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The projects constituting the SEURAT-1 research initiative have received funding from the European Union Seventh Framework Programme (FP7/2007-2013). The projects constituting the SEURAT-1 research initiative have received financing from Cosmetics Europe.

Background

A full ban of animal testing for cosmetics came into force on the 11th of March 2013 in the European Union. Since this date, cosmetic ingredients tested on animals cannot be marketed within the EU. Based on the Seventh Amendment of the Cos­me­tics Directive (Council Directive 76/768/EEC), animal testing was already prohibited since 2004 for cosmetic products and since 2009 for cosmetic ingredients. For the most complex human health effects (repeated-dose toxicity including skin sensitisation and carcinogenicity, reproductive toxicity and toxicokinetics) the deadline for the testing ban was extended to March 2013.

To overcome the lack of scientific knowledge needed to implement alternative safety testing solutions, the Health Theme of the Directorate General of Research and Innovation of the European Commission and Cosmetics Europe launched the Research Initiative "Towards the replacement ofin vivo repeated dose systemic toxicity testing".

Repeated dose systemic toxicity testing is not only relevant for the ingredients of cosmetic products. If successful, the results of this Research Initiative will have an impact on many other areas of application such as drug development, food production, and safety assessment of industrial chemicals, plant protection products and biocides.

In June 2009 the framework for this Research Initiative was created through a call for proposals under the Health Theme of the 7th European RTD Framework Programme (FP7): ”Alternative Testing Strategies: Towards the replacement of in vivo repeated dose systemic toxicity testing” with a total budget of EUR 50 million.

EUR 25 million funding are provided by the FP7 HEALTH theme and EUR 25 million by Cosmetics Europe. 

The SEURAT-1 Research Initiative is unique in several aspects:

  • Joint funding by the European Commission and a specific industrial sector (cosmetics industry / Cosmetics Europe)
  • Coordinated cluster of RTD projects right from the start
  • Support through a data management and servicing project right from the start

The SEURAT-1 Research Initiative has started in January 2011 and even though the SEURAT-1 Research Initiative was initially motivated by the cosmetic industry, it is also relevant in the context of the European Union Regulation REACH (Registration, Evaluation, Authorization and Restriction of Chemicals), in the development of pharmaceuticals, and in other industrial sectors. SEURAT-1 is the first EU-funded project that addresses the issue of alternatives to animal testing for prediction of repeated dose systemic toxicity.