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The projects constituting the SEURAT-1 research initiative have received funding from the European Union Seventh Framework Programme (FP7/2007-2013). The projects constituting the SEURAT-1 research initiative have received financing from Cosmetics Europe.

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The first COSMOS workflows have been relased with the launch of the COSMOS KNIME WebPortal and COSMOS Space at SOT 2015!

04/07/2015
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The workflows are freely accessible to execute in a web browser in the COSMOS KNIME WebPortal (http://knimewebportal.cosmostox.eu).

Free registration, model description and user guidance are available through COSMOS Space (http://cosmosspace.cosmostox.eu). Login to the COSMOS KNIME WebPortal with COSMOS Space credentials.

The models include

- Physiologically-Based Kinetic (PBK) models to simulate concentration-time profiles and internal dose metrics for dermal or oral scenarios

- Extrapolation of in vitro intracellular concentrations with the Virtual Cell Based Assay

- Human bioaccumulation factor (hBCF)

- Gastrointestinal absorption

- Skin permeability

- Prediction of potential binding to nuclear receptors related to steatosis.

More workflows will be added over the next months.

Keep updated at ww.cosmostox.eu. See also the Workflow leaflet at http://tinyurl.com/COSMOS-workflows .

Last changed: 04/07/2015

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