers. Involved http://minf.vub.ac.be/~fafy/
Marsalek	Lukas	NOTOX	German Research Center for Artificial Intelligence (DFKI) GmbH	Lukas Marsalek +49 681 302 3836 - lukas[dot]marsalek[at]dfki[dot]de German Research Center for Artificial Intelligence (DFKI) GmbH Campus D3.2, 66123 Saarbrücken , Germany Resume Lukas Marsalek is a researcher at German Research Center for Artificial Intelligence, where he is finishing his doctoral studies. Before he was working as a researcher at Intel Visual Computing Institute and between 2007 and 2010 was a stipendiate at International Max Planck Research School for Computer Science (IMPRS-CS). His core focus is the transfer of research results into an industry practice, where he has been leading several technology transfer projects. His scientific research focuses on applications of rendering technologies in life sciences, especially bioinformatics. Publications Lukas Marsalek, Iliyan Georgiev, Anna Katharina Dehof, Hans-Peter Lenhof, Philipp Slusallek, and Andreas Hildebrandt, "Real-Time Ray Tracing of Complex Molecular Scenes", Information Visualization: Information Visualization in Biomedical Informatics (IVBI), London, July 2010. Mike Phillips, Anna Dehof, Iliyan Georgiev, Stefan Nickels, Lukas Marsalek, Hans-Peter Lenhof, Andreas Hildebrandt, and Philipp Slusallek, "Measuring Properties of Molecular Surfaces Using Ray Casting", 9th International Workshop on High Performance Computational Biology, 2010. Jan Horacek, Lukas Marsalek, Martin Horak, Josef Pelikan and Philipp Slusallek, "Segmentation of Femoral Head from CT after Femoral Neck Fracture", APR Conf. on Machine Vision Applications, 2009. Contribution to the project We develop new approaches to 3D tomographic reconstructions using algebraic techniques and ray tracing methods, leveraging our experiences in high-performance and many-core algorithms. We design novel reconstruction pipeline using prior information, hierarchical approaches, and proper acquisition modelling leading to improved noise characteristics and higher performance. Using this data we perform 3D analysis and identification of macromolecular structures, combining image processing and volumetric visualization to improve the ability to understand the structure-toxicology relationship. Involved http://www.dfki.de
Masson	Yolande	SCR&Tox	INSERM/UEVE UMR861, I-STEM, AFM	Yolande Masson +33 1 69 90 85 27 - ymasson[at]istem[dot]fr INSERM/UEVE UMR861, I-STEM, AFM Génopole Campus 1 5 rue Henri Desbruères 91030 Evry cedex , France Resume 2011: Engineer at INSERM U861/ISTEM, SCR&Tox Program. 2010: Master in Tissular, Cellular and Geni c Biotherapies (Evry University, France) 2008: Licence in Cellular and Physiologycal Biology (Evry University, France) Publications - Contribution to the project Differentiation of hES and hIPS cells into progenitors and Keratinocytes. Banking and characterization. Involved www.istem.eu
Mauch	Klaus	COSMOS & NOTOX	Insilico Biotechnology AG	Klaus Mauch +49(0)711460594-11 - Klaus[dot]mauch[at]insilico-biotechnology[dot]com Insilico Biotechnology AG Meitnerstr. 8, 70563 Stuttgart, Germany Resume Klaus Mauch is co-founder and CEO of Insilico Biotechnolgy AG. In his previous role of the company’s CTO from 2001 to 2005, he was responsible for the design and development of Insilico’s modeling and simulation platform by establishing novel methods for computer aided construction and analysis of cellular networks. As a group leader at the Institute of Biochemical Engineering at the University of Stuttgart, Klaus Mauch gained extensive experience in metabolic engineering and systems biotechnology. Klaus Mauch (co)-authored more than twenty peer-reviewed research articles and is inventor of many of Insilico’s patents and patent applications. He received a Masters in Chemical Engineering from the Technical University of Karlsruhe, Germany. Publications Maier K, Hofmann U, Reuss M, Mauch K. Dynamics and control of the central carbon metabolism in hepatoma cells. BMC Syst Biol. 2010 Apr 28;4:54. Maier K, Hofmann U, Bauer A, Niebel A, Vacun G, Reuss M, Mauch K. Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis. Metab Eng. 2009 Jul-Sep;11(4-5):292-309 Maier K, Hofmann U, Reuss M, Mauch K. Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation. Biotechnol Bioeng. 2008 Jun 1;100(2):355-70. Contribution to the project A Dose-effects models at molecular level B Reconstruction of a 2D in silico liver C High-performance grid computing Involved www.insilico-biotechnology.com
Meinl	Thorsten	COSMOS	KNIME.com AG	Thorsten Meinl +41 44 445 2660 - thorsten[dot]meinl[at]knime[dot]com KNIME.com AG Technoparkstrasse 1, 8005 Zurich, Switzerland Resume • 2010-07-09 Graduation to PhD (Dr.-Ing.) with the topic of Maximum Score Diversity Selection • since January 2010 Co-Secretary of the IEEE SMC Society, together with Heather Fyson • since March 2006 PhD student at Konstanz University at the Nycomed Chair for Bioinformatics and Information Mining • 2006-09-18 Organization of the workshop on Mining and Learning with Graphs at the ECML/PKDD 2006 together with Gemma C. Garriga and Thomas Gärtner • 2005-10-07 Organization of the workshop on Mining Graphs, Trees and Sequences at the ECML/PKDD 2005 conference together with Siegfried Nijssen • April 2005 - September 2005 Internship at ALTANA Pharma at Konstanz in the Molecular Modelling group • August 2004 - February 2006 PhD student at the Computer Science Department 2 of the Friedrich-Alexander University Erlangen-Nuremberg • January 2003 - July 2003 Intership at the Data Analysis Research Lab of Tripos Inc. in San Francisco • December 1999 - February 2004 Working student at Framatome ANP for programming intranet applications • October 1999 - July 2004 Student for Computer Science at the FAU Erlangen-Nuremberg Publications 1. January 2003 - July 2003 Intership at the Data Analysis Research Lab of Tripos Inc. in San Francisco 2. December 1999 - February 2004 Working student at Framatome ANP for programming intranet applications 3. October 1999 - July 2004 Student for Computer Science at the FAU Erlangen-Nuremberg Contribution to the project The open source platform KNIME is the application that is used to integrate the project’s algorithms and the partner’s software into a central common workflow platform that is freely available. KNIME.com is a software company. Our contribution is in making available the KNIME platform, and giving free access to our commercial professional software tools around the open source platform.KNIME.com is educating the project partners in the usage of the KNIME platform and the integration possibilities it provides. Partner’s software developers are trained to integrate their software and algorithms seamlessly into the platform. They are guided and supported in their development. In addition KNIME.com works together with the partners in order to assure best possible integration and compliance with the KNIME methodology. KNIME.com is consulting partners during the creation of workflows in KNIME that implement the project’s flows and make them easily available and accessible to others.KNIME.com also consults in any data mining or machine learning task and general KNIME extension programming issues.KNIME.com makes freely available for the project partners its commercial Involved http://www.knime.com
Mellier	Valérie	DETECTIVE	ARTTIC	Valérie Mellier + 33 1 53 94 54 74 - mellier[at]arttic[dot]eu ARTTIC 58a, Rue du Dessous des Berges – 75013 Paris, France Resume Valérie Mellier has a wide experience in project facilitation and management. For 5 years, she was Project Manager at Groupe Cap Gemini Sogeti leading informatics projects in the fields of aerospace and accounting information systems. At ARTTIC, for the last twenty years, Valérie has been managing many projects in different programmes (FP4-FP7, ESPRIT, ACTS, AAL and EUREKA) in various technological and educational sectors. Valérie holds three Master's degrees in Computer Science, Company Management and Training Management. Publications Contribution to the project In DETECTIVE, ARTTIC constitutes the Project Office and provides methods, tools and operational support for the project collaboration. ARTTIC thus supports the consortium in the daily management and administrative tasks to ensure the collaboration is working, the project is properly monitored and decisions and actions are prepared and taken according to the project progress. ARTTIC’s role is also to simplify the work of the researchers and to develop a collaborative team spirit inside the consortium. Valérie manages the DETECTIVE Project Office on a day-to-day basis. Involved http://www.arttic.com/
Mellor	Claire	COSMOS	Liverpool John Moores University	Claire Mellor +447528349789 - c[dot]l[dot]mellor[at]ljmu[dot]ac[dot]uk Liverpool John Moores University School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK Resume Claire gained a BSc (HONS) in Pharmacology and Therapeutics in 2006. She then carried out a Masters of research (MRes) in the field of Biomedical science, drug safety science. This then lead on to her PhD in pharmacology and therapeutics, drug safety science. Within her PhD she concentrated on elucidating the toxicological mechanisms of the antiretroviral Tenofovir, utalising in vitro, in vivo and in silico platforms (undertaken at the University of Liverpool). Currently she is a post-doctoral research fellow at Liverpool John Moores University and is involved with working on predictive computational toxicology. Publications Publication summarising quotient point of PhD research currently being finalised. Contribution to the project Toxicological data collection, curation, quality and databasing (WP1) Development of innovative computational approaches to predict toxicity (WP3) Dissemination of results and integration of COSMOS with other projects (WP6) Involved http://www.ljmu.ac.uk/PBS/research/114935.htm
Mitic Potkrajac	Dragana	NOTOX	Cambridge Cell Networks Ltd (CCN)	Dragana Mitic Potkrajac +381 21 533908 - dragana[dot]mitic[at]camcellnet[dot]com Cambridge Cell Networks Ltd (CCN) St John's Innovation Centre - Cowley RoadCB4 0WS Cambridge, United Kingdom Resume PhD in Biology from University of Dusseldorf (DE). M.Sc. in Molecular Biology and Physiology from University of Belgrade (SR). I was doing research in cell biology and biochemistry. For the last years I have been responsible for scientific knowledge extraction and data integration in field of toxicology, management duties and organization of events. I work on systems biology data (knowledge bases and various –omics data) in order to create models of mechanism of action and biological pathways. Publications - Contribution to the project CCN will be involved in the knowledge extraction from the legacy publication, tools for modeling of biological pathways, integration of the data generated by the experimental partners. CCN will conduct a systematic knowledge extraction from the literature and all other publicly available resources and create the most comprehensive NOTOX Knowledge Base. CCN will integrate relevant data from the experimental partners and map them onto existing NOTOX knowledge base. CCN will design, implement and test the systems biology data integration and deliver NOTOX pathway models in a form of a database and an easy-to-use visualization module. By combining the legacy literature data and the experimental results, CCN will create predictive methods for a) predicting the toxicity of compounds and b) creating hypothesis on mechanistic models. CCN will run multiple workshops and trainings. Involved www.camcellnet.com
Mostrąg-Szlichtyng	Aleksandra	COSMOS	Altamira, LLC	Aleksandra Mostrąg-Szlichtyng +48 785-604-128 - aleksandra[at]altamira-llc[dot]com Altamira, LLC 1455 Candlewood Drive, Columbus, Ohio 43235, USA Resume Currently: Altamira, LLC and the Ohio State University (Post-doctoral Research Fellow and Visiting Research Scientist). Will also be a visiting Scientist at US FDA CFSAN (2012). Previous work experience: Laboratory of Environmental Chemometrics (University of Gdańsk, Poland), EC JRC IHCP Computational Toxicology Group (Ispra, Italy), Interdisciplinary Center for Nanotoxicity (Jackson State University, USA), National Institute for Environmental Studies (Tsukuba, Japan). Scientific interests: application and development of computational modelling tools for risk assessment of chemicals. Publications Puzyn T, Mostrag-Szlichtyng A, Gajewicz A, Skrzyński M & Worth A (2011) Investigating the influence of data splitting on the predictive ability of QSAR/QSPR models. Structural Chemistry22(4):795-804. Mostrag-Szlichtyng A, Zaldívar Comenges JM, Worth AP (2010) Computational toxicology at the European Commission's Joint Research Centre. Expert Opinion On Drug Metabolism And Toxicology 6: 785-882. Mostrąg A, Puzyn T, Haranczyk M (2010) Modelling the overall persistence and environmental mobility of sulfur-containing polychlorinated organic compounds. Environmental Science And Pollution Research 17: 470-477. Puzyn T, Mostrag A, Falandysz J, Kholod Y, Leszczyński J (2009) Predicting water solubility of congeners: Chloronaphthalenes – a case study. Journal Of Hazardous Materials 170(2-3): 1014-1022. Contribution to the project Threshold of Toxicological Concerns (TTC) Approach (WP2); Chemoinformatics and Computational Toxicology methods development (WP3/WP4) Involved http://www.altamira-llc.com/news.php
Mueller	Daniel	NOTOX	Universitaet des Saarlandes – Biochemical Engineering	Daniel Mueller 0049-681/3024157 - daniel[dot]mueller[at]mx[dot]uni-saarland[dot]de Universitaet des Saarlandes – Biochemical Engineering Campus A 1 5 66123 Saarbruecken, Germany Resume currently: PostDoc at Saarland University, Biochemical Engineering Institute, Prof. Elmar Heinzle 2008-2011: PhD at Saarland University, Biochemical Engineering Institute, Prof. Elmar Heinzle, BMBF “HepaTox” Project 2002-2007: Studies of human- and molecular biology at Saarland University; Diploma thesis at the José-Carreras-Institute for immune- and gene therapy, Homburg Publications Mueller, D., Tascher, G., Muller-Vieira, U., Knobeloch, D., Nuessler, A. K., Zeilinger, K., Heinzle, E., and Noor, F. (2011).In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor. J Tissue Eng Regen Med 5, e207-18, DOI: 10.1002/term.418. Mueller D., Koetemann A and Noor F. (2011). Organotypic cultures of HepG2 cells for in vitro toxicity studies. J Bioeng Biomed Sci, DOI: 10.4172/2155-9538.S2-002. Heyne K., Schmitt K., Mueller D. Armbruester V., Mestres P. and Roemer K (2008):Resistance of mitochondrial p53 to dominant inhibition. Mol. Cancer, DOI: 10.1186/1476-4598-7-54. Contribution to the project Organotypic cultures for long-term repeated dose testing of compounds Metabolomics / fluxomics to characterize organotypic cultures and to assess compound-induced long-term effects Involved http://www.uni-saarland.de/fak8/heinzle/
Myatt	Glenn	ToxBank	Leadscope, Inc.	Glenn Myatt 16146753731 - gmyatt[at]leadscope[dot]com Leadscope, Inc. 1393 Dublin Road, Columbus, Ohio 43082, USA Resume Glenn J. Myatt, Chief Scientific Officer, Leadscope Inc. EDUCATION Oxford Brookes University, UK B.Sc. 1990 Computing Heriot-Watt University, UK M.Sc, 1991 Knowledge-based Systems University of Leeds, UK Ph.D. 1994 Chemoinformatics POSITIONS 1997- Co-founder and Chief Scientific Officer, Leadscope, Columbus, OH 2006- Guest lecturer in Chemoinformatics, Georgia State University, GA 1995-1997 Visiting Research Scientist, American Chemical Society, Columbus, OH 1994 Research Assistant, University of Leeds, UK Publications Gillet, V.J.; Myatt, G.J.; Zsoldos, Z.; Johnson, A.P. “SPROUT, HIPPO and CAESA: Tools for de novo structure generation and estimation of synthetic accessibility.” Perspect, Drug Disc. Res., 1995, 3, 34-50. Blower, P.E. Jr.; Myatt, G.J.; Petras, M.W. “Exploring Functional Group Transformations on CASREACT.” J. Chem. Inf. Comput. Sci., 1997, 37, 54-58. Roberts, G.; Myatt, G.J.; Johnson, W.P.; Cross, K.P.; Blower, P.E.; “Leadscope: Software for Exploring Large Sets of Screening Data.” J. Chem. Inf. Comput. Sci., 2000, 40, 1302-1314. Johnson, D.E.; Blower, P.E.; Myatt, G.J.; Wolfgang, G.; “Chem-tox informatics: Data mining using a medicinal chemistry building block approach.” Current Opin. Drug Disc. Develop., 2001, 4(1), 92-101. Cross, K.P.; Myatt, G.; Yang, C.; Fligner, M.F.;Verducci, J.S.; Blower, Jr., P.E. Finding Discriminating Structural Features by Reassembling Common Building Blocks, J. Med. Chem., 2003, 46, 4770-4775. Yang, C.; Cross, K.; Myatt, G.; Blower, P.; Rathman, J. Building Predictive Models For PTP1B Inhibitors Based On Discriminating Structural Features By Reassembling Medicinal Chemistry Building Blocks, J. Med. Chem., 2004, 47, 5984 – 5994. Netzeva, T.I., Worth, A.P., Aldenberg, T., Benigni, R., Cronon, M.T., Gramatica, P., Jaworska, J.S., Kahn, S., Klopman, G., Marchant, C.A., Myatt, G., Nikolova-Jeliazkova, N., Patlewicz, G.Y., Perkins, R., Roberts, D.W., Schultz, T.W., Stanton, D. T., van de Sandt, J. J., Tong, W., Veith, G., Yang, C., Current Status of Methods for Defining the Applicability Domain of (Quantitative) Structure Activity Relationships – The Report and Recommendations of ECVAM Workshop 52, ATLA, 2005, 33, 1-19 Blower, P.E.; Cross, K.C.; Eichler, G.S.; Myatt, G.J.; Weinstein, J.N.; and Yang, C. Comparison of Methods for Sequential Screening of Large Compound Sets, Comb. Chem. High Throughput Screen., 2006 Feb; 9:115-22 Myatt, G.J., Making Sense of Data: A Practical Guide to Exploratory Data Analysis and Data Mining, John Wiley & Sons, 2007 Myatt, G.J. and Blower, P.E., “Data Mining Chemical Structures and Biological Information” in Chen, J.Y. and Lonardi, S., Biological Data Mining, CRC Press, 2009 Myatt, G.J. and Johnson, W.P., Making Sense of Data II: A Practical Guide to Data Visualization, Advanced Data Mining Methods, and Applications, John Wiley & Sons, 2009 Contribution to the project Technology development for the ToxBank work package 1 (Data Warehouse) and work package 2 (Gold compounds database), extension of ToxML language, as well as provision of data warehouse components, including databases, data marts, web services, and user interfaces for the data warehouse. Involved www.leadscope.com
Neagu	Daniel	COSMOS	University of Bradford	Daniel Neagu +44 127 4235704 - d[dot]neagu[at]bradford[dot]ac[dot]uk University of Bradford Department of Computing, Richmond Road, Bradford BD7 1DP, UK Resume Daniel Neagu is Professor of Computing and the AIRe (AI Research) Group Leader at University of Bradford. His research addresses computational intelligence techniques for data quality, mining and integration, and knowledge discovery for predictive toxicology and web applications. He coordinates EPSRC, BBSRC, EC FP7 and industry financed projects. Daniel is an invited referee for EPSRC, EC IMI, Beilstein Institute and The Leverhulme Trust, and PC member of renowned international conferences and journals. He authored 5 books and over 100 refereed journal and conference papers. Daniel is IEEE CS, ACM and BCS member, and committee member of BCS SGAI. Publications Negoita M, Neagu D, Palade V (2005) Computational Intelligence - Engineering of Hybrid Systems, Series: Studies in Fuzziness and Soft Computing, Vol. 174, Springer Series in Fuzziness. Neagu D, Guo G, Trundle PR, Cronin MTD (2007): A Comparative Study of Machine Learning Algorithms Applied to Predictive Toxicology Data Mining, J. of Alternatives to Laboratory Animals ATLA 35/1: 25-32. Trundle PR, Neagu D, Chaudhry Q (2007) Multi-source Data Modelling: Integrating Related Data to Improve Model Performance, 5th Int’l Conf MLDM 2007, Leipzig, Springer LNCS 4571, pp. 32-46. Makhtar M, Neagu D. and Ridley M. (2010): "Predictive Model Representation and Comparison: Towards Data and Predictive Models Governance", Proceedings of the 10th UK Workshop on Computational Intelligence UKCI 2010 (IEEE Xplore), pages 1-6, Colchester, UK Contribution to the project The UNIBRAD team contribute on data curation and data mining, multivariate modelling and predictive toxicology model management as WP1 coordinator and contributor to WP3 and WP5. The key tasks allocated to UNIBRAD are data representation, data curation, development of computational intelligence techniques, data and model integration, and data mining tools. Involved http://www.comp.brad.ac.uk/~dneagu/
Nelms	Mark	COSMOS	School of Pharmacy and Chemistry, Liverpool John Moores University	Mark Nelms +44 (0)151 231 2422 - m[dot]d[dot]nelms[at]2011[dot]ljmu[dot]ac[dot]uk School of Pharmacy and Chemistry, Liverpool John Moores University Byrom Street, Liverpool, L3 3AF, UK Resume Mark Nelms graduated in 2008 with a degree in Biological Sciences from Lancaster University and since September 2011 has been a PhD student in Computational Toxicology at LJMU. The aim of his study is to develop in silico models that will aid in the regulatory assessment of repeat dose toxicity. Publications Contribution to the project Toxicological data collection, curation, quality and databasing (WP1) Development of innovative computational approaches to predict toxicity (WP3) Dissemination of results and integration of COSMOS with other projects (WP6) Involved http://www.staff.livjm.ac.uk/phamcron/qsar/qsar1.htm
Nguemo	Filomain	DETECTIVE	Institute of Neurophysiology, Medical School University of Cologne	Filomain Nguemo +49 221 478 6940 - filo[dot]nguemo[at]uni-koeln[dot]de Institute of Neurophysiology, Medical School University of Cologne Robert-Koch-Str. 39, 50931 Cologne, Germany Resume Filomain Nguemo, Dr (PhD in Biology) is team leader of electrophysiology group at the Institute of Neurophysiology. After studying biology at the University of Yaoundé (Cameroon), he joined the the medical school of the University of Cologne where he obtained his PhD in Physiology. Nguemo´ scientific work aims to better understanding the networks controlling cells specification (e.g. cardiomyocytes, smooth muscles, hapatocytes) and improving the physiological understanding of developing and diseased heart. For this propose several techniques such as molecular, cell biology and physiology, are combined with embryonic stem (ES) and induced pluripotent stem (iPS) models from mouse, rhesus and human sources. His current research involves functional expression of ion channels, the long-term exposure effect of compounds/drugs on ES and iPS during the differentiation process. He is also focusing on large-scale electrophysiological recordings and studying pharmacology in an in vitro control and transplantation model. Publications Fatima A, Xu G, Shao K, Papadopoulos S, Lehmann M, Arnáiz-Cot JJ, Rosa AO, Nguemo F, et al. In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells. Cell Physiol Biochem. 2011;28(4):579-92 Gupta MK, Illich DJ, Gaarz A, Matzkies M, Nguemo F, Pfannkuche K, Liang H, Classen S, Reppel M, Schultze JL, Hescheler J, Sarić T.Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar. BMC Dev Biol. 2010;10:98. Nguemo F, Sasse P, Fleischmann BK, Kamanyi A, Schunkert H, Hescheler J, Reppel M. Modulation of L-type Ca(2+) channel current density and inactivation by beta-adrenergic stimulation during murine cardiac embryogenesis. Basic Res Cardiol. 2009; 104(3):295-306. Mauritz C, Schwanke K, Reppel M, Neef S, Katsirntaki K, Maier LS, Nguemo F, Menke S, Haustein M, Hescheler J, Hasenfuss G, Martin U.Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation. 2008;118(5):507-17. Contribution to the project Sub-project 2: With his great experience and knowledge in electrophysiology, Filomain Nguemo is responsible for Functional readouts experiment at the UKK. The contractile properties as well as the electrophysiological characteristics of electrically active cells such as cardiomyocytes will be monitored using multi-electrode arrays (MEA) and xCELLigence instruments. The MEA technology allow qualification of candidate biomarkers of e.g. cardiotoxicity by assessing the cellular physiology whereas xCELLigence instruments offer the opportunity to record compound-induced beating variabilities in real-time and in a high throughput 96 well format. Activation, repolarization and conduction properties of stem cell-derived cardiomyocytes after exposure to test substances are assessed by measuring extracellular signals in single and repeated dose scenarios. Involved www.uni-koeln.de/med-fak/physiologie/
Noor	Fozia	NOTOX	Biochemical Engineering Institute	Fozia Noor +49 (0) 6813022205 - fozia[dot]noor[at]mx[dot]uni-saarland[dot]de Biochemical Engineering Institute Campus A1.5, Saarland University, Saarbrücken, Germany Resume Fozia Noor is a research scientist currently working at the Saarland University. She studied Pharmacy and received her MPhil degree in Pharmaceutical Chemistry in Karachi. She then did her DEA in Pharmaceutical Chemistry, Pharmacology and Metabolism of Drugs in Paris (Paris V) and afterwards her PhD -summa cum laude- at the Institute of Pharmacy and Molecular Biotechnology at the University of Heidelberg. Her research interests include alternative methods to animal testing, metabonomics and systems toxicology. Publications D. Mueller et al., In-depth physiological characterization of primary human hepatocytes in a 3D-hollow fiber bioreactor, *J Tiss Eng Reg Med., in press 2011. Strigun et al., Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes, Toxicol Appl Pharmacol, in press 2011. Beckers et al.,High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements, Toxicol in vitro, 2010, 24(2):686-94. J. Niklas et al.,Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicol Appl Pharmacol;2009, 240(3):327-36. F. Noor et al., An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells. Toxicol Appl Pharmacol;* 2009 Jun 1;237(2):221-31 Contribution to the project Dr. Fozia Noor is group leader of systems biology of mammalian cell and systems toxicology in the group of Prof. Heinzle and is actively involved in leading the projects VITROCELLOMICS, INVITROHEART, HEPATOX and VIRTUAL LIVER. She has published several scientific papers in the field of alternative methods for compound testing. She will act as sub co-ordinator for the NOTOX project and participate in the co-ordination of research activities within the NOTOX project as well as collaborations with the SEURAT cluster. In addition, she will be responsible for supervising and execution of the research activities of the partners, USSAR-HE in the NOTOX project. Involved http://www.uni-saarland.de/fak8/heinzle/fozianoor
Notelaers	Tineke	HeMiBio	Stem Cell Institute K.U.Leuven	Tineke Notelaers 016/330292 - tineke[dot]notelaers[at]med[dot]kuleuven[dot]be Stem Cell Institute K.U.Leuven O&N1, Herestraat 49, PB 804, 3000 Leuven, Belgium Resume Graduated as Master in Science in 2007. Since 2008 active as a lab technician in the laboratory of Catherine Verfaillie, where I mainly worked on the differentiation of ESC and iPSC towards hepatocytes. Started as a PhD student in 2010 in the Stem cell Institute. The aim of my study is to obtain a better insight in the early stages of differentiation of pluripotent stem cells towards hepatocyte-like cells. Publications Sancho-Bru P, Roelandt P, Pauwelyn K, Narain N, Notelaers T, Shimizu T, Ott M, Verfaillie CM. Directed differentiation of murine induced pluripotent stem cells to functional hepatocyte-like cells. J. Hepatol. 2011 Jan;54(1):98-10 Epub 06- 09-2010 Contribution to the project By obtaining better insights in the early stages of liver differentiation I hope to contribute in improving the labs current protocol for differentiation of iPSC towards hepatocytes and hereby obtain an enriched population of mature and functional hepatocytes. Involved http://www.kuleuven.be/scil
Ohl	Peter	COSMOS	KNIME.com AG	Peter Ohl +41 44 445 2660 - peter[dot]ohl[at]knime[dot]com KNIME.com AG Technoparkstrasse 1, 8005 Zurich, Switzerland Resume • since 10/2008 Software-Developer and Manager KNIME Server at KNIME.com AG, Zurich, Switzerland. • 11/2003 - 9/2008 Research Assistant at the Konstanz University, Nycomed Chair for Bioinformatics and Information Mining, Konstanz, Germany. • 2/2000 - 11/2003 Sr. R&D Engineer, Software-Development, Synopsys, CA, USA and Munich, Germany. • 8/1997 - 1/2000 R&D Engineer, Software-Development, Verysys, Fremont, CA, USA. • 2/1993 Masters in Computer Science at the University of Karlsruhe, Germany. Publications Berthold, Michael R., Cebron, Nicolas, Dill, Fabian, Gabriel, Thomas R., Kötter, Tobias, Meinl, Thorsten, Ohl, Peter, Thiel, Kilian, Wiswedel, Bernd, KNIME - The Konstanz Information Miner, SIGKDD Explorations, vol. 11, no. 1, 2009 (http://www.sigkdd.org/explorations/issues/11-1-2009-07/p4V11n1.pdf) Contribution to the project The open source platform KNIME is the application that is used to integrate the project’s algorithms and the partner’s software into a central common workflow platform that is freely available. KNIME.com is a software company. Our contribution is in making available the KNIME platform, and giving free access to our commercial professional software tools around the open source platform.KNIME.com is educating the project partners in the usage of the KNIME platform and the integration possibilities it provides. Partner’s software developers are trained to integrate their software and algorithms seamlessly into the platform. They are guided and supported in their development. In addition KNIME.com works together with the partners in order to assure best possible integration and compliance with the KNIME methodology. KNIME.com is consulting partners during the creation of workflows in KNIME that implement the project’s flows and make them easily available and accessible to others.KNIME.com also consults in any data mining or machine learning task and general KNIME extension programming issues.KNIME.com makes freely available for the project partners its commercial. Involved http://www.knime.com
Ordovas	Laura	HeMiBio	KU Leuven	Laura Ordovas +32 16 33 02 92 - Laura[dot]ordovas[at]med[dot]kuleuven[dot]be KU Leuven Herestraat 49, O&N1 Bus 804, Belgium Resume Laura Ordovás, PhD, obtained her PhD degree in December 2006 at the University of Zaragoza, Faculty of Veterinary in the Dpt. of Animal Embryology and Genetics under the direction of Dr C. Rodellar and Prof. P Zaragoza. She joined the lab of Dr. Verfaillie at KULeuven in January 2009 to work in the generation of liver-specific hESC/iPSC reporter cell lines with the aim of enriching stage-specific cell types during their differentiation towards the hepatic lineage. Publications Roelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Ordovas L, et al. (2010) Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS One 5: e12101. Ordovas L, Roy R, Pampin S, Zaragoza P, Osta R, et al. (2008) The g.763G>C SNP of the bovine FASN gene affects its promoter activity via Sp-mediated regulation: implications for the bovine lactating mammary gland. Physiol Genomics 34: 144-148 Ordovas L, Roy R, Zaragoza P, Rodellar C (2006) Structural and functional characterization of the bovine solute carrier family 27 member 1 (SLC27A1) gene. Cytogenet Genome Res 115: 115-122 Contribution to the project Laura will contribute in the following objectives of the project: - To develop tools for efficient enrichment of cells that have the potential to differentiate to cells with functional properties of mature hepatocytes, hepatic sinusoidal endothelial cells (HSEC), and(3) hepatic stellate cells (HSC) from human iPSC; - To develop tools for efficient non-invasive assessment of the differentiated state of hepatocytes, HSEC and HSC as well as the quiescent vs. activated/diseased state of HSEC and HSC; - To provide the engineered cell populations for studies in WP3, 4 and 5 Involved http://www.kuleuven.be/scil/
Paini	Alicia	COSMOS	Joint Research Centre	Alicia Paini +39-0332-783986 - Alicia[dot]PAINI[at]ec[dot]europa[dot]eu Joint Research Centre Via E. Fermi 2749, I-21027 Ispra (VA), Italy Resume Alicia Paini, holds a 5 year degree in Food Science and Technology at the University of Parma (Italy). With an Erasmus scholarship she conducted part of the specialization thesis in Food Analytical Chemistry at the Department of Food Chemistry at Wageningen University (The Netherlands), in collaboration with Douwe Egberts under the supervision of Dr. Hank Schols. After obtaining the laurea in Food Science and Technology from the University of Parma, in 2006 she started the Master program in Food Safety at Wageningen University. From November 2007 to December 2011 she was appointed the PhD position at the Toxicology Department in collaboration with the Chemical Food Safety Group of the Nestlé Research Center under the supervision of Dr. Gabriele Scholz, Dr. Benoit Schilter, Prof. Ivonne M.C.M. Rietjens and Prof. P.J. van Bladeren. The PhD research title was Generation of in vitro data to model dose dependent in vivo DNA binding of genotoxic carcinogens and its consequences: -the case of estragole-. Currently she works as a postdoc - grant holder within the System Toxicology unit in Dr. Andrew Worth group at the Joint Research Centre (JRC), Ispra, Italy. Publications Martati E, Boersma MG, Spenkelink A, Boonpawa R, Paini A, van Bladeren PJ , Punt A, Rietjens IMCM. (Accepted in Food and Chemical Toxicology). Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo. Alhusainy W, Paini A, Taylor S, Vervoort J, Scholz G, Schilter B, Adams T, van Bladeren PJ, Rietjens IMCM. (2013). In vivo validation and physiologically based biokinetic modeling of the inhibition of SULT-mediated estragole DNA adduct formation in the liver of male sprague-dawley rats by the basil flavonoid nevadensin. Molecular Nutrition and Food Research 57 11, pp. 1969-1978. Al-Subeihi A, Paini A, van Bladeren PJ, Rietjens IMCM. (2013). Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiology based kinetic modelling. Food and Chemical Toxicology 59, pp. 564-571. Contribution to the project Within the COSMOS project I am involved in establishing kinetic and PBPK models, in vitro, in silico and other relevant data to predict target organ concentrations and long term toxicity to humans. As well as to establish a mitochondria model to address multi-scale modeling approach. I am also involved in integrating open source and open access modeling approaches into adaptable and flexible in silico workflows using the KNIME workbench. Involved http://ihcp.jrc.ec.europa.eu/
Pajeva	Ilza	COSMOS	Institute of Biophysics and Biomedical Engineering	Ilza Pajeva +359 2 979 3605 - pajeva[at]biomed[dot]bas[dot]bg Institute of Biophysics and Biomedical Engineering Acad. G. Bonchev Str. Bl. 105, 1113 Sofia, Bulgaria Resume MSc (1978) in Chemical Cybernetics from Mendeleev Institute of Chemical Technology, Moscow; PhD in Biological Science (1989) and DSc in Pharmacology (2007) from Bulgarian Academy of Sciences; Fellow of the Alexander von Humboldt Foundation in Borstel Research Center, Germany (1993-1994); Professor in Theoretical Chemistry (2008) and Head of QSAR and Molecular Modeling department (since 2010) in Institute of Biophysics and of Biomedical Engineering, Bulgarian Academy of Sciences. The scientific interests include QSAR and molecular modeling, multidrug resistance and transport proteins. Publications Pajeva, I., M. Wiese. Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators. AAPS J, 2009, 11, 435-444. Pajeva, I. K., C. Globisch, M. Wiese. Combined pharmacophore modeling, docking and 3D QSAR study of ABCB1 and ABCC1 transporter inhibitors. ChemMedChem, 2009, 4, 1883-1896. Pajeva, I., M. Wiese. Application of in silico methods to study ABC transporters involved in multidrug resistance. In: In Silico Lead Discovery (M. A. Miteva, Ed.), Bentham Science Publishers Ltd., 2011, 144-162. Contribution to the project Participation in: (i) collection of relevant information and data related to the in vivo toxicity of cosmetics; (ii) evaluation of existing QSAR models predicting the chronic toxicity endpoints for groups of chemicals of the cosmetic inventory; (iii) application of in silico methods for the purpose of long-term toxicity prediction of cosmetic ingredients: grouping of chemicals into categories and read-across, development of new QSAR models. Involved www.biomed.bas.bg
Park	Yonsil	HeMiBio	Stamcelinstituut, Katholieke Universiteit Leuven	Yonsil Park +32 16 33 0295 - Yonsil[dot]Park[at]med[dot]kuleuven[dot]be Stamcelinstituut, Katholieke Universiteit Leuven Leuven 3000, Belgium Resume Yonsil Park, PhD, obtained her PhD degree at the University of Minnesota , USA, under the guidance of Dr W. Hu and Dr Verfaillie. She joined the laboratory of Dr Verfaillie at KULeuven in the fall of 2010 to work on scale-up of hESC expansion and hepatic differentiation and ECM substrates for more mature hepatic differentiation. She has experiences in microcarrier and 3D cell culture in bioreactor systems. Publications Park, Y., Subramanian, K., Verfaillie, C., Hu, W.(2010). Expansion and hepatic differentiation of rat multipotent adult progenitor cells in microcarrier suspension culture. Journal of Biotechnology, 150:131-139. Subramanian, K., Park, Y., Verfaillie, C., Hu, W.(2011). Scalable expansion of multipotent adult progenitor cells as three-dimensional cell aggregates. Biotechnology and Bioengineering, 108:364-375. Subramanian, K., Geraerts, M., Pauwelyn, K.A., Park, Y., Owens, D.J., Muijtjens, M., Ulloa-Montoya, F., Jiang, Y., Verfaillie, C. (2010). Isolation procedure and characterization of multipotent adult progenitor cells from rat bone marrow. Methods in Molecular Biology: Cellular Programming and Reprogramming, 636:55-78 Contribution to the project To develop tools for efficient enrichment of cells that have the potential to differentiate to cells with functional properties of (1) mature hepatocytes, (2) hepatic sinusoidal endothelial cells (HSEC), and(3) hepatic stellate cells (HSC) from human iPSC Involved http://www.kuleuven.be/scil/index.html
Pavan	Manuela	COSMOS	S-IN Soluzioni Informatiche srl	Manuela Pavan 3 904 441 821 160 - manuela[dot]pavan[at]s-in[dot]it S-IN Soluzioni Informatiche srl Via Ferrari 14, 36100 Vicenza, Italy Resume Dr Manuela Pavan is a computational toxicology research scientist. She is an experienced professional of in silico methods such as (Q)SAR and read-across with significant experience in their use for the regulatory assessment of chemicals. She has broad experience in the use of computer-based methods for assessing the environmental distribution and fate of chemicals, and their effects on human health and the environment. She acquired a solid knowledge in the fields of a) chemometrics and ranking methods (University of Milano-Bicocca); b) QSARs and molecular descriptors (Talete S.r.l); c) computational toxicology (European Commission); d) in silico predictions (S-IN Soluzioni Informatiche). Publications Bassan, A., Fioravanzo, E., Pavan, M, Stocchero, M. Report on Applicability of physicochemical data, QSARs and read-across in Threshold of Toxicological Concern assessment. EFSA Technical Report EFSA-Q-2009-00919, 2011. Pavan M., Worth A. P., Publicly-accessible QSAR software tools developed by the Joint Research Centre, SAR and QSAR in Environmental Research., 19, 1-15, (2008) Pavan, M., Todeschini, R. Total Order Ranking Methods. InData Handling in Science and Technology, Vol 27, Scientific Data Ranking Methods: Theory and Applications, ed. Pavan, M., Todeschini, R. 51-72, 2008, Elsevier Contribution to the project She is part of the team who will aim at optimising in silico methods, such as (Q)SAR and read-across, for the purpose of long-term toxicity prediction of cosmetic ingredients. The tasks of the team include: a) Characterisation of the chemical space of cosmetic inventories; b) Read-across, grouping and structural analogues analysis; c)Evaluation of existing QSAR models and expert systems for cosmetic ingredients; d) Development of new QSAR regression and classification models. e) Application of innovative chemometric tools. Involved www.s-in.it
Pearson	Nick	SCR&Tox	CIT, Safety & Health Research Laboratories	Nick Pearson +33 2 32 29 59 92 - nick[dot]pearson[at]citox[dot]com CIT, Safety & Health Research Laboratories BP 563 Miserey, 27005 Exreux cedex, France Resume Extensive background in molecular cell physiology with the last 8 years in pharmaceutical industry. Expertise in In vitro predictive toxicology and investigative toxicology including toxicogenomics. Currently responsible for Investigative toxicology at CIT. Publications - Contribution to the project As a partner in SCR&Tox, we have responsibility of establishing the industrial scale platform of the screening assays with all protocols and SOPs determined by other partners. Involved www.citox.com
Pencheva	Tania	COSMOS	Institute of Biophysics and Biomedical Engineering	Tania Pencheva +359 2 9793647 - tania[dot]pencheva[at]biomed[dot]bas[dot]bg Institute of Biophysics and Biomedical Engineering Acad. G. Bonchev Str. Bl. 105, 1113 Sofia, Bulgaria Resume Graduated with a MSc degree in bioengineering(1994) and applied mathematics and Informatics (1998) from Technical University, Sofia;PhD in Technical Science(2003) from Bulgarian Academy of Sciences;1995-2006 - worked in the field of modelling and optimization of bioprocess systems; 2006-2007 - postdoc in Laboratoire de Pharmacochimie Moléculaire et Cellulaire, INSERM 648, Paris, France; associate professor (since 2006) in Institute of Biophysics and of Biomedical Engineering, Bulgarian Academy of Sciences; currently interests - in the fields of bioinformatics and computational chemistry. Publications Pencheva T., O. Samna, I. Pajeva, M. Miteva,Post-docking Virtual Screening of Diverse Binding Pockets: Comparative Study using DOCK, AMMOS, X-Score and FRED Scoring Functions, European Journal of Medicinal Chemistry, 2010, 45(6), 2622-2628. Lagorce D., T. Pencheva,B. Villoutreix, M. Miteva, DG-AMMOS: A New Tool to Generate 3D Conformation of Small Molecules using Distance Geometry and Automated Molecular Mechanics Optimization for in silico Screening, BMC Chemical Biology, 2009, 9:6. Pencheva T., D. Lagorce, I. Pajeva, Br. Villoutreix, M. Miteva,AMMOS: Automated Molecular Mechanics Optimization Tool for in silico Screening, BMC Bioinformatics, 2008, 9:438. Contribution to the project Participation in: (i) collection of relevant information and data related to the in vivo toxicity of cosmetics; (ii) evaluation of existing QSAR models predicting the chronic toxicity endpoints for groups of chemicals of the cosmetic inventory; (iii) application of in silico methods for the purpose of long-term toxicity prediction of cosmetic ingredients: grouping of chemicals into categories and read-across, development of new QSAR models. Involved http://www.biomed.bas.bg/
Perea	Luis	HeMiBio	Institut d’Investigacions Biomediques August Pi I Sunyer	Luis Perea 93 2275400 - perea[at]clinic[dot]ub[dot]es Institut d’Investigacions Biomediques August Pi I Sunyer C/Roselló, 153, Planta3, Barcelona, 08036,, Spain Resume Luis Perea obtained his M.Sc. degree at the University of Seville (US) in 2011. His master thesis, entitled “Conversion pancreas to liver lineage in absence of transcription factor Gata4/Gata6”, was supervised by Prof. Dr. Felipe Cortés-Ledesma and Dra Anabel Rojas Gonzalez. From May 2013, Luis started as a PhD student in the lab of Dr. Pau Sancho-Bru at the Liver Unit of Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), where his main task is the development of conditions that will allow the expansion of human quiescent HSCs to be used in mid-high throughput screenings for anti-fibrotic compounds and for populating artificial liver devices for drug and cosmetic toxicity assays. Publications Contribution to the project IDIBAPS will be involved in: 1- the isolation of primary human hepatic stellate cells and other liver cells as a reference for cells generated from iPS; 2- the development of culture conditions to expand quiescent and activated stellated cells; 3- providing quiescent and activated stellate cells for WP1, 3 and 5; 4- evaluating the effect of ECM and medium modifications on primary HSC phenotype; 5- evaluating stellate cell phenotype and function in 2D and 3D culture; 6-developing in vitro conditions for human precision cut liver slices. Involved www.idibaps.org
Perillous	Sophie	SCR&Tox	Ectycell SAS	Sophie Perillous +33 141 83 99 09 ext 564 - Sophie[dot]perillous[at]cellectis[dot]com Ectycell SAS 102 avenue Gaston Roussel, 93235 Romainville, France Resume 2008 : MSc Biology and biotechnology (France). 2006: BSc in biochemistry and molecular biology (France). High Throughput Screening of small molecules. In vitro and cellular inhibitors characterization. Publications Zoltán Bochdanovits, David Sondervan, Sophie Perillous, Toos van Beijsterveldt, Dorret Boomsma, and Peter Heutink. Genome-Wide Prediction of Functional Gene-Gene Interactions Inferred from Patterns of Genetic Differentiation in Mice and Men. PLoS One 2008. Contribution to the project Support for cellular reprogrammation experiments for WP2 and WP3. Field of expertise: cell biology. Involved http://www.cellectis.com
Pery	Alexandre	COSMOS	INERIS	Alexandre Pery +33 3 44 55 61 26 - Alexandre[dot]pery[at]ineris[dot]fr INERIS Parc ALATA BP 2 65550 Verneuil en Halatte, FRANCE Resume Dr Alexandre Péry is the head of the INERIS unit METO. He has expertise in PBPK models, QSAR approaches and mechanistic models in toxicology, with a particular focus on DEB and DEBtox models. He published over 40 papers in this field. Publications Péry ARR, Bois FY (2009) Stochasticity in Physiologically Based Kinetics Models: Implications for Cancer Risk Assessment. Risk Anal. 29: 1182–1191. Henegar A, Mombelli E (2009). Maximum-Likelihood Estimation of Predictive Uncertainty in Probabilistic QSAR Modeling. QSAR Comb. Sci. 28: 338-344 Péry ARR, Brochot C, Desmots S, Boize M, Sparfel L, Fardel O (2011). Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models. Toxicol Lett. In press. Contribution to the project DEB and DEBtox modelling to analyse in vitro tests + PBPK modelling for toxicokinetics prediction. Involved http://www.ineris.fr/
Peschanski	Marc	SCR&Tox	INSERM/UEVE 861, I-STEM/AFM	Marc Peschanski 33 169 908 517 - mpeschanski[at]istem[dot]fr INSERM/UEVE 861, I-STEM/AFM 5 rue Henri Desbruères Evry 91030 cedex, France Resume Founder and scientific director of I-Stem is a medical doctor in Neurosciences. Entered at INSERM in 1982, he first worked on the neurophysiology and anatomy of pain in Paris and San Francisco. From 1985 his work was oriented towards the study of neuroplasticity and transplantation of foetal neurons, with which his team conducted the first clinical studies in France, starting in 1991 in patients with Parkinson’s disease, and the first world trial in Huntington’s patients from 1996, followed by a European study of Phase II. Co-founder of the Clinical Investigation Centre at the Henri-Mondor Hospital and to its associated Biotherapy branch. Publications Guenou H, Nissan X, Larcher F, Feteira J, Lemaitre G, Saidani M, Del Rio M, BarraultCC, Bernard FX, Peschanski M, BaldeschiC, Waksman G.Human embryonic stem cells derivatives enablefull reconstruction of the pluristratified epidermis. The Lancet 2009, published online Nov. 21, 2009; doi:10.1016/S0140-6736(09)61496-3 Lefort N, Feyeux M, Bas C, Féraud O, Bennaceur-Griscelli A, Tachdjian G, Peschanski M, Perrier AL. Human embryonic stem cells reveal recurrent genomic instability at 20q11.21.Nat Biotechnol. 2008 Dec;26(12):1364-6. Epub 2008 Nov 23. Aubry L, Bugi A, Lefort N, Rousseau F, Peschanski M, Perrier AL. Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats.Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16707-12. Epub 2008 Oct 15 Contribution to the project Coordinator. Participation to the establishment of stem cell derivatives in the ectodermal and the myogenic lineages. Development of large-scale technologies for screening predictive toxicology. Involved www.istem.eu
Peters	Peter	NOTOX	Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital NKI-AVL	Peter Peters +31 6 5538 4705 - p[dot]peters[at]nki[dot]nl Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital NKI-AVL Plesmanlaan 121, Amsterdam, The Netherlands Resume Peters obtained his PhD from Utrecht University, where he analyzed the ultrastructure of MHC class II antigen processing and discovered the 'MHC class II compartment' (MIIC) (Peters PJ et al., Nature, 1991, Peters PJ et al., J Exp Med 1995) and studied exocytosis of cytotoxic mediators in T cells. He established that secretory granules are of lysosomal nature (Peters PJ et al., J Exp Med. 1991). Peters joined the group of Rick Klausner at the National Institutes of Health in Bethesda, USA and identified ARF6 as a regulator for endocytosis (Peters PJ et al., J Cell Biol. 1995). In 1998, he became Principal Investigator at the Netherlands Cancer Institute and was appointed as professor at the Free University of Amsterdam. Since 2010 he holds a 0.2 FTE professorship at the Kavli Institute of Nanoscience at the University of Technology in Delft. Publications Sato,T., Vries,R.G., Snippert,H.J., van de Wetering,M., Barker,N., Stange,D.E., van Es,J.H., Abo,A., Kujala,P., Peters, P.J., and Clevers,H. (2009). Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265. Godsave,S.F., Wille,H., Kujala,P., Latawiec,D., DeArmond,S.J., Serban,A., Prusiner,S.B., and Peters,P.J. (2008). Cryo-immunogold electron microscopy for prions: toward identification of a conversion site. J. Neurosci. 28, 12489-12499. van der Wel,N., Hava,D., Houben,D., Fluitsma,D., van Zon,M., Pierson,J., Brenner,M., and Peters, P.J. (2007). M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 129, 1287-1298. Contribution to the project One focal point of our structural biology group is to reveal and manipulate the macromolecular organization of cells under normal and pathogenic conditions at the nano-scale level. We use cryo-electron tomography of vitreous sections, currently the only method that can obtain molecular resolution of macromolecular machines in cells in a near-native situation. The tomograms contain a 3D map of the cellular proteome at about 4 nm resolution and we are just beginning to explore its potential by placing high priority on developing methods for nanotechnology. The other central point of our group is to visualize gene products in cells by electron microscopy at the highest resolution with gold probes on cryo-sections. Within this consortium we try to visualize alterations in 3D structures of nanomachines imposed by drugs. Involved www.nki.nl/research/peters
Pistollato	Francesca	SCR&Tox	Joint Research Centre (JRC) - European Commission	Francesca Pistollato +39 0332 78 5993 - francesca[dot]PISTOLLATO[at]ec[dot]europa[dot]eu Joint Research Centre (JRC) - European Commission Via Enrico Fermi, 2749 21027 Ispra (VA), Italy, Italy Resume Pistollato Francesca graduated in Biology at the University of Padova in 2003 and she got her PhD in Developmental Sciences and Reprogramming Medicine in 2007 in the same university. She worked as research associate in Children’s National Medical Centre, Washington, DC, USA, in the laboratories of the center of Neuroscience. Her experience in neuroscience and neuro-oncology involves the characterization of cancer stem cells within brain tumors and their interaction with the tumor hypoxic niche. Results of her studies have been published in international journals. She is currently working as grantholder at the In Vitro Methods Unit (ECVAM) of the Institute for Health and Consumer Protection (IHCP), in the Joint Research Centre of the European Commission. Publications Pistollato F, et al.Interaction of hypoxia-inducible factor-1αand Notch signaling regulates medulloblastoma precursor proliferation and fate. Stem Cells. 2010 Nov;28(11):1918-29. Pistollato F, et al.Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma. Stem Cells. 2010 May;28(5):851-62. Pistollato F, et al.Hypoxia and HIF1alpha repress the differentiative effects of BMPs in high-grade glioma. Stem Cells. 2009 Jan;27(1):7-17. Contribution to the project I will optimize in vitro culture conditions for the maintenance of undifferentiated Human Induced Pluripotent Stem Cells (Hu-iPSCs), in comparison with Hu-ESCs, in the effort to standardize appropriate cell culturing methods and QC for undifferentiated Hu-iPSCs, comparing them to protocols already standardized for HuESCs. I will also assess appropriate culturing protocol for efficient differentiation of Hu-iPSCs into post-mitotic neurons and mixed cardiomyocytes. Moreover, I will confirm the phenotypic identity of Hu-iPSCs-derived hepatocytes that will be provided by other groups. The final aim will be to define appropriate threshold data serving as acceptance criteria for entering into toxicity testing (ECVAM criteria for entering into prevalidation). Involved http://www.jrc.ec.europa.eu
Pistoni	Marielena	HeMiBio	Interdepartmental Stem Cell Institute	Marielena Pistoni +32-(0)16-333140 - elena[dot]pistoni[at]med[dot]kuleuven[dot]be Interdepartmental Stem Cell Institute O&N IV Herestraat 49 3000 Leuven, Belgium Resume Mariaelena Pistoni, PhD, obtained her PhD degree at the European Institute of Oncology, Milan in Molecular Biology, and did his first postdoctoral research at the Scientific Institute San Raffaele, Milan on alternative splicing in FSHD muscular dystrophy. She joined the laboratory of Dr. Verfaillie at K.U.Leuven in September 2011 to work on the function of Polycomb group of protein in guiding hPSCs differentiation towards hepatocyte-like cells. Publications Neguembor MV, Xynos A, Onorati MC, Caccia R, Bortolanza S, Godio C, Pistoni M, Corona DF, Schotta G, Gabellini D. (2013) FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. J Mol Cell Biol. Pistoni M, Shiue L, Cline MS, Bortolanza S, Neguembor MV, Xynos A, Ares M Jr, Gabellini D. (2013) Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a mouse model of Facioscapulohumeral muscular dystrophy (FSHD). Plos Genetics Pistoni M, Ghigna C, Gabellini D. (2010) Alternative splicing and muscular dystrophy. RNA Biol. Pistoni M, Verrecchia A, Doni M, Guccione E, Amati B. (2010) Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a. EMBO J. Contribution to the project Enrichment of staged cells (mesendodermal, hepatoblast and hepatocytes) to assess the functional properties of hPSC-derived progenitors or “mature cells” with that of primary tissue-derived hepatocytesto compare the transcriptome and epigenome of the hPSCderived hepatocytes. Potential application Polycomb group of protein and their target genes in regulating the liver development. To provide the engineered cell populations for studies in WP3, 4 and 5. Involved http://www.kuleuven.be/samenwerking/scil/
Plošnik	Alja	COSMOS	Slovenia Chemical Institute	Alja Plošnik 01-4760-315 - alja[dot]plosnik[at]ki[dot]si Slovenia Chemical Institute Hajdrihova 19, 1001 Ljubljana, Slovenia Resume I finished primary school in 2003 and entered high school (Prva gimnazija) in Maribor, Slovenia. After my high school graduation I studied at the Faculty of Chemistry and Chemical Engineering in Maribor where I graduated in 2012. In the same year I started my doctoral program in biomedicine, in the field of toxicology at the University of Ljubljana. I am currently employed as a young researcher at the National Institute of Chemistry in Ljubljana, Slovenia. Publications Contribution to the project Development of QSAR models. Involved www.ki.si
Plumel	Marine	NOTOX	IPHC – DSA - LSMBO	Marine Plumel 0033368852624 - IPHC – DSA - LSMBO 25 rue Becquerel 67087 Strasbourg cedex, France Resume 2011-2012: PhD student in proteomics (first year) in LSMBO, IPHC, Strasbourg, France. 2010-2011: Masters degree in chemistry (speciality: analytical chemistry) in Strasbourg, France. 2007-2011: ECPM (European engineering school of polymer sciences, chemistry and material sciences, Strasbourg, France) speciality analytical chemistry Publications Contribution to the project Proteomics of HepaRG cells (2D cultures and spheroids); Differential proteomics: HepaRG intracellular proteome and secretome in response to drugs Involved
Prieto-Peraita	Maria del Pilar	COACH	European Commission, Joint Research Centre, IHCP-ECVAM	Maria del Pilar Prieto-Peraita 390332785534 - maria[dot]prieto-pilar[at]jrc[dot]ec[dot]europa[dot]eu European Commission, Joint Research Centre, IHCP-ECVAM Via E. Fermi 2749, Italy Resume Pilar Prieto received her PhD degree in 1991 at the Faculty of Pharmacy of the Salamanca University (Spain). She continued her research at Novartis Pharma AG (Basel, Switzerland). In 1996 she joined the European Commission’s Joint Research Centre (JRC) and become a member of the European Centre for the Validation of Alternative Methods (ECVAM).Currently she coordinates the validation activities in the area of systemic toxicity and participates in validation studies relevant for acute toxicity testing. She is contributing to the EU FP7 project Predict-IV and she has participated in several EU FP6 projects relevant to the area of systemic toxicity (Predictomics, ACuteTox, Pulmonet, and Liintop). Publications Forti E, Salovaara S, Cetin Y, Bulgheroni A, Tessadri R, Jennings P, Pfaller W, Prieto P. (2011) In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells. Toxicol In Vitro 25(2):454-61. Prieto P, Hoffmann S, Tirelli V, Tancredi F, González I, Bermejo M, De Angelis I. (2010) An exploratory study of two Caco-2 cell models for oral absorption: a report on their within-laboratory and between-laboratory variability, and their predictive capacity. Hoffmann S, Kinsner-Ovaskainen A, Prieto P, Mangelsdorf I, Bieler C, Cole T.(2010) Acute oral toxicity: variability, reliability, relevance and interspecies comparison of rodent LD50 data from literature surveyed for the ACuteTox project. Regul Toxicol Pharmacol.58(3):395-407. Altern Lab Anim. 38(5):367-86. Seidle T, Robinson S, Holmes T, Creton S, Prieto P, Scheel J, Chlebus M. (2010) Cross-sector review of drivers and available 3Rs approaches for acute systemic toxicity testing. Toxicol Sci. 116(2):382-96. Bulgheroni A, Kinsner-Ovaskainen A, Hoffmann S, Hartung T, Prieto P. (2009) Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats. Regul Toxicol Pharmacol. 53(1):16-9. Prieto P, Baird AW, Blaauboer BJ, Castell Ripoll JV, Corvi R, Dekant W, Dietl P, Gennari A, Gribaldo L, Griffin JL, Hartung T, Heindel JJ, Hoet P, Jennings P, Marocchio L, Noraberg J, Pazos P, Westmoreland C, Wolf A, Wright J, Pfaller W. (2006) The assessment of repeated dose toxicity in vitro: a proposed approach. The report and recommendations of ECVAM workshop 56. Altern Lab Anim. 34(3):315-41. Contribution to the project Facilitation of cluster-internal cooperation in collaboration with COACH partners (WP1) Advice on how to fulfil ECVAM’s criteria for entering Prevalidation (WP1) Input to annual books (WP2) Contribute to the preparation of the meetings and its follow-up (WP3) Involved http://www.ihcp.jrc.ec.europa.eu
Prill	Sebastian	HeMiBio	Fraunhofer Institute for Biomedical Engineering (IBMT)	Sebastian Prill +49 / 3 31 / 581 87 - 328 - sebastian[dot]prill[at]ibmt[dot]fraunhofer[dot]de Fraunhofer Institute for Biomedical Engineering (IBMT) Am Muehlenberg 13, 14476 Potsdam, Germany Resume Publications - Contribution to the project To develop sensors for real-time basic culture conditions To develop sensors for real-time cell function Develop a 2D bioreactor for the efficient isolation of differentiated iPSC mixtures by trapping different cell types on micropatterned surfaces Fabrication of high-throughput microfluidics addressable array Fabricated multi-electrode plate Integrate sensor electronics using UTCP Computer interface and recording subrouting Involved www.ibmt.fraunhofer.de
Przybylak	Katarzyna	COSMOS	School of Pharmacy and Chemistry, Liverpool John Moores University	Katarzyna Przybylak +44(0)151 231 2422 - k[dot]r[dot]przybylak[at]ljmu[dot]ac[dot]uk School of Pharmacy and Chemistry, Liverpool John Moores University Byrom Street, Liverpool, L3 3AF, UK Resume Katarzyna Przybylak is a post-doctoral researcher in Predictive Toxicology at Liverpool John Moores University, England. She obtained her PhD degree in Chemistry at the University of Wroclaw, Poland. She has an extensive experience in using in silico tools to predict human health effects of chemicals based on their chemical structure. Her particular interest and expertise relates to the understanding the key interactions that initiate a number of biological pathways that lead to adverse toxicity outcomes. She has been involved in a number of European Union research projects (REALISE, OSIRIS, the OECD (Q)SAR Toolbox). Publications Przybylak KR, Madden JC, Cronin MT, Hewitt M. 2012. Assessing toxicological data quality: basic principles, existing schemes and current limitations. SAR QSAR Environ Res, vol. 23(5-6), 435-459. Przybylak KR and Cronin MT. 2012. In silico models for drug-induced liver injury--current status. Expert Opin Drug Metab Toxicol, vol. 8(2), 201-217. Przybylak KR and Cronin MTD. 2011. In Silico Studies of the Relationship Between Chemical Structure and Drug Induced Phospholipidosis. Mol Inform, vol. 30(5), 415-429. Contribution to the project Toxicological data retrieval, curation, quality and databasing Development of innovative computational approaches to predict toxicity Dissemination of results and integration of COSMOS with other projects Involved http://www.staf.livjm.ac.uk/pharmcron/qsar/qsar1.htm
Rathman	James	COSMOS	Altamira, LLC and The Ohio State University	James Rathman 1-614-433-7098 - james[at]altamira-llc[dot]com Altamira, LLC and The Ohio State University 1455 Candlewood Drive, Columbus OH 43235, USA Resume James Rathman is a Professor of Chemical and Biomolecular Engineering at the Ohio State University and a co-founder of Altamira, LLC. Before coming to OSU in 1991, he spent seven years in industrial R&D with Conoco Inc. and The Clorox Company. His research areas of interest include molecular informatics, interfacial and colloidal phenomena, nanoparticles, nanostructured materials, surface active agents, statistical analysis and experimental design. In addition to COSMOS, his current research efforts focus on nanomaterials in foods and computational risk assessment of complex chemical systems. Publications Nilsen, M., Rathman, J.F. “Molecular dynamics simulation of nanoparticle and surfactant monolayers at a liquid/vapor interface” (manuscript in preparation) Triplett, M.D., Rathman, J.F., J. Nanoparticle Research, 2009, 11(3), 601-614. “Optimization of b-carotene loaded solid lipid nanoparticles.” C. Yang; C. H. Arnby-Hasselgren; S. Boyer; K. Arvidson; S. Aveston; P. Dierkes; R. Benigni; R. D. Benz; J. Contrera; N. L. Kruhlak; E. J. Matthews; X. Han; J. Jaworska; R. A. Kemper; J. F. Rathman; A. M. Richard. “Understanding Genetic Toxicity through Data Mining: The Process of Building Knowledge by Integrating Multiple Genetic Toxicity Databases.”Toxicology Mechanisms and Methods 2008:18:277–295. Yang, C.; Cross, K.; Myatt, G.J., Blower, P.E., Rathman, J.F. Journal of Medicinal Chemistry, 2004, 47(24), 5984-5994. “Building predictive models for protein tyrosine phosphatase 1B inhibitors based on discriminating structural features by reassembling medicinal chemistry building blocks.” Contribution to the project Chemoinformatics and Computational Toxicology methods development (WP3/WP4); KNIME workflow definition (WP5) Involved http://www.altamira-llc.com/news.php
Reif	Raymond	NOTOX	Leibniz Institut for Working Environment and Human Factors	Raymond Reif 492 311 084 275 - reif[at]ifado[dot]de Leibniz Institut for Working Environment and Human Factors Ardeystr. 67, 44139 Dortmund, Germany Resume currently Junior Group Leader at the Leibniz Research Institut for Working Environment and Human Factors, Dortmund 2007-2009 Postdoctoral Fellowship at the Institute of Pharmacology and Toxicology and at the Department of Biochemistry University of Zurich 2001-2007 PhD at the Department of Biochemistry and the Neuroscience Center, University of Zurich 2001 approbation as a pharmacist 1995-2000 studies in Pharmacy at the University of Marburg Publications Godoy P, Lakkapamu S, Schug M, Bauer A, Stewart JD, Bedawi E, Hammad S, Amin J, Marchan R, Schormann W, Maccoux L, von Recklinghausen I, Reif R, Hengstler JG. (2010) Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytes.Biol Chem. 391: 73-83 Reif R, Sales S, Hettwer S, Dreier B, Gisler C, Wölfel J, Lüscher D, Zurlinden A, Stephan A, Ahmed S, Baici A, Ledermann B, Kunz B, Sonderegger P. (2007) Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J.21: 3468-78 Contribution to the project In vitro systems with hepatocytes Molecular- and cell biology Involved www.ifado.de
Richarz	Andrea	COSMOS	School of Pharmacy and Chemistry, Liverpool John Moores University	Andrea Richarz + 44 (0)151 231 2422 - a[dot]richarz[at]ljmu[dot]ac[dot]uk School of Pharmacy and Chemistry, Liverpool John Moores University Byrom Street, Liverpool, L3 3AF, UK Resume Andrea Richarz is project manager of the COSMOS project. She holds a PhD in Chemistry from the Technical University Berlin, Germany, her studies including six-month stays at the Ecole Nationale Supérieure de Chimie de Montpellier, France and Harvard Medical School, Boston, USA. She has been a post-doctoral researcher at the TU Berlin and Managing Editor of the Journal of Trace Elements in Medicine and Biology. From 2007-2011 she has managed the international EU funded project OSIRIS on Integrated Testing Strategies for the risk assessment of industrial chemicals. She has organised several project/stakeholder meetings in the field of alternative testing strategies as well as a conference of the German Society of Minerals and Trace Elements. Publications AN Richarz, MTD Cronin, DC Neagu, C Yang, JM Zaldivar-Comenges, M Berthold (2011) COSMOS – A new European project to develop computational models for the repeat dose toxicity of cosmetic ingredients to humans. ALTEX 28 Spec. Issue: 39 A Richarz, E Pauné, MTD Cronin, TG Vermeire, E Benfenati, M Scheringer, G Schüürmann (2010) Integrated Testing Strategies for the risk assessment of chemicals under REACH: the OSIRIS Webtool. Poster at the Joint Meeting of the SETAC-GLB and GDCh, Dessau, Germany, 6-9 September 2010 A Richarz, C Wolf, P Brätter (2003) Determination of protein-bound trace elements in human cell cytosols of different organs and different pathological states. The Analyst 128: 640-645 Contribution to the project Toxicological data retrieval, curation, quality and databasing (WP1) Dissemination of results and integration of COSMOS with other projects (WP6) Co-ordination and management of the project (WP7) Involved http://www.staff.livjm.ac.uk/phamcron/qsar/qsar1.htm
Ridley	Mick	COSMOS	University of Bradford	Mick Ridley +44 127 4233946 - m[dot]j[dot]ridley[at]bradford[dot]ac[dot]uk University of Bradford Department of Computing, Richmond Road, Bradford BD7 1DP, UK Resume Mick Ridley is Head of Department of Computing. His current research interests encompass a number of areas related to databases, particularly web based interfaces to database systems and has published widely on database related topics. He is co-author of two books and over 40 conference papers on databases. Mick’s research expertise in bibliographic database research covers more than 15 years. He has been involved with the development of standards including contribution to the “The Principles and Future of AACR”. Mick is HEA Fellow, member of the ACM and HEA-ICS contact point. Publications Eaglestone B. and Ridley M. (2001): "Web Database Systems", McGraw-Hill, London, UK. ISBN: 0077096002. Naser T., Alhajj R. and Ridley M.J. (2009): "Two-Way Mapping between Object-Oriented Databases and XML" Informatica, 33 (3): 297-308. Rifaie M., Kianmehr K., Alhajj R. and RIidley M. (2009): "Data modelling for effective data warehouse architecture and design" International Journal of Information and Decision Sciences, Inderscience, 1 (3): 282-300 Makhtar M, Neagu D. and Ridley M. (2010): "Predictive Model Representation and Comparison: Towards Data and Predictive Models Governance", Proceedings of the 10th UK Workshop on Computational Intelligence UKCI 2010 (IEEE Xplore), pages 1-6, Colchester, UK Contribution to the project The UNIBRAD team contribute on data curation and data mining, multivariate modelling and predictive toxicology model management as WP1 coordinator and contributor to WP3 and WP5. The key tasks allocated to UNIBRAD are data representation, data curation, development of computational intelligence techniques, data and model integration, and data mining tools. Involved http://computing.brad.ac.uk/people/?u=mick&p=f
Ringwald	Annette	DETECTIVE	ARTTIC	Annette Ringwald +33 1 53 94 54 67 - ringwald[at]arttic[dot]eu ARTTIC 58a, Rue du Dessous des Berges - 75013 Paris, France Resume Senior Consultant at ARTTIC, Annette is currently in charge of several FP7 projects in the Health theme as part of the “Management Office” of these projects, among which the FP7 IPs “ESNATS” and “DETECTIVE”. Annette managed several IST and Life Sciences projects in FP5 and FP6 and prepared successfully proposals for the FP6/FP7 Life Programme/Health Theme. Before joining ARTTIC, Annette worked in the field of international communications. Publications - Contribution to the project In DETECTIVE, ARTTIC constitutes the Project Office and provides methods, tools and operational support for the project collaboration. ARTTIC thus supports the consortium in the daily management and administrative tasks to ensure the collaboration is working, the project is properly monitored and decisions and actions are prepared and taken according to the project progress. ARTTIC’s role is also to simplify the work of the researchers and to develop a collaborative team spirit inside the consortium. Annette supervises the Project Office and gives advice on project management, quality assurance as well as on strategic, contractual and IPR issues arising in the project. Involved http://www.arttic.com/
Robitzki	Andrea	SCR&Tox	University of Leipzig – Centre for Biotechnology and Biomedicine (BBZ)	Andrea Robitzki 493419731241 - andrea[dot]robitzki[at]bbz[dot]uni-leipzig[dot]de University of Leipzig – Centre for Biotechnology and Biomedicine (BBZ) Deutscher Platz 5, 04103 Leipzig, Germany Resume Chair of Management Board, respectively Director of the Research Centre BBZ since 10/02 Full Professor and Chair for Molecular biological-biochemical Processing Technology, BBZ 2000-2002 Head of Department “Biohybrid Systems”, Fraunhofer-Institute of Biomedical Engineering IBMT), St. Ingbert 1999-2002 Coordination Manager of Fraunhofer-IBMT for USA (Florida) and China (Shenzen and Xiamen) 1998-2000 Head of Work Group “Biohybrid Systems”, Fraunhofer-IBMT, St. Ingbert, Head of Group “Molecular Neurobiology”, Dept. of Developmental Biology and Neurogenetics (Prof. Layer), TU Darmstadt 05/1998 Habilitation and venia legendi in Cell Biology, Technical University Darmstadt 10/1989 Ph. D. in Applied Molecular Biology, Johannes-Gutenberg University Mainz Publications Real-time monitoring of relaxation and contractility of smooth muscle cells on a novel biohybrid chip. Haas, S.; Jahnke, H. G.; Glass, M.; Azendorf, R.; Schmidt, S.; Robitzki, A. A. Lab on a Chip 2010 (10) 21, pp 2965-2971. A microelectrode-based sensor for label-free in vitro detection of ischemic effects on cardiomyocytes. Krinke, D.; Jahnke, H. G.; Panke, O.; Robitzki, A. A. Biosensors & Bioelectronics 2009 (24) 9, pp 2798-2803. An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphos-phorylation in human cells. Jahnke, H. G.; Rothermel, A.; Sternberger, I.; Mack, T. G. A.; Kurz, R. G.; Panke, O.; Striggow, F.; Robitzki, A. A. Lab on a Chip 2009 (9) 10, pp 1422-1428. Kloß D, Fischer M, Rothermel A, Simon JC, Robitzki AA. Drug testing on 3D in vitro tissues trapped on a microcavity chip. Lab-On-Chip 2008 8, pp 879-884 (highlighted in RCS) Contribution to the project 1.) Cell- and tissue-based impedance spectroscopy and electrophysiological recordings on chip, 2.) Semiconductor technology for cell-based chip fabrication, 3.) High Content Screening combined with photonic/optic high resolution monitoring and electrophysiological (functional) / impedimetric (toxicol.) 4.) Bioengineering and cultivation of 2D and 3D hES/iPS related clusters on microarrays, 5.) Biosensoric and electronic real time iPS/hES related cell assay development, 6.) Training in cell based microarray screening. Involved http://www.uni-leipzig.de/~dmpt/
Rochon	Christelle	SCR&Tox	Ectycell SAS	Christelle Rochon +33 141 83 99 09 ext 535 - christelle[dot]rochon[at]cellectis[dot]com Ectycell SAS 102 avenue Gaston Roussel, 93235 Romainville, France Resume Ph. D. in Cellular and Molecular biology, University of Evry Val d’Essonne (2007), France. 2007-2009: Postdoctoral Fellow. Laboratory of stem cell biology and pharmacology of neurodegenerative diseases (Milan, Italy). 2005-2007: Ph. D. 2003-2005 : CEA, Evry ; 2005-2007 : I-Stem, Evry, France. Publications Denis JA, Rochon-Beaucourt C, et al. 2010. Global transcriptional profiling of neural and mesenchymal progenitors derived from human embryonic stem cells reveals alternative developmental signaling pathways. Stem Cells Dev. Dec 8 Giraud-Triboult K, Rochon-Beaucourt C, et al. 2010. Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1. Physiol Genomics. Nov 16 Sylvie Bortoli, et al.2008. Functional and Molecular Characterization of SP Cell Population Isolated from Mouse Primary Myoblast Culture. J. of Stem Cells. 3(2) 73-86. Rochon C, et al. 2006. Comparison of gene expression pattern in SP cell populations from four tissues to define common "stemness functions".Exp Cell Res. 2006 Jul 1;312(11):2074-82. Decraene C, et al. 2005. Global transcriptional characterization of SP and MP cells from the myogenic C2C12 cell line: effect of FGF6. Physiol Genomics. 23(2):132-49. Contribution to the project Reprogrammation of iPS and hES cells for WP2 and WP3. Fields of expertise: iPS and hES. Involved http://www.cellectis.com
Roelandt	Philip	HeMiBio	Interdepartmental Stem Cell Institute Leuven	Philip Roelandt +32 16 33 02 95 - Philip[dot]roelandt[at]med[dot]kuleuven[dot]be Interdepartmental Stem Cell Institute Leuven Herestraat 49 box 804; 3000 Leuven, Belgium Resume Philip Roelandt obtained his MD degree at K.U.Leuven in 2003 and is currently in clinical training as a gastroenterologist/hepatologist at University Hospital Leuven. He started his PhD in the labs of Prof. Nevens and Verfaillie in 2007. He is well versed in ESC/iPSC differentiation to hepatocytes and non-parenchymal liver-specific cells from rat, mouse and human origin. In collaboration with others in the lab he has optimized a panel of functional tests (secretion, storage, phase I and II detoxicification) to characterize the stem cell progeny. Publications Roelandt P, Sancho-Bru P, Pauwelyn K, Verfaillie C. Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development. Nat Protoc 2010; 5 (7): 1324-1336. Roelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Bose B, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, Fevery J, Nevens F, Hu WS, Verfaillie CM. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally to hepatocyte-like cells. PLoS ONE 2010 ; 5 (8) : e12101. Sancho-Bru P, Roelandt P, Pauwelyn K, Narain N, Notelaers T, Shimizu T, Ott M, Verfaillie C. Directed Differentiation of Murine Induced Pluripotent Stem Cells to Hepatocyte-like Cells. J Hepatol 2011; 45 (1): 98-107. Contribution to the project Provide enriched population of different cell types (hepatocytes, HSC, HSEC) for studies in WP3, 4 and 5 Optimize the protocol to generate higher number and/or more mature progeny Provide tools to assess the functional properties of iPSC-derived progeny Involved www.kuleuven.be/scil
Rogiers	Vera	HeMiBio & DETECTIVE	Vrije Universiteit Brussel – Department of Toxicology	Vera Rogiers +32.2.477.45.16 - vrogiers[at]vub[dot]ac[dot]be Vrije Universiteit Brussel – Department of Toxicology Laarbeeklaan 103 – 1090 Brussels , Belgium Resume Head of the Department of Toxicology, Dermato-Cosmetology and Pharmacognosy at the Vrije Universiteit Brussel-Belgium. She is full-time professor in toxicology and organises on a regular basis postgraduate courses on risk assessment of cosmetics in the EU. Research activities concern the development of liver-based in vitro models for pharmaco-toxicological purposes. She is author of more than 200 publications in peer-reviewed journals and has obtained 5 scientific awards in the field of alternative methods. She is co-chair of the SCCS, member of ESAC and the epaa mirror group. Publications Snykers S, Henkens T, De Rop E, Vinken M, Fraczek J, De Kock J, De Prins E, Geerts A, Rogiers V and Vanhaecke T. Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation. J Hepatol 51(1): 187-211, 2009. Pauwels M, Dejaegher B, Vander Heyden Y and Rogiers V. Critical analysis of the SCCNFP/SCCP safety assessment of cosmetic ingredients (2000-2006). Food Chem Toxicol 47(4): 898-905, 2009. Vinken M, Doktorova T, Decrock E, Leybaert L, Vanhaecke T and Rogiers V. Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity. Crit Rev Biochem Mol Biol 44(4): 201-222, 2009. Contribution to the project 1. HeMiBio - Workpackage 5 leader: * Selection of chemicals for testing hepatocellular functionality and toxicity. * Selection of cosmetic ingredients for testing hepatocellular toxicity. * Establishment of standard operating procedures for hepatocellular functionality testing. * Establishment of standard operating procedures for hepatocellular toxicity testing. 2. DETECTIVE - Subproject 2 – workpackage 4 partner: * Establishment of standard operating procedures for the characterization of functionality and the testing of toxicity in cultures of primary hepatocytes. * Testing of a set of selected compounds in cultures of primary hepatocytes. - Subproject 4 leader: * Selection and reporting of functional read-outs as in vitro biomarkers. * Selection and reporting of -omics read-outs as in vitro biomarkers. Involved http://minf.vub.ac.be/~fafy/
Rosas	Vania	SCR&Tox	INSERM – ISTEM/UEVE/AFM	Vania Rosas +33 (0)1.69.90.85.41 - vrosas[at]istem[dot]fr INSERM – ISTEM/UEVE/AFM Campus 1, Genopole, 5 rue H. Desbruères – 91030 Evry, France Resume Vania Rosas is the SCR&Tox Junior Project Manager since April 2011. Vania obtained her Ph.D. in microbiology at the Pasteur Institute in 2006 and worked as a post-doctoral fellow for a European Systems Biology project (BaSysBio) at the French National Institute of Agricultural Research. Before joining the SCR&Tox Project, she was collaborating as a consultant for the OECD’s Directorate for Education. Publications Rosas-Magallanes V, Stadthagen-Gomez G, Rauzier J, Barreiro LB, Tailleux L, Boudou F, Griffin R, Nigou J, Jackson M, Gicquel B, Neyrolles O. Signature-tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages. Infection and Immunity 2007 Jan; 75(1):504-7. Rosas-Magallanes V, Deschavanne P, Quintana-Murci L, Brosch R, Gicquel B, Neyrolles O. Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis. Molecular Biology and Evolution 2006 Jun; 23(6): 1129-35. A review on Lower Secondary Education Systems in OECD Countries, OECD, Directorate for Education, Education and Training Policy Division, Paris, 2010. Contribution to the project SCR&Tox Junior Project Manager, collaborating directly on the SCR&Tox management and coordination activities. Involved www.istem.eu
Sachinidis	Agapios	DETECTIVE	University Hospital Cologne, Institute for Neurophysiology	Agapios Sachinidis +49 (221) 478-7373 - a[dot]sachinidis[at]uni-koeln[dot]de University Hospital Cologne, Institute for Neurophysiology Robert-Koch-Strasse 39, 50931 Cologne, Germany Resume He studied Chemistry and Biochemistry (Diploma: 1984) and got his PhD (1987) at the Institute of Biochemistry at the University of Münster. He was employed at the University of Zürich and Bonn and became 1998 in Bonn Prof. of Pathobiochemistry. He became 2002 Prof. for Physiology and Pathobiochemistry at the University of Cologne. His current scientific activities are focused on the stem cell genomics of cardiovascular and other cell types derived from stem cells. He has expertise in identifying gene signatures and transduction pathways in stem cells applying large-scale Microarray gene expression methodologies and on developing new differentiation protocols using small molecules. Publications Doss MX, Winkler J, Chen S, Hippler-Altenburg R, Sotiriadou I, Halbach M, Pfannkuche K, Liang H, Schulz H, Hummel O, Hubner N, Rottscheidt R, Hescheler J, Sachinidis A: Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes. Genome Biology 2007, 8: R56 Potta SP, LiangH, Pfannkuche K, Winkler J, Chen S, Doss MX, Obernier K, Kamisetti N, Schulz H, Hescheler J, Sachinidis A. Functional characterization and global transcriptome analysis of contractile smooth muscles cells derived from a murine transgenic Acta2 embryonic stem cell lineage. Hypertension 2009;53:196-204 Ding L, Paszkowski-Rogacz M, Nitzsche A, Slabicki MM, Heninger AK, Vries ID, Kittler R, Junqueira M, Shevchenko A, Schulz H, Hubner N, Doss MX, Sachinidis A, Hescheler J, Iacone R, Anastassiadis K, Stewart AF, Pisabarro MT, Caldarelli A, Poser I, Theis M, Buchholz F. A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity. Cell Stem Cell. 2009;8:403-415. Jagtap S, Meganathan K, Wagh V, Gaspar A, Winkler, Hescheler J, Sachinidis A. Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cell during multi-lineage differentiation. British Journal of Pharmacology 2011;162:1743-56. Contribution to the project He established the stem cell genomics and bioinformatics unit in the Institute of Neurophysiology and is responsible for the transcriptomic analyses of the samples generating in DETECTIVE. He is working on the developing of toxicity readouts/biomarkers and on identifying gene signatures and transduction pathways relevant for the toxicity of human stem cell-derived cardiomyocytes and other differentiated somatic cells. Involved http://www.uni-koeln.de/med-fak/physiologie/np/index.htm
Sala Benito	José Vicente	COSMOS	European Commission DG JRC IHCP	José Vicente Sala Benito +39 0332 785735 - benito[dot]sala[at]ec[dot]europa[dot]eu European Commission DG JRC IHCP Via Fermi 1 Ispra Varese, Italia Resume Publications Contribution to the project Involved http://ihcp.jrc.ec.europa.eu/
Salvo	Pietro	HeMiBio	Centre for Microsystems Technology (CMST) affiliated with IMEC (Interuniversity Microelectronics Centre)	Pietro Salvo + 32-9-2645354 - pietro[dot]salvo[at]elis[dot]ugent[dot]be Centre for Microsystems Technology (CMST) affiliated with IMEC (Interuniversity Microelectronics Centre) Technology Park 914, B-9052 Gent-Zwijnaarde, Belgium Resume Pietro Salvo received the M.S. degree in Electronics Engineering, specialization in biomedical applications, and the Ph.D. degree in Automation, Robotics and Bioengineering from University of Pisa, Italy, in 2004 and 2009 respectively. He is currently a post doctoral researcher at Centre for Microsystems Technology (CMST), University of Ghent, Belgium, where he joined in 2009. His current research interests include the study of sensors for bioengineering applications, the design and fabrication of 3D dry electrodes for electrocardiography and electroencephalography recording and monitoring, and the development of an inertial measurement unit for tracking fast human movements. Publications Salvo P., Di Francesco F., Costanzo D., Ferrari C., Trivella M.G., De Rossi D., "A wearable sensor for measuring sweat rate", IEEE Sensors Journal, Vol. 10 , N. 10, pp. 1557-1558, 2010. Coyle S., Lau K.T., Moyna N., Diamond D., Di Francesco F., Costanzo D., Salvo P., Trivella M.G., De Rossi D., Taccini N., Paradiso R., Porchet J.A., Luprano J., Ridolfi A., Chuzel c., Lanier T., RevolCavalier F., Schoumacker S., Mourier V., Convert R., Chartier L, DeMoncuit H., Bini C., "BIOTEX - Biosensing textiles for personalised healthcare management", IEEE Transactions on Information Technology in Biomedicine, Vol. 14, N. 2, pp. 364-370, March 2010. Pioggia G., Di Francesco F., Ferro M., Sorrentino F., Salvo P., Ahluwalia A., "Characterisation of a Carbon Nanotube Polymer Composite Sensor for an Impedimetric Electronic Tongue", Microchimica Acta, 163(1-2):57-62,2008. Contribution to the project Main tasks of IMEC in HeMiBio are the following : integration of sensors for real-time basic culture conditions integration of sensors in 2D-bioreactors development of technology for 3D-multi-well bioreactor fabrication, esp. development of technology for sensor arrays and read-out electronics integration in a 3D-bioreactor organisation of training events for HeMiBio partners on microsystem engineering, interconnection and packaging technology Involved http://www.cmst.be
Sancho-Bru	Pau	HeMiBio	Institut d’Investigacions Biomediques August Pi I Sunyer	Pau Sancho-Bru 34699952330 - psancho[at]clinic[dot]ub[dot]es Institut d’Investigacions Biomediques August Pi I Sunyer C/ Rosellón, 153, Planta 3, Barcelona, 08036, Spain Resume Pau Sancho-Bru received his Ph.D in 2006 from the University of Barcelona. He worked on the molecular and cellular mechanisms of liver fibrosis in the Liver Unit of Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). In 2007 he joined the group of Dr. C. Verfaillie at the Stem Cell Institute Leuven at the KULeuven as a postdoctoral researcher and worked on pluripotent stem cell differentiation to hepatic lineages. In 2010 he joined the group of Dr. Bataller in IDIBAPS to investigate the role of liver progenitor/stem cells in chronic liver disease. Publications Sancho-Bru P, Roelandt P, Narain N, Pauwelyn K, Notelaers T, Shimizu T, Ott M, Verfaillie C. Directed differentiation of murine-induced pluripotent stem cells to functional hepatocyte-like cells. J Hepatol. 2011 Jan;54(1):98-107. Sancho-Bru P, Bataller R, Fernandez-Varo G, Colmenero J, Moreno M, Jiménez W, Arroyo V, Ginès P. Bradykinin exerts hepatoprotective and antifibrogenic effects in experimental liver fibrosis. Gastroenterology 2007 Dec;133(6):2019-28. Sancho-Bru P, Bataller R, Gasull X, Colmenero J, Khurdayan V, Gual A, Nicolas JM, Arroyo V, Gines P. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol. 2005 Aug;43(2):272-82. Contribution to the project Partners in WP1, 3, 5 and coordinator of WP6. IDIBAPS will be involved in: 1- the isolation of primary human hepatic stellate cells and other liver cells as a reference for cells generated from iPS; 2- the development of culture conditions to expand quiescent and activated stellated cells; 3- providing quiescent and activated stellate cells for WP1, 3 and 5; 4- evaluating the effect of ECM and medium modifications on primary HSC phenotype; 5- evaluating stellate cell phenotype and function in 2D and 3D culture; 6-developing in vitro conditions for human precision cut liver slices. Involved www.idibaps.org
Sartipy	Peter	SCR&Tox	Cellartis AB	Peter Sartipy 0046 31 7580930 - peter[dot]sartipy[at]cellartis[dot]com Cellartis AB Arvid Wallgrens backe 20, Sweden Resume Current Position 02-10-15 – Present Senior Principal Scientist (former Senior Scientist) and Line Manager, Cellartis AB (Göteborg. Member of the company management team). Education 00-10-18 – 02-09-30 Post-doctoral training, The Scripps Research Institute, La Jolla, CA, USA. 95-11-15 – 00-04-07 Ph.D., Faculty of Medicine, Göteborg University. 94-09-28 – 95-11-14 Preparatory Ph.D. studies, Wallenberg Laboratory for Cardiovascular Research, Faculty of Medicine, Göteborg University, 89-08-24 - 94-09-28 M.Sc. Chemical Engineering, Chalmers University of Technology, Göteborg Publications Synnergren J, Améen C, Lindahl A, Olsson B, and Sartipy P. Expression of microRNAs and their target mRNAs in human stem cell derived cardiomyocyte clusters and in heart tissue. Physiol Genomics Sep 14 [Epub ahead of print]. Asp J, Steel D, Jonsson J, Améen C, Dahlenborg K, Jeppsson A, Lindahl A, and Sartipy P. Cardiomyocyte Clusters Derived from Human Embryonic Stem Cells Share Similarities with Human Heart Tissue. J Mol Cell BiolAug 27. [Epub ahead of print]. Andersson H, Steel D, Asp J, Dahlenborg K, Jonsson M, Jeppsson A, Lindahl A, Kågedal B, Sartipy P, and Mandenius CF. Assaying Cardiac Biomarkers for Toxicity Testing using Biosensing and Cardiomyocytes Derived from Human Embryonic Stem Cells. J Biotechnol. 2010 Jul 12. [Epub ahead of print]. Contribution to the project Sartipy will provide: management skills in-depth knowledge in stem cell biology expertise stem cell differentiation into mesodermal cell types in-depth know-how in industrial product development expertise in industrial use of stem cell platforms Involved www.cellartis.com
Schaeffer-Reiss	Christine	NOTOX	Institut Pluridisciplinaire Hubert Curien (IPHC) - CNRS / UdS - UMR 7178- Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO)	Christine Schaeffer-Reiss (+33) 03.68.85.27.79 - christine[dot]schaeffer[at]unistra[dot]fr Institut Pluridisciplinaire Hubert Curien (IPHC) - CNRS / UdS - UMR 7178- Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO) 25 rue Becquerel, F-67087 STRASBOURG CEDEX 2 Resume 45 years old. Engineer researcher CNRS. Specialized in analytical sciences in chemistry and biology. New methodological approaches in Proteomics. Management of the Strasbourg Grand Est proteomic platform. PhD thesis(1994) in organic chemistry. University of Strasbourg. 1996-1998: Characterisation and origin of residual organo-sulfur compounds in gas oils (Strasbourg). 1995: Characterisation, quantitation of lipids released by chemical degradation of sedimentary organic matter (Bristol, U.K Publications Ossareh-Nazari, B., Bonizec, M., Cohen, M., Dokudovskaya, S., Delalande, F., Schaeffer, C., Van Dorsselaer, A., and Dargemont, C. (2010). Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy. EMBO Rep 11, 548-554. Olguin-Lamas, A., Madec, E., Hovasse, A., Werkmeister, E., Callebaut, I., Slomianny, C., Delhaye, S., Mouveaux, T., Schaeffer-Reiss, C., Van Dorsselaer, A., et al. (2011). A Novel Toxoplasma gondii Nuclear Factor TgNF3 Is a Dynamic Chromatin-Associated Component, Modulator of Nucleolar Architecture and Parasite Virulence. PLoS Pathog 7, e1001328. Van Dorsselaer, A., Carapito, C., Delalande, F., Schaeffer-Reiss, C., Thierse, D., Diemer, H., McNair, D.S., Krewski, D., and Cashman, N.R. (2011). Detection of prion protein in urine-derived injectable fertility products by a targeted proteomic approach. PLoS One 6, e17815. Contribution to the project Proteomics of HepaRG cells (2D cultures and spheroids); Differential proteomics: HepaRG intracellular proteome and secretome in response to drugs. Involved
Schmitz	Markus	DETECTIVE	Roche Applied Science	Markus Schmitz +49-8856606404 - Markus[dot]Schmitz[dot]ms1[at]roche[dot]com Roche Applied Science Nonnenwald 2, D-82372 Penzberg, Germany Resume 11/2010 – today Roche Diagnostics GmbH, Penzberg - Roche Applied Science Manager R&D – LCT Cellular 11/2008 – 10/2010 Roche Diagnostics GmbH, Penzberg - Roche Applied Science Postdoc – Technology Development/Cellular Assays 02/2009 – 07/2009 F.Hoffmann-La Roche, Basel: Non-Clinical Safety / In vitro mechanistic toxicology 07/2007 – 10/2008 Laboratory of Prof. Dr. med. Dr. h.c. Thomas Krieg Department of Dermatology, University Hospital Cologne 01/2006 – 06/2007 Laboratory of Prof. Dr. med. Mats Paulsson Center for Biochemistry, Medical Faculty, University of Cologne 03/2002 – 12/2005 PhD thesis in the Laboratory of Prof. Dr. med. Mats Paulsson Center for Biochemistry, Medical Faculty, University of Cologne PhD thesis: Establishment of transgenic mice and cell culture models Publications Schmitz M, Seiler A, Watt MA, Alexandritis R, Walch H, Boess F and Roth A (2010) Improved Cellular Analysis for the early detection of compound-induced hepatic cytotoxicity to reduce animal testing.Application NoteRoche Applied Science, Cancer Research No. 5. Schmitz M, Boess F, Watzele M, Suter-Dick L and Roth A (2009) In vitro assessments of hepatic toxicity using the xCELLigence Real-time Cell Analyzer. *Toxicology Letters, Volume 189, Supplement 1, 74-75 Schmitz M, Seiler A, Kustermann S, Boess F, Watzele M, Suter-Dick L and Roth A (2010) Improved Cellular Analysis for the early detection of compound-induced hepatic cytotoxicity.XII International Congress* of Toxicology (IUTOX). Barcelona, Spain, July 19-23. Schmitz M, Boess F, Watzele M, Suter-Dick L and Roth A (2009) In vitro assessments of hepatic toxicity using the xCELLigence Real-time Cell Analyzer.46^th Congress of the European Societies of Toxicology (EUROTOX). Dresden, Germany, Sep 13-16 and VII World Congress on Alternatives & Animal Use in the Life Sciences. Rom, Italy, August 30 – Sep 03. Contribution to the project Roche will mainly contribute to toxicity studies with label-free technologies. This will be based on impedance measurement using the xCELLigence technology. Here the influence of different compounds with known hepatotoxic effects on hepatocytes will be determined. Short and long-term toxicity patterns to compounds will be mapped and categorised. Cardiac toxicity of compounds will be tested with the new xCELLigence Cardio System. Dose response curves of short and long-term toxicity with different compounds with known clinical effects on cardiac toxicity will be mapped and categorised. Influence of compounds on beating activities (amplitude, frequency) of cardiomyocytes will be analysed. Finally cDNA from cells (hepatocytes, cardiomyocytes) with signs of toxicity will be collected and forwarded for further genomic analysis. Involved https://www.roche-applied-science.com
Schouteet	Tom	HeMiBio	Vrije Universiteit Brussel	Tom Schouteet 32 478 492 815 - tschoute[at]vub[dot]ac[dot]be Vrije Universiteit Brussel Laarbeeklaan 103, 1090 Jette, Belgium Resume 2004 – 2009 - Diploma Master in Biology at the Vrije Universiteit Brussels (with distinction) 2000 – 2003 - Diploma Graduate Chemistry and Environmental Sciences + Certificate Environmental coordinator B, at the Erasmushogeschool Brussels, Department HORTECO Publications - Contribution to the project Isolate, characterize and distribute human HSCs. Assist with hiPSC differentiation towards HSCs Involved www.vub.ac.be
Schrattenholz	Andre	DETECTIVE	ProteoSys AG	Andre Schrattenholz +49 (0)6131 501 92-15 - andre[dot]schrattenholz[at]proteosys[dot]com ProteoSys AG Carl-Zeiss-Str. 51, Germany Resume Studies of Biology and Chemistry at the University of Mainz, Germany and the University of California in San Diego and Berkeley, USA; Ph.D. at the Institute of Biochemistry, University of Mainz, Germany; 1990-2000: Position as postdoctoral fellow, lecturer and research assistant, Laboratory of Molecular Neurobiology at the Institute of Physiological Chemistry und Pathobiochemistry at the Johannes Gutenberg-University in Mainz, Germany. From 2005: Professor of Physiological Chemistry and Pathobiochemistry at the Johannes Gutenberg-University in Mainz, Germany. 2000-today (2011): Founder and Chief Scientific Officer of ProteoSys AG (as a member of the board) (www.proteosys.com). Publications Carlsson T, Schindler FR, Höllerhage M, Depboylu C, Arias-Carrión O, Schnurrbusch S, Rösler TW, Wozny W, Schwall GP, Groebe K, Oertel WH, Brundin P, Schrattenholz A, and Höglinger GU (2011) Systemic administration of Neuregulin-1ß₁protects dopaminergic neurons in a mouse model of Parkinson’s disease. J. Neurochemistry, in press Groebe K, Hayess K, Klemm-Manns M, Steemans M, Peters A, Schwall G, Wozny W, Sastri S, Jaeckel P, Stegmann W, Zengerling H, Schöpf R, Poznanovic S, Stumman T, Seiler A, Spielmann H, Schrattenholz A (2010) Protein biomarkers for in vitro testing of embryotoxicity, J. Proteome Res., 9(11), 5727-5738 Schrattenholz A, Šoškić V and Groebe K (2010)Synchronisation of posttranslational modifications during ageing: time is a crucial biological dimension. Ann. NY Acad. Sci. 1197, 118-28. Schrattenholz A, Groebe K and Šoškić V (2010) Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-Target Drugs, Methods in Molecular Biology 662, 29-58 Contribution to the project Expertise for differential protein biomarker discovery and validation and clinical development; Experience with data acquisition, treatment and mining from European projects related to in vitro toxicology like Reprotect, Esnats and now Detective. Contribution to data base and systems biology strategies in these and other European projects; Involved www.proteosys.com
Schwab	Christof H.	COSMOS	Molecular Networks GmbH	Christof H. Schwab +49 9131 815670 - schwab[at]molecular-networks[dot]com Molecular Networks GmbH Henkestr. 91, 91052 Erlangen, Germany Resume Christof H. Schwab studied Chemistry at the University of Erlangen-Nuremberg in Germany and joined the research group of Prof. Johann Gasteiger in Erlangen in 1996. He graduated in 1997 on conformational analysis and its application in automatic 3D structure generation. He continued his work with Prof. Gasteiger’s group and received his PhD in 2001 on the development and the application of conformational analysis software for small and medium-sized, typically drug-like molecules. Since then, he has been working with Molecular Networks in the areas of structure encoding and representation, 3D structure generation, conformational analysis, QSAR and QSPR and their application in the life, health and environmental sciences. Publications Schwab, C.H., 2010. Conformations and 3D pharmacophore searching. Drug Discovery Today: Technologies. 7(4), e245-e253. Zaliani, A.; Boda, K.; Seidel, T.; Herwig, A.; Schwab, C.H.; Gasteiger, J.; Claußen, H.; Lemmen, C.; Degen; J.; Pärn, J.; Rarey, M. 2009. Second-generation de novo design: a view from a medicinal chemist perspective. J. Comput. Aided Mol. 23, 593-602. Renner, S.; Schwab, C.H.; Gasteiger, J.; Schneider, G., 2006. Impact of Conformational Flexibility on Three-Dimensional Similarity Searching Using Correlation Vectors. J. Chem. Inf. Model. 46, 2324-2332. Contribution to the project Provision of Molecular Networks software, such as ADRIANA.Code, isoCYP, MOSES.Metabolism Development of TTC categories based on structural categories and physicochemical properties Analysis of metabolic rules as part of the molecular descriptors for prediction of chronic toxicity Generation and ranking of conceivable metabolites by MOSES.Metabolism software Extensions of knowledge base of isoCYP and MOSES.Metabolism to cover cosmetic ingredients Delivering analysis tools and QSAR/computational models as software tools Involved www.molecular-networks.com
Schwarz	Michael	COACH	University of Tuebingen, Institute of Exp. and Clin. Pharm. & Tox., Dept. Toxicology	Michael Schwarz 0049-7071-29-77398 - Michael[dot]schwarz[at]uni-tuebingen[dot]de University of Tuebingen, Institute of Exp. and Clin. Pharm. & Tox., Dept. Toxicology Wilhelmstr. 56, 72074 Tübingen, Germany Resume MS is the Director of the Department of Toxicology in the Institute of Pharmacology and Toxicology at the University of Tübingen, Germany. MS has a PhD in Biology and the “Habilitation” in Toxicology (University of Tübingen). He is member of executive board of the Society of Toxicology in the German Society of Experimental and Clinical Pharmacology and Toxicology (DGPT). His special expertise is in molecular toxicology and chemical carcinogenesis. MS was the coordinator of the Euro FP6 EU-project ReProTect, coordinating the work of 33 partners from large drug and chemical companies, SMEs and academia, and has therefore intense insight into alternative test strategies in the field of reproductive toxicology. MS is also a partner in the FP7 EU-projects CancerSys, ChemScreen, and COACH and the EU/IMI project MARCAR. Publications Stahl, S., Ittrich, C., Marx-Stoelting, P., Koehle, C., Altug-Teber, O., Riess, O., Bonin, M., Jobst, J., Kaiser, S., Buchmann, A., Schwarz, M. Genotype-phenotype relationships in hepatocellular tumors from mice and man. Hepatology, 42, 353-61, 2005 Strathmann, J., Paal, K., Ittrich, C., Krause, E., Appel, K. E., Glauert, H. P., Buchmann, A., Schwarz, M. Proteome analysis of chemically induced mouse liver tumors with different genotype. Proteomics7, 3318-31, 2007 Uibel F, Muhleisen A, Kohle C, Weimer M, Stummann TC, Bremer S, Schwarz M. ReProGlo: a new stem cell-based reporter assay aimed to predict embryotoxic potential of drugs and chemicals. Reprod Toxicol;30:103-112., 2010 Schenk B, Weimer M, Bremer S, van der Burg B, Cortvrindt R, Freyberger A, Lazzari G, Schwarz, M. et al. The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants. Reprod Toxicol;30:200-218, 2010 Contribution to the project The Department of Toxicology at the University of Tübingen (Acronym EKUT) has its focus on two major topics: molecular mechanisms of chemical carcinogenesis and drug metabolism in liver. In addition, the group has taken up in the last 5 years research on the development of in vitro assays for the prediction of embryotoxic activity of drugs and chemicals. The group is therefore experienced both in the conventional approaches used in toxicological risk assessment employing animal experimentation, and in the developing field of alternative methods. Through the coordination of the ReProTect project and the active participation in 3 ongoing European projects, the director of the Dept. of Toxicology, Prof. Dr. Michael Schwarz, has gained a broad overview and in depth knowledge on diverse technologies relevant for repeated dose toxicity testing employing “alternative methods”. Coming from basic research this expertise will excellently supplement the more applied view brought in by the JRC/ECVAM within the COACH project. Involved http://www.uni-tuebingen.de/toxikologie/
Schwobel	Johannes	COSMOS	Molecular Networks	Johannes Schwobel 499131815670 - Schwoebel[at]molecular-networks[dot]com Molecular Networks Henkestr. 91, 91052 Erlangen, Germany Resume Since 2011: Molecular Networks GmbH, Germany \| Prof. Johnny Gasteiger Software developer of chemoinformatic tools 2008 - 2010: Liverpool John Moores University, England \| Prof. Mark Cronin Post-doctoral researcher (in silico investigation of protein-toxicant reactivity) 2005 - 2008: Helmholtz-Centre for Environ. Res. - UFZ, Germany \| Prof. Gerrit Schüürmann Doctoral thesis (Quantum chemical modelling of hydrogen bond strength) 2000 - 2005: Technical University of Darmstadt and University of Leipzig, Germany Studies in Chemistry \| Master thesis : Prof. Harald Morgner (MD simulations and XPS spectroscopy of the phospholipid-solvent surface) Publications Schwöbel, J. A. H., Wondrousch, D., Koleva, Y.K., Madden, J.C., Cronin, M.T.D., Schüürmann, G., 2010. Prediction of Michael type acceptor reactivity toward glutathione. Chem. Res. Toxicol. 23, 1576-1585. Schwöbel, J., Ebert, R.-U., Kühne, R., Schüürmann, G., 2009. Prediction of intrinsic hydrogen bond acceptor strength from molecular structure. J. Phys. Chem. A 113, 10104-10112. Schwöbel, J.A.H., Koleva, Y.K., Enoch, S.J., Bajot, F., Hewitt, M., Madden, J.C., Roberts, D.W., Schultz, T.W., Cronin, M.T.D., 2010. Measurement and estimation of electrophilic reactivity for predictive toxicology. Chem. Rev. accepted. Contribution to the project Provision of Molecular Networks software, such as ADRIANA.Code, isoCYP, MOSES.Metabolism Development of TTC categories based on structural categories and physicochemical properties Analysis of metabolic rules as part of the molecular descriptors for prediction of chronic toxicity Generation and ranking of conceivable metabolites by MOSES.Metabolism software Extension of knowledge base of isoCYP and MOSES.Metabolism to cover cosmetic ingredients Delivering analysis tools and QSAR/computational models as software tools Involved www.molecular-networks.com
Seiller	Alexander	DETECTIVE	Roche Applied Science	Alexander Seiller +49-8856607266 - Alexander[dot]Seiler[at]roche[dot]com Roche Applied Science Nonnenwald 2, D-82372 Penzberg, Germany Resume Manager R&Dand Group Leader since 07/2008 at Roche Diagnostics GmbH, Roche Applied Science, R&D Department for Cellular Analysis, in Penzberg, Germany Post-Doc 12/2007-06/2008 at the Helmholtz Center Munich (GSF) – in Munich, Germany. PhD 11/2007 Helmholtz Center Munich (GSF) –National Research Center for Environmental Health,Institute of Clinical Molecular Biology and Tumor Genetics“Dissecting the molecular mechanism of glutathionedependentregulation of cell proliferation and cell death”. 05-07/2006 Joint research project at the Karolinska Institute, Department of Medical Biochemistry and Biophysics (MBB), Physiological Chemistry II (Prof. Jesper Haeggström) in Stockholm, Sweden. Publications Mandal PK‡, Seiler A‡, Perisic T‡, Koelle P, Banjac Canak A, Foerster H, Weiss N, Kremmer E, Lieberman MW, Bannai S, Kuhlencordt P, Sato H, Bornkamm GW, Conrad M. System xC- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency. J Biol Chem. 2010 Jul 16;285(29):22244-53. (‡=equal contribution). Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C. Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ. 2010 Aug 6. Conrad M, Sandin A, Förster H, Seiler A, Frijhoff J, Dagnell M, Bornkamm GW, Rådmark O, Hooft van Huijsduijnen R, Aspenström P, Böhmer F, Ostman A. 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases. Proc Natl Acad Sci U S A. 2010 Aug 23. Illner D, Zinner R, Handtke V, Rouquette J, Strickfaden H, Lanctot C, Conrad M, Seiler A, Imhof A, Cremer T, Cremer M. Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin. Exp Cell Res. 2010 Jun 10;316(10):1662-80. Contribution to the project Roche will mainly contribute to toxicity studies with label-free technologies. This will be based on impedance measurement using the xCELLigence technology. Here the influence of different compounds with known hepatotoxic effects on hepatocytes will be determined. Short and long-term toxicity patterns to compounds will be mapped and categorised. Cardiac toxicity of compounds will be tested with the new xCELLigence Cardio System. Dose response curves of short and long-term toxicity with different compounds with known clinical effects on cardiac toxicity will be mapped and categorised. Influence of compounds on beating activities (amplitude, frequency) of cardiomyocytes will be analysed. Finally cDNA from cells (hepatocytes, cardiomyocytes) with signs of toxicity will be collected and forwarded for further genomic analysis. Involved https://www.roche-applied-science.com
Slusallek	Philipp	NOTOX	German research Center for Artificial Intelligence (DFKI) GmbH	Philipp Slusallek 49681857755377 - slusallek[at]dfki[dot]de German research Center for Artificial Intelligence (DFKI) GmbH Campus D3.2, 66123 Saarbrücken , Germany Resume Philipp Slusallek is Scientific Director at the German Research Center for Artificial Intelligence (DFKI) since 2008. He is also Director for Research at the "Intel Visual Computing Institute" established in 2009. Here he is also a professor for Computer Graphics since 1999 and a Principle Investigator at the German Excellence-Cluster. Before coming to Saarland University, he has been a Visiting Assistant Professor at Stanford University, USA. His research interests are focused on 3D Internet technology, integrating graphics and artificial intelligence, distributed simulation and visualization, as well as on exploiting multi- and many-core hardware for visual computing and simulation. Publications Lukas Marsalek, Iliyan Georgiev, Anna Katharina Dehof, Hans-Peter Lenhof, Philipp Slusallek, and Andreas Hildebrandt, "Real-Time Ray Tracing of Complex Molecular Scenes", Information Visualization: Information Visualization in Biomedical Informatics (IVBI), London, July 2010. Mike Phillips, Anna Dehof, Iliyan Georgiev, Stefan Nickels, Lukas Marsalek, Hans-Peter Lenhof, Andreas Hildebrandt, and Philipp Slusallek, "Measuring Properties of Molecular Surfaces Using Ray Casting", 9th International Workshop on High Performance Computational Biology, 2010. Gerd Marmitt, Heiko Friedrich and Philipp Slusallek, "Interactive Volume Rendering with Ray Tracing", Eurographics State of the Art Reports, 2006. Contribution to the project We develop new techniques for 3D electron and light tomographic reconstructions using SART and ray tracing methods using our experience in high-performance and parallel, many-core algorithms. We design novel reconstruction pipeline using prior information, hierarchical approaches, and proper acquisition modelling leading to improved noise characteristics and higher performance. Using this data we perform3D analysis and identification of macromolecular structures also using novel information provided by ray casting. Finally, we combine image processing and volumetric visualization to improve the researcher's ability to browse and understand the structure-toxicology relationship Involved http://www.dfki.de
Sourdive	David	SCR&Tox	Cellectis SA	David Sourdive +33 141 83 99 00 - sourdive[at]cellectis[dot]com Cellectis SA 102 avenue Gaston Roussel, 93235 Romainville, France Resume David J.D. Sourdive, PhD, EVP Corporate Development David J.D. Sourdive, Ph.D., co-founded Cellectis SA with Dr Choulika, and has served as Director since 2000. Prior to inception of the company, Dr Sourdive was the head of Biotechnology Laboratory at the Centre d'Etudes du Bouchet (French Ministry of Defense). At the same time, Dr Sourdive was heading a research group in Immunology at the Pasteur Institute. Dr. Sourdive attended Ecole Polytechnique and received a Ph.D. in Molecular Virology form University of Paris VII/ Institut Pasteur. Dr Sourdive then applied recombination tracking technologies to anti-viral immune memory, at the Emory University Vaccine Center in Atlanta. Publications Slifka MK, Blattman JN, Sourdive DJ, Liu F, Huffman DL, Wolfe T, Hughes A, Oldstone MB, Ahmed R, Von Herrath MG. Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy.J Immunol. 2003 Blattman JN, Antia R, Sourdive DJ, Wang X, Kaech SM, Murali-Krishna K, Altman JD, Ahmed R. Estimating the precursor frequency of naive antigen-specific CD8 T cells.J Exp Med. 2002 Blattman JN, Sourdive DJ, Murali-Krishna K, Ahmed R, Altman JD. Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection.J Immunol. 2000 Contribution to the project Team leader Involved http://www.cellectis.com
Stacey	Glyn	SCR&Tox & ToxBank	National Institute for Biological Standards and Control-HPA	Glyn Stacey 441707641500 - glyn[dot]stacey[at]nibsc[dot]hpa[dot]org[dot]uk National Institute for Biological Standards and Control-HPA Blanche Lane South Mimms, UK Resume Qualifications: BSC in microbiology and PhD on T cell lymphoma Fellow of Institute for Biomedical Scientists Current Positions: Head of NIBSC Division of Cell Biology and Imaging and Director of the UK Stem Cell Bank Professor in Biotechnology at University of Bedfordshire Experience: Wide ranging experience in quality safety and suitability of cell substrates for manufacture of products and cell therapies. Establishment of three suites of cell culture laboratories designed to work to GMP. Specialist advisor to WHO and EMA and chair of SAB for the Public Private Partnership Stem Cell for Safer Medicine (2008-2011). Member of numerous steering groups in the area of stem cells and the UK KTN steering group on ATMPs.. Publications G Stacey, Stem Cell bank Reality Roles and Challenges, in: Translational Stem Cell Research : Issues Beyond the Debate on the Moral Status of the Human Embryo. Eds Hermerren and Hug, PP225-236 Young L., Sung, J., Stacey, G. and J Masters J.R. (2010) Detection of mycoplasma in cell cultures. Nature Protocols, 5; 929-934. ISCBI (2009) Consensus Guidance for Banking and Supply of Human Embryonic Stem Cell Lines for Research Purposes; The International Stem Cell Banking Initiative. Stem Cell Rev and Rep. 5:301–314. Contribution to the project PI for NIBSC-HPA partner in Toxbank and SCR&Tox, providing expertise in cell culture best practice, governance, banking and characterisation Involved ukstemcellbank.org.uk
Stanzel	Sven	DETECTIVE	Deutsches Krebsforschungszentrum	Sven Stanzel +49 (0)6221 42-2135 - s[dot]stanzel[at]dkfz[dot]de Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Resume Dr. Sven Stanzel is a biostatistician at the German Cancer Research Center (DKFZ) in Heidelberg. Holding a degree in statistics he joined the Department of Biostatistics of the DKFZ in 2009. His research area focuses on statistical dose-response modelling, statistical classification methods and experimental design of experiments. He was involved with experimental design, statistical consulting and statistical analysis within ACuteTox, a project of the European Union advancing alternative methods for assessment of acute oral toxicity. He is co-author of more than 40 peer reviewed papers. Publications Contribution to the project Experimental design Data management and monitoring Statistical analysis of derived endpoints, e.g. EC50 estimation Identification and analysis ob biomarkers for toxicity Analysis of the relationship between molecular biomarkers, functional readouts, and clinical signs Involved www.dkfz.de
Stocchero	Matteo	COSMOS	S-IN Soluzioni Informatiche srl	Matteo Stocchero 3904441821160 - matteo[dot]stocchero[at]s-in[dot]it S-IN Soluzioni Informatiche srl Via Ferrari 14, 36100 Vicenza, Italy Resume Dr. Matteo Stocchero is an applications specialist. He has a significant expertise in applications of multivariate statistical data analysis in the field of “omics” science. He has a deep knowledge in the analysis of data produced by different platforms such as LC(GC)-MS, NMR, microarray technology. At present his field of interest is systems biology. Publications D. Paris, D. Melck, M. Stocchero, O. D’Apolito, R. Calemma, G. Castello, F. Izzo, G. Palmieri, G. Corso, A. Motta, Monitoring liver alterations during hepatic tumorigenesis by NMR profiling and pattern recognition, Metabolomics 6 (2010) 405-416 A. Zamboni, M. Di Carli, F. Guzzo, M. Stocchero, S. Zenoni, A. Ferrarini, P. Tononi, K. Toffali, A. Desiderio, K.S. Lilley, M.E. Pè, E. Benvenuto, M. Delledonne, M. Pezzotti, Identification of putative stage-specific grapevine berry biomarkers and omics data integration into networks, Plant Physiology 154(3) (2010) 1439-59 E. Mattarucchi, M. Stocchero, J. M. Moreno-Rojas, G. Giordano, F. Reniero, C. Guillou, Authentication of Trappist Beers by LC-MS Fingerprints and Multivariate Data Analysis, Journal of Agricultural and Food Chemistry 58 (2010) 12089-12095 Contribution to the project He is part of the team who will aim at optimising in silico methods, such as (Q)SAR and read-across, for the purpose of long-term toxicity prediction of cosmetic ingredients. The tasks of the team include: a) Characterisation of the chemical space of cosmetic inventories; b) Read-across, grouping and structural analogues analysis; c) Evaluation of existing QSAR models and expert systems for cosmetic ingredients; d) Development of new QSAR regression and classification models. e) Application of innovative chemometric tools. Involved www.s-in.it
Strehl	Raimund	SCR&Tox	Cellartis AB	Raimund Strehl 0046 31 7580950 - raimund[dot]strehl[at]cellartis[dot]com Cellartis AB Arvid Wallgrens backe 20, Sweden Resume Jan 2000: PhD degree in Cell Biology, Universität Regensburg Feb 2000 - Oct 2000: Postdoctoral position at RCEM1, Sahlgrenska Sjukhuset, Göteborg, Sweden, Autologous Cartilage Transplantation Oct 2000 - Dec 2002: Postdoctoral position at the Institute of Anatomy and Cell Biology, Universität Regensburg, Bioreactors and Tissue Engineering Since Jan 2003: Principal Scientist with Cellartis AB, Göteborg, Sweden Currently: Chief Technical Officer, Cellartis AB, Göteborg, Sweden Publications Andrews PD, Becroft M, Aspegren A, Gilmour J, James MJ, McRae S, Kime R, Allcock RW, Abraham A, Jiang Z, Strehl R, Mountford JC, Milligan G, Houslay MD, Adams DR, Frearson JA. High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules. Biochem J. 2010 Oct 25;432(1):21-33 International Stem Cell Banking Initiative. Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. Stem Cell Rev. 2009 Dec;5(4):301-14. Bigdeli N, Karlsson C, Strehl R, Concaro S, Hyllner J, Lindahl A (2009) Coculture of hES cells and human articular chondrocytes results in significantly altered phenotype and improved chondrogenic differentiation. Stem Cells 27:1812-1821. Contribution to the project Raimund Strehl will contribute with expertise in the area of production, characterization and banking of human pluripotent stem cells. Key focus within SCR&Tox will be the industrialization and scale up of bioprocessing required within the program as well as productification of developments achieved Involved www.cellartis.com
Tanay	Amos	NOTOX	Weizmann Inst.	Amos Tanay 972-8-9343579 - Amos[dot]tanay[at]weizmann[dot]ac[dot]il Weizmann Inst. 1 Herzl St., Israel Resume 2007-Present: Senior Scientist, Department of Computer Science and Departmanet of Biological Regulation, The Weizmann Institute 2005-2007: Independent fellow, Rockefeller University 2002-2005: PhD Tel-Aviv University Selected Awards: 2010: EMBO Young investigator, 2010: Morris Levinson prize, 2007: Alon fellowship, 2005: Rothschield Fellowship, 2005: Center for physics and biology fellowship, Rockefeller University, 2002: Complexity fellowship Publications Widespread Compensatory Evolution Conserves DNA-Encoded Nucleosome Organization in Yeast. Kenigsberg E, Bar A, Segal E, Tanay A. PLoS Comput Biol. 2010 Dec 23;6(12):e1001039. Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models. Pencovich N, Jaschek R, Tanay A, Groner Y. Blood. 2011 Jan 6;117(1):e1-e14. H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes. Kelly TK, Miranda TB, Liang G, Berman BP, Lin JC, Tanay A, Jones PA. Mol Cell. 2010 Sep 24;39(6):901-11. Contribution to the project The Tanay group will develop techniques for comprehensive analysis of transcriptional, metabolic and epigenomic states, aiming at the identification and modeling of links among different layers of response to toxicity. By studying the response to several characterized compounds, the Tanay group will work toward algorithms that can identify toxicity from various molecular reporters and predict different modes of phenotypic impact based on them. To this end, we will apply machine learning techniques, including probabilistic models of regulatory networks and epigenomic organization. A high performance computing infrastructure that is operated by the group will be used for analysis of consortium generated data. Involved www.wisdom.weizmann.ac.il/~atanay
Tascher	Georg	NOTOX	CNRS-UdS, UMR7178, Institut Pluridisciplinaire Hubert Curien, LSMBO	Georg Tascher - CNRS-UdS, UMR7178, Institut Pluridisciplinaire Hubert Curien, LSMBO ECPM, Bat R5-0, 25 rue Becquerel, F-67087 Strasbourg, France Resume Georg Tascher studied human- and molecularbiology at the Saarland University and performed his PhD studies in Elmar Heinzle`s lab to characterize the secretome of primary human hepatocytes for in-vitro drug testing. For the NOTOX project, he joined the lab of Alain van Dorsselaer at the French National Center for Scientific Research(CNRS) at Strasbourg University. His main topic is toxicoproteomics with special emphasis on the development and optimization of proteomic approaches to describe and understand proteome changes of human hepatocytes in response to drug-application. Publications Ott, M., Tascher, G., Hassdenteufel, S., Zimmermann, R., Haas, J. and Bailer, S. M. (2011). "Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34." J Gen Virol 92(Pt 12): 2734-2745. Mueller, D., Tascher, G., Muller-Vieira, U., Knobeloch, D., Nuessler, A. K., Zeilinger, K., Heinzle, E. and Noor, F. (2011). "In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor." J Tissue Eng Regen Med 5(8): e207-218. Contribution to the project Proteomics of HepaRG cells (2D cultures and spheroids); Differential proteomics: HepaRG intracellular proteome and secretome in response to drugs Involved http://www.iphc.cnrs.fr/
Teng	Sophie	COSMOS	INERIS	Sophie Teng (+33)0344618291 - Sophie[dot]teng[at]live[dot]fr INERIS Parc ALATA - 60550 Verneuil-en-Halatte, France Resume Sophie Teng graduated in 2012 with a degree in Pharmacy and a master degree in Pharmacokinetics from University René Descartes, in Paris. She has been a PhD student since April 2013 in modeling hepatotoxicity of cosmetic related ingredients at repeated doses. The aim of the project is to develop models to extrapolate from in-vitro to in-vivo in order to assess hepatotoxicity. Publications Contribution to the project Developing models to predict hepatotoxicity of single compounds and mixtures to predict acute and chronic hepatotoxicity. Involved www.ineris.fr
Terfloth	Lothar	COSMOS	Molecular Networks GmbH	Lothar Terfloth 4991319790623 - Terfloth[at]molecular-networks[dot]com Molecular Networks GmbH Henkestr. 91, 91052 Erlangen, Germany Resume Dr. Lothar Terfloth studied chemistry at the University of Münster. After he received a PhD in organic chemistry on the "Investigation of the synthesis, structure and reactivity of chiral 1-azapentadienyl-lithium compounds" in 1999 he started a postdoc in chemoinformatics in Prof. Gasteiger's research group at the Computer-Chemie-Centrum of the University Erlangen-Nuremberg. Since 2007 he works as senior research scientist at Molecular Networks. The special research interests are the development and application of chemoinformatics methods to the modeling of chemical reactivity and metabolism. Publications Terfloth, L., Bienfait, B., Gasteiger, J., 2007. Ligand-Based Models for the Isoform Specificity of Cytochrome P450 3A4, 2D6, and 2C9 Substrates. J. Chem. Inf. Model. 47, 1688-1701. Kornhuber, J., Tripal, P., Reichel, M., Terfloth, L., Bleich, S. Wiltfang, J., Gulbins, E., 2008. Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure-Property-Activity Relation Model. J. Med. Chem. 51, 219-237. Michielan, L., Terfloth, L., Gasteiger, J., Moro, S. 2009. Comparison of Multilabel and Single-Label Classification Applied to the Prediction of the Isoform Specificity of Cytochrome P450 Substrates. J. Chem. Inf. Model. 49, 2588-2605. Contribution to the project Provision of Molecular Networks software, such as ADRIANA.Code, isoCYP, MOSES.Metabolism Development of TTC categories based on structural categories and physicochemical properties Analysis of metabolic rules as part of the molecular descriptors for prediction of chronic toxicity Generation and ranking of conceivable metabolites by MOSES.Metabolism software Extensions of knowledge base of isoCYP and MOSES.Metabolism to cover cosmetic ingredients Delivering analysis tools and QSAR/computational models as software tools Involved www.molecular-networks.com
Thierse	Danièle	NOTOX	CNRS ; UdS ; UMR7178 ; Institut Pluridisciplinaire Hubert Curien ; LSMBO	Danièle Thierse +33 (0)3 68 85 26 79 - dthierse[at]unistra[dot]fr CNRS ; UdS ; UMR7178 ; Institut Pluridisciplinaire Hubert Curien ; LSMBO 25 rue Becquerel, 67087 STRASBOURG CEDEX, FRANCE Resume Research engineer. Realize 1D and 2D gels and 2D-DIGE (2-Dimensional Differential in-Gel Electrophoresis). Using spot detection software are compared the obtained electrophoretic profiles. Experiments are realized to measure peptide masses from tryptic digest (Peptide Mass Fingerprint) are made using MALDI, mass spectrometer with a lift system allowing both liner and reflectron mode from amino acid sequence determination. Data processing software used are FlexAnalysis, DataAnalysis and BioTools. Identification of proteins by comparison of mass spectrometry data with that of protein sequence databases using the Mascot search engine. Publications Van Dorsselaer A, Carapito C, Delalande F, Schaeffer-Reiss C, Thiersé D, Diemer H, McNair DS, Krewski D, Cashman NR. Detection of prion protein in urine-derived injectable fertility products by a targeted proteomic approach. PLoS One 2011, 6, (3), e17815 Biarc J., S.Nguyen I., Pini A., Gosse F., Richert S., Thiersé D., Van Dorsselaer A., Leize-Wagner E., Raul F., Klein J.P. , Scholler-Guinard M. Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formely S. bovis). Carcinogenesis 2004, 25.8, 1477-1484 Cavusoglu N, Thiersé D., Mohand-Said S., Chalmel F., Poch O., Van Dorsselear A., Sahel J.A, Leveillard T. Différential proteomic analysis of the mouse retina. The induction of crystallin proteins by retinal degeneration in the rd1 mouse. Molecular & Cellular Proteomics 2003, 2.8, 494-505 Contribution to the project Proteomics of HepaRG cells (2D cultures and spheroids); Differential proteomics: HepaRG intracellular proteome and secretome in response to drugs. Involved http://iphc.in2p3.fr
Tierling	Sascha	NOTOX	Saarland University, FR8.3 Life Sciences, Genetics/Epigenetics	Sascha Tierling +49 (0) 681 302 3295 - s[dot]tierling[at]mx[dot]uni-saarland[dot]de Saarland University, FR8.3 Life Sciences, Genetics/Epigenetics Campus, building A2 4, 66123 Saarbrücken, Germany Resume 1997-2002 Saarland University studies: Biology with focus on Epigenetics 2002 diploma 2002-2006 Saarland University: PhD student in epigenetics lab (Jörn Walter) 2006-today: Post-Doc in epigenetics lab (Jörn Walter) Publications S. Tierling, C. Sers, A. Lehmann and J. Walter.A fast, cost-efficient and sensitive approach for KRAS mutation detection using multiplexed primer extension with IP/RP-HPLC separation. Int J Cancer 2011, Epub Mar 8. N.Y. Souren, S. Tierling, J.P. Fryns, C. Derom, J. Walter and M.P. Zeegers.DNA Methylation variability at growth-related imprints does not contribute to overweight in monozygotic twins discordant for BMI. Obesity 2011, Epub Jan 27. S. Tierling, N.Y. Souren, S. Reither, K.D. Zang, J. Meng-Hentschel, D. Leitner, B. Öhl-Jaschkowitz and J. Walter.DNA methylation studies on imprinted loci in a male monozygotic twin pair discordant for Beckwith-Wiedemann syndrome. Clin Genet. 2010, Epub Jun 7. S. Tierling, M. Schuster, R. Tetzner and J. Walter.A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation. Epigenetics Chromatin. 2010, 3(1):12. S. Tierling, N.Y. Souren, J. Gries, C. Lo Porto, M. Groth, P. Lutsik, H. Neitzel, I. Utz-Billing, G. Gillessen-Kaesbach, H. Kentenich, G. Griesinger, K. Sperling, E. Schwinger, J. Walter.Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in human. J Med Genet 2009. Epub Nov 30 Y. Zhang, C. Rohde, S. Tierling, T. P. Jurkowski, C. Bock, D. Santacruz, S. Ragozin, R. Reinhardt, M. Groth, J. Walter, A. Jeltsch.DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet 2009 5(3) : e1000438. C. Bock, M. Paulsen, S. Tierling, T. Mikeska, T. Lengauer, J. Walter.CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. PLoS Genet, 2006 2(3): e26. Contribution to the project Primary hepatocytes are widely used as the „gold standard“ for testing of toxic substances in vitro. However, their availability is limited. Conventional culturing on collagen-coated dishes leads to rapid dedifferentiation accompanied with considerable morphological and molecular changes. Although having the advantage of infinite culturing, frequently used liver-derived cell lines, like HepG2, fail to maintain key hepatic features crucial for the toxicological testing. Currently the only cell line with a good spectrum of drug metabolizing enzymes even after prolonged cultivation is HepaRG which makes it a reasonable candidate for an in vitro hepatocyte model. Our group is responsible for genome-wide and high-resolution local DNA methylation and RNA expression analysis of primary hepatocytes and in vitro liver cell models. Involved http://epigenetik.uni-saarland.de
Tsakovska	Ivanka	COSMOS	Institute of Biophysics and Biomedical Engineering	Ivanka Tsakovska +359 2 9793605 - ITsakovska[at]clbme[dot]bas[dot]bg Institute of Biophysics and Biomedical Engineering Acad. G. Bonchev Str., Bl. 105, 1113 Sofia, Bulgaria Resume Ivanka Tsakovska, graduated from the University of Chemical Engineering, Sofia, Bulgaria. In 2003 she obtained a PhD in biological sciences from the Bulgarian Academy of Sciences. In 2005 she joined the European Chemicals Bureau, Joint Research Centre, Italy, where she spent two years working in the field of computational toxicology. Since 2009 she is an Associate Professor at the Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences. Her main scientific interests include QSAR and molecular modelling related to drug design and toxicology. Publications Tsakovska, I. Lessigiarska, T. Netzeva, A.P. Worth. A Mini Review of Mammalian Toxicity (Q)SAR Models. QSAR Comb Sci., 27(1), 2008, 41-48. Tsakovska, A.G. Saliner, T. Netzeva, M. Pavan, A.P. Worth. Evaluation of SARs for the prediction of eye irritation/corrosion potential - structural inclusion rules in the BfR decision support system. SAR QSAR Environ. Res., 18(3-4), 2007, 221-235. I. Tsakovska, I. Pajeva. Phenothiazines and structurally related compounds as modulators of cancer multidrug resistance. Curr Drug Targets, 7, 2006, 1123-1134. Contribution to the project Participation in: (i) collection of relevant information and data related to the in vivo toxicity of cosmetics; (ii) evaluation of existing QSAR models predicting the chronic toxicity endpoints for groups of chemicals of the cosmetic inventory; (iii) application of in silico methods for the purpose of long-term toxicity prediction of cosmetic ingredients: grouping of chemicals into categories and read-across, development of new QSAR models. Involved http://www.clbme.bas.bg/
Van breda	Simone	DETECTIVE	Maastricht University; Department of Toxicogenomics	Simone Van breda + 31 43 3881103 - s[dot]vanbreda[at]maastrichtuniversity[dot]nl Maastricht University; Department of Toxicogenomics Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands Resume 2000-2004: PhD-student, dep. of Health Risk Analyses and Toxicology, Maastricht University: The main topic of the PhD project was to investigate the effect of an altering vegetables diet on the expression of genes and proteins in the colon and lung of humans and mice in vivo using microarray technology. 2005-current: Postdoctoral fellow, dep. of Health Risk Analyses and Toxicology, Maastricht University (since 1st January 2011 dep. of Toxicogenomics): after her PhD, she received a fellowship grant and worked at the Human Nutrition Research Centre at the lab of Prof.dr. J.C. Mathers, Newcastle upon Tyne, United Kingdom where she performed DNA methylation analyses using COBRA assays investigating the methylation status of several genes identified in the PhD studies. Next, she was involved in several European networks (NuGo, ECNIS, and NewGeneris). At the moment, she is working on a project of the Transnational University Limburg (Tul) aimed at investigating the molecular mechanisms behind the chemopreventive effects of blueberries. Publications van Breda, S.G. et al (2004) Altered vegetable intake affects pivotal carcinogenesis pathways in colon mucosa from adenoma patients and controls. Carcinogenesis, 25, 2207-16. de Kok T.M., de Waard P, Wilms LC, and van Breda S.G.Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: The value of genomics biomarkers in molecular epidemiology.2010Molecular Nutrition and Food Research, 54, 1–10 Van Breda S.G., van Delft J.H., Engels L.G., Kleinjans J.C., Mathers J.C. Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake. 2009 Br.J. of Nutr.;22-8-2011101:1295–9 Complete list: http://www.ncbi.nlm.nih.gov/pubmed?term=vanbreda%20sg Contribution to the project Involved in the epigenetic analyses described in WP 11: setting up of the different techniques, data analyses, and implementation in the DETECTIVE project. Involved www.maastrichtuniversity.nl
Van de Water	Bob	DETECTIVE	Leiden Amsterdam Center for Drug Research, division of Toxicology – Leiden University	Bob Van de Water 31715276223 - b[dot]water[at]lacdr[dot]leidenuniv[dot]nl Leiden Amsterdam Center for Drug Research, division of Toxicology – Leiden University Gorlaeus Laboratories Einsteinweg 55, NL-2333CC Leiden, The Netherlands Resume Professor Van de Water studied bio-pharmaceutical sciences at Leiden University where he graduated in 1990 (specialization: toxicology). He obtained his PhD (cum laude) from the same university in 1995. After a postdoctoral position in the USA in the lab of Dr James L Stevens, he rejoined the Division of Toxicology. In 1999 he received a fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW). In 2006 he was appointed as professor of drug safety sciences and head of the division. His research interest is on identifying molecular mechanisms of xenobiotic-induced cytotoxicity using a systems toxicology approach by integrating both gene expression profiling, phospho-proteomics and functional genomics. A central theme is the control of cellular signaling by cell-matrix and cell-cell interactions in the context of molecular mechanisms of cytotoxicity and cancer progression. These studies provide fundamental insight on the consequences of cellular stress conditions on cell adhesion, migration, differentiation and survival in context of both xenobiotic-induced acute tissue injury and repair as well as cancer treatment. Publications de Graauw M, van Miltenburg MHAM, Schmidt MK, Pont C, Lalai R, Kartopawiro J, Pardali E, Le Dévédec SE, Smit V, van der Wal A, Van’t Veer LJ, Cleton-Jansen AM, ten Dijke P, van de Water B. (2010) Annexin A1 regulates TGFβ-signaling and promotes metastasis formation of basal-like breast cancer cells. Proc. Natl. Acad. Sci USA 107:6340-5 IF 9.6 Le Devedec SE, Yan K, de Bont H, Ghotra V, Truong H, Danen E, Verbeek F, van de Water B. (2010)A systems microscopy approach towards understanding tumour cell migration: quantitative evaluation of cellular and molecular measurements. Cell. Mol. Life Sci. in press. IF 6.1 Le Devedec SE, Lalai R, Pont C, de Bont H,van de Water B.(2010) Two-photon intravital multi-color imaging combined with inducible gene expression to distinguish metastatic behavior of breast cancer cells in vivo. Mol. Imaging Biol., in press. (S) IF 3.4 Contribution to the project Involved www.lacdr.nl
Van Grunsven	Leo	HeMiBio	Vrije Universiteit Brussel	Leo Van Grunsven + 32 2 477 44 07 - leo[dot]van[dot]grunsven[at]vub[dot]ac[dot]be Vrije Universiteit Brussel Liver Cell Biology Lab, Department of Cell biology, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, 1090 Brussel, Belgium Resume Leo van Grunsven received his Ph.D, from the Ecole Normale Superieure de Lyon in 1996 and had his postdoctoral training at the NINDS/NIH (Bethesda, USA) and the K.U.Leuven (Belgium). He joined the group of late Prof. A. Geerts at the V.U.B. in 2006, became a research professor in 2009 and heads the LIVR research group since the death of Prof. Geerts. He has a background in developmental biology, molecular mechanisms of transcription and liver cell biology. His current work includes several hepatic stellate cell and hepatic progenitor cell related projects (in vitro and in vivo). Publications Mannaerts I, Nuytten NR, Rogiers V, Vanderkerken K, Geerts A, van Grunsven LA. Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo.Hepatology 51:603-14 (2010). Dollé L, Best J, Mei J, Battah FA, Reynaert H, Geerts A, van Grunsven LA. The quest for liver progenitor cells: A practical point of view. J Hepatol;52:117-129. (2010). Guimaraes EL, Empsen C, Geerts A, van Grunsven LA. Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells. J Hepatol; 52:389-397 (2010). Tchouate Gainkam, L., Keyaerts, M., Caveliers, V., Devoogdt, N., Vanhove, C., van Grunsven, L., Muyldermans, S., and Lahoutte, T.. Correlation Between Epidermal Growth Factor Receptor-Specific Nanobody Uptake and Tumor Burden: A Tool for Noninvasive Monitoring of Tumor Response to Therapy. Molecular Imaging and Biology, 1-9. (2010) Liu, Z., Rossen, E.V., Timmermans, J.P., Geerts, A., Reynaert, H, and van Grunsven, L.A. Distinct roles for non-muscle myosin II isoforms in mouse hepatic stellate cells. J Hepatol 54, 132-141 (2011). C. Van Steenkiste, J. Ribera, A. Geerts, M. Pauta, S. Tugues, C. Casteleyn, L. Libbrecht, K. Olievier, B. Schroyen, H. Reynaert, L. A. van Grunsven, B. Blomme, S. Coulon, F. Heindryckx, M. De Vos, J. Marie Stassen, S. Vinckier, J. Altamirano, R. Bataller, P. Carmeliet, H. Van Vlierberghe, I. Colle and M. Morales-RuizInhibition of PlGF activity reduces the severity of fibrosis, inflammation and portal hypertension in cirrhotic mice. Hepatology; accepted article available online. Contribution to the project The LIVR group will be mainly involved in WP1 and more specifically with the development of tools for efficient enrichment of HSC from human iPSC culture and the actually enrichment and testing of the identity of these HSC once isolated. They will also be implicated in the non-invasive assessment of the differentiated state of HSC in the 2D-and 3D-models Involved http://cyto.vub.ac.be/
Vanfleteren	Jan	HeMiBio	IMEC (Interuniversity Microelectronics Centre)	Jan Vanfleteren +32-9-2645360 - Jan[dot]Vanfleteren[at]elis[dot]ugent[dot]be IMEC (Interuniversity Microelectronics Centre) Technology Park 914, B-9052 Gent-Zwijnaarde, BELGIUM Resume Jan Vanfleteren obtained his PhD in electronic engineering from Ghent University (Belgium) in 1987. He is currently a senior engineer at the IMEC-CMST group and is involved in the development of novel interconnection, assembly and substrate technologies, especially in wearable electronics technologies. As a project manager for CMST he has a long standing experience in co-ordination and co-operation in EC funded projects. In 2004 he was appointed as part time professor at the Ghent University. He is a member of IMAPS and IEEE and (co)-author of over 200 papers in international journals and conferences and he holds 14 patents / patent applications. Publications R. Carta, P. Jourand, B. Hermans, J.Thoné, D. Brosteaux, T. Vervust, F. Bossuyt, F. Axisa, J. Vanfleteren, R. Puers, “Design and implementation of advanced systems in a flexible-stretchable technology for biomedical applications”, Sensors and Actuators A-Physical, Vol. 156 (1): pp. 79-87 Sp. Iss. SI, November 2009. N. De Geyter, R. Morent, T. Jacobs, F. Axisa, L. Gengembre, C. Leys, J. Vanfleteren, E. Payen, “Remote Atmospheric Pressure DC Glow Discharge Treatment for Adhesion Improvement of PDMS”, Plasma Processes and Polymers, Vol. 6, Suppl. S, pp. S406-411, 2009. J. Govaerts, E. Bosman, W. Christiaens, J. Vanfleteren, “Fine-Pitch Capabilities of the Flat Ultra-Thin Chip Packaging (UTCP) Technology”, IEEE Trans. on Advanced Packaging, Vol.33, No.1, pp. 72-78, Feb. 2010. Contribution to the project Main tasks of IMEC in HeMiBio are the following : integration of sensors for real-time basic culture conditions integration of sensors in 2D-bioreactors development of technology for 3D-multi-well bioreactor fabrication, esp. development of technology for sensor arrays and read-out electronics integration in a 3D-bioreactor Organisation of training events for HeMiBio partners on microsystem engineering, interconnection and packaging technology Involved http://www.cmst.be/
Vanhaecke	Tamara	HeMiBio & DETECTIVE	Vrije Universiteit Brussel – Department of Toxicology	Tamara Vanhaecke +32-2-4774518 - Tamara[dot]Vanhaecke[at]vub[dot]ac[dot]be Vrije Universiteit Brussel – Department of Toxicology Laarbeeklaan 103, 1090 Brussels, Belgium Resume Head Docent at the Department of Toxicology of the Vrije Universiteit Brussel-Belgium and European registered toxicologist. As workleader of the research unit in Experimental in vitro toxicology, she has professional experience in basic research and managing several national and international (EU) research projects related to the development of liver-based in vitro alternative methods. More specifically, her expertise is situated in the optimization of functional cultures of primary hepatocytes, stem cell research (differentiation of various types of adult progenitor/stem cells into functional hepatocytes) and basic mechanistic research (metabolic competence). She has more than 70 scientific publications in peer-reviewed journals and is reviewer for several scientific journals in the field of (in vitro) toxicology. Publications Snykers S., Henkens T., De Rop E., Vinken M., Fraczek J., De Kock J., De Prins E., Geerts A., Rogiers V. and Vanhaecke T. (2009) Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation, and stem cell reprogrammation. Journal ofHepatology 51(1), 187-211. Snykers S., De Kock J., Rogiers V. and Vanhaecke T. (2009) In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art. Stem Cells 27(3), 577-605. Vanhaecke T., Snykers S., Rogiers V., Garthoff B., Castell J.V. and Hengstler J. (2009) EU research activities in alternative testing strategies: current status and future perspectives. Editorial for Archives of Toxicology 83, 1037-1042. Contribution to the project Establishment of standard operating procedures for hepatocellular toxicity testing. 2. DETECTIVE - Subproject 2 – workpackage 4: Establishment of standard operating procedures for the characterization of functionality and the testing of toxicity in cultures of primary hepatocytes. Testing of a set of selected compounds in cultures of primary hepatocytes. - Subproject 4: Selection and reporting of functional read-outs as in vitro biomarkers. Selection and reporting of -omics read-outs as in vitro biomarkers. Involved http://minf.vub.ac.be/~fafy/
Vanhove	Jolien	HeMiBio	Interdepartmental Stem Cell Institute	Jolien Vanhove +32 (0)16 33 02 92 - Jolien[dot]vanhove[at]med[dot]kuleuven[dot]be Interdepartmental Stem Cell Institute Herestraat 49, bus 804, 3000, Leuven, Belgium Resume JOLIEN VANHOVE, M.Sc. , obtained her M.Sc. degree at the University of Hasselt in 2010. For her senior internship, she investigated MAPKAP Kinase 3 mediated Polycomb group signalling under hypoxic stress at the University of Maastricht under direction of Dr. W. Voncken. From September 2010, she started as a PhD student in the lab of Dr. Verfaillie where she will investigate and compare the transcriptome and epigenome from human embryonic stem cells (hESC) at different stages of hepatocyte differentiation with primary tissue-derived hepatocytes. Publications - Contribution to the project I will contribute to the following objectives of the HeMiBio project: 1-To develop tools for efficient enrichment of cells that have the potential to differentiate to cells with functional properties of (1) mature hepatocytes from human iPSC. 2- To develop tools for efficient non-invasive assessment of the differentiated state of hepatocytes. 3- To compare the transcriptome and epigenome of iPSC-derived progenitors or “mature cells” with that of primary tissue-derived hepatocytes. 4- To assess the functional properties of iPSC-derived progenitors or “mature cells” with that of primary tissue-derived hepatocytes. 5- To provide the engineered cell populations for studies in WP3, 4 and 5 Involved www.kuleuven.be/SCIL
Verfaillie	Catherine	HeMiBio	K.U.Leuven	Catherine Verfaillie +32 16 330295 - Catherine[dot]verfaillie[at]med[dot]kuleuven[dot]be K.U.Leuven Herestraat 49, box 806, 3000 Leuven, Belgium Resume Catherine Verfaillie received her Medical degree from the K.U.Leuven in 1982. She then trained as an internist/hematologist at the K.U.Leuven between 1982 and 1987. She went to the U. of Minnesota in 1987 for a postdoctoral fellowship. After completing her post-doctoral fellowship, she was appointed consecutively as Instructor, assistant professor, associate professor and finally full professor of Medicine in 1998. In 2001, she became the first Director of the University of Minnesota’s Stem Cell Institute. In 2006, she accepted to become the director of the Interdepartementeel Stamcel Instituut at the K.U.Leuven. She has a longstanding career in stem cell biology, initially focusing on normal hematopoietic stem cells and leukemic stem cells, and the role played by the microenvironment in regulating their selfrenewal and differentiation ability. Since 1997 she has also focused extensively on more pluripotent stem cells. Her group described in 2002 a novel cell population culture from rodent and human bone marrow samples with greater expansion and differentiation potency, named multipotent adult progenitor cells or MAPC. The current research of the Verfaillie lab is focused on understanding what regulates selfrenewal and (de)differentiation of adult as well as embryonic pluripotent stem cells, and testing the possible use of stem cell based and stem cell derived therapies in animal models of hematopoietic, liver, CNS-degenerative and metabolic (diabetes) disorders, and as tools for drug discovery and metabolization studies. Publications Jiang Y, Jahagirdar B, Reinhard L, Schwartz RE, Keene CD, Ortiz X, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, LisbergA, Largaespada DA, Verfaillie CM. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41-9, 2002. Sancho-Bru P, Roelandt P, Pauwelyn K, Narain N, Shimizu T, Verfaillie CM. Directed differentiation of murine induced pluripotent stem cells to hepatocyte-like cells. J Hepatol. 2010 Sep 6. Roelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, Fevery J, Nevens F, Hu W-S, Verfaillie CM. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS One5:e12101, 2010. Contribution to the project Dr Verfaillie is promoter of the project HeMiBio and lead partner Wp1, wherein hepatocytes, hepatic stellate cells and hepatic sinusoidal endothelial cells will be isolated from human induced pluripotent stem cells, and engineered using zinc finger nuclease technology to allow isolation and identification of mature cells, as well as to follow toxicologic damage from cosmetic and pharmaceutical products. She will also be responsible for providing cells to generate the sequential bioreactors to be made and assess the viability and function of the cells in the reactors. Involved www.kuleuven.be/SCIL
Vilo	Jaak	DETECTIVE	Quretec OÜ	Jaak Vilo 3725049365 - vilo[at]quretec[dot]com Quretec OÜ Ülikooli 6a, 51003 Tartu, Estonia Resume Started bioinformatics research in 1994 at University of Helsinki, where he also obtained the PhD. From 1999 to 2002 he worked as a researcher at the European Bioinformatics Institute EMBL-EBI, the Europe's leading bioinformatics research centre. In 2002 Jaak Vilo repatriated to start a research group related to the bioinformatics analysis of Estonian Biobank. Research is carried on both at Quretec, whose team has been the main developer of the biobank software, and University of Tartu, the Estonia's leading national university.. Publications Reimand J, Kull M, Peterson H, Hansen J, Vilo J. g:Profiler--a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res. 2007 Brazma A, Parkinson H, Sarkans U, Shojatalab M, Vilo J, Abeygunawardena N, Holloway E, Kapushesky M, Kemmeren P, Lara GG, Oezcimen A, Rocca-Serra P, Sansone SA. ArrayExpress--a public repository for microarray gene expression data at the EBI. Nucleic Acids Res. 2003 Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, Vingron M. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.Nat Genet. 2001 Contribution to the project Database solutions for the DETECTIVE project and contributions to integrative analysis of the omics data, produced in the project. Involved http://www.quretec.com/
Vinken	Mathieu	HeMiBio & DETECTIVE	Vrije Universiteit Brussel – Department of Toxicology	Mathieu Vinken +32.2.477.45.87 - mvinken[at]vub[dot]ac[dot]be Vrije Universiteit Brussel – Department of Toxicology Laarbeeklaan 103 – 1090 Brussels , Belgium Resume Postdoctoral researcher at the Department of Toxicology of the Vrije Universiteit Brussel-Belgium and European registered toxicologist. His expertise is situated in the field of liver-based in vitro modelling, epigenetics, connexin-related cellular signalling and cell death research. He is author of about 50 publications in peer-reviewed journals and books. He received 2 scientific awards for his research. He is member of the editorial board of 3 journals and reviewer for several journals in the field of toxicology. He is executive board member of the European Society of Toxicology in Vitro. He is currently a trainee as a chemical risk assessor in the European TRISK progamme. Publications Vinken M., Doktorova T., Ellinger-Ziegelbauer H., Ahr H.J., Lock E., Carmichael P., Roggen E., van Delft J., Kleinjans J., Castell J., Bort R., Donato T., Ryan M., Corvi R., Keun H., Ebbels T., Atersuch T., Sansone S.-A., Rocca-Serra P., Stierum R., Jennings P., Pfaller W., Gmuender H., Vanhaecke T., Rogiers V. (2008) “The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays” Mutation Research Reviews 629: 202-210. Vinken M., Decrock E., De Vuyst E., De Bock M., Vandenbroucke R.E., De Geest B.G., Demeester J., Sanders N.N., Vanhaecke T., Leybaert L., Rogiers V. (2010) “Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death.” Cellular and Molecular Life Sciences 67: 907-918. Vinken M., Decrock E., De Vuyst E., Ponsaerts R., D’hondt C., Bultynck G., Ceelen L., Vanhaecke T., Leybaert L., Rogiers V. (2011) “Connexins: sensors and regulators of cell cycling” Biochimica et Biophysica Acta Reviews on Cancer 1815: 13-25. Contribution to the project 1. HeMiBio - Workpackage 5: Selection of chemicals for testing hepatocellular functionality and toxicity. Selection of cosmetic ingredients for testing hepatocellular toxicity. Establishment of standard operating procedures for hepatocellular functionality testing. Establishment of standard operating procedures for hepatocellular toxicity testing. 2. DETECTIVE - Subproject 2 – workpackage 4: Establishment of standard operating procedures for the characterization of functionality and the testing of toxicity in cultures of primary hepatocytes. Testing of a set of selected compounds in cultures of primary hepatocytes. - Subproject 4: Selection and reporting of functional read-outs as in vitro biomarkers. Selection and reporting of -omics read-outs as in vitro biomarkers. Involved http://minf.vub.ac.be/~fafy/
Vinklatova	Sara	COACH	ARTTIC	Sara Vinklatova +33 1 53 94 54 86 - coach-arttic[at]eurtd[dot]com, vinklatova[at]arttic[dot]eu ARTTIC 58a, Rue du Dessous des Berges – 75013 Paris, France Resume Sara holds a Master’s degree in Management of European Projects with focus on Research and Development. She has been working at ARTTIC since 2011, starting as an intern and currently occupying a Project Manager position. She has experience with proposal submissions & project negotiations in several FP7 research domains. Additionally to COACH, she currently works on the HYCARUS project under the FCH JU initiative. Publications Contribution to the project Sara runs the COACH project office and carry out project management activities. She contributes to: Monitoring the progress towards the goals of the SEURAT-1 initiative Organisation and follow-up of annual workshops, Scientific expert panels, summer schools and additional ad-hoc meetings <li style="\"margin-left:" 18pt;\"=""> Preparation of strategic information material and targeted dissemination activities Involved http://www.arttic.com/
Vivier	Manon	DETECTIVE	Vrije Universiteit Brussel – Department of Toxicology	Manon Vivier +386 1 4760 315 - Manon[dot]Vivier[at]vub[dot]ac[dot]be Vrije Universiteit Brussel – Department of Toxicology Laarbeeklaan 103 – 1090 Brussels , Belgium Resume Bachelor in Pharmaceutical and Biological Sciences since 2004. She was assistant in a Pharmacy for 1,5 year and is now employed by the Vrije Universiteit Brussel at the Department of Toxicology from 2005 as scientific administrative collaborator. She organises several scientific congresses and she is involved in several running FP6 and FP7 EU-projects. She got the epaa poster award of 2009 with regard to dissemination of 3Rs information. Publications - Contribution to the project Assistance and coordination of work in SP1 - WP5. Involved http://minf.vub.ac.be/~fafy/
Vracko	Marjan	COSMOS	Kemijski inštitut/National Institute of Chemistry (NIC)	Marjan Vracko +386 1 4760 315 - marjan[dot]vracko[at]ki[dot]si Kemijski inštitut/National Institute of Chemistry (NIC) Hajdrihova 19, 1000 Ljubljana, Slovenia Resume Education and Experience Diploma, 1981 in Physics (University of Ljubljana, Slovenia) PhD, 1990 in Theoretical Chemistry (University of Erlangen, FR Germany) Postdoctoral fellow, 1991-1994 (Columbia University of New York) Visitor scientist, 1994-1995 (University Notre-Dame de la Paix in Namur, Belgium) Since 1995 Research associate at NIC Since 2001 Senior research associate at NIC Areas of Research Interest Using of Quantitative structure property/activity relationship (QSPR/QSAR) in predictive toxicology and in drug design Using of neural networks and genetic algorithm in analysis of multidimensional data Publications M. Vračko, D. Mills, S.C. Basak. Structure-mutagenicity modelling using counter propagation neural networks. Environ Toxicol Pharmacol., 2004, 16, 25-36. M. Bolčič Tavčar, M. Vračko. Assessing the reproductive toxicity of some (con)azole compounds using a structure-activity relationship approach. SAR QSAR environ. res., 2009, 20, 711-725. N. Fjodorova, M. Vračko, A. Jezierska, M. Novič. Counter propagation artificial neural networks categorical models for prediction of carcinogenicity for non-congeneric chemicals. SAR QSAR environ. res., 2010, 21, 57-75. Contribution to the project WP 6 - Dissemination and Training Tasks: Workshop, Training Events Involved http://www.ki.si/
Wasquel	Dominique	COACH	ARTTIC	Dominique Wasquel +33 (0)1 53 94 54 73 - wasquel[at]arttic[dot]eu ARTTIC 58a Rue du Dessous des Berges – 75013 Paris , France Resume Dominique Wasquel is a project administrator within ARTTIC since 2003. She has been involved in the management of R&D projects in the 5th, 6th and 7th framework programmes. Besides her experience in project management activities, the organization of public events is part of her responsibilities. Before joining ARTTIC, Dominique worked for 9 years as Commercial and Administrative Assistant in the radio-communications industry, followed by 6 years for Reed Midem, a leading company in the organisation of international professional exhibitions and conferences. Dominique has a Bachelor’s degree in Economics and Languages (English and Chinese) from the University Paris V in 1986. Publications - Contribution to the project Will be mainly involved in the organisation of the Cluster meetings and Summer Schools Involved www.arttic.com
Watzele	Manfred	DETECTIVE	Roche Applied Science	Manfred Watzele +49-8856603121 - Manfred. Watzele[at]roche[dot]com Roche Applied Science Nonnenwald 2, D-82372 Penzberg, Germany Resume Experience in Profession 03/03 - actual Director R&D for cellular analysis at Roche Applied Science. 04/95-03/03 Senior scientist in research and development (from 1998 Roche Diagnostics GmbH). Development of kits for in vitro protein synthesis protein detection and protein purification. 06/91-04/95 Manager for research and development at Boehringer Mannheim GmbH. Development of reagent kits for glycoprotein analysis for research laboratories. Responsibility for a group of 2 scientists. 11/89-05/91 Postdoc at the institute of physiology at the University of Zurich. Work was focussed on the isolation, cloning and overexpression of glycosyltransferases involved in cellular recognition processes. University and Degrees 01/86-08/89 Ph.D. Biology - University of Regensburg Publications - Contribution to the project Roche will mainly contribute to toxicity studies with label-free technologies. This will be based on impedance measurement using the xCELLigence technology. Here the influence of different compounds with known hepatotoxic effects on hepatocytes will be determined. Short and long-term toxicity patterns to compounds will be mapped and categorised. Cardiac toxicity of compounds will be tested with the new xCELLigence Cardio System. Dose response curves of short and long-term toxicity with different compounds with known clinical effects on cardiac toxicity will be mapped and categorised. Influence of compounds on beating activities (amplitude, frequency) of cardiomyocytes will be analysed. Finally cDNA from cells (hepatocytes, cardiomyocytes) with signs of toxicity will be collected and forwarded for further genomic analysis. Involved https://www.roche-applied-science.com
Whelan	Maurice	COACH, COSMOS & DETECTIVE	European Commission, Joint Research Centre (JRC), Institute for Health and Consumer Protection (IHCP)	Maurice Whelan 390332786234 - maurice[dot]whelan[at]ec[dot]europa[dot]eu European Commission, Joint Research Centre (JRC), Institute for Health and Consumer Protection (IHCP) Via E. Fermi 2749, TP202, 21027-Ispra (VA), Italy Resume Maurice Whelan is Head of the Systems Toxicology Unit of the Institute for Health and Consumer Protection of the European Commission's Joint Research Centre. The main focus of his Unit is the development and evaluation of integrated alternative methods for predictive toxicology, useful for the hazard and risk assessment of chemicals and nanomaterials. Maurice obtained a Ph.D. in Bioengineering in 1993 from the University of Limerick (Ireland) and since then has worked in the areas of functional imaging and optical sensing, and more recently on high throughput toxicological testing and advanced diagnostic methods for analysing cellular response. He has over 60 peer-reviewed papers and 16 international patents, and holds an external appointment as adjunct Professor of Biophotonics at the University of Limerick. He is also co-chair of the Scientific Panel of the AXLR8 project and is responsible for the JRC contribution to the Tox21 and ToxCast programmes in the USA. Publications H. T. Hogberg, T. Sobanski, A. Novellino, M. Whelan, D.G. Weiss, A.K. Bal-Price, Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: Evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons, NEUROTOXICOLOGY, 32 (2011) 158–168 Bednarkiewicz A, Marcelino Rodrigues R, Whelan M., Enrichment of hepatocytes in a HepaRG culture using spatially selective photodynamic treatment. JOURNAL OF BIOMEDICAL OPTICS 5 (2); 2010. p. 028002-1 - 028002-7. Buzanska L, Zychowicz M, Ruiz A, Ceriotti L, Coecke S, Rauscher H, Sobanski T, Whelan M, Domanska-Janik K, Colpo P, Rossi F. Neural Stem Cells from Human Cord Blood on Bioengineered Surfaces-Novel Approach to Multiparameter Bio-Tests. TOXICOLOGY 270 (1); 2010. p. 35-42. Contribution to the project Contact partner for the JRC in COACH. Responsible for facilitating the scientific contributions from my Unit to COSMOS and DETECTIVE. Involved http://ec.europa.eu/dgs/jrc/
Wilmes	Anja	DETECTIVE	Innsbruck Medical University	Anja Wilmes 43512900370839 - Anja[dot]Wilmes[at]i-med[dot]ac[dot]at Innsbruck Medical University Fritz-Pregl-Strasse-3, Austria Resume Born 1979 in Gelsenkirchen, Germany. Graduated with Dipl. Biol. degree in 2004 from the University of Heidelberg, Germany. PhD thesis was conducted under Prof. John H. Miller at Victoria University of Wellington, New Zealand, entitled "Differences in Mode of Action between Peloruside A and Paclitaxel, two Microtubule Stabilizing Agents". Graduated with PhD in 2008. Currently working as a Post-doc in Paul Jenning’s group investigating underlying mechanisms of chronic renal disease. Publications Wilmes, A., D. Crean, S. Aydin, W. Pfaller, P. Jennings, and M. Leonard ”Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity”. Toxicology In Vitro, 2010. [IN PRESS.] Wilmes, A., A. Chan, P. Rawson, W.T. Jordan and J.H. Miller “Paclitaxel effects on the proteome of HL-60 promyelocytic leukemic cell: A comparison to Peloruside A. Invest New Drugs, 2010. [IN PRESS.] Wilmes, A., D. O’Sullivan, A. Chan, C. Chandrahasen, I. Paterson, P.T. Northcote, A. C. La Flamme and J.H. Miller “Synergistic interaction between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cell and murine T-cells. Cancer Chemother Pharmacol, 2010. [IN PRESS.] Contribution to the project Human renal epithelial cell culture models and development and elucidation of molecular mechanisms of chemical induced toxicity and biomarker discovery. Involved http://physiologie.i-med.ac.at/jennings
Wiseman	Jeff	ToxBank	Pharmatrope	Jeff Wiseman 12677186318 - jwiseman[at]pharmatrope[dot]com Pharmatrope 1425 Carolina Place, Downingtown, PA 19335, USA Resume Dr. Wiseman has 30 years of experience in drug discovery research in the pharmaceutical and biotechnology industries. He started his professional career establishing biochemistry capabilities, first at Merrell Dow Pharmaceuticals and then Glaxo Pharmaceuticals, which at the time was building their first research capability in the US. In 2003, he joined Locus Pharmaceuticals in the biotechnology industry as Chief Technology Officer and led development of a new software approach to the design of drugs. In 2009, Locus transformed from a drug discovery to a contract research company, and he departed to co-found Pharmatrope to advance new ideas in the field of Cheminformatics software. A native of southeastern Ohio, Dr. Wiseman has served since May, 2010 as an Executive In Residence at the Edison Biotechnology Institute to help develop life sciences technologies in that region. Dr. Wiseman holds an undergraduate degree, summa cum laude, in chemistry from Ohio University, a graduate degree in chemistry from Harvard University and trained as a Postdoctoral Research Fellow in biochemistry at Stanford and Brandeis Universities. Publications Meshkat S, Klon AE, Zou J, Wiseman JS, and Konteatis Z (2011) J Chem Inf Model, 51, 52-60. “Transplant−Insert−Constrain−Relax−Assemble (TICRA): Protein−Ligand Complex Structure Modeling and Application to Kinases.” Clark M, and Wiseman, JS (2009) J Chem Inf Model, 49, 2617-2626. “Fragment-Based Prediction of Clinical Occurrence of Long QT Syndrome and Torsade de Pointes.” Clark M, Meshkat S, Talbot G, Carnevali P, and Wiseman J (2009) J Chem Inf Model, 49, 1901-1913. “Fragment-Based Computation of Binding Free Energies by Systematic Sampling.” Clark M, Meshkat S, Talbot G, Konteatis Z, Ludington J, Zou J, and Wiseman JS (2009) Drug Devel Res, 70, 279-287. “Developing Technologies in Biodefense Research: Computational Drug Design.” Contribution to the project Deputy Leader of Work Package 2 (Compound Database) Data Warehouse and Compounds Database user requirements gathering and analysis Establish Selection Criteria for ToxBank Gold Compounds Populate ToxBank Gold Compound Database Development and distribution of protocols and SOPs Operation and Support of ToxBank Gold Compounds Database Create a Business Plan and Service Model for longer-term sustainability In addition, Dr. Wiseman’s current company, Pharmatrope, specializes in mining the FDA’s adverse events databases. The capabilities developed in these efforts will be applied to the selection of compounds into the Gold Gold Compounds database based on linkage of adverse events to specific pharmacological mechanisms. Involved Pharmatrope.com
Worth	Andrew	COSMOS	European Commission - Joint Research Centre, Institute for Health and Consumer Protection	Andrew Worth +39 0332 789566 - andrew[dot]worth[at]ec[dot]europa[dot]eu European Commission - Joint Research Centre, Institute for Health and Consumer Protection Via Enrico Fermi 2749, Ispra 21027 (VA) , Italy Resume Andrew Worth is a senior scientific officer at the European Commission’s Joint Research Centre (JRC), where he leads the Computational Toxicology and Modelling Group in the Systems Toxicology Unit, which is part of the JRC’s Institute for Health & Consumer Protection (IHCP). Andrew has degrees in Physiological Sciences and in Linguistics from Oxford University, and a PhD in Computational Toxicology from Liverpool John Moores University. He has over 100 publications in the area of predictive toxicology, and has a particular interest in the development and assessment of computational methods and their application in the regulatory assessment of chemical safety. Publications Worth A, Fuart-Gatnik M, Lapenna S, Lo Piparo E, Mostrag-Szlichtyng A & Serafimova R (2011). The Use of Computational Methods in the Toxicological Assessment of Chemicals in Food: Current Status and Future Prospects. JRC report EUR 24748 EN. Worth AP (2010). The Role of QSAR Methodology in the Regulatory Assessment of Chemicals, Chapter 13 in Recent Advances in QSAR Studies: Methods and Applications. T Puzyn, J Leszczynski & MTD Cronin (Eds). Springer, Heidelberg, Germany, pp. 367-382. Mostrag-Szlichtyng A, Zaldivar JM & Worth AP (2010). Computational Toxicology at the European Commission`s Joint Research Centre. Expert Opinion On Drug Metabolism and Toxicology 6, 785-792. Contribution to the project Development and application of quantitative structure-activity (QSAR) models, physiologically-based biokinetic (PBBK) models, and the Threshold of Toxicological Concern (TTC) approach in the assessment of cosmetic ingredients (COSMOS WPs 2,3,4). Involved http://ihcp.jrc.ec.europa.eu/
Yang	Chihae	COSMOS	Altamira, LLC	Chihae Yang 1-614-433-7098 - chihae[at]altamira-llc[dot]com Altamira, LLC 1455 Candlewood Drive, Columbus OH 43235, USA Resume Chihae Yang is a Chief Science Officer at Altamira, LLC. She is also a visiting scientist at the US FDA CFSAN and a lecturer at the Ohio State University. Altamira develops computational methods for toxicology and safety assessment of diverse materials. Until November 2008, she was the Chief Scientific Officer at Leadscope. During this time, she developed ToxML database standard, computational modeling system based on structural features, and chemoinformatics-based data mining techniques. She joined Leadscope in 2000 from her position as a tenured chemistry professor at Otterbein College. Publications Lo Piparo E; Worth A; Manibusan M; Yang C; Schilter B; Mazzatorta P; Jacobs MN; Steinkellner H; Mohimont L. “Use of computational tools in the field of food safety.” Regul. Toxicol. Pharmacol. 2011, doi:10.1016/j.yrtph.2011.05.003 Yang C; Valerio L; Arvidson KB. “Computational Toxicology Approaches at the US Food and Drug Administration.”ATLA, 37, 523-531, 2009. Yang C; Arnby-Hasselgren CH; Boyer S; Arvidson K; Aveston S; Dierkes P; Benigni R; Benz RD; Contrera J; Kruhlak NL; Matthews EJ; Han X; Jaworska J; Kemper RA; Rathman JF; Richard AM. “Understanding Genetic Toxicity through Data Mining: The Process of Building Knowledge by Integrating Multiple Genetic Toxicity Databases.”Toxicology Mechanisms and Methods 2008:18:277–295. Yang C.; Cross K; Myatt GJ; Blower PE; Rathman JF. Journal of Medicinal Chemistry, 2004, 47(24), 5984-5994. “Building predictive models for protein tyrosine phosphatase 1B inhibitors based on discriminating structural features by reassembling medicinal chemistry building blocks.” Contribution to the project COSMOS database (WP1); Threshold of Toxicological Concerns (TTC) Approach and TTC workflow system (WP2); Chemoinformatics and Computational Toxicology methods development (WP3/WP4); KNIME workflow definition (WP5); Training (WP6). Involved http://www.altamira-llc.com/news.php
Yang	Longzhi	COSMOS	School of Computing, Informatics and Media, University of Bradford	Longzhi Yang +44 (0)1274 233949 - L[dot]Yang8[at]Bradford[dot]ac[dot]uk School of Computing, Informatics and Media, University of Bradford Bradford, BD7 1DP, UK Resume Dr. Longzhi Yang is a research assistant in the Department of Computing. His research interests include information processing with uncertainty, automated diagnosis, data mining, and real-world applications on such techniques. Dr. Yang is the recipient of the Best Student Paper Award at the 19^th IEEE International Conference on Fuzzy Systems for his paper entitled “Adaptive fuzzy interpolation and extrapolation with multiple-antecedent rules.” Publications L. Yang and Q. Shen, “Adaptive fuzzy interpolation,” IEEE Trans. Fuzzy Syst., vol. 19, no. 6, 2011, pp. 1107-1126. L. Yang and Q. Shen, “Adaptive fuzzy interpolation with Prioritized Component Candidates,” in Proc. IEEE Int. Conf. Fuzzy Syst., 2011, pp. 428-435. L. Yang and Q. Shen, “Adaptive fuzzy interpolation and extrapolation with multiple-antecedent rules,” in Proc. IEEE Int. Conf. Fuzzy Syst., 2010, pp. 1-8. Contribution to the project The UNIBRAD team contribute on data curation and data mining, multivariate modelling and predictive toxicology model management as WP1 coordinator and contributor to WP3 and WP5. The key tasks allocated to UNIBRAD are data representation, data curation, development of computational intelligence techniques, data and model integration, and data mining tools. Involved
Zaldivar Comenges	Jose-Manuel	COSMOS	European Commission, Joint Research Centre (JRC), Institute for Health and Consumer Protection (IHCP)	Jose-Manuel Zaldivar Comenges 390332789202 - Jose[dot]zaldivar-comenges[at]jrc[dot]ec[dot]europa[dot]eu European Commission, Joint Research Centre (JRC), Institute for Health and Consumer Protection (IHCP) Via E. Fermi 2749, TP202, 21027-Ispra (VA), Italy Resume PhD Chemical Engineering (Twente University, the Netherlands), MSc Organic Chemistry (IQS, Barcelona). Senior Scientists at IHCP. >100 peer review papers, >200 scientific reports, two patents and 5 software copyrights. Main fields of research: mathematical modelling and numerical simulation of cell-based assays, PBPK models and Systems biology approaches to toxicity. Publications Zaldivar and Baraibar. 2011. A biology-based dynamic approach for the reconciliation of acute and chronic toxicity tests: Application to Daphnia magna. Chemosphere (Available online 17 December 2010) Daginnus et al. 2011.A Model-Based Prioritisation Exercise for the European Water Framework Directive. Int. J. Environ. Res. Public Health, 8(2), 435-455. Zaldivar et al. 2011. An integrated approach for bioaccumulation assessment in mussels: Towards the development of Environmental Quality Standards for biota .Ecotoxicology and Environmental Safety(Available online 30 October 2010 ) Contribution to the project WP4 (Toxicokinetics in the Safety Assessment of Cosmetics Ingredients) leader. Development of a virtual cell-based assays model able to simulate the free concentrations and cell-internal concentrations during in vitro experiments. Compare these values with the values obtained using PBPK models and assess the validity of in vitro in vivo extrapolation for repeated dose toxicity in a proof of concept set-up. Connect cellular level with molecular level using systems biology approaches for selected chemicals. Involved http://ec.europa.eu/dgs/jrc/

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SEURAT-1 - Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing

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Petko Alov

Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences

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Tommy Andersson

Clinical Pharmacology and DMPK

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Kirk Arvidson

U.S. FDA, Office of Food Additive Safety

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Edward Balbirnie

Ectycell SAS

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Laurent Barbe

CSEM SA, Nanomedicine Division

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Arianna Bassan

S-IN Soluzioni Informatiche srl

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Ramon Bataller

Liber Unit, Hospital Clinic, IDIBAPS, Barcelona

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Sofia Batista Leite

Vrije Universiteit Brussel

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Emilio Benfenati

Istituto di Ricerche Farmacologiche Mario Negri

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Michael R. Berthold

KNIME.com AG

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Fabrice Bertile

CNRS-UdS, UMR7178, Institut Pluridisciplinaire Hubert Curien, LSMBO

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Petter Bjorquist

Cellartis AB

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Julia Boecker

European Research and Project Office GmbH, EURICE

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