Animals are traditionally used for hazard identification, safety testing or disease modelling in pharmaceutical, (agro)chemical, food and environmental industry laboratories. Though in vivo tests give an insight into systemic effects of chemicals, the physiological differences between animals and man can undermine extrapolation of animal data to the human system. Human-relevant organoid in vitro systems that mimic human physiology are a novel solution to this problem and provide a new basis for in vitro-in vivo extrapolation (IVIVE).
Static human 3D cell culture models mimic human biology at a more physiological level than traditionally used 2D cell cultures. They add value to predictive toxicology but still do not fully emulate systemic human biology in vitro. Recent advanced microfabrication techniques enable the development of microfluidic ‘organ-on-a-chip’ or even ‘human-on-a-chip’ devices. These promise to emulate relevant aspects of single organ functionand interaction among organs on a microphysiological scale, enabling a new level of physiologically relevant assays.
This Information Day brings together renowned experts in the field to inform about the status quo, promises and current shortcomings of microphysiological systems.
Dr. Mardas Daneshian (CEO)
Center for Alternatives to Animal Testing-Europe
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