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Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro
2016
Biomaterials Vol. 78
pp. 1-10 10.1016/j.biomaterials.2015.11.026
Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making
Environ Health Perspect
2015 10.1289/ehp.1409342
Functionality testing of primary hepatocytes in culture by measuring urea synthesis
2015
Methods in Molecular Biology-Protocols in In Vitro Hepatocyte Research 1250
pp. 317-321 10.1007/978-1-4939-2074-7_24
Proposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes
Archives of Toxicology
2015
733-741 10.1007/s00204-014-1277-8
Immortalized human hepatic cell lines for in vitro testing and research purposes
2015
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
53-76 10.1007/978-1-4939-2074-7_4
Establishment and characterization of an in vitro model of Fas-mediated hepatocyte cell death
2015
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
95-104 10.1007/978-1-4939-2074-7_6
Human skin-derived precursor cells: isolation, expansion and hepatic differentiation
2015
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
113-122 10.1007/978-1-4939-2074-7_8
Measurement of cytochrome P450 enzyme induction and inhibition in HepaRG cells
2015
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
279-286 10.1007/978-1-4939-2074-7_20
Measurement of albumin secretion as functionality test in primary hepatocyte cultures
2015
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
303-308 10.1007/978-1-4939-2074-7_22
Measurement of apoptotic and necrotic cell death in primary hepatocyte cultures
2015
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
349-362 10.1007/978-1-4939-2074-7_27
Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis.
GUT
2015 10.1136/gutjnl-2014-307979
Radiolabeling strategies for radionuclide imaging of stem cells
2015
Stem Cell Rev 11(2)
254-74 10.1007/s12015-014-9575-3
Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone
Archives of Toxicology
2015 10.1007/s00204-015-1537-2
Integrative miRNA and Gene expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells
2015
Scientific Reports 10.1038/srep11549
Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells–derived and fetal hepatocytes
2015
Hepatology 62(1)
265-278 10.1002/hep.27803
MicroprocessorBased Integration of Microfluidic Platforms for the Realization of Multithreaded Optimization Algorithms
2015
Biomed Microdevices 17(4)
82 10.1007/s10544-015-9989-y
Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells
2015
Biochem Pharmacol 96(3)
190-201 10.1053/j.gastro.2014.01.039
Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells
2015
Oncotarget 6 (29)
26729-45 10.18632/oncotarget.4925
Progressive Stochastic Reconstruction Technique (PSRT) for Cryo Electron Tomography
2015
Journal of Structural Biology March 2015
pp. 195-206 10.1016/j.jsb.2015.01.011
TiQuant: software for tissue analysis, quantification and surface reconstruction
2015
Bioinformatics Epub ahead of print 10.1093/bioinformatics/btv346
Matched Backprojection Operator for Combined Scanning Transmission Electron Microscopy Tilt- and Focal Series
2015
Microscopy and Microanalysis Volume 21 / Issue 03 / June 2015
pp. 725-738 10.1017/S1431927615000525
Bile canalicular dynamics in hepatocyte sandwich cultures
2015
Archives of Toxicology 2015 Aug 18. 10.1007/s00204-015-1575-9
In silico modeling for the prediction of dose and pathway related adverse effects in humans from in vitro repeated-dose studies
2015
Toxicological Sciences, 2015 Sep 29 10.1093/toxsci/kfv218
Marker detection in Electron Tomography: A comparative study
2015
Microscopy and Microanalysis Volume 21 / Issue 06 10.1017/S1431927615015433
Model guided identification and therapeutic implications of an ammonia sink mechanism
2015
Journal of Hepatology http://dx.doi.org/10.1016/j.jhep.2015.11.018
A shift in paradigm towards human biology-based systems for cholestatic-liver diseases
2015
Journal of Physiology Vol. 593/Issue 23
pp. 5043-5055 10.1113/JP271124
Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes
2015
Glia 10.1002/glia.22882.
A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspensions
2015
Biotechnology Journal 10.1002/biot.201400757.
Cytostatic Effect of Repeated Exposure to Simvastatin: A Mechanism for Chronic Myotoxicity Revealed by the Use of Mesodermal Progenitors Derived from Human Pluripotent Stem Cells
2015
Stem Cells 10.1002/stem.2107.
Label-Free Impedance Measurements for Profiling Drug-Induced Cardiotoxicity
Springer
2015
Methods in Pharmacology and Toxicology 1557-2153
pp. 283-305 10.1007/978-1-4939-2617-6_16
In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells
Springer
2015
Archives of Toxicology
Functionality testing of primary hepatocytes in culture by measuring urea synthesis
Humana Press
2015
Methods in Molecular Biology-Protocols in In Vitro Hepatocyte Research 1250
pp. 317-321 10.1007/978-1-4939-2074-7_24
Adverse outcome pathways and drug-induced liver injury testing
ACS Publications
2015
Chemical Research in Toxicology
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells
Elsevier
2015
Journal of Hepatology 10.1016/j.jhep.2015.05.013
Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing
Elsevier
2015
Toxicology in Vitro
Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity
2015
Arch Toxicol.
In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine
2015
Food and Chemical Toxicology 75
pp. 9-49
Evaluation of toxic endpoints for a set of cosmetic ingredients with CAESAR models
2015
Chemosphere 120
pp. 492-499
Screening chemicals for receptor-mediated toxicological and pharmacological endpoints: Using public data to build screening tools within a KNIME workflow
2015
Mol. Inf. 34
pp. 171–178
Chemical safety assessment using readacross: How can novel testing methods strengthen evidence base for decisionmaking?
2015 Environ. Health Perspect., in press
A strategy for structuring and reporting a read-across prediction of toxicity
2015 Reg. Toxicol. Pharmacol. 72: pp. 586–601
Structural and dynamical insight into PPARγ antagonism: in silico study of the ligand-receptor interactions of non-covalent antagonists
2015 Int. J. Mol. Sci. 16(7): pp. 15405-15424
Putative adverse outcome pathways relevant to neurotoxicity
2015
Crit. Rev. Toxicol., 45
pp. 83-91
SEURAT: Safety Evaluation Ultimately Replacing Animal Testing – Recommendations for future research in the field of predictive toxicology
2015
Arch. Toxicol., 89
PP. 15-23
The SEURAT-1 approach towards animal free human safety assessment
2015
ALTEX, 32
pp. 9-24
Primary hepatocytes and their cultures in liver apoptosis research
Springer Verlag
2014
Vol. 88/Issue 2
pp.199-212 DOI: 10.1007/s00204-013-1123-4
CCL20 mediateslipopolysaccharide induced liver injuryand is a potential driver of inflammation and fibrosis in alcoholic hepatitis
BMJ Publishing Group, United Kingdom
2014
Gut 10.1136/gutjnl-2013-306098
Adverse outcome pathways: hype or hope?
Springer Verlag, Germany
2014
Archives of Toxicology, Vol. 88/Issue 1
pp. 1-2
Human Skin-Derived Stem Cells as a Novel Cell Source for In Vitro Hepatotoxicity Screening of Pharmaceuticals
Mary Ann Liebert Inc. Publishers, United States
2014
Stem Cells and Development, Vol. 23/Issue 1
pp. 44-55 10.1089/scd.2013.0157
Long-term microfluidic glucose and lactate monitoring in hepatic cell culture
2014
Biomicrofluidics 8, 034102
Primary hepatocytes and their cultures in liver apoptosis research
2014
Archives of Toxicology 88(2)
199-212
Characterization of hepatic markers in human Wharton's Jelly-derived mesenchymal stem cells
2014
Archives of Toxicology 88(2)
199-212
Biliary cells to the rescue of Prometheus
2014
Gastroenterology 146(3)
611-614 10.1053/j.gastro.2014.01.039
Hepatic differentiation of human embryonic stem cells on microcarriers
2014
J Biotechnol 174
39-48 10.1016/j.jbiotec.2014.01.025
Optimization of multimodal imaging of mesenchymal stem cells using the human sodium iodide symporter for PET and Cerenkov luminescence imaging
2014
PLoS One 9(4)
e94833 10.1371/journal.pone.0094833
MicroRNAs: the fine modulators of liver development and function
2014
Liver Int 34(7)
pp. 39-48 10.1111/liv.12496
Strategies for immortalization of primary hepatocytes
2014
Journal of Hepatology 61 (4)
pp. 925-943 10.1016/j.jhep.2014.05.046
Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife
Philosophical Transactions of The Royal Society B Biological Sciences
2014
369 (1656)
20130584 10.1098/rstb.2013.0584
Assessment of Liver Fibrotic Insults In Vitro
2014
Protocols in In Vitro Hepatocyte Research
391-401 10.1007/978-1-4939-2074-7_30
3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
2014
Toxicol In Vitro 28
pp. 104-12 10.1016/j.tiv.2013.06.024
MSDA, a proteomics software suite for in-depth Mass Spectrometry Data Analysis using grid computing
2014
PROTEOMICS 10.1002/pmic.201300415
Combined Scanning Transmission Electron Microscopy Tilt- and Focal Series
2014
Microscopy and Microanalysis Vol. 20/Issue 02
pp. 548-560 10.1017/S1431927614000075
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis
2014
Arch Toxicol 88
pp. 1161–1183 10.1007/s00204-014-1243-5
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity
2014
Archives of Toxicology 2014 Jun;88(6)
pp. 1267-80 10.1007/s00204-014-1240-8
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration
2014
Hepatology 60(6)
2040-51 10.1002/hep.27136
BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives
2014
Nucleic Acids Res 2014 July 1; 42 10.1093/nar/gku457
Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: cytotoxicity, genotoxicity and epigenetics
2014
Toxicology Research 10.1039/C4TX00036F
How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis
2014
Journal of Hepatology Volume 61, Issue 4
pp. 951–956 10.1016/j.jhep.2014.06.013
Quantifying resolution limiting factors in subtomogram averaged cryo-electron tomography using simulations
2014
Journal of Structural Biology Volume 187, Issue 2
pp. 103–111 10.1016/j.jsb.2014.06.007
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
2014
ALTEX (31)4
pp. 441-477 10.14573/altex1406111.
A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models
Biosystems ;124:26-38. 2014 Oct 124
2014
pp. 26-38 10.1016/j.biosystems.2014.07.002
TFS: Combined Tilt- and Focal Series Scanning Transmission Electron Microscopy
2014
Microscopy and Microanalysis 20 (Suppl 3)
pp. 786-787 10.1017/S1431927614005650
Comprehensive analysis of DNA methylation data with RnBeads
2014
Nature Methods 11, 2014
pp. 1138–1140 10.1038/nmeth.3115
Genetic and epigenetic regulation of gene expression in fetal and adult human livers
2014
BMC Genomics 2014, 15:860 10.1186/1471-2164-15-860
Fluorescence based cell counting in collagen monolayer cultures of primary hepatocytes
2014
Cytotechnol 10.1007/s10616-014-9821-1
Unraveling liver complexity from molecular to organ level: Challenges and perspectives
2014
Prog Biophys Mol Biol 10.1016/j.pbiomolbio.2014.11.005
Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes
2014
Drug Metabolism and Disposition 42(9)
pp. 1401-06 10.1124/dmd.114.059154
Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, cell lines and primary hepatocytes
2014
Arch Toxicol. 88(7)
pp. 14127-1437 10.1007/s00204-014-1265-z
Human stem cell-derived hepatocytes: breakthrough of an expedient tool for preclinical assessment of drug-induced liver injury?
Springer
2014
Archives of Toxicology 88 (2)
pp. 183-184
Proposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes
Springer
2014
Archives of Toxicology 89 (5)
pp. 733-741
Strategies for immortalization of primary hepatocytes
Elsevier
2014
Journal of Hepatology 61 (4)
pp. 925-943
Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action
ALTEX
2014
Alternatives to Animal Experimentation 31 (4)
pp. 407-421
MicroRNAs as key regulators of xenobiotic biotransformation and drug response
Springer
2014
Archives of Toxicology
Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife
Royal Society Publishing
2014
Philosophical Transactions of The Royal Society B Biological Sciences 369 (1656)
Toxicogenomics directory of chemically exposed human hepatocytes
Springer
2014
Archives of Toxicology 88 (12)
pp. 2261-2287
Identification of potential biomarkers of hepatitis B-induced acute liver failure in human skin-derived precursors upon hepatogenic differentiation
Elsevier
2014
Toxicology In Vitro 29 (6)
pp. 1231-1239
Evaluation of a new standardized enzymatic isolation protocol for human umbilical cord-derived stem cells
Elsevier
2014
Toxicology In Vitro 29 (6)
pp. 1254-1262
SEURAT-1 liver gold reference compounds: a mechanism-based review
Springer
2014
Archives of Toxicology
A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity
MDPI
2014
Toxins
pp. 371-9
Current approaches and future role of high content imaging in safety sciences and drug discovery.
ALTEX
2014
Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment
2014
Chem Res Toxicol. 17;27(3)
pp. 338-55
Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity
2014
Toxicol Sci. 2014 Jul;140(1)
pp. 144-59
Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells
American Chemical Society
2014
Chemical research in toxicology
pp. 408-420
Methods for assigning confidence to toxicity data with multiple values - Identifying experimental outliers
2014
Sci Total Environ
482-483: pp. 358-365
Modes-of-action related to repeated dose toxicity: from PPARgamma ligand-dependent dysregulation to non-alcoholic fatty liver disease
2014
PPAR Research, Special issue „PPARs and Metabolic Syndrome”, Volume 2014 (2014), Article ID 432647
Experimental verification of structural alerts for the protein binding of sulfur-containing compounds
2014
SAR and QSAR in Environmental Research 25(4)
pp. 325-341
Application of physiologically based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients
2014
Toxicology Letters 227
pp. 189-202
Molecular modelling study of the PPARγ receptor in relation to the Mode of Action/Adverse Outcome Pathway framework for liver steatosis
2014
Int. J. Mol. Sci. 15(5)
pp. 7651-7666
How does the quality of phospholipidosis data influence the predictivity of structural alerts?
2014
J. Chem. Inf. Model 54
pp. 2224−2232
The acute effects of daily nicotine intake on heart rate – A toxicokinetic and toxicodynamic modelling study
2014
Regulatory Toxicology and Pharmacology 70(1)
pp. 312-324
SEURAT-1 liver gold reference compounds: a mechanism-based review
2014
Arch. Toxicol., 88
pp. 2099-2133
A strategy for structuring and reporting a read-across prediction of toxicity
2014
Regul. Toxicol. Pharmacol. 72
pp. 586-601
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
Springer
2013
p.45 http://link.springer.com/article/10.1007%2Fs00204-012-0999-8
Characterization of hepatic markers in human Wharton’s Jelly-derived mesenchymal stem cells
Elsevier
2013
Toxicology In Vitro DOI: 10.1016/j.tiv.2013.06.014
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signalling and ADME
Springer
2013
Archives of Toxicology
p.1315-1530 http://link.springer.com/article/10.1007%2Fs00204-013-1078-5
The state of the art and future directions of category formation and read-across for toxicity prediction
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
2013
pp. 168-179
Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters
Informa Healthcare
2013
Drug Metabolism Reviews
p.196-217 DOI: 10.3109/03602532.2012.756010
Drug-induced liver injury: mechanisms types and biomarkers
Bentham Science Publishers
2013
Current Medicinal Chemistry
p.3011-3021 DOI: 10.2174/0929867311320240006
Adverse outcome pathways: hype or hope?
Springer
2013
Archives of Toxicology DOI: 10.1007/s00204-013-1093-6
The adverse outcome pathway concept: a pragmatic tool in toxicology
Elsevier
2013
Toxicology
p.158-165 DOI: 10.1016/j.tox.2013.08.011
Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals
Mary Ann Liebert Inc. Publishers
2013
Stem Cells and Development DOI: 10.1089/scd.2013.0157
Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury
Oxford Journals
2013
Toxicological Sciences DOI: 10.1093/toxsci/kft177
Regenerative toxicology”: the role of stem cells in the development of chronic toxicities
Informa Healthcare
2013
Expert Opinion On Drug Metabolism and Toxicology
Hepatotoxicity: A scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action
Critical Reviews in Toxicology
2013
43: pp. 537–558
Experimental verification, and domain definition, of structural alerts for protein binding: epoxides, lactones, nitroso, nitros, aldehydes and ketones
SAR and QSAR in Environmental Research
2013
24(9): pp. 695-709
The definition of the toxicologically relevant applicability domain for the SNAr reaction for substituted pyridines and pyrimidines
SAR and QSAR in Environmental Research
2013
24(5): pp. 385-392
Pragmatic approaches to using computational methods to predict xenobiotic metabolism
J. Chem. Inf. Model.
2013
53 (6), pp. 1282–1293
Prediction of dose – hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: A case study with acetaminophen
Toxicology Letters 220
2013
pp. 26–34
Towards Model Governance in Predictive Toxicology
International Journal of Information Management
2013
33(3): pp. 567-582
Towards a fuzzy expert system on toxicological data quality assessment
2013
Mol. Inf. 32(1): pp. 65-78
Quantitative evaluation and prediction of drug effects and toxicological risk using mechanistic multiscale models
2013
Mol. Inf. 32(1): pp. 14-23
A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk
Front Pharmacol
2013
3: p. 204 doi: 10.3389/fphar.2012.00204
An introduction to chemical grouping, categories and read-across to predict toxicity
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge,
2013
pp. 1-29
Approaches for grouping chemicals into categories
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
2013
pp. 30-43
Informing chemical categories through the development of Adverse Outcome Pathways
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
2013
pp. 44-71
Category formation case studies
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
2013
pp. 127-154
Tools for grouping chemicals and forming categories
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
2013
pp. 72-97
Sources of chemical information, toxicity data and assessment of their quality
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
2013
pp. 98-126
Evaluation of categories and read-across for toxicity prediction allowing for regulatory acceptance
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
2013
pp. 155-167
Modelling local and systemic toxicity: incorporation of in silico predictions in the development of adverse outcome pathways
2013
ALTEX Proceedings
2(2): 74
The COSMOS project – developing integrated computational approaches to predict repeated dose toxicity
2013
ALTEX Proceedings
2(2): 75
Threshold of toxicological concern (TTC) task force: a strategy to support application of TTC to dermally applied cosmetic ingredients
2013
Toxicology Letters 221
Supplement: S35
TTC Task Force: Development of a cosmetics database to support application of TTC to cosmetic ingredients
2013
Toxicology Letters 221
Supplement: S35
Applying read-across for quantitative chronic toxicity prediction
2013
Toxicology Letters 221
Supplement: S52
Category formation and read-across for toxicity prediction: A review of the current status and future directions
2013
Toxicology Letters 221
Supplement: S79-S80
Development of new COSMOS oRepeatDose and non-cancer Threshold of Toxicological Concern (TTC) databases to support alternative testing methods for cosmetics related chemicals
2013
Toxicology Letters 221
Supplement: S80
Data mining toxicity effects through an ontology approach to investigate toxicity mode of action
2013
Toxicology Letters 221
Supplement: S80
Development of integrated in silico models for toxicity prediction focussing on cosmetic ingredients
2013
Toxicology Letters 221
Supplement: S81
In silico workflows for toxicity prediction implemented into KNIME
2013
Toxicology Letters 221
Supplement: S81
Modelling chemically-induced cell toxicity: An open source implementation of a virtual cell based assay model
2013
Toxicology Letters 221
Supplement: S82
Human bioaccumulation potential simulated in R and implemented into KNIME interface
2013
Toxicology Letters 221
Supplement: S82
Molecular modelling of LXR binding to evaluate the potential for liver steatosis
2013
Toxicology Letters 221
Supplement: S83
Multi-scale modeling for individualized spatiotemporal prediction of drug effects
2013
Toxicology Letters 221
Supplement: S83-84
Toward better understanding of liver steatosis MoA: Molecular modelling study of PPAR gamma receptor
2013
Toxicology Letters 221
Supplement: S85
Improved in silico methods to group liver toxicants related to Adverse Outcome Pathways
2013
The Toxicologist – A Supplement to Toxicological Sciences
132: 189
Flexible and transparent computational workflows for the prediction of target organ toxicity
2013
The Toxicologist – A Supplement to Toxicological Sciences
132: 183
Development of a COSMOS Database to support in silico modelling for cosmetics ingredients and related chemicals
2013
The Toxicologist – A Supplement to Toxicological Sciences
132: 185
Multiscale modeling for individualized spatiotemporal prediction of drug effects
2013
The Toxicologist – A Supplement to Toxicological Sciences
132: 118
Integrated in silico modeling for the prediction of chronic toxicity
2013
International Journal of Toxicology
32: 72-73
Linking chemical categories to adverse outcome pathways for chronic toxicity
2013
International Journal of Toxicology
32: 65
Toxicity risk assessment from heterogeneous uncertain data with possibility-probability distribution
2013
Proceedings of the 2013 IEEE International Conference on Fuzzy Systems (FUZZ), Hyderabad, India.
1-8
COSMOS: Integrated in Silico Models for the Prediction of Human Repeated Dose Toxicity of COSMetics to Optimise Safety.
2013
Gocht T, Schwarz M (eds) Towards the replacement of in vivo repeated dose systemic toxicity testing.
Volume 3, pp. 146-178
Molecular modelling to predict and understand chemical toxicity in the AOP framework – Case study: MoA from LXR activation to liver steatosis.
2013
Gocht T, Schwarz M (eds) Towards the replacement of in vivo repeated dose systemic toxicity testing.
Volume 3, pp. 249-252
Human bioaccumulation potential simulated in R and implemented in the KNIME interface
2013
Gocht T, Schwarz M (eds) Towards the replacement of in vivo repeated dose systemic toxicity testing.
Volume 3, pp. 253-256
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis.
John Wiley and Sons Ltd, United Kingdom
2013
Hepatology, Vol. 58/Issue 5
pp. 1742-1756 10.1002/hep.26521
Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury
Oxford University Press, United Kingdom
2013
Toxicological Sciences, Vol. 136/Issue 1
pp. 97-106 10.1093/toxsci/kft177
The adverse outcome pathway concept: A pragmatic tool in toxicology
Elsevier, Ireland Ltd
2013
Toxicology, Vol. 312
pp. 158-165 10.1016/j.tox.2013.08.011
Drug-Induced Liver Injury: Mechanisms, Types and Biomarkers
Bentham Science Publishers B.V., Netherlands
2013
Current Medicinal Chemistry, Vol. 20/Issue 24
pp. 3011-3021 10.2174/0929867311320240006
Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters
Informa Healthcare, United Kingdom
2013
Drug Metabolism Reviews, Vol. 45/Issue 2
pp. 196-217 10.3109/03602532.2012.756010
Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells
Elsevier Inc.
2013
Biochemical Pharmacology, Vol. 86/Issue 5
pp. 691-702 10.1016/j.bcp.2013.06.029
A Novel 3D Label-Free Monitoring System of hES-Derived Cardiomyocyte Clusters: A Step Forward to In Vitro Cardiotoxicity Testing
Public Library of Science, United States
2013
PLoS One, Vol. 8/Issue 7
pp. 145-156 10.1371/journal.pone.0068971
Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor
Mary Ann Liebert Inc. Publishers, United States
2013
Stem Cells and Development, Vol. 22/Issue 4
pp. 581-594 10.1089/scd.2012.0202
Quantitative Evaluation and Prediction of Drug Effects and Toxicological Risk Using Mechanistic Multiscale Models
Wiley - VCH Verlag GmbH & CO. KGaA
2013
Molecular Informatics, 1/32
14 - 23 10.1002/minf.201200043
In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes
Oxford University Press, United Kingdom
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