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The projects constituting the SEURAT-1 research initiative have received funding from the European Union Seventh Framework Programme (FP7/2007-2013). The projects constituting the SEURAT-1 research initiative have received financing from Cosmetics Europe.

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Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro
Biomaterials Vol. 78
pp. 1-10
Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making
Environ Health Perspect
Functionality testing of primary hepatocytes in culture by measuring urea synthesis
Methods in Molecular Biology-Protocols in In Vitro Hepatocyte Research 1250
pp. 317-321
10.1007/978-1-4939-2074-7_24
Proposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes
Archives of Toxicology
733-741
10.1007/s00204-014-1277-8
Immortalized human hepatic cell lines for in vitro testing and research purposes
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
53-76
10.1007/978-1-4939-2074-7_4
Establishment and characterization of an in vitro model of Fas-mediated hepatocyte cell death
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
95-104
10.1007/978-1-4939-2074-7_6
Human skin-derived precursor cells: isolation, expansion and hepatic differentiation
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
113-122
10.1007/978-1-4939-2074-7_8
Measurement of cytochrome P450 enzyme induction and inhibition in HepaRG cells
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
279-286
10.1007/978-1-4939-2074-7_20
Measurement of albumin secretion as functionality test in primary hepatocyte cultures
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
303-308
10.1007/978-1-4939-2074-7_22
Measurement of apoptotic and necrotic cell death in primary hepatocyte cultures
Methods in Molecular Biology - Protocols in In Vitro Hepatocyte Research 1250
349-362
10.1007/978-1-4939-2074-7_27
Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis.
GUT
10.1136/gutjnl-2014-307979
Radiolabeling strategies for radionuclide imaging of stem cells
Stem Cell Rev 11(2)
254-74
10.1007/s12015-014-9575-3
Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone
Archives of Toxicology
10.1007/s00204-015-1537-2
Integrative miRNA and Gene expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells
Scientific Reports
10.1038/srep11549
Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells–derived and fetal hepatocytes
Hepatology 62(1)
265-278
10.1002/hep.27803
Microprocessor­Based Integration of Microfluidic Platforms for the Realization of Multithreaded Optimization Algorithms
Biomed Microdevices 17(4)
82
10.1007/s10544-015-9989-y
Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells
Biochem Pharmacol 96(3)
190-201
10.1053/j.gastro.2014.01.039
Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells
Oncotarget 6 (29)
26729-45
10.18632/oncotarget.4925
Progressive Stochastic Reconstruction Technique (PSRT) for Cryo Electron Tomography
Journal of Structural Biology March 2015
pp. 195-206
TiQuant: software for tissue analysis, quantification and surface reconstruction
Bioinformatics Epub ahead of print
Matched Backprojection Operator for Combined Scanning Transmission Electron Microscopy Tilt- and Focal Series
Microscopy and Microanalysis Volume 21 / Issue 03 / June 2015
pp. 725-738
Bile canalicular dynamics in hepatocyte sandwich cultures
Archives of Toxicology 2015 Aug 18.
In silico modeling for the prediction of dose and pathway related adverse effects in humans from in vitro repeated-dose studies
Toxicological Sciences, 2015 Sep 29
Marker detection in Electron Tomography: A comparative study
Microscopy and Microanalysis Volume 21 / Issue 06
Model guided identification and therapeutic implications of an ammonia sink mechanism
Journal of Hepatology
A shift in paradigm towards human biology-based systems for cholestatic-liver diseases
Journal of Physiology Vol. 593/Issue 23
pp. 5043-5055
Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes
Glia
10.1002/glia.22882.
A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspensions
Biotechnology Journal
10.1002/biot.201400757.
Cytostatic Effect of Repeated Exposure to Simvastatin: A Mechanism for Chronic Myotoxicity Revealed by the Use of Mesodermal Progenitors Derived from Human Pluripotent Stem Cells
Stem Cells
10.1002/stem.2107.
Label-Free Impedance Measurements for Profiling Drug-Induced Cardiotoxicity
Springer
Methods in Pharmacology and Toxicology 1557-2153
pp. 283-305
10.1007/978-1-4939-2617-6_16
In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells
Springer
Archives of Toxicology
Functionality testing of primary hepatocytes in culture by measuring urea synthesis
Humana Press
Methods in Molecular Biology-Protocols in In Vitro Hepatocyte Research 1250
pp. 317-321
10.1007/978-1-4939-2074-7_24
Adverse outcome pathways and drug-induced liver injury testing
ACS Publications
Chemical Research in Toxicology
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells
Elsevier
Journal of Hepatology
10.1016/j.jhep.2015.05.013
Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing
Elsevier
Toxicology in Vitro
Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity
Arch Toxicol.
In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine
Food and Chemical Toxicology 75
pp. 9-49
Evaluation of toxic endpoints for a set of cosmetic ingredients with CAESAR models
Chemosphere 120
pp. 492-499
Screening chemicals for receptor-mediated toxicological and pharmacological endpoints: Using public data to build screening tools within a KNIME workflow
Mol. Inf. 34
pp. 171–178
Chemical safety assessment using readacross: How can novel testing methods strengthen evidence base for decisionmaking?
A strategy for structuring and reporting a read-across prediction of toxicity
Structural and dynamical insight into PPARγ antagonism: in silico study of the ligand-receptor interactions of non-covalent antagonists
Putative adverse outcome pathways relevant to neurotoxicity
Crit. Rev. Toxicol., 45
pp. 83-91
SEURAT: Safety Evaluation Ultimately Replacing Animal Testing – Recommendations for future research in the field of predictive toxicology
Arch. Toxicol., 89
PP. 15-23
The SEURAT-1 approach towards animal free human safety assessment
ALTEX, 32
pp. 9-24
Primary hepatocytes and their cultures in liver apoptosis research
Springer Verlag
Vol. 88/Issue 2
pp.199-212
DOI: 10.1007/s00204-013-1123-4
CCL20 mediateslipopolysaccharide induced liver injuryand is a potential driver of inflammation and fibrosis in alcoholic hepatitis
BMJ Publishing Group, United Kingdom
Gut
Adverse outcome pathways: hype or hope?
Springer Verlag, Germany
Archives of Toxicology, Vol. 88/Issue 1
pp. 1-2
Human Skin-Derived Stem Cells as a Novel Cell Source for In Vitro Hepatotoxicity Screening of Pharmaceuticals
Mary Ann Liebert Inc. Publishers, United States
Stem Cells and Development, Vol. 23/Issue 1
pp. 44-55
Long-term microfluidic glucose and lactate monitoring in hepatic cell culture
Biomicrofluidics 8, 034102
Primary hepatocytes and their cultures in liver apoptosis research
Archives of Toxicology 88(2)
199-212
Characterization of hepatic markers in human Wharton's Jelly-derived mesenchymal stem cells
Archives of Toxicology 88(2)
199-212
Biliary cells to the rescue of Prometheus
Gastroenterology 146(3)
611-614
10.1053/j.gastro.2014.01.039
Hepatic differentiation of human embryonic stem cells on microcarriers
J Biotechnol 174
39-48
10.1016/j.jbiotec.2014.01.025
Optimization of multimodal imaging of mesenchymal stem cells using the human sodium iodide symporter for PET and Cerenkov luminescence imaging
PLoS One 9(4)
e94833
10.1371/journal.pone.0094833
MicroRNAs: the fine modulators of liver development and function
Liver Int 34(7)
pp. 39-48
10.1111/liv.12496
Strategies for immortalization of primary hepatocytes
Journal of Hepatology 61 (4)
pp. 925-943
10.1016/j.jhep.2014.05.046
Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife
Philosophical Transactions of The Royal Society B Biological Sciences
369 (1656)
20130584
10.1098/rstb.2013.0584
Assessment of Liver Fibrotic Insults In Vitro
Protocols in In Vitro Hepatocyte Research
391-401
10.1007/978-1-4939-2074-7_30
3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
Toxicol In Vitro 28
pp. 104-12
MSDA, a proteomics software suite for in-depth Mass Spectrometry Data Analysis using grid computing
PROTEOMICS
Combined Scanning Transmission Electron Microscopy Tilt- and Focal Series
Microscopy and Microanalysis Vol. 20/Issue 02
pp. 548-560
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis
Arch Toxicol 88
pp. 1161–1183
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity
Archives of Toxicology 2014 Jun;88(6)
pp. 1267-80
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration
Hepatology 60(6)
2040-51
BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives
Nucleic Acids Res 2014 July 1; 42
Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: cytotoxicity, genotoxicity and epigenetics
Toxicology Research
How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis
Journal of Hepatology Volume 61, Issue 4
pp. 951–956
Quantifying resolution limiting factors in subtomogram averaged cryo-electron tomography using simulations
Journal of Structural Biology Volume 187, Issue 2
pp. 103–111
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
ALTEX (31)4
pp. 441-477
A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models
Biosystems ;124:26-38. 2014 Oct 124
pp. 26-38
TFS: Combined Tilt- and Focal Series Scanning Transmission Electron Microscopy
Microscopy and Microanalysis 20 (Suppl 3)
pp. 786-787
Comprehensive analysis of DNA methylation data with RnBeads
Nature Methods 11, 2014
pp. 1138–1140
Genetic and epigenetic regulation of gene expression in fetal and adult human livers
BMC Genomics 2014, 15:860
Fluorescence based cell counting in collagen monolayer cultures of primary hepatocytes
Cytotechnol
Unraveling liver complexity from molecular to organ level: Challenges and perspectives
Prog Biophys Mol Biol
Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes
Drug Metabolism and Disposition 42(9)
pp. 1401-06
10.1124/dmd.114.059154
Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, cell lines and primary hepatocytes
Arch Toxicol. 88(7)
pp. 14127-1437
10.1007/s00204-014-1265-z
Human stem cell-derived hepatocytes: breakthrough of an expedient tool for preclinical assessment of drug-induced liver injury?
Springer
Archives of Toxicology 88 (2)
pp. 183-184
Proposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes
Springer
Archives of Toxicology 89 (5)
pp. 733-741
Strategies for immortalization of primary hepatocytes
Elsevier
Journal of Hepatology 61 (4)
pp. 925-943
Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action
ALTEX
Alternatives to Animal Experimentation 31 (4)
pp. 407-421
MicroRNAs as key regulators of xenobiotic biotransformation and drug response
Springer
Archives of Toxicology
Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife
Royal Society Publishing
Philosophical Transactions of The Royal Society B Biological Sciences 369 (1656)
Toxicogenomics directory of chemically exposed human hepatocytes
Springer
Archives of Toxicology 88 (12)
pp. 2261-2287
Identification of potential biomarkers of hepatitis B-induced acute liver failure in human skin-derived precursors upon hepatogenic differentiation
Elsevier
Toxicology In Vitro 29 (6)
pp. 1231-1239
Evaluation of a new standardized enzymatic isolation protocol for human umbilical cord-derived stem cells
Elsevier
Toxicology In Vitro 29 (6)
pp. 1254-1262
SEURAT-1 liver gold reference compounds: a mechanism-based review
Springer
Archives of Toxicology
A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity
MDPI
Toxins
pp. 371-9
Current approaches and future role of high content imaging in safety sciences and drug discovery.
ALTEX
Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment
Chem Res Toxicol. 17;27(3)
pp. 338-55
Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity
Toxicol Sci. 2014 Jul;140(1)
pp. 144-59
Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells
American Chemical Society
Chemical research in toxicology
pp. 408-420
Methods for assigning confidence to toxicity data with multiple values - Identifying experimental outliers
Sci Total Environ
482-483: pp. 358-365
Modes-of-action related to repeated dose toxicity: from PPARgamma ligand-dependent dysregulation to non-alcoholic fatty liver disease
PPAR Research, Special issue „PPARs and Metabolic Syndrome”, Volume 2014 (2014), Article ID 432647
Experimental verification of structural alerts for the protein binding of sulfur-containing compounds
SAR and QSAR in Environmental Research 25(4)
pp. 325-341
Application of physiologically based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients
Toxicology Letters 227
pp. 189-202
Molecular modelling study of the PPARγ receptor in relation to the Mode of Action/Adverse Outcome Pathway framework for liver steatosis
Int. J. Mol. Sci. 15(5)
pp. 7651-7666
How does the quality of phospholipidosis data influence the predictivity of structural alerts?
J. Chem. Inf. Model 54
pp. 2224−2232
The acute effects of daily nicotine intake on heart rate – A toxicokinetic and toxicodynamic modelling study
Regulatory Toxicology and Pharmacology 70(1)
pp. 312-324
SEURAT-1 liver gold reference compounds: a mechanism-based review
Arch. Toxicol., 88
pp. 2099-2133
A strategy for structuring and reporting a read-across prediction of toxicity
Regul. Toxicol. Pharmacol. 72
pp. 586-601
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
Springer
p.45
Characterization of hepatic markers in human Wharton’s Jelly-derived mesenchymal stem cells
Elsevier
Toxicology In Vitro
DOI: 10.1016/j.tiv.2013.06.014
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signalling and ADME
Springer
Archives of Toxicology
p.1315-1530
The state of the art and future directions of category formation and read-across for toxicity prediction
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
pp. 168-179
Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters
Informa Healthcare
Drug Metabolism Reviews
p.196-217
DOI: 10.3109/03602532.2012.756010
Drug-induced liver injury: mechanisms types and biomarkers
Bentham Science Publishers
Current Medicinal Chemistry
p.3011-3021
Adverse outcome pathways: hype or hope?
Springer
Archives of Toxicology
DOI: 10.1007/s00204-013-1093-6
The adverse outcome pathway concept: a pragmatic tool in toxicology
Elsevier
Toxicology
p.158-165
DOI: 10.1016/j.tox.2013.08.011
Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals
Mary Ann Liebert Inc. Publishers
Stem Cells and Development
DOI: 10.1089/scd.2013.0157
Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury
Oxford Journals
Toxicological Sciences
DOI: 10.1093/toxsci/kft177
Regenerative toxicology”: the role of stem cells in the development of chronic toxicities
Informa Healthcare
Expert Opinion On Drug Metabolism and Toxicology
Hepatotoxicity: A scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action
Critical Reviews in Toxicology
43: pp. 537–558
Experimental verification, and domain definition, of structural alerts for protein binding: epoxides, lactones, nitroso, nitros, aldehydes and ketones
SAR and QSAR in Environmental Research
24(9): pp. 695-709
The definition of the toxicologically relevant applicability domain for the SNAr reaction for substituted pyridines and pyrimidines
SAR and QSAR in Environmental Research
24(5): pp. 385-392
Pragmatic approaches to using computational methods to predict xenobiotic metabolism
J. Chem. Inf. Model.
53 (6), pp. 1282–1293
Prediction of dose – hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: A case study with acetaminophen
Toxicology Letters 220
pp. 26–34
Towards Model Governance in Predictive Toxicology
International Journal of Information Management
33(3): pp. 567-582
Towards a fuzzy expert system on toxicological data quality assessment
Mol. Inf. 32(1): pp. 65-78
Quantitative evaluation and prediction of drug effects and toxicological risk using mechanistic multiscale models
Mol. Inf. 32(1): pp. 14-23
A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk
Front Pharmacol
3: p. 204
An introduction to chemical grouping, categories and read-across to predict toxicity
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge,
pp. 1-29
Approaches for grouping chemicals into categories
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
pp. 30-43
Informing chemical categories through the development of Adverse Outcome Pathways
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
pp. 44-71
Category formation case studies
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
pp. 127-154
Tools for grouping chemicals and forming categories
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
pp. 72-97
Sources of chemical information, toxicity data and assessment of their quality
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
pp. 98-126
Evaluation of categories and read-across for toxicity prediction allowing for regulatory acceptance
M.T.D. Cronin, J.C. Madden, S.J. Enoch, D.W. Roberts (eds) Chemical Toxicity Prediction: Category Formation and Read-Across. The Royal Society of Chemistry, Cambridge
pp. 155-167
Modelling local and systemic toxicity: incorporation of in silico predictions in the development of adverse outcome pathways
ALTEX Proceedings
2(2): 74
The COSMOS project – developing integrated computational approaches to predict repeated dose toxicity
ALTEX Proceedings
2(2): 75
Threshold of toxicological concern (TTC) task force: a strategy to support application of TTC to dermally applied cosmetic ingredients
Toxicology Letters 221
Supplement: S35
TTC Task Force: Development of a cosmetics database to support application of TTC to cosmetic ingredients
Toxicology Letters 221
Supplement: S35
Applying read-across for quantitative chronic toxicity prediction
Toxicology Letters 221
Supplement: S52
Category formation and read-across for toxicity prediction: A review of the current status and future directions
Toxicology Letters 221
Supplement: S79-S80
Development of new COSMOS oRepeatDose and non-cancer Threshold of Toxicological Concern (TTC) databases to support alternative testing methods for cosmetics related chemicals
Toxicology Letters 221
Supplement: S80
Data mining toxicity effects through an ontology approach to investigate toxicity mode of action
Toxicology Letters 221
Supplement: S80
Development of integrated in silico models for toxicity prediction focussing on cosmetic ingredients
Toxicology Letters 221
Supplement: S81
In silico workflows for toxicity prediction implemented into KNIME
Toxicology Letters 221
Supplement: S81
Modelling chemically-induced cell toxicity: An open source implementation of a virtual cell based assay model
Toxicology Letters 221
Supplement: S82
Human bioaccumulation potential simulated in R and implemented into KNIME interface
Toxicology Letters 221
Supplement: S82
Molecular modelling of LXR binding to evaluate the potential for liver steatosis
Toxicology Letters 221
Supplement: S83
Multi-scale modeling for individualized spatiotemporal prediction of drug effects
Toxicology Letters 221
Supplement: S83-84
Toward better understanding of liver steatosis MoA: Molecular modelling study of PPAR gamma receptor
Toxicology Letters 221
Supplement: S85
Improved in silico methods to group liver toxicants related to Adverse Outcome Pathways
The Toxicologist – A Supplement to Toxicological Sciences
132: 189
Flexible and transparent computational workflows for the prediction of target organ toxicity
The Toxicologist – A Supplement to Toxicological Sciences
132: 183
Development of a COSMOS Database to support in silico modelling for cosmetics ingredients and related chemicals
The Toxicologist – A Supplement to Toxicological Sciences
132: 185
Multiscale modeling for individualized spatiotemporal prediction of drug effects
The Toxicologist – A Supplement to Toxicological Sciences
132: 118
Integrated in silico modeling for the prediction of chronic toxicity
International Journal of Toxicology
32: 72-73
Linking chemical categories to adverse outcome pathways for chronic toxicity
International Journal of Toxicology
32: 65
Toxicity risk assessment from heterogeneous uncertain data with possibility-probability distribution
Proceedings of the 2013 IEEE International Conference on Fuzzy Systems (FUZZ), Hyderabad, India.
1-8
COSMOS: Integrated in Silico Models for the Prediction of Human Repeated Dose Toxicity of COSMetics to Optimise Safety.
Gocht T, Schwarz M (eds) Towards the replacement of in vivo repeated dose systemic toxicity testing.
Volume 3, pp. 146-178
Molecular modelling to predict and understand chemical toxicity in the AOP framework – Case study: MoA from LXR activation to liver steatosis.
Gocht T, Schwarz M (eds) Towards the replacement of in vivo repeated dose systemic toxicity testing.
Volume 3, pp. 249-252
Human bioaccumulation potential simulated in R and implemented in the KNIME interface
Gocht T, Schwarz M (eds) Towards the replacement of in vivo repeated dose systemic toxicity testing.
Volume 3, pp. 253-256
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis.
John Wiley and Sons Ltd, United Kingdom
Hepatology, Vol. 58/Issue 5
pp. 1742-1756
Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury
Oxford University Press, United Kingdom
Toxicological Sciences, Vol. 136/Issue 1
pp. 97-106
The adverse outcome pathway concept: A pragmatic tool in toxicology
Elsevier, Ireland Ltd
Toxicology, Vol. 312
pp. 158-165
Drug-Induced Liver Injury: Mechanisms, Types and Biomarkers
Bentham Science Publishers B.V., Netherlands
Current Medicinal Chemistry, Vol. 20/Issue 24
pp. 3011-3021
Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters
Informa Healthcare, United Kingdom
Drug Metabolism Reviews, Vol. 45/Issue 2
pp. 196-217
Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells
Elsevier Inc.
Biochemical Pharmacology, Vol. 86/Issue 5
pp. 691-702
A Novel 3D Label-Free Monitoring System of hES-Derived Cardiomyocyte Clusters: A Step Forward to In Vitro Cardiotoxicity Testing
Public Library of Science, United States
PLoS One, Vol. 8/Issue 7
pp. 145-156
Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor
Mary Ann Liebert Inc. Publishers, United States
Stem Cells and Development, Vol. 22/Issue 4
pp. 581-594
Quantitative Evaluation and Prediction of Drug Effects and Toxicological Risk Using Mechanistic Multiscale Models
Wiley - VCH Verlag GmbH & CO. KGaA
Molecular Informatics, 1/32
14 - 23
In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes
Oxford University Press, United Kingdom
Nucleic Acids Research, 6/41
e72 - e72
A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk
Frontiers Research Foundation
Frontiers in Pharmacology
3D Hepatic In Vitro Models as Tools for Toxicity Studies
Bentham Science Publishers B.V., Netherlands
Current Tissue Engineering, Vol. 2/Issue 1
78-89
3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies
Oxford University Press
Toxicological Sciences, 1/133
67 - 78
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
Springer Verlag, Germany
Archives of Toxicology, 2/87
337 - 345
Stable isotope-assisted metabolomics to detect metabolic flux changes in mammalian cell cultures
Elsevier Limited
Current Opinion in Biotechnology, 1 / 24
54 - 59
Bi-PROF: Bisulfite profiling of target regions using 454 GS FLX Titanium technology
Landes Bioscience
Epigenetics, Vol. 8/Issue 7
765-771
3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
Elsevier Limited
Toxicology in Vitro, Vol. 28/Issue 1
104-112
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
Springer Verlag, Germany
Archives of Toxicology, Vol. 87/Issue 8
1315-1530
Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study
John Wiley and Sons Ltd, United Kingdom
Journal of Applied Toxicology
Analysis of Initial Cell Spreading Using Mechanistic Contact Formulations for a Deformable Cell Model
Public Library of Science, United States
PLoS Computational Biology, 10 / 9
Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies
Archives of Toxicology 87(4)
pp. 577-610
Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures
Archives of Toxicology 87(5)
883-94
Primary hepatocytes and their cultures in liver apoptosis research
Springer
Archives of Toxicology 88 (2)
pp. 199-212
Way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance?
Elsevier
Toxicology In Vitro 28 (1)
pp. 54-59
SEURAT-1: Development of a research strategy for the replacement of in vivo repeated dose systemic toxicity testing
AltTox.org
Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury
Toxicol. Sci. 136
pp. 97-106
In vitro - in vivo correlation of gene expression
Bentham Science Publishers
Current Medicinal Chemistry
pp. 1721-30
PMID: 2241
Modifications in connexin expression in liver development and cancer
Informa Healthcare
Cell Communication and Adhesion
p.55-62
DOI:10.3109/15419061.2012.712576
Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies
Springer
Archives of Toxicology
pp. 577-610
DOI: 10.1007/s0024-012-0983-3
Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures
Springer
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